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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Myocardium (1):
Recent article
Myocardium
Abstract
Injectable hydrogels are being developed as potential translatable materials to influence the cascade of events that occur after myocardial infarction. These hydrogels, consisting of both synthetic and natural materials, form through numerous chemical crosslinking and assembly mechan...
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PMID: 21710332
PDF is available here.
PDF is available here.
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Abstract
We demonstrate for the first time that HD-induced diabetes diminished both AMPK-dependent and AMPK-independent APN cardioprotection, suggesting an unreported diabetic heart APN resistance....
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PMID: 21091073
PDF is available here.
PDF is available here.
Abstract
Recent pre-clinical and clinical studies indicate that certain exogenous stem cells and biomaterials can preserve cardiac tissue after myocardial infarction. Regarding stem cells, a growing body of data suggests that the short-term positive outcomes are mainly attributed to paracrine...
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PMID: 21735303
PDF is available here.
PDF is available here.
Abstract
We describe different strategies such as direct injection of cells and/or biomaterials as well as direct replacement therapies with tissue mimics. In this regard, the latest research has shown promising results demonstrating the improvement of cardiac function with different strategies. It is clear...
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PMID: 21748529
PDF is available here.
PDF is available here.
Abstract
Tissue-engineered cardiac constructs are a high potential therapy for treating myocardial infarction. These therapies have the ability to regenerate or recreate functional myocardium following the infarction, restoring some of the lost function of the heart and thereby preventing con...
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PMID: 21818697
PDF is available here.
PDF is available here.
Biomedical Materials (6)5 2011
Abstract
Our studies strengthen the application of electrospun PLGA/Gel nanofibers as a bio-mechanical support for injured myocardium and as a potential substrate for induction of endogenous cardiomyocyte proliferation, ultimately reducing the cardiac dysfunction and improving cardiac remodeling....
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PMID: 21813957
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Circulation (124)11 Suppl 2011
Abstract
We performed a cell trafficking experiment, which demonstrated significantly greater recruitment of bone marrow cells to the ischemic myocardium in the double-knockdown group. Fluorescence-activated cell sorting showed significantly higher activation of endogenous c-kit(+) cardiac progenitor cells....
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PMID: 21911818
PDF is available here.
PDF is available here.
Abstract
We concluded that fibroblast activity correlates to the viability of the tissue rather than to the specific drug used for immunosuppression.
© 2011 The Authors. APMIS © 2011 APMIS....
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PMID: 21851416
PDF is available here.
PDF is available here.
Journal of Cell Biology (194)3 2011
Abstract
The heart exhibits remarkable adaptive responses to a wide array of genetic and extrinsic factors to maintain contractile function. When compensatory responses are not sustainable, cardiac dysfunction occurs, leading to cardiomyopathy. The many forms of cardiomyopathy exhibit a set o...
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PMID: 21825071
PDF is available here.
PDF is available here.
Circulation Research (109)4 2011
Abstract
Acta Biomaterialia (7)8 2011
Abstract
The objective of the present in vitro research was to investigate cardiac tissue cell functions (specifically cardiomyocytes and neurons) on poly(lactic-co-glycolic acid) (PLGA) (50:50 wt.%)-carbon nanofiber (CNF) composites to ascertain their potential for myocardial tissue engineer...
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PMID: 21571106
PDF is available here.
PDF is available here.
Abstract
We have investigated the evolution of myocardial leptin expression following myocardial infarction (MI) and evaluated the consequences of specific cardiac leptin inhibition on subsequent LV dysfunction. Anaesthetized rats were subjected to temporary coronary occlusion. An antisense oligodesoxynucleo...
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PMID: 20731748
PDF is available here.
PDF is available here.
Abstract
I (IGF-1) levels are closely associated with cardiac performance although the role of IGF-1 in alcoholic cardiac dysfunction is unknown. This study was designed to evaluate the impact of severe liver IGF-1 deficiency (LID) on chronic alcohol-induced cardiomyocyte contractile and intracellular Ca(2+)...
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PMID: 20731752
PDF is available here.
PDF is available here.
Proteomics (11)16 2011
Abstract
We analysed hearts of HCRs and LCRs from generation 22 of selection using DIGE and identified proteins from MS database searches. The running capacity of HCRs was six-fold greater than LCRs. DIGE resolved 957 spots and proteins were unambiguously identified in 369 spots. Protein expression profiling...
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PMID: 21751351
PDF is available here.
PDF is available here.
