Abstract
Epilepsy and seizures can have a dramatic effect on the autonomic nervous system by involvement of the central autonomic control centers. The peri-ictal changes can lead to short-term alteration of cardiac functions in patients with seizures, and are partially hemispheric specific. Changes in heart...
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PMID: 20688543
PDF is available here.
Abstract
We studied 23 patients with PIFS and 25 healthy matched control subjects. A heartbeat discrimination task and a pressure pain threshold test were used to assess interoceptive sensitivity. Cardiac response was assessed over a 4-min Stroop task. PIFS was associated with higher accuracy in heartbeat di...
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PMID: 20678991
PDF is available here.
Abstract
There are three diseases classified as primary autonomic failure (PAF), multiple system atrophy, Parkinson's disease, pure autonomic failure. Compensatory mechanisms preventing from decrease in blood pressure are inefficient in PAF. Among half of the patients with PAF occur orthostatic hypotension (...
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PMID: 20859904
PDF is available here.
Abstract
Dramatic advances have been made in the treatment of motor dysfunction in both the early and late phases of Parkinson disease. Effective therapies for the nonmotor symptoms of this disease, however, remain a major unmet clinical need. A recent study has highlighted the dearth of clinical trials for...
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PMID: 20689560
PDF is available here.
Abstract
Cardiac autonomic function plays a crucial role in health and disease, with abnormalities both reflecting the severity of the disease and contributing specifically to clinical deterioration and poor prognosis. Radiotracer analogs of the sympathetic mediator norepinephrine have been investigated exte...
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PMID: 20454877
PDF is available here.
Abstract
A very rare case of continuous hypertension and tachycardia after excision of a cerebellar hemangioblastoma at the dorsal medulla oblongata is presented. This 21-year-old man was admitted to the authors' hospital with a headache and dizziness. Radiological examination revealed a tumor located behind...
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PMID: 19911894
PDF is available here.
Abstract
The article is concerned with the topical issue of aeromedicine--diagnosis and correction of the vegetative dysfunction of the aircrew. Causative factors leading to the dysfunction are discussed. Clinical and instrumental methods of the valuation of vegetative status and vegetative supporting of act...
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PMID: 21089433
PDF is available here.
Abstract
We performed a meta-analysis of relevant randomized controlled trials (RCTs) identified in PubMed, Cochrane library, Embase, and American Society of Clinical Oncology conferences. Overall incidence rates, relative risks (RRs), and 95% confidence intervals (CIs) were calculated using a random-effects...
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PMID: 20401474
PDF is available here.
Abstract
Although extrapyramidal diseases are commonly thought to solely affect the (extrapyramidal) motor system, non-motor symptoms such as behavioural abnormalities, dysautonomia, sleep disturbances and sensory dysfunctions are also frequently observed. Autonomic dysfunction as an important clinical compo...
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PMID: 20648415
PDF is available here.
Erik Storkebaum,
Carmen Ruiz de Almodovar,
Merlijn Meens,
Serena Zacchigna,
Massimiliano Mazzone,
Greet Vanhoutte,
Stefan Vinckier,
Katarzyna Miskiewicz,
Koen Poesen,
Diether Lambrechts,
Ger M J Janssen,
Gregorio E Fazzi,
Patrik Verstreken,
Jody Haigh,
Paul M Schiffers,
Hermann Rohrer,
Annemie Van der Linden,
Jo G R De Mey and
Peter Carmeliet
Abstract
These findings uncover a novel role for VEGF in the maintenance of arterial neuroeffector function and may help us better understand how VEGF inhibitors cause vascular regulation defects in cancer patients....
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PMID: 20606119
PDF is available here.
Abstract
Laboratories able to test autonomic function are increasingly available and rely on batteries of well-accepted, noninvasive tests. Tests of parasympathetic cardiovagal, sympathetic vasoconstriction, and sudomotor (sweating) function are most commonly employed. Common examples include heart rate vari...
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PMID: 20592565
PDF is available here.
Abstract
We describe the case of a 33 year old male patient with severe orthostatic hypotension, which was at times even in upright (sitting) position not tolerated, thus leading to complete immobilisation. The diagnostic measurements pointed to the group of primary autonomic degenerative disorders, the so-c...
