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Autoimmune Diseases of the Nervous System (9):
Recent article
Autoimmune Diseases of the Nervous System
Abstract
Mesenchymal stromal cells (MSC) are part of the bone marrow stem cells repertoire which also includes the main stem cells population of the bone marrow, the hematopoietic stem cells. The main role of MSCs is to support hematopoiesis but they can also give rise to cells of the mesoder...
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PMID: 20955154
PDF is available here.
PDF is available here.
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Abstract
We profiled Ngb immunohistochemistry in murine models of traumatic brain injury, cerebral malaria, experimental autoimmune encephalitis, and kainic acid (KA)-mediated epileptic seizures that, to our knowledge, have not been studied in the context of Ngb. In control mice Ngb was expressed exclusively...
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PMID: 20544857
PDF is available here.
PDF is available here.
Abstract
We profiled Ngb immunohistochemistry in murine models of traumatic brain injury, cerebral malaria, experimental autoimmune encephalitis, and kainic acid (KA)-mediated epileptic seizures that, to our knowledge, have not been studied in the context of Ngb. In control mice Ngb was expressed exclusively...
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PMID: 20544857
PDF is available here.
PDF is available here.
Abstract
We profiled Ngb immunohistochemistry in murine models of traumatic brain injury, cerebral malaria, experimental autoimmune encephalitis, and kainic acid (KA)-mediated epileptic seizures that, to our knowledge, have not been studied in the context of Ngb. In control mice Ngb was expressed exclusively...
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PMID: 20544857
PDF is available here.
PDF is available here.
Abstract
We profiled Ngb immunohistochemistry in murine models of traumatic brain injury, cerebral malaria, experimental autoimmune encephalitis, and kainic acid (KA)-mediated epileptic seizures that, to our knowledge, have not been studied in the context of Ngb. In control mice Ngb was expressed exclusively...
|
PMID: 20544857
PDF is available here.
PDF is available here.
Abstract
We profiled Ngb immunohistochemistry in murine models of traumatic brain injury, cerebral malaria, experimental autoimmune encephalitis, and kainic acid (KA)-mediated epileptic seizures that, to our knowledge, have not been studied in the context of Ngb. In control mice Ngb was expressed exclusively...
|
PMID: 20544857
PDF is available here.
PDF is available here.
Abstract
We profiled Ngb immunohistochemistry in murine models of traumatic brain injury, cerebral malaria, experimental autoimmune encephalitis, and kainic acid (KA)-mediated epileptic seizures that, to our knowledge, have not been studied in the context of Ngb. In control mice Ngb was expressed exclusively...
|
PMID: 20544857
PDF is available here.
PDF is available here.
Abstract
We profiled Ngb immunohistochemistry in murine models of traumatic brain injury, cerebral malaria, experimental autoimmune encephalitis, and kainic acid (KA)-mediated epileptic seizures that, to our knowledge, have not been studied in the context of Ngb. In control mice Ngb was expressed exclusively...
|
PMID: 20544857
PDF is available here.
PDF is available here.
Abstract
We profiled Ngb immunohistochemistry in murine models of traumatic brain injury, cerebral malaria, experimental autoimmune encephalitis, and kainic acid (KA)-mediated epileptic seizures that, to our knowledge, have not been studied in the context of Ngb. In control mice Ngb was expressed exclusively...
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PMID: 20544857
PDF is available here.
PDF is available here.
Abstract
We review some of the mechanisms by which mycobacterial infection might modulate the clinical course of CNS autoimmunity. A more complete understanding of these mechanisms may lead to the development of novel immunotherapeutic tools for treating autoimmune diseases....
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PMID: 20333556
PDF is available here.
PDF is available here.
Abstract
We describe the case of an 11-year-old boy who developed PANDAS with severe choreic movements. The criteria for PANDAS diagnosis were met. Moreover, serum antibrain antibodies were present. The patient was initially treated with tetrabenazine 12.5 mg twice daily with remission of the neurological sy...
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PMID: 20207613
PDF is available here.
PDF is available here.
Abstract
We report a 36-year-old man who developed weakness of his left little finger adduction 3 years earlier. The weakness progressed to his other limbs. Examination revealed mildly high-arched feet with asymmetric weakness of ulnar-innervated muscles (left > right) and asymmetric weakness of peroneal-inn...
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PMID: 20215982
PDF is available here.
PDF is available here.
Muscle & Nerve (41)3 2010
Abstract
We report the case of a 55-year-old man with non-small-cell lung cancer who underwent radiation, chemotherapy with carbotaxol and paclitaxel, and left upper lobe removal 2 years prior to evaluation. He was referred for disabling orthostatic hypotension (113/69 mm Hg supine and 66/47 mm Hg standing a...
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PMID: 19882640
PDF is available here.
PDF is available here.