Abstract
Experimental data indicate that moderate uncoupling oxidative phosphorylation induces reduction in production of reactive oxygen species (ROS) and promotes an increase in survival of neurons and cardiomyocytes under hypoxia and re-oxygenation conditions. Uncoupling proteins (UCP) are...
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PMID: 21961301
PDF is available here.
PDF is available here.
Abstract
Stress cardiomyopathy (SC) is a transient form of acute heart failure triggered by stressful events and associated with a distinctive left ventricular (LV) contraction pattern. Various aspects of its clinical profile have been described in small single-center populations, but larger,...
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PMID: 21771988
PDF is available here.
PDF is available here.
Abstract
We reported an in vitro test-bed for screening cell integration between injected test cells and host CM using the engineered heart tissue as a recipient. The objective of this study is to expand our system to diabetic cardiomyopathy conditions. Patients with diabetes show dysfunction of CMs independ...
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PMID: 21417718
PDF is available here.
PDF is available here.
Abstract
We investigated the effects of Tan IIA on cardiac hypertrophy and fibrosis in two-kidney, two-clip (2K2C) hypertensive rats and by which, if any, mechanisms. Administration of 2K2C hypertensive rats with Tan IIA attenuated cardiac dysfunction and fibrosis. However Tan IIA treatment had no effects on...
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PMID: 21812327
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of stable over-expression of constitutively active HIF-1α on cardiosphere-derived cell (CDC) engraftment and left ventricular function. CDCs were transduced with a lentivirus expressing a constitutively active mutant of human HIF-1α (LVHIF-1α). Two million male rat CDCs...
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PMID: 21538185
PDF is available here.
PDF is available here.
Abstract
Cell therapy has developed as a complementary treatment for myocardial regeneration. While both autologous and allogeneic uses have been advocated, the ideal candidate has not been identified yet. Amniotic fluid-derived stem (AFS) cells are potentially a promising resource for cell t...
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PMID: 21120638
PDF is available here.
PDF is available here.
Abstract
We review the possible mechanisms of PSC-derived cardiomyocytes rejection, summarize the current knowledge pertaining to immunogenicity of such cells and describe the existing controversies. Myocardial graft rejection can be reduced by modifying PSCs prior to their differentiation into cardiomyocyte...
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PMID: 21086071
PDF is available here.
PDF is available here.
Abstract
We found that field stimulation using symmetric biphasic square pulses at 2.5 V/cm, 1 Hz, 1 ms (per pulse phase) was an improved stimulation protocol, as compared to no stimulation and stimulation using monophasic square pulses of identical total amplitude and duration (5 V/cm, 1 Hz, 2 m...
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PMID: 18783322
PDF is available here.
PDF is available here.
Abstract
We observed decreased levels of mitochondrial proteins involved in oxidative phosphorylation and tricarboxylic acid cycle. Furthermore, deregulation of proteins of carbohydrate metabolism, the actin cytoskeleton, and extracellular matrix remodeling was observed. Proteomic observations were confirmed...
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PMID: 21417265
PDF is available here.
PDF is available here.
Abstract
We investigated whether microdialysis results obtained from epicardial (surface) sampling reflect acute changes in the same way as myocardial sampling from within the substance of the ventricular wall. In anaesthetized open-thorax pigs a coronary snare was placed. One microdialysis probe was placed...
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PMID: 21091606
PDF is available here.
PDF is available here.
Abstract
Heart failure remains the leading cause of death in many industrialized nations owing to the inability of the myocardial tissue to regenerate. The main objective of this work was to develop a cardiac patch that is biocompatible and matches the mechanical properties of the heart muscl...
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PMID: 21247338
PDF is available here.
PDF is available here.
New England Journal of Medicine (364)17 2011
Abstract
New England Journal of Medicine (364)15 2011
Abstract
Cytotherapy (13)4 2011
Abstract
For many years the human heart has been considered a terminally differentiated organ with no regenerative potential after injury. Recent studies, however, have cast doubt on this long-standing dogma. The objective of this study was to investigate the presence of and characterize mese...
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PMID: 21090918
PDF is available here.
PDF is available here.
Abstract
We observed that MMP-10 and -7 abundance increased, accompanied by decreased TIMP-4 in DCM failing hearts (n= 8) compared with non-failing hearts (n= 8). The results were further validated in a cohort of 34 end-stage HF patients derived from three forms of cardiomyopathies. Cardiac and plasma MMP-10...
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PMID: 20219015
PDF is available here.
PDF is available here.