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PMID: 20372869
PDF is available here.
Abstract
Simple bedside tests can detect CAN. HRV and SBS provide additional elements on CAN severity. Diabetes duration did not discriminate sufficiently patients with CAN. The association with retinopathy is in favor of the role of poor glycemic control in CAN development. This study shows the interest of...
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PMID: 20354891
PDF is available here.
Abstract
We describe the effects of chronic droxidopa in a patient with Dopamine beta-hydroxylase deficiency diagnosed at the age of 73. Investigations were performed to assess sympathetic activity (MIBG scintigraphy, catecholamines) and cardiovascular droxidopa safety.
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PMID: 20063034
PDF is available here.
Abstract
The SSR latencies to electrical stimuli in the ON patients were significantly prolonged in the upper and lower extremities (p = 0.013-0.002), indicating sudomotor dysfunction. No statistically significant thermoregulatory sweating dysfunction could be found in the ON patients compared to the control...
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PMID: 20213266
PDF is available here.
Abstract
Pupillary supersensitivity to a parasympathomimetic agent (0.05% pilocarpine hydrochloride) and to a sympathomimetic agent (0.02% dipivefrine hydrochloride) was examined by assessing changes in pupil diameter. Pupillary supersensitivity to 0.05% pilocarpine was greatest among the PD patients (PD -23...
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PMID: 20127386
PDF is available here.
Abstract
Infants with history of IALTE and GER have a significant abnormality in their autonomic control that is marked in the coupled events of apnea and GER. This finding is possibly related to medullary autonomic regulation....
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PMID: 20127385
PDF is available here.
Abstract
Clinically manifest AD is associated with lower quality of life and higher healthcare utilization in IBD patients. They may represent a cohort at risk for worse outcomes....
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PMID: 19727003
PDF is available here.
Abstract
Patients with chronic pancreatitis may have abnormal gastrointestinal transit, but the factors underlying these abnormalities are poorly understood. Gastrointestinal transit was assessed, in 40 male outpatients with alcohol-related chronic pancreatitis and 18 controls, by scintigraphy after a liquid...
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PMID: 19390966
PDF is available here.
Abstract
TTD was significantly associated with total spectrum power (TP) (r=0.55, P=0.001) and high frequency (HF power) (r=0.44, P=0.010) of HRV measurement. The accuracy of within-one-week TTD prediction was 67% for TP and HF power. The accuracy of within-two-week TTD prediction was 82% for TP and 73% for...
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PMID: 20413055
PDF is available here.
Abstract
Diabetic autonomic bladder dysfunction is rare in the pediatric age group. An adolescent girl aged 16 years and 7 months, with type 1 diabetes mellitus since the age of 6 years, was diagnosed as having diabetic cystopathy. Ultrasonography of the urinary tract showed a distended bladder with normal k...
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PMID: 20583546
PDF is available here.
Abstract
Early sub-clinical assessment of severity of cardiac autonomic neuropathy (CAN) and intervention are of prime importance for risk stratification and early treatment in preventing sudden death due to silent myocardial infarction. The Ewing battery is currently the diagnostic tool of choice but is una...
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PMID: 20004128
PDF is available here.
Abstract
To our knowledge this is the first description of unruptured aneurysms presenting with insular-related symptoms....
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PMID: 20437932
PDF is available here.
Abstract
We hypothesized that upregulation of RAMP1 would favorably enhance autonomic regulation and attenuate hypertension. Blood pressure, heart rate, and locomotor activity were measured by radiotelemetry in transgenic mice with ubiquitous expression of human RAMP1 (hRAMP1) and littermate controls. Compar...
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PMID: 20100989
PDF is available here.
Abstract
We hypothesized that CSA is associated with stenosis of the internal carotid artery (ICA). The mechanism of this association is an autonomic imbalance induced by stenosis-mediated chemoreceptor and baroreceptor dysfunction....
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PMID: 20337190
PDF is available here.
Abstract
Patients who undergo DBS must be well-selected, weighing the risks and benefits, in order to obtain the best results with this treatment. Further multicentre studies are necessary to understand the role of DBS on NMS....
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PMID: 20205149
PDF is available here.
Abstract
Although recent reviews offer insufficient evidence for treatment of non-motor symptoms with dopaminergic therapy, involvement of the dopaminergic pathways in the aetiopathogenesis of some of these disorders and the clinical observation that such symptoms undergo fluctuations in relation to pulsatil...
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PMID: 20205148
PDF is available here.
Abstract
PD affects systems other than the dopaminergic nigrostriatal. A better understanding of this pathology will make it possible to approach and optimise the treatment of the conditioning symptoms, thereby enhancing the welfare of patients with PD....
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PMID: 20205147
PDF is available here.
Abstract
Even 5 years after the diagnosis of CRPS I of the upper extremity we detected significant impairments of the pSNS in nearly two thirds of our patients. Patients still have pain and present with a significant deterioration of their hand function in comparison with the not affected hand. In our study...
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PMID: 20090439
PDF is available here.
Abstract
We will discuss the use of noninvasive methods to evaluate the immune system, ANS and HPA axis. Collection of sweat and saliva, and measurement of heart rate variability are noninvasive methods that can be applied to evaluate neuroimmune interactions. Recently, we validated a new methodology to simu...
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PMID: 20134204
PDF is available here.
Abstract
Despite significant functional improvement of hibernating myocardium as a result of PCI or pravastatin therapy, there were no changes in HED defect size or severity. Thus, inhomogeneity in myocardial sympathetic innervation persisted, and the lack of plasticity suggests that even in the absence of s...
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PMID: 19902319
PDF is available here.
Abstract
The results of this study indicate that, in addition to identifying and controlling biomechanical risk factors, dental schools, dental practices, and dental hygienists themselves should pay attention to the identification and control of psychosocial risk factors in the workplace....
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PMID: 20448323
PDF is available here.
Abstract
Contrary to common perception, many NMS of PD occur early in PD and some may even predate the diagnosis of PD that is based on motor signs. These include olfactory deficit, sleep problems such as rapid eye movement behaviour disorder, constipation and the more recently described male erectile dysfun...
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PMID: 20642073
PDF is available here.
Abstract
We examined the efficacy and safety of intravenous magnesium sulphate for control of rigidity and spasms in adults with tetanus. A prospective clinical study of intravenous magnesium sulphate was carried out over a period of two years in a tertiary care teaching hospital. In addition to human tetanu...
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PMID: 20191795
PDF is available here.
Abstract
The first data illustrating work efficiency of health centres in this country are presented. They suggest the necessity to change both the strategy of activities and the patient population. Studies on variability of cardiac rhythms and characteristics of vegetative status in adolesce...
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PMID: 21395037
PDF is available here.
Abstract
We examined 157 patients with DM to study manifestations of CAN depending on the presence of MS components. MS was diagnosed using WHO criteria and CAN based on two or more pathologic results in Ewing"s cardiovascular tests (deep respiration test, Valsalva test, orthostatic test with estimation of H...
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PMID: 21089455
PDF is available here.
Abstract
The aim of the work was to elucidate peculiarities of neurovegetative mechanisms underlying cardiovascular regulation in patients with metabolic syndrome (MS) compared with healthy subjects and patients with arterial hypertension (AH). 46 patients presented with AH without obesity an...
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PMID: 21395027
PDF is available here.
Abstract
Appreciation for the role of aldosterone and mineralocorticoid receptors in cardiovascular disease is accelerating rapidly. Recent experimental work has unveiled a strong relationship between brain mineralocorticoid receptors and sympathetic drive, an important determinant of outcome in heart failur...
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PMID: 19648480
PDF is available here.
Abstract
We show that visceral and subcutaneous adipose tissue were both increased at 1 month, but not at 1 week, after complete T3 SCI in rats. Additionally, at 1 month post injury, T3 SCI rats exhibited nonfasting serum hypertriglyceridemia, a result obtained using both standard clinical methods and a home...
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PMID: 19772460
PDF is available here.
Abstract
We encountered two patients with acute pandysautonomia who subacutely exhibited extensive autonomic dysfunction after antecedent infections. Although these patients had been suffering from autonomic disturbance for several months, they both had a good clinical course after plasma exchange and intrav...
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PMID: 20046006
PDF is available here.
Abstract
Quantitative evaluation of ECG P-wave changes evoked by an orthostatic test by using a newly developed method provides a quantitative estimate for functionality and efficiency of the heart rate control mechanisms. The method could be used in eHealth systems....
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PMID: 20177647
PDF is available here.
Abstract
These findings reflect an involvement of both the parasympathetic and sympathetic systems in GBS. Our results suggest that SSR and heart rate variability parameters may be used for early detection of any autonomic dysfunction in patients with GBS....
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PMID: 20644267
PDF is available here.
Abstract
ECG body surface mapping (BSM) parameters in patients with diabetes mellitus Type 1 (DM1) are significantly different comparing to healthy non-diabetic subjects. Hypothesis that these changes are more pronounced in DM1 patients with autonomic neuropathy (AN) was tested. The parameters of BSM were re...
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PMID: 19537926
PDF is available here.
Abstract
In all cardiovascular reflex tests, the frequencies of abnormal results were significantly higher among the patients than among the healthy subjects. Severe autonomic dysfunction was more common in RA. QTc interval was more prolonged in patients with SLE. Both diseases were associated with depressed...
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PMID: 20422909
PDF is available here.
Abstract
PAH patients present a significant impairment of CR and HRR(1) in relation to disease severity, indicating profound autonomic nervous system abnormalities....
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PMID: 19944365
PDF is available here.
Abstract
We ascertained whether HRV predicts SUDEP in chronic epilepsy using a case-control design and investigated parameters of inter-ictal HRV in 14 patients (7 had died from SUDEP). No HRV parameter was associated with SUDEP. Thus, although altered HRV might be involved in SUDEP, HRV parameters are not c...
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PMID: 19747799
PDF is available here.
Abstract
Children with Panayiotopoulos syndrome may have static MRI brain findings which are likely to be coincidental and do not affect prognosis....
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PMID: 19736167
PDF is available here.
Abstract
We present two new cases and evaluate the data of 83 patients described in the literature. We provide diagnostic and therapeutic guidelines....
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PMID: 19902816
PDF is available here.
Abstract
Sera from 11 of 15 chronic chagasic patients had some activity (Ab-beta: 7; Ab-M: 1; Ab-Mbeta: 3); however, there was no significant correlation between the presence of antibodies and the autonomic system function or the presence of hyperintensities in MRI. CONCLUSION: The mechanism involved in the...
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PMID: 19722040
PDF is available here.
Abstract
Moderate to large effect sizes for physiological changes were demonstrated. Physiological and psychological treatment effects were found to be unrelated. DISCUSSION: Our treatment approach, which combined biofeedback therapy with CBT elements, was found to be highly effective in reducing psychophysi...
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PMID: 19079954
PDF is available here.
Abstract
Functional somatic syndrome (FSS) with abdominal pain include functional gastrointestinal disorder, chronic pancreatitis, chronic pelvic pain syndrome, which generally contain autonomic dysfunction. Regarding the treatment of FSS, it is important to know about FSS for a therapist at first. Secondly,...
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PMID: 19768915
PDF is available here.
Abstract
We believe this term will not be useful in Japan, because most Japanese clinicians are already aware of this fact and treatment is different in each syndrome included in FSS....
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PMID: 19768908
PDF is available here.
Abstract
We quantified alphasynuclein, tau, ubiquitin and Heat Shock Protein 27 (HSP27) containing neurons in the DMV, NA, RO, in addition to the hypoglossal nucleus in 12 LBD patients. alphaSynuclein, ubiquitin and tau aggregates most greatly affected the DMV followed by the NA, RO, but never the hypoglossa...
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PMID: 19501577
PDF is available here.
Abstract
Parkinson's disease is a hypokinetic movement disorder with cardinal motor features of bradykinesia, resting tremor and rigidity. However, non-motor symptoms, such as cognitive, neuropsychiatric, sleep, autonomic and sensory disturbances are gaining increasing attention. These non-motor symptoms may...
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PMID: 19711119
PDF is available here.