Muscle & Nerve (41)3 2010
Abstract
We report the case of a 55-year-old man with non-small-cell lung cancer who underwent radiation, chemotherapy with carbotaxol and paclitaxel, and left upper lobe removal 2 years prior to evaluation. He was referred for disabling orthostatic hypotension (113/69 mm Hg supine and 66/47 mm Hg standing a...
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PMID: 19882640
PDF is available here.
PDF is available here.
Muscle & Nerve (41)3 2010
Abstract
We report the case of a 55-year-old man with non-small-cell lung cancer who underwent radiation, chemotherapy with carbotaxol and paclitaxel, and left upper lobe removal 2 years prior to evaluation. He was referred for disabling orthostatic hypotension (113/69 mm Hg supine and 66/47 mm Hg standing a...
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PMID: 19882640
PDF is available here.
PDF is available here.
Muscle & Nerve (41)3 2010
Abstract
We report the case of a 55-year-old man with non-small-cell lung cancer who underwent radiation, chemotherapy with carbotaxol and paclitaxel, and left upper lobe removal 2 years prior to evaluation. He was referred for disabling orthostatic hypotension (113/69 mm Hg supine and 66/47 mm Hg standing a...
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PMID: 19882640
PDF is available here.
PDF is available here.
Muscle & Nerve (41)3 2010
Abstract
We report the case of a 55-year-old man with non-small-cell lung cancer who underwent radiation, chemotherapy with carbotaxol and paclitaxel, and left upper lobe removal 2 years prior to evaluation. He was referred for disabling orthostatic hypotension (113/69 mm Hg supine and 66/47 mm Hg standing a...
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PMID: 19882640
PDF is available here.
PDF is available here.
Muscle & Nerve (41)3 2010
Abstract
We report the case of a 55-year-old man with non-small-cell lung cancer who underwent radiation, chemotherapy with carbotaxol and paclitaxel, and left upper lobe removal 2 years prior to evaluation. He was referred for disabling orthostatic hypotension (113/69 mm Hg supine and 66/47 mm Hg standing a...
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PMID: 19882640
PDF is available here.
PDF is available here.
Muscle & Nerve (41)3 2010
Abstract
We report the case of a 55-year-old man with non-small-cell lung cancer who underwent radiation, chemotherapy with carbotaxol and paclitaxel, and left upper lobe removal 2 years prior to evaluation. He was referred for disabling orthostatic hypotension (113/69 mm Hg supine and 66/47 mm Hg standing a...
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PMID: 19882640
PDF is available here.
PDF is available here.
Muscle & Nerve (41)3 2010
Abstract
We report the case of a 55-year-old man with non-small-cell lung cancer who underwent radiation, chemotherapy with carbotaxol and paclitaxel, and left upper lobe removal 2 years prior to evaluation. He was referred for disabling orthostatic hypotension (113/69 mm Hg supine and 66/47 mm Hg standing a...
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PMID: 19882640
PDF is available here.
PDF is available here.
European Neurology (63)4 2010
Abstract
Multifocal motor neuropathy (MMN) is an acquired immune-mediated neuropathy characterized by chronic or stepwise progressive asymmetrical limb weakness without sensory deficits. The upper extremities are more often affected than the lower extremities with distal paresis dominating over proximal pare...
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PMID: 20150737
PDF is available here.
PDF is available here.
Lakartidningen (107)9 2010
Abstract
Abstract
We report a 15-year-old boy with SCAD deficiency who suffered from pernicious anaemia, vitiligo, scleroatrophic lichen and autoimmune thyroiditis. As has been reported in other mitochondrial disorders, we hypothesised that autoimmune diseases are also present in SCAD deficiency. Furthermore, we disc...
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PMID: 20389114
PDF is available here.
PDF is available here.
Abstract
We encountered two patients with acute pandysautonomia who subacutely exhibited extensive autonomic dysfunction after antecedent infections. Although these patients had been suffering from autonomic disturbance for several months, they both had a good clinical course after plasma exchange and intrav...
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PMID: 20046006
PDF is available here.
PDF is available here.
Neuroimmunomodulation (17)3 2010
Abstract
We will summarize the regulatory signals leading to the differentiation of tolerogenic DCs and their participation in CNS inflammation. In addition, we will underscore recent findings on the emerging role of galectin-glycan interactions in the establishment of immunosuppressive networks during the r...
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PMID: 20134191
PDF is available here.
PDF is available here.
Abstract
We discuss the potential induction of autoimmune CD8 T cells by infections, the impact of the microenvironment of the CNS on CD8 T-cell responses, and the potential interaction of CD8 T cells with autoantigen-expressing resident brain-cell populationsneurons in particularin light of clinical and exp...
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PMID: 20666705
PDF is available here.
PDF is available here.