Abstract
We observed that MMP-10 and -7 abundance increased, accompanied by decreased TIMP-4 in DCM failing hearts (n= 8) compared with non-failing hearts (n= 8). The results were further validated in a cohort of 34 end-stage HF patients derived from three forms of cardiomyopathies. Cardiac and plasma MMP-10...
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PMID: 20219015
PDF is available here.
PDF is available here.
Abstract
We show that although MSCs effectively engraft in AMI tissue, this engraftment leads to downregulation of CP expression in the implanted MSCs. We also found that pretransplantation cardiac specification of MSCs by exposure of the cells to transforming growth factor beta 1 (TGF-β1) led to sustained...
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PMID: 20666606
PDF is available here.
PDF is available here.
Abstract
Velocity vector imaging of the LA was acquired from apical four- and two-chamber views in 41 normal and 43 subjects with chronic MR due to MMVD. All had normal left ventricular systolic function. The LA subendocardium was traced to obtain atrial volumes, ejection fraction, velocities, and strain (ε...
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PMID: 21447498
PDF is available here.
PDF is available here.
Abstract
We investigated whether alterations in cardiac energy metabolism contribute to the cardioprotective effects induced by CR. Hearts from control or short-term CR mice were subjected to ex vivo I/R and metabolism, as well as post-ischemic functional recovery was measured. Even in the presence of elevat...
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PMID: 21140129
PDF is available here.
PDF is available here.
Abstract
To evaluate the effects of angiopoietin-1 (Ang-1) on myocardial endothelial cell function under high glucose (HG) condition.
Mouse heart myocardial endothelial cells (MHMECs) were cultured and incubated under HG (25 mmol/L) or normal glucose (NG, 5 mmol/L) conditions...
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PMID: 21113176
PDF is available here.
PDF is available here.
Abstract
Abstract
We describe the generation of fibrin-based EHT from a transgenic rat strain with ubiquitous expression of firefly luciferase (ROSA/luciferase-LEW Tg; ). Implantation is performed into the greater omentum of different rat strains to assess immune responses of the recipient organism following EHT impl...
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PMID: 21673633
PDF is available here.
PDF is available here.
Acta Biomaterialia (7)1 2011
Abstract
Cardiac tissue engineering aims to regenerate damaged myocardial tissues by applying heart patches created in vitro. The present study was undertaken to explore the possible role of matrix-attached RGD peptide in the engineering of cardiac tissue within macroporous scaffolds. Neonata...
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PMID: 20688198
PDF is available here.
PDF is available here.
Abstract
We discuss ways whereby we sought to treat myocardial infarctions using extracellular-matrix derived peptides. Using an ischemia/reperfusion myocardial infarction rodent model, we targeted these extracellular matrix-derived peptides to the myocardial infarct site and were able to induce angiogenesis...
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PMID: 21048428
PDF is available here.
PDF is available here.
Abstract
We show for the first time the ability to bio-electrospray the three major cell types of the myocardium, both independently and simultaneously, for forming a fully functional cardiac tissue. Several samples are characterized in vitro and found to be indistinguishable in comparison to controls. Thus,...
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PMID: 21053334
PDF is available here.
PDF is available here.
Abstract
The hexosamine biosynthesis pathway (HBP) flux and protein O-linked N-acetyl-glucosamine (O-GlcNAc) levels have been implicated in mediating the adverse effects of diabetes in the cardiovascular system. Activation of these pathways with glucosamine has been shown to mimic some of the...
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PMID: 21494549
PDF is available here.
PDF is available here.
Abstract
We have generated a zebrafish line carrying a stop mutation in the kinase domain of the Tie-2 receptor. Mutant embryos lack Tie-2 protein, but do not display any defect in heart and vessel development. Simultaneous loss of Tie-1 and Tie-2, however, leads to a cardiac phenotype. Our study shows that...
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PMID: 21045210
PDF is available here.
PDF is available here.
Abstract
We performed two-dimensional polyacrylamide gel electrophoresis to determine differentially expressed proteins. Peptides of interest were further analysed by mass spectrometry and Mascot software was employed to identify protein matches.
Our data showed that ATP synthase D chain, ubi...
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PMID: 20859605
PDF is available here.
PDF is available here.
Abstract
We evaluated the effects of exogenous apoA-I expression on cardiac differentiation of ESCs and maturation of ESC-derived cardiomyocytes. We stably over-expressed full-length human apoA-I cDNA with lentivirus (LV)-mediated gene transfer in undifferentiated mouse ESCs and human induced pluripotent ste...
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PMID: 21589943
PDF is available here.
PDF is available here.
