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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Neoplasms (16):
- Neoplasms, Second Primary
- Neoplasms, Hormone-Dependent
- Neoplasms, Experimental
- Tumor Virus Infections
- Pregnancy Complications, Neoplastic
- Neoplasms by Histologic Type
- Hamartoma
- Cysts
- Neoplasms, Multiple Primary
- Neoplasms, Post-Traumatic
- Paraneoplastic Syndromes
- Neoplasms, Radiation-Induced
- Neoplasms by Site
- Precancerous Conditions
- Neoplastic Processes
- Neoplastic Syndromes, Hereditary
Recent article
Neoplasms
Cancer Research (71)22 2011
Abstract
We developed a curated database of 88 nuclear receptor cistrome data sets and other associated high-throughput data sets including 121 collaborating factor cistromes, 94 epigenomes, and 319 transcriptomes. Through integrative analysis of the curated nuclear receptor ChIP-chip/seq data sets, we disco...
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PMID: 21940749
PDF is available here.
PDF is available here.
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Journal of Biological Chemistry (286)44 2011
Abstract
We report here that testicular nuclear receptor 4 (TR4), a member of the nuclear receptor family, modulates DNA repair specifically through the transcription-coupled (TC) NER pathway but not the global genomic NER pathway. The level of Cockayne syndrome B protein (CSB), a member of the TC-NER pathwa...
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PMID: 21918225
PDF is available here.
PDF is available here.
Abstract
Solid organ transplant recipients have elevated cancer risk due to immunosuppression and oncogenic viral infections. Because most prior research has concerned kidney recipients, large studies that include recipients of differing organs can inform cancer etiology.
To d...
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PMID: 22045767
PDF is available here.
PDF is available here.
The Lancet (378)9798 2011
Abstract
Psycho-Oncology (20 Suppl 1) 2011
Abstract
Tumor Biology (32 Suppl 1) 2011
Abstract
Abstract
This paper in the series from the World Congress of Gastroenterology addresses the safety and immunogenicity of biological therapy. The safety profile in randomized controlled studies of all biological agents in Crohn's disease (CD) and ulcerative colitis has been generally favorable...
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PMID: 21844919
PDF is available here.
PDF is available here.
Abstract
This paper in the series from the World Congress of Gastroenterology addresses the safety and immunogenicity of biological therapy. The safety profile in randomized controlled studies of all biological agents in Crohn's disease (CD) and ulcerative colitis has been generally favorable...
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PMID: 21844919
PDF is available here.
PDF is available here.
Abstract
Abstract
Junctional adhesion molecules are transmembrane proteins that belong to the immunoglobulin superfamily. In addition to their localization in close proximity to the tight junctions in endothelial and epithelial cells, junctional adhesion molecules are also expressed in circulating cel...
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PMID: 21254840
PDF is available here.
PDF is available here.
Abstract
Polyethylenimine-cyclodextrin-tegafur (PEI-CyD-tegafur) conjugate was synthesized as a novel multifunctional prodrug of tegafur for co-delivery of chemotherapeutic agent tegafur and enhanced green fluorescent protein (EGFP) reporter plasmid DNA. Conjugation of tegafur to PEI-CyD via...
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PMID: 21887847
PDF is available here.
PDF is available here.
Milbank Quarterly (89)3 2011
Abstract
We examined agency experiences through three distinct lenses: (1) the nature of the actors (both human and nonhuman), (2) the nature of the actions, and (3) the nature of the domains for action. The actors were individuals and teams, drugs and technologies, and the cancer itself. Actions could be in...
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PMID: 21933273
PDF is available here.
PDF is available here.
Abstract
I studies. Significant progress has been made in the last 2 years both in the development of novel immunobiologics such as CARs, and in establishing survival benefits of an anti-GD2 monoclonal antibody in randomized studies. Although there is much excitement going forward, a great deal of laboratory...
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PMID: 21854215
PDF is available here.