Neuroimmunomodulation (17)3 2010
Abstract
Clinical Neuropathology (29)1 2010
Abstract
Lymphocytic hypophysitis (LYH) is a rare autoimmune inflammatory disorder of the pituitary gland usually affecting young women, often in pregnancy or post partum period. It is rare in non-pregnant females and in men. Patients present with symptoms of an expanding pituitary mass and/or varying degree...
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PMID: 20040330
PDF is available here.
PDF is available here.
Abstract
BACKGROUND: Autism spectrum disorders (ASDs) are neurodevelopmental disorders characterized by difficulties in communication and by repetitive and stereotypic behaviors, as well as by social impairment, attention, cognitive, and learning defects. ASDs present in early childhood and their prevalence...
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PMID: 19640207
PDF is available here.
PDF is available here.
Pediatric Emergency Care (25)8 2009
Abstract
An 11-year-old boy with a high fever (39.4 degrees C) presented at a local medical institution. His condition was diagnosed as hemolytic streptococcal infection, and he was prescribed an antibiotic. After returning home, he took a dose of his medication and rested; however, he suddenly began to run...
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PMID: 19687712
PDF is available here.
PDF is available here.
Neurologist (15)4 2009
Abstract
Investigacion clinica (50)2 2009
Abstract
Transverse myelitis (TM) is an inflammatory process involving restricted areas of the spinal cord. The usually dramatic presentation with rapidly progressive symptoms involving motor, sensory and autonomic functions makes acute TM a medical emergency. Acute TM has been cited as a rare and unusual co...
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PMID: 19662820
PDF is available here.
PDF is available here.
Military Medicine (174)3 2009
Abstract
Although these diseases are considered rare, they can be endemic to current areas of deployment. Awareness of these conditions may prevent unnecessary and invasive treatment as well as make the clinician aware of possible disease complications....
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PMID: 19354098
PDF is available here.
PDF is available here.
Abstract
Autoimmune limbic encephalitis (LE) can arise both by paraneoplastic and non-paraneoplastic mechanisms. Patients with LE usually have a subacute onset of memory impairment, disorientation and agitation, but can also develop seizures, hallucinations and sleep disturbance. The following investigations...
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PMID: 19566502
PDF is available here.
PDF is available here.
Abstract
Abstract
We have reviewed the most common audiovestibular features that may be observed in patients with systemic vasculitides. Audiovestibular manifestations may be the first symptom of a systemic vasculitis. Audiological manifestations include sudden hearing loss and progressive sensorineural hearing loss....
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PMID: 19909720
PDF is available here.
PDF is available here.
Abstract
We report a 59-year-old man who developed polyradiculoneuropathy during treatment with PEG-IFN alpha-2b for chronic HCV infection. Serum levels of anti-asialo-GM1 (GA1) and anti-GM1 antibodies were elevated. Cessation of therapy with double filtration plasmapheresis resulted in marked improvement in...
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PMID: 19336961
PDF is available here.
PDF is available here.
Molecular Medicine (15)7-8 2009
Abstract
Conventional treatment options, including corticosteroids, intravenous immunoglobulin, or plasma exchange, often fail to treat dysimmune neuropathies, such as chronic inflammatory demyelinating polyneuropathy, multifocal motor neuropathy, and monoclonal gammopathy with its subtypes. Therefore, a sig...
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PMID: 19593413
PDF is available here.
PDF is available here.
Abstract
We present 2 patients that were referred for psychiatric assessment, because their neurological symptoms initially could not be explained by a neurological disease, and subsequently diagnosed as SPS. The aim of this case report is to draw attention to the psychiatric presentations of SPS and to emph...
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PMID: 20013431
PDF is available here.
PDF is available here.
Abstract
In the first half of the 20th century, during the Spanish flu pandemic, more than half a million people died from a mysterious disease sleeping sickness which was named 'encephalitis lethargica'. Despite extensive research, the cause of the disease has not yet been established. In the Netherlands ma...
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PMID: 19785795
PDF is available here.
PDF is available here.
Abstract
Sensory neuron diseases was associated with dysimmune conditions in six, hepatitis C in one, B12 deficiency in another, and in one patient SND was related to organophosphate intoxication. In the remaining eleven, it was considered as idiopathic. Nineteen patients experienced sensory symptoms. Worse...
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PMID: 19049561
PDF is available here.
PDF is available here.
Lancet Neurology (7)12 2008
Abstract
Lancet Neurology (7)12 2008
Abstract
Median age of patients was 23 years (range 5-76 years); 91 were women. All patients presented with psychiatric symptoms or memory problems; 76 had seizures, 88 unresponsiveness (decreased consciousness), 86 dyskinesias, 69 autonomic instability, and 66 hypoventilation. 58 (59%) of 98 patients for wh...
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PMID: 18851928
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)46 2008
Abstract
We found that HSP27 and HSP60 immunization in the Lewis rat induced RGC degeneration and axon loss 1-4 months later in vivo in a pattern with similarities to human glaucoma, including topographic specificity of cell loss. Infiltration of increased numbers of T-cells in the retina occurred much earli...
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PMID: 19005073
PDF is available here.
PDF is available here.
Abstract
T cell mediated immunotherapies are proposed for many cancers including malignant astrocytoma. As such therapies become more potent, but not necessarily more tumor-specific, the risk of collateral autoimmune damage to normal tissue increases. Tumors of the brain present significant challenges in thi...
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PMID: 18551629
PDF is available here.
PDF is available here.
Abstract
A two-year-old male entire border collie dog was evaluated for a short history of mixed bowel diarrhoea, coughing, vomiting and stranguria. Physical examination revealed dyspnoea with increased ventral lung sounds and a flaccidly distended bladder. Neurological examination revealed poor pupillary li...
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PMID: 18684149
PDF is available here.
PDF is available here.
Abstract
I episodic ataxia, and limbic encephalitis with hyponatremia. Plasma exchanges and immunotherapy are effective. In patients without detectable antibodies, hippocampic anti-neuropil antibodies should be sought, particularly those targeting N-methyl-D-aspartate receptors. Ovarian teratoma is the usual...
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PMID: 19445370
PDF is available here.
PDF is available here.
Abstract
B cells have a fundamental role in the pathogenesis of various autoimmune neurological disorders, not only as precursors of antibody-producing cells, but also as important regulators of the T-cell activation process through their participation in antigen presentation, cytokine produc...
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PMID: 18813230
PDF is available here.
PDF is available here.
Archives of Neurology (65)10 2008
Abstract
Clinical, radiologic, electrophysiologic, and laboratory findings in VGKC autoantibody-associated encephalopathy may be confused with those of CJD. Serologic evaluation for markers of neurologic autoimmunity, including VGKC autoantibodies, may be warranted in suspected CJD cases....
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PMID: 18852349
PDF is available here.
PDF is available here.
Abstract
Abstract
In 1984, Jean Aicardi and Françoise Goutières described 8 children showing both severe brain atrophy and chronic cerebrospinal fluid lymphocytosis, with basal ganglia calcification in at least one member of each affected family. The course was rapid to death or a vegetative outcome. Aicardi and Go...
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PMID: 18343173
PDF is available here.
PDF is available here.
Der Nervenarzt (79 Suppl 2)s2 2008
Abstract
We review the clinical applications and recommendations for the use of IVIg in neurological diseases....
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PMID: 18679643
PDF is available here.
PDF is available here.
Pediatrics (122)2 2008
Abstract
Our results support our hypothesis that pediatric autoimmune neuropsychiatric disorders associated with streptococcus are frequently diagnosed in the community without the application of all working diagnostic criteria. This phenomenon has resulted in unwarranted use of antibiotic treatment for tics...
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PMID: 18676543
PDF is available here.
PDF is available here.
Abstract
Interest in the possibility of an immune-mediated pathophysiology of obsessive-compulsive disorder and related disorders has increased. In the late 1980s, the National Institute of Mental Health reported an increase in obsessive-compulsive symptoms (OCS) in patients with Sydenham chorea (SC). Subseq...
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PMID: 18262706
PDF is available here.
PDF is available here.
Journal of Neurochemistry (106)1 2008
Abstract
Interleukin15 (IL 15) is a proinflammatory cytokine with elevated concentrations in autoimmune diseases involving the periphery (e.g. rheumatoid arthritis) and CNS (e.g. multiple sclerosis). Its interactions with the blood-brain barrier (BBB) were studied in normal and lipopolysaccharide (LPS)-treat...
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PMID: 18384647
PDF is available here.
PDF is available here.
Journal of Neurology (255 Suppl 3)s3 2008
Abstract
A number of autoimmune disorders have been identified in which IVIg treatment may be beneficial. Evidence for the use of IVIg in inflammatory myopathies comes from controlled trials in dermatomyositis (DM) and sporadic-inclusion body myositis (s-IBM). In DM, muscle strength was increased and neuromu...
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PMID: 18685921
PDF is available here.
PDF is available here.
Journal of Neurology (255 Suppl 3)s3 2008
Abstract
The IgG molecule is the main component of IVIg. Commercial preparations of IVIg are derived from a pool of donors and subsequently, IVIg products contain smaller amounts of IgA and IgM antibodies as well as Th2 cytokines and cytokine antagonists that may also contribute to therapeutic effects. Numer...
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PMID: 18685919
PDF is available here.
PDF is available here.
Journal of Neurology (255 Suppl 3)s3 2008
Abstract
Archives of Neurology (65)7 2008
Abstract
Archives of Neurology (65)7 2008
Abstract