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Neurotoxicity Syndromes (7):
Recent article
Neurotoxicity Syndromes
Toxicology (289)1 2011
Abstract
We hypothesized that the effects of these compounds could be reflected by changes in biochemical substrates and cholinergic receptors and have examined the levels of four proteins involved in maturation of the brain, neuronal growth and synaptogenesis and the densities of both muscarinic and nicotin...
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PMID: 21820030
PDF is available here.
PDF is available here.
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Anesthesiology (114)1 2011
Abstract
Anesthesiology (114)1 2011
Abstract
The mechanisms by which isoflurane injured the developing brain are not clear. Recent work has demonstrated that it is mediated in part by activation of p75 neurotrophin receptor. This receptor activates RhoA, a small guanosine triphosphatase that can depolymerize actin. It is therefore conceivable...
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PMID: 21169791
PDF is available here.
PDF is available here.
Abstract
There are few true international meetings dedicated to covering multiple areas of toxicology. The XII International Congress of Toxicology (IUTOX) held from 19 to 23 July 2010 in Barcelona, Spain is one such meeting. The IUTOX is important as its emphasis is on chemical safety and integrating approa...
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PMID: 20843280
PDF is available here.
PDF is available here.
Military Medicine (175)11 2010
Abstract
Scopolamine (SCP) is an anticholinergic drug used clinically for decades to treat motion sickness, as a surgical preanesthetic, and as a smooth muscle antispasmodic. It has also been used experimentally as a pretreatment and/or treatment adjunct to mitigate the toxic sequelae of organophosphorus (OP...
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PMID: 21121499
PDF is available here.
PDF is available here.
Abstract
We have systematically reviewed the literature of both rtPA and L-arginine administration in mechanical focal ischemia. The rtPA worsens ischemic damage under certain conditions, whereas L-arginine can have both beneficial and deleterious effects dependent on the time of administration. The interact...
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PMID: 20736961
PDF is available here.
PDF is available here.
Neurotoxicity Research (18)2 2010
Abstract
We aimed to determine whether or not minocycline, a semi-synthetic tetracycline antibiotic capable of inhibiting microglial activation, could prevent the inflammatory response and reduce the toxicity induced by MDMA. Adult male Dark Agouti rats were given minocycline twice a day for 2 days (45 mg/kg...
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PMID: 19777321
PDF is available here.
PDF is available here.
Abstract
To investigate the health effects of 1-bromopropane (1-BP) and its dose-dependency in 1-BP production factories in China.
Data of 60 female and 26 male workers in three 1-BP factories and the same number of age-, sex-, and region-matched controls were interviewed and examined. The time-weighed avera...
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PMID: 20657306
PDF is available here.
PDF is available here.
Behavioral Neuroscience (124)4 2010
Abstract
We explored the behavioral and neurotoxic effects of intraventricular NMDA administration in mice. After NMDA injection, acute seizures were followed by impairments in locomotor activity, motor performance on a rotarod, and climbing ability. Mice killed 1 day after NMDA administration showed increas...
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PMID: 20695653
PDF is available here.
PDF is available here.
Abstract
Inappropriate use of toxic chemicals is common in developing countries, where it leads to excessive exposure and high risks of unintentional poisoning. Risks are particularly high with the pesticides used in agriculture, poor rural populations live and work in close proximity to these compounds and...
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PMID: 20929053
PDF is available here.
PDF is available here.
Transplant Immunology (23)3 2010
Abstract
The introduction of cyclosporine in the early 1980s meant a decisive improvement in post-transplant outcomes for all solid-organ transplants and, in particular, it allowed heart transplantation to emerge as a viable therapeutic option for patients with end-stage cardiac failure. Many factors, includ...
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PMID: 20434559
PDF is available here.
PDF is available here.
FASEB Journal (24)7 2010
Abstract
Oxidative stress induced by inhibition of glutathione (GSH) biosynthesis with D,L-buthionine-S,R-sulfoximine (BSO) causes human microglia, human astrocytes, THP-1 cells, and U373 cells to secrete materials toxic to human neuroblastoma SH-SY5Y cells and stimulates them to release TNF-alpha, IL-6, and...