Trends in Cell Biology (21)1 2011
Abstract
We discuss the current evolutionary, biochemical, and functional data for the nebulin family of proteins - a family whose members, both large and small, function as cytoskeletal scaffolds and stabilizers.
Copyright © 2010 Elsevier Ltd. All rights reserved....
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PMID: 20951588
PDF is available here.
PDF is available here.
Abstract
Delayed ventricular repolarization, as measured by a prolongation of the QT interval on the electrocardiogram, is a major safety issue in the drug development process. It is now recognized that most cases of drug-induced QT prolongation arise from direct pharmacological inhibition of the human ether...
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PMID: 20972752
PDF is available here.
PDF is available here.
Abstract
We showed that C/EBPβ was downregulated with exercise, whereas the expression of CITED4 was increased. Reduction of C/EBPβ in vitro and in vivo resulted in a phenocopy of endurance exercise with cardiomyocyte hypertrophy and proliferation. This proliferation was mediated, at least in part, by the...
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PMID: 21183071
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)52 2010
Abstract
Abstract
We found that hypoxia significantly increased the mobilisation of Ca(2+) from intracellular stores in response to BK whilst capacitative Ca(2+) entry (CCE) remained unchanged. The enhanced store mobilisation was due to a striking increase in CMF intracellular Ca(2+)-store content under hypoxic condi...
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PMID: 21094145
PDF is available here.
PDF is available here.
Abstract
Detectable levels of cardiac troponin T (cTnT) are strongly associated with structural heart disease and increased risk of death and adverse cardiovascular events; however, cTnT is rarely detectable in the general population using standard assays.
To determine the prevalence and determinants of dete...
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PMID: 21139111
PDF is available here.
PDF is available here.
Abstract
Systemic available circulating cells play a role in cardiac maintenance and ameliorate cardiac recovery and repair after myocardial infarction. However, only a small number of cells will be incorporated during cardiac damage. Cell mobilization, homing to the ischemic myocardium and e...
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PMID: 20528755
PDF is available here.
PDF is available here.
Abstract
Nuclear reprogramming of somatic cells with ectopic stemness factors to bioengineer pluripotent autologous stem cells signals a new era in regenerative medicine. The study of developmental biology has provided a roadmap for cardiac differentiation from embryonic tissue formation to a...
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PMID: 20956984
PDF is available here.
PDF is available here.
Cardiology in the Young (20)6 2010
Abstract
We evaluated the long-term histopathology of the myocardium, especially of intramural small vessels in asymptomatic Kawasaki disease with giant aneurysms.
The initial study comprised 16 consecutive Kawasaki patients - male-to-female ratio was 12:4 - aged from 2 to 12 years, and in the subsequent stu...
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PMID: 20584347
PDF is available here.
PDF is available here.
Anesthesiology (113)6 2010
Abstract
The concentration-response and time-response relationships of lipid emulsions used to reverse bupivacaine-induced asystole are poorly defined.
Concentration response across a range of lipid concentrations (0-16%) to reverse bupivacaine-induced asystole were observed using isolated rat heart Langendo...
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PMID: 21068661
PDF is available here.
PDF is available here.
Anesthesiology (113)6 2010
Abstract
We investigated (1) whether SevoPC is strengthened by multiple preconditioning cycles, (2) whether SevoPC is blocked by aprotinin, and (3) whether endothelial NOS plays a crucial role in SevoPC.
Anesthetized male Wistar rats were randomized to 15 groups (each n = 6) and underwent 25-min regional myo...
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PMID: 21068666
PDF is available here.
PDF is available here.
Abstract
The efficacy of mesenchymal stem cell (MSC) therapy for myocardial regeneration is limited by the poor survival of stem cells after transplantation into the infarcted heart. To improve the cell survival of MSCs in the infarcted heart, MSCs were genetically engineered to overexpress phosphoinositide-...
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PMID: 20937252
PDF is available here.
PDF is available here.
Macromolecular Bioscience (10)11 2010
Abstract
We combined micromolding and microablation technologies to create muscle tissue engineering scaffolds from the biodegradable elastomer poly(glycerol sebacate). These scaffolds exhibited well defined surface patterns and pores and robust elastomeric tensile mechanical properties. Cultured C2C12 muscl...
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PMID: 20718054
PDF is available here.
PDF is available here.
Macromolecular Bioscience (10)11 2010
Abstract
We focus on biomaterial scaffolds designed to mediate the development and maturation of vascular networks, by immobilized growth factors. The interactive effects of multiple vasculogenic factors are discussed in the context of cardiac tissue engineering....
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PMID: 20857391
PDF is available here.
PDF is available here.