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Nervous System Neoplasms (5):
Recent article
Nervous System Neoplasms
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Molecular Carcinogenesis (49)8 2010
Abstract
We report our observation that resveratrol can also promote the growth of certain human cancer cells when they are grown either in culture or in athymic nude mice as xenografts. At relatively low concentrations (
PDF is available here.
PDF is available here.
Abstract
We have investigated further the roles of p38 and Chk1 in the G(2) DNA damage checkpoint in cancer cells. We find that although p38 activation is strongly induced by DNA damage, its activity is not required for the G(2) DNA damage checkpoint. In contrast, Chk1 kinase is responsible for the execution...
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PMID: 20516219
PDF is available here.
PDF is available here.
British Journal of Cancer (102)12 2010
Abstract
The total number of patients with nervous system tumour was 63 307, of whom 32 347 belonged to the offspring generation. Of 851 familial patients (2.6%) in the offspring generation, 42 (4.7%) belonged to the families of a parent and at least two siblings affected. The SIR of brain tumours was 1.7 in...
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PMID: 20502456
PDF is available here.
PDF is available here.
Acta Oncologica (49)5 2010
Abstract
There have been some notable changes in survival that can be linked to epidemiological and clinical factors in different countries over time. Time-varying proportions of the major histological subtypes might however have affected the survival estimates for a number of the cancer forms reviewed here....
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PMID: 20192877
PDF is available here.
PDF is available here.
Kidney International (77)9 2010
Abstract
Biomarkers hold promise for personalizing renal cancer care by potentially identifying patients most likely to benefit from novel therapies. Porta and colleagues report that among subjects with advanced renal-cell carcinoma receiving sunitinib treatment, those with above-normal levels of the circula...
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PMID: 20393489
PDF is available here.
PDF is available here.
Abstract
Nerves induced a polarized neurotrophic migration of cancer cells (PNMCs) along their axons, which was more efficient than in the absence of nerves (migration distance: mean = 187.1 microm, 95% confidence interval [CI] = 148 to 226 microm vs 14.4 microm, 95% CI = 9.58 to 19.22 microm, difference = 1...
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PMID: 20068194
PDF is available here.
PDF is available here.
Abstract
We will focus on the mechanisms of action of antisense oligonucleotides and report clinical and experimental studies on the treatment of high-grade gliomas. We will also report the patents of preclinical and/or clinical studies that adopt the antisense oligonucleotide therapy list in cerebral glioma...
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PMID: 19832690
PDF is available here.
PDF is available here.
Voprosy onkologii (56)5 2010
Abstract
Abstract
Neurofibromatosis (NF) is one of the most common genetic disorders. Inherited in an autosomal dominant fashion, this phacomatosis is classified into two genetically distinct subtypes characterized by multiple cutaneous lesions and tumors of the peripheral and central nervous system. Neurofibromatosi...
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PMID: 19380279
PDF is available here.
PDF is available here.
Abstract
We have previously detected an increased number of alterations in the ATP2A2 gene in various cancer types and in the ATP2A3 gene in head and neck squamous cell carcinoma. Here, we further analyzed the ATP2A3 gene in colon, lung, and CNS cancers. We identified a statistically significant increase of...
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PMID: 19100511
PDF is available here.
PDF is available here.
Abstract
We have recently evidenced a temozolomide-associated anti-angiogenic activity in vitro and in vivo on preclinical human glioblastoma models. We describe in the current review the temozolomide-associated antiangiogenic activity. We also describe here the major signaling pathways that can be constitut...
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PMID: 19998795
PDF is available here.
PDF is available here.
Abstract
We first studied the in vitro anti-cancer activity of Pien Tze Huang on neuroblastoma cells (SH-SY5Y) as compared with normal fibroblasts (NIH-3T3). Results showed that Pien Tze Huang significantly decreased (p < .05) cell survival of SH-SY5Y as compared to NIH-3T3. Furthermore, the decreases in cel...
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PMID: 19125378
PDF is available here.
PDF is available here.
Abstract
The study includes an analysis of the state of health of the inhabitants of the City of Trino, County of Vercelli, 15 km south-west of the capital town. With industries making a significant environmental impact and an old nuclear centre under dismantlement, in recent years, the City has often been m...
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PMID: 20058540
PDF is available here.
PDF is available here.
Molecular Cancer (8)1 2009
Abstract
Glial tumours had significantly (two tailed t-test p < 0.05) higher creatine and glutamine and lower taurine, phosphoethanolamine, phosphorylcholine and choline compared with primitive neuro-ectodermal tumours. Classification accuracy was 90%. Medulloblastomas (n = 9) had significantly (two tailed t...
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PMID: 19208232
PDF is available here.
PDF is available here.
Neurology India (57)1 2009
Abstract
Clinical Journal of Pain (25)3 2009
Abstract
We decided to use the US to better target the stump neuroma. Color flow Doppler showed extensive vascularity around the posterior aspect of the neuroma where there was scar tissue. During a follow-up visit for intra-articular steroid injection to the L5-S1 left lumbar facet for coincidental lumbar f...
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PMID: 19333177
PDF is available here.
PDF is available here.
Abstract
The currently available data provide clear evidence for the involvement of MMPs in the pathophysiology of astrocytomas, glioblastomas, meningiomas, medulloblastomas/primitive neuroectodermal tumors and pituitary tumors. The use of MMPIs in the treatment of CNS malignancies has, until now, reached co...
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PMID: 19007324
PDF is available here.
PDF is available here.
Abstract
Abstract
We performed a mutation analysis for LNX1 and Numbl genes. In addition, gene copy numbers of LNX1, Numbl, and KIT in human nervous system tumors were analyzed by chromogenic in situ hybridization. Tissue samples from 90 patients were screened for LNX1 and Numbl mutations, and tissue sections from 56...
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PMID: 18940473
PDF is available here.
PDF is available here.
Abstract
bcl-XL, bax, bcl-2, and p53 are apoptotic proteins essential to normal neural development. Aberrant expression of these proteins has been observed in several central nervous system neoplasms. Immunoexpression of these markers is studied in 21 patients with focal cortical dysplasia type II (Taylor-ty...
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PMID: 18594472
PDF is available here.
PDF is available here.
Abstract
Operative surgery remains the major therapeutic modality for most serious nerve injuries, entrapments, and many nerve tumors. This article highlights the advancements that have been made in nerve surgery since World War I, including nerve action potential recording, MRI, timing of repair, grafts, tu...
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PMID: 19010277
PDF is available here.
PDF is available here.
Abstract
Except unique metastases classified in groups 1 and 2, which are susceptible of surgery or radiosurgery, in which in response may be expected; the rest of lesions secondary to germ cell tumors have an ominous prognosis and outcomes, with short survivals....
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PMID: 19040166
PDF is available here.
PDF is available here.
Neurochirurgie (54)5 2008
Abstract
We discuss the major types of neurocutaneous disorders most frequently encountered by the neurosurgeon and followed beyond childhood. They include neurofibromatosis types 1 and 2, tuberous sclerosis, Sturge-Weber syndrome and von Hippel-Lindau disease. In each case, a review of the literature, inclu...
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PMID: 18752812
PDF is available here.
PDF is available here.
Human Genetics (124)3 2008
Abstract
We studied five individuals from a three-generation cancer-prone family with a KIF1B beta germline variant and seven of their tumors, both of neural crest and nonneural origin. Genetic studies including sequencing, copy number analysis and fluorescence in situ-hybridization (FISH) showed retention o...
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PMID: 18726616
PDF is available here.
PDF is available here.
Abstract
Abstract
We explored the association between birth record variables and subsequent NB development in a population-based case-cohort study in Minnesota by linking the birth and cancer registries. NB cases included 155 children born during 1976-2004 who were diagnosed from 28 days through 14 years of age. The...
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PMID: 18546287
PDF is available here.
PDF is available here.
Abstract
In human tumor cell lines of different tissue origins, sensitivity to neocarzinostatin is proportional to the product of the relative contents of Bcl-2 and caspase-3 (r (2) = 0.9; P < 0.01). Neuroblastoma and brain tumor cell lines are particularly sensitive to neocarzinostatin; the sensitivity of b...
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PMID: 18338171
PDF is available here.
PDF is available here.
Abstract
The blood-brain barrier (BBB) limits the bioavailability of most bioactive molecules and drugs in the CNS, leaving clinicians with only a few options for pharmacotherapy. In this issue Regina et al. demonstrate that a 'Trojan horse' drug conjugate, acting as a substrate of a physiological BBB recept...
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PMID: 18587417
PDF is available here.
PDF is available here.
Abstract
We investigated the status of p53 in the rp(+/-) MPNSTs. Using monoclonal antibodies that we raised to zebrafish p53, we found that cells derived from rp(+/-) MPNSTs are significantly impaired in their ability to produce p53 protein even in the presence of a proteasome inhibitor and gamma-irradiatio...
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PMID: 18641120
PDF is available here.
PDF is available here.
Abstract
These tumors tend to affect the nerves of the upper extremities in children or young adults. The predominant symptom is a slow-progressive paralysis. Two of the four patients showed a partial improvement of their motor and sensorial nerve deficits in the long-term follow-up following complete tumor...
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PMID: 18666052
PDF is available here.
PDF is available here.
Cancer Research (68)14 2008
Abstract
FASEB Journal (22)6 2008
Abstract
We hypothesized that oncolytic therapy using HSV engineered to minimize neurotoxicity would be appropriate for this clinical setting. Attenuated HSV (NV1023) injected to sciatic nerves of nude mice had no toxic effect on nerve function (n=30). NV1023 had significant oncolytic effect on prostate carc...
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PMID: 18234972
PDF is available here.
PDF is available here.
Abstract
Clinical Endocrinology (68)4 2008
Abstract
Germline SDHD mutations underlying metastatic PGL were G148D, Y114X, L85X, W43X, D92Y, and IVS2+5G-->A. CONCLUSION: Our findings indicate that malignant SDHD-related PGL is associated with several mutations besides D92Y....
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PMID: 17973943
PDF is available here.
PDF is available here.
Abstract
We report a 2-year-old girl with cervicothoracic neuroblastoma who had an excellent outcome with this approach....
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PMID: 18358271
PDF is available here.
PDF is available here.
Abstract
Abstract
Cancer is one of the most common and severe problems in clinical medicine, and nervous system tumors represent about 2% of the types of cancer. The central role of the nervous system in the maintenance of vital activities and the functional consequences of the loss of neurons can explain how severe...
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PMID: 18551412
PDF is available here.
PDF is available here.
Abstract
We have treated in excess of 75 patients using four Zeiss Intrabeam x-ray sources (XRS). To date there has been no published data of any dosimetric intercomparison of this type of x-ray source used at other cancer centres worldwide. This paper describes the design of a simple dosimetry intercomparis...
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PMID: 18705612
PDF is available here.
PDF is available here.
Endocrine Pathology (19)2 2008
Abstract
We report a case of an autopsy of unusual retroperitoneal sympathetic paraganglioma (SPG) that directly invaded the duodenum and showed expansive growth mimicking a submucosal tumor. The tumor was clinically suspected to be a gastrointestinal stromal tumor (GIST) of the duodenum because of its locat...
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PMID: 18438726
PDF is available here.
PDF is available here.
Pediatric Neurosurgery (44)2 2008
Abstract
Based on a large hospital series of pediatric patients, the present survey revealed the histopathological diversity of childhood neurological neoplasms, and provides a reliable profile of the epidemiology of nervous system tumors in children in a developing country....
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PMID: 18230922
PDF is available here.
PDF is available here.
NeuroSignals (16)2-3 2008
Abstract
We analyzed the acidic lipid fractions of 13 neural tumor cell lines using enzyme-linked immunoabsorbent assay (ELISA) and high-performance thin-layer chromatography (HPTLC) immunostaining. Sulfated glucuronosyl glycosphingolipids (SGGLs) are cell surface molecules that are endowed with the Human Na...
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PMID: 18253060
PDF is available here.
PDF is available here.
Abstract
Revista de Neurologia (47)6 2008
Abstract
Stereotactic biopsy presents a quite high morbi-mortality with a real accuracy diagnostic of 75.8% after considering the diagnostic yield. With regard to MRS, there are very few studies about accuracy diagnostic but, however; there are many about sensitivity, specificity, PPV and NPV, being these la...
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PMID: 18803159
PDF is available here.
PDF is available here.
Journal of the Neurological Sciences (263)1-2 2007
Abstract
Neuroreport (18)17 2007
Abstract
We provided evidence that embryonic stem cell-derived embryoid body (EB) cells also exhibited a tropism for gliomas. Chemotaxis assays and organotypic hippocampal slice culture experiments showed that EB cells were attracted by the conditioned medium from C6 glioma cells and by C6 glioma cells depos...
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PMID: 18090319
PDF is available here.
PDF is available here.
Abstract
Abstract
The available literature does not allow firm conclusions with regard to pesticides and any type of childhood cancer. But even if the reported associations were true, exposure to pesticides could not explain the vast majority of childhood cancer cases. Investing in the acquisition and critical review...
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PMID: 17434797
PDF is available here.
PDF is available here.
Cancer Research (67)18 2007
Abstract
We have previously shown that macrophages can slow the progression of malignant gliomas through a tumor necrosis factor-dependent mechanism. Here, we provide evidence suggesting that this antitumor effect could be mediated by T lymphocytes, as their number was drastically reduced in tumor necrosis f...
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PMID: 17875729
PDF is available here.
PDF is available here.
Abstract
Intraneural perineurioma is a neoplastic proliferation of perineurial cells with unique immunohistochemistry and ultrastructural features, and it is distinct from other onion bulb Schwann cell-derived entities. Despite harboring molecular abnormalities of the long arm of chromosome 22, intraneural p...
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PMID: 17824794
PDF is available here.
PDF is available here.
Clinical Radiology (62)9 2007
Abstract
Benign soft-tissue tumours are many times more common than their malignant counterparts, and magnetic resonance imaging (MRI) is the technique of choice for imaging the lesions. This review illustrates the MRI appearances of the most common benign soft-tissue tumours, based on consecutive referrals...
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PMID: 17662731
PDF is available here.
PDF is available here.
Abstract
Temporal paragangliomas (PGL) are usually limited to the paraganglionar system with a sporadic or familial origin. Familial PGL have recently been shown to be associated with germline alterations in SDH group of genes, and occasionally are associated with a variety of genetic multisystemic disorders...
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PMID: 17333230
PDF is available here.
PDF is available here.
Ophthalmology (114)7 2007
Abstract
Diagnosis of PIOL is difficult but can be improved. Severe bilateral vitreitis in an elderly patient is a characteristic finding of PIOL. Alcohol fixation may jeopardize the identification of PIOL cells in the vitreous sample. Optimal handling of the vitreous specimens and examination of the slides...
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PMID: 17324466
PDF is available here.
PDF is available here.
Abstract
The results of our study have shown that the presence of PNI is an independent risk factor associated with an increased risk of biochemical recurrence in patients with prostate cancer undergoing external beam radiotherapy....
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PMID: 17656219
PDF is available here.
PDF is available here.
Abstract
Not all patients with multiple schwannomas of cranial nerve, spinal nerve root, or peripheral nerve origin have NF-1 or NF-2. In schwannomatosis, these lesions are present in the absence of cutaneous stigmata, neurofibromas, vestibular schwannomas, or parenchymal brain tumors. Schwannomas in schwann...
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PMID: 17538359
PDF is available here.
PDF is available here.
Radiation Medicine (25)5 2007
Abstract
We report the case of a sporadic gastric submucosal neurofibroma underneath a T1 stage cancer. A 61-year-old man underwent gastroscopy because of epigastralgia and was diagnosed as having T1 stage gastric cancer by an experienced gastroenterologist. Subsequently performed computed tomography (CT) sh...
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PMID: 17581713
PDF is available here.
PDF is available here.
Cancer Letters (250)1 2007
Abstract
We used spectral karyotyping (SKY), to compare the individual chromosomal instability of two chromosome types: chromosomes that have a primary aberration and chromosomes without an aberration, in 13 primary childhood neural tumors and seven cell lines. We found that chromosomes that contain a primar...
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PMID: 17084022
PDF is available here.
PDF is available here.
Abstract
Cancer Research (67)8 2007
Abstract
We have previously detected a large germ-line deletion, which included the entire p15/CDKN2B-p16/CDKN2A-p14/ARF gene cluster, in the largest melanoma-neural system tumor (NST) syndrome family known to date by means of heterozygosity mapping based on microsatellite markers. Here, we used gene dose ma...
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PMID: 17440112
PDF is available here.
PDF is available here.
Abstract
We present guidelines to standardize the reporting of surgically based neuro-oncology trials. The guidelines are summarized in a checklist format that can be used as a framework from which to construct a surgically based trial. This manuscript follows and is taken in part from GNOSIS: Guidelines for...
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PMID: 17146595
PDF is available here.
PDF is available here.