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PMID: 20228251
PDF is available here.
PDF is available here.
Neuroscience (167)4 2010
Abstract
These results demonstrate: (1) Unlike adults, juvenile mice show neither a sex difference for MA-induced neurotoxicity or body temperature increases, nor MA neurotoxicity, (2) Initial effects of MA (0.5 h) in adult females and males are similar, but at 72 h post-MA females show no further striatal D...
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PMID: 20211701
PDF is available here.
PDF is available here.
Journal of the Neurological Sciences (292)1-2 2010
Abstract
This study describes the clinical and neuroimaging features of five patients with 1, 2-Dichloroethane (DCE) toxic encephalopathy. From January 1st 1998 to June 30th 2009, five patients who were subsequently diagnosed with DCE toxic encephalopathy were admitted to our hospital. All were female worker...
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PMID: 20163807
PDF is available here.
PDF is available here.
Neurobiology of Disease (38)2 2010
Abstract
We tested whether phosphodiesterase 5 (PDE5) inhibitors, sildenafil and vardenafil, would afford protection against 3-nitropropionic acid (3NP), which produces striatal lesions that closely mimic some of the neuropathological features of Huntington's Disease (HD). The neurotoxin was given over 5 day...
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PMID: 20109548
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
Our goal was to determine whether in vivo exposure affects microtubule structure. One group of mice was treated daily for 14 days with a dose of chlorpyrifos that did not significantly inhibit acetylcholinesterase. Beta-tubulin from the brains of these mice was diethoxyphosphorylated on tyrosine 281...
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PMID: 20142434
PDF is available here.
PDF is available here.
Abstract
We report 3 patients who experienced severe vinblastine-associated neurotoxicity during concomitant treatment with ritonavirboosted antiretrovirals. The implications for the treatment of patients with HL in the current era of cART are discussed....
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PMID: 20371439
PDF is available here.
PDF is available here.
Abstract
We present the case of a 51-year-old male who, 30 min after successful angiography for treatment of a right carotid-ophthalmic fusiform aneurysm with a stent, developed psychomotor agitation, disorientation, and progressive left faciobrachial hemiparesis (4/5). An emergency nonenhanced CT showed mar...
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PMID: 19504154
PDF is available here.
PDF is available here.
Abstract
We will review many of these articles, focusing on those that address intracranial hemorrhage, intracranial procedures, carotid endarterectomy, spine surgery, and the determinants of outcome in patients with evolving or new-onset neurologic disease. Additionally, we will review articles addressing n...
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PMID: 20308816
PDF is available here.
PDF is available here.
Abstract
We present a child with Down syndrome who had received previous chemotherapy, cranial radiation, and a stem cell transplant with total body irradiation for her acute lymphoblastic leukemia. She subsequently relapsed and was treated with clofarabine. After her third course, she had a stroke that was...
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PMID: 20216234
PDF is available here.
PDF is available here.
Abstract
Damage to the nervous system is a common side effect of antineoplastic therapy. The improvements in treating systemic malignancies have been accompanied by the reports of neurological toxicity that has important impact on quality of life and may even limit the use of the treatment. Neurotoxicity can...
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PMID: 20167398
PDF is available here.
PDF is available here.
Abstract
We present a 90-year-old man with paroxysmal atrial fibrillation undergoing low-dose amiodarone therapy for a period of 18 months without medical follow-up who developed signs and symptoms consistent with neurotoxicity and hepatotoxicity in association with hyperammonemia. Upon discontinuation of th...
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PMID: 18757154
PDF is available here.
PDF is available here.
Anesthesiology (112)3 2010
Abstract
Arterial blood gas samples drawn at a sevoflurane concentration of 2.1% showed no evidence of either hypoxia or hypoventilation in spontaneously breathing rats. Higher doses of sevoflurane (e.g., 2.9%) caused respiratory depression. During anesthesia maintenance, the electroencephalography exhibited...