PDF is available here.
Abstract
We investigated the protective effect of oral rehydration solution(ORS)against CDDP-induced nephrotoxicity, and found that ORS could be beneficial to outpatients for oral hydration. Male F344 rats were intraperitoneally injected with 2mg/kg once a week for 9 weeks. Sixty mL/kg/day of water or ORS we...
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PMID: 21918344
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
We examined the effects of aneuploidy on genomic stability. We analyzed 13 budding yeast strains that carry extra copies of single chromosomes and found that all aneuploid strains exhibited one or more forms of genomic instability. Most strains displayed increased chromosome loss and mitotic recombi...
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PMID: 21852501
PDF is available here.
PDF is available here.
Abstract
We have identified a clue to the mechanistic origins of aneuploidy through integrative genomic analyses of human tumors. A diverse range of tumor types were found to harbor deletions or inactivating mutations of STAG2, a gene encoding a subunit of the cohesin complex, which regulates the separation...
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PMID: 21852505
PDF is available here.
PDF is available here.
British Journal of Cancer (105)5 2011
Abstract
We reviewed 861 episodes of FN in outpatients with solid tumours, including 692 (80%) episodes with apparent clinical stability. We aimed to investigate the prognosis of this latter group and explore the possibility of stratifying it according to the presenting features. A case-control study was per...
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PMID: 21811253
PDF is available here.
PDF is available here.
Abstract
Abstract
Most of patients with hematological malignancies are elderly (more than 60 years). Allogeneic stem cell transplantation is an important and effective treatment for most of these diseases. However, the toxicity and the supposed frailty of elderly patients, have limited the applicability of allogene...
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PMID: 21835732
PDF is available here.
PDF is available here.
Nature Medicine (17)8 2011
Abstract
Hereditas (Beijing) (33)8 2011
Abstract
We focus on the miRNA-related genetic variations and cancer susceptibility and progression....
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PMID: 21831803
PDF is available here.
PDF is available here.
Hereditas (Beijing) (33)8 2011
Abstract
We review the recent development of these algorithms and models; then list the related software and data sources; and finally discuss the existence problems and perspectives in this field....
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PMID: 21831798
PDF is available here.
PDF is available here.
Abstract
The Quantitative Assay Database (QuAD), http://proteome.moffitt.org/QUAD/, facilitates widespread implementation of quantitative mass spectrometry in cancer biology and clinical research through sharing of methods and reagents for monitoring protein expression and modification....
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PMID: 21656910
PDF is available here.
PDF is available here.
Abstract
We will discuss the involvement of the CD40 ligand/CD40 interaction in the pathophysiology of inflammatory diseases, including autoimmune diseases, atherothrombosis, cancer, and respiratory diseases....
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PMID: 21928689
PDF is available here.
PDF is available here.
Abstract
The Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study) is a long-term cohort study to investigate the interactions among genotypes, lifestyles, and lifestyle-related diseases, especially cancer. This article reports the outline of the baseline survey of the Daiko Stu...
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PMID: 21928700
PDF is available here.
PDF is available here.
Abstract
Patient navigation is an intervention aimed at reducing barriers to health care for underserved populations as a means to reduce cancer health disparities. Despite the proliferation of patient navigation programs across the United States, information related to the economic impact an...
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PMID: 21780096
PDF is available here.
PDF is available here.
Abstract
We developed a monoclonal antibody (mAb) against the extracellular domain of B7-H4 through immunization of Balb/c mice with 3T3-mB7-H4 cells which expressed extrinsic B7-H4. A stable hybridoma cell line was established. Then, we analysed the characterization of the mAb through Enzyme linked immunoso...
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PMID: 21813370
PDF is available here.
PDF is available here.
Abstract
The eIF2α kinases integrate translation initiation rates with nutrient availability, thus allowing cells to adapt to nutrient scarcity. Recent evidence has uncovered new functions of these kinases in tumour cell biology, ranging from regulation of cell cycle progression, maintenance...
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PMID: 21775270
PDF is available here.
PDF is available here.
Abstract
Integrative Biology (3)7 2011
Abstract
We now routinely scan cells and organisms at practically all levels, from genome to protein, metabolism, signaling and other cellular functions. This methodology allowed biological studies to move from a reductionist approach, such as isolation of specific pathways and mechanisms, to a more integrat...
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PMID: 21674097
PDF is available here.
PDF is available here.
Abstract
Hematopoietic stem cells (HSCs) differentiate into mature lineage restricted blood cells under the influence of a complex network of hematopoietic cytokines, cytokine-mediated transcriptional regulators, and manifold intercellular signaling pathways. The classical model of hematopoie...
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PMID: 21426948
PDF is available here.
PDF is available here.
Abstract
Recent investigations of regulatory myeloid cell mobilization and amplification in response to cancer and chronic inflammation associated with infectious disease and autoimmunity have provided numerous insights into the suppressive mechanisms, pathobiology and potential pharmaceutica...
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PMID: 21315784
PDF is available here.
PDF is available here.
Abstract
Multifunctional lipid nanoemulsions have shown to combine several advantages e.g. tissue targeting, cell targeting, imaging analysis, barrier permeability enhancement, and therapeutic purposes. Depending on the choice of lipid composition, surfactants and additional surface modifiers...
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PMID: 21812320
PDF is available here.
PDF is available here.
Cancer Letters (305)2 2011
Abstract
We discuss the evidence suggesting a causal relationship between selected infectious agents and the pro-tumoral reprogramming of inflammatory cells, as well as its significance in tumor development. Finally, we discuss the implications of this phenomenon for both cancer prevention and therapy....
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PMID: 21093147
PDF is available here.
PDF is available here.
Abstract
We applied multilayered polyelectrolyte assemblies on nanoparticles to create viable systemic delivery systems. Focusing on tumor-specific delivery, LbL nanoparticles that exhibit a pH-sensitive outer stealth layer are demonstrated to target and be retained in hypoxic tumor regions. The neutral laye...
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PMID: 21513353
PDF is available here.
PDF is available here.
Abstract
We applied multilayered polyelectrolyte assemblies on nanoparticles to create viable systemic delivery systems. Focusing on tumor-specific delivery, LbL nanoparticles that exhibit a pH-sensitive outer stealth layer are demonstrated to target and be retained in hypoxic tumor regions. The neutral laye...
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PMID: 21513353
PDF is available here.
PDF is available here.
Biomacromolecules (12)6 2011
Abstract
Currently, biomedical engineering is rapidly expanding, especially in the areas of drug delivery, gene transfer, tissue engineering, and regenerative medicine. A prerequisite for further development is the design and synthesis of novel multifunctional biomaterials that are biocompati...
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PMID: 21469742
PDF is available here.
PDF is available here.
Abstract
Survivors of childhood cancer are at excess risk of developing subsequent primary neoplasms but the long-term risks are uncertain.
To investigate long-term risks of subsequent primary neoplasms in survivors of childhood cancer, to identify the types that contribute mo...
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PMID: 21642683
PDF is available here.
PDF is available here.
New England Journal of Medicine (364)23 2011
Abstract
New England Journal of Medicine (364)23 2011
Abstract
New England Journal of Medicine (364)23 2011
Abstract
Abstract
Integration of cellular and extracellular signals maintains tissue homeostasis under conditions of normal proliferation and stress. A central player in regulating responses to stress is the serine/threonine kinase mammalian target of rapamycin (mTOR). In many cancers, mTOR complex 1...
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PMID: 21499767
PDF is available here.
PDF is available here.
Abstract
In the quest for personalized medicine, only a few biological parameters are routinely used to select patients prior to the initiation of anticancer targeted therapies, including mTOR inhibitors. Identifying biological factors that may predict efficacy or resistance to mTOR inhibitor...
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PMID: 21533544
PDF is available here.
PDF is available here.
Abstract
The activation of the phosphatidylinositol 3 kinase (PI3K)-Akt pathway is a known causal mechanism of oncogenesis and resistance to cancer treatments. The process of PI3K-Akt pathway activation is complex and includes receptor tyrosine kinase(RTK) activation, PIK3CA mutations, loss o...
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PMID: 21547565
PDF is available here.
PDF is available here.
Abstract
We have investigated whether or not the novel and promising hypoxia-selective cytotoxin 4-[3-(2-nitro-1-imidazolyl)-propylamino]-7-chloroquinoline hydrochloride (NLCQ-1, NSC 709257) can cause hypoxia-dependent retinal toxicity in BALB/c mice alone or in combination with cyclophosphamide (CPM), one o...
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PMID: 21205223
PDF is available here.
PDF is available here.
Abstract
We have developed multifunctional nanomicelles for both drug and gene delivery application. Polyethylenimine (PEI) was modified by grafting stearic acid (SA) and further formulated to polymeric micelles (PEI-SA) with positive surface charge for gene delivery evaluation. Our results showed that PEI-S...
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PMID: 21465641
PDF is available here.
PDF is available here.
Oncotarget (2)6 2011
Abstract
STAT transcription factors transduce signals from the cell surface to the nucleus, where they regulate the expression of genes that control proliferation, survival, self-renewal, and other critical cellular functions. Under normal physiological conditions, the activation of STATs is...
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PMID: 21680956
PDF is available here.
PDF is available here.
Abstract
The cancer preventive activities of tea (Camellia sinensis, Theaceae) have been demonstrated in animal models for cancers at different organ sites and suggested by some epidemiological studies. Many mechanisms for cancer prevention have been proposed based on studies in cell lines, w...
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PMID: 21538856
PDF is available here.
PDF is available here.
New England Journal of Medicine (364)21 2011
Abstract
Cancer Biology & Therapy (11)10 2011
Abstract
We developed a new tumor vaccine, FAPτ-MT, which was produced by conjugating 1-MT to a tumor associated antigen, fibroblast activation protein α (FAPα). The results in vitro confirmed that 1-MT could be dissociated from the FAPτ-MT vaccine and inhibit intracellular IDO activity. In an FAPα-posi...
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PMID: 21372637
PDF is available here.
PDF is available here.
MMW Fortschritte der Medizin (153)19 2011
Abstract
New England Journal of Medicine (364)19 2011
Abstract
Abstract
We now report an in-depth assessment of the toxicity of cyclophosphamide during the year of therapy and the year after therapy was completed, during which time the investigators were still masked to the treatment assignment....
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PMID: 21531236
PDF is available here.
PDF is available here.
Abstract
We highlight some recent data on the transcriptional regulation of hyaluronan synthase (Has1-3) expression and on the post-transcriptional control of hyaluronan synthase activity, which, in close association with the supply of the UDP-sugar substrates of hyaluronan synthase, adjust the rate of hyalu...
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PMID: 21362137
PDF is available here.
PDF is available here.
Abstract
It is becoming increasingly clear that signals generated in tumor microenvironments are crucial to tumor cell behavior, such as survival, progression and metastasis. The establishment of these malignant behaviors requires that tumor cells acquire novel adhesion and migration properti...
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PMID: 21362138
PDF is available here.
PDF is available here.
Journal of Surgical Oncology (103)6 2011
Abstract
Harvard Men's Health Watch (15)10 2011
Abstract
Abstract
Macrophage migration inhibitory factor (MIF) was originally described as a cytokine that inhibits migration of macrophages at the site of inflammation. Subsequently it was also identified as a stress-induced hormone released from the anterior pituitary lobe in response to some pro-in...
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PMID: 21091281
PDF is available here.
PDF is available here.