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PMID: 20124973
PDF is available here.
PDF is available here.
Abstract
We report a very rare case of an overdose intrathecal GD injection presenting with neurotoxic manifestations, including a decreased level of consciousness, global aphasia, rigidity, and visual disturbance....
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PMID: 20191058
PDF is available here.
PDF is available here.
Abstract
Neurotoxicity from intravenous fludarabine is a rare but recognized clinical entity. Its brain imaging features have not been extensively described. Three patients received 38.5 mg or 40 mg/m per day fludarabine in a 5-day intravenous infusion before bone marrow transplantation in treatment of hemat...
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PMID: 20182205
PDF is available here.
PDF is available here.
Neurotoxicology (31)2 2010
Abstract
I (50%), II (50%) and IV(62%)) as compared to sham operated animals. Chronic treatment with rofecoxib (10 and 20 mg/kg, p.o.) and nimesulide (10 and 20mg/kg, p.o.) significantly attenuated quinolinic acid-induced behavioral and biochemical alterations as compared to quinolinic acid 300 nmol treated...
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PMID: 20043943
PDF is available here.
PDF is available here.
Abstract
To determine the effects of kaempferol, rat pheochromocytoma cells (PC12) and Institute of Cancer Research (ICR) mice were utilized as neuronal models. Using in vitro assays, kaempferol was shown to have protective effects against oxidative stress-induced cytotoxicity in PC12 cells. Administration o...
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PMID: 20139605
PDF is available here.
PDF is available here.
Southern Medical Journal (103)2 2010
Abstract
A case of prolonged encephalopathy and worsened parkinsonism in a Parkinson disease patient exposed to a short course of metoclopramide is described. Parkinson disease (PD) is the second most common neurodegenerative disease in the United States. Because of the increased susceptibili...
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PMID: 20065895
PDF is available here.
PDF is available here.
Pediatric Research (67)2 2010
Abstract
Recent advances in neonatal intensive care include and are partly attributable to growing attention for comfort and pain control in the term and preterm infant requiring intensive care.Limitation of painful procedures is certainly possible, but most critically ill infants require unavoidable painful...
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PMID: 20091937
PDF is available here.
PDF is available here.
Abstract
We demonstrated a significant weight loss of parotid gland tissue, a marked decrease in 3H-thymidine incorporation, a decreased volume of saliva and amylase activity of the glandular tissue in response to PEF. Animals received intraperitoneal injection of PEF (20 mg/100 g body weight daily) for 3 an...
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PMID: 19937634
PDF is available here.
PDF is available here.
Abstract
The data demonstrate the complexity of CO pathophysiology and support a view that exposure causes acute inflammatory events in humans. This pilot study has insufficient power to discern reliable differences among patients who develop neurological sequelae but future trials are warranted to determine...
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PMID: 20095814
PDF is available here.
PDF is available here.
Abstract
We still do not know which cytotoxic agents are responsible, which characteristics make patients vulnerableand which biologic mechanisms are involved. This chapter reviews the recent literature and provides an actualized definition of chemo brain, including recent functional imaging data and discuss...
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PMID: 20738010
PDF is available here.
PDF is available here.
Abstract
Although it is now clear that cognitive dysfunction is a common accompaniment of cancer chemotherapy, its implications await further research and direction. Most of the clinical research relies on standard neuropsychological tests that were developed to diagnose stable traits. Cognitive dysfunction...
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PMID: 20738011
PDF is available here.
PDF is available here.
Abstract
Our results show that H-290/51 significantly attenuated heat stress induced BBB impairment, brain edema formation and neurotoxicity in nanoparticle treated rats. However, no significant diminution of nanoparticle induced BBB breakdown, or neurotoxicity was observed in H-290/51 treated rats kept at r...
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PMID: 19812976
PDF is available here.
PDF is available here.
Klinicheskaia meditsina (88)2 2010
Abstract
Examination and treatment of 262 patients with severe acute intoxication by neurotropic poisons and unaffected oxygen delivery system showed that inclusion of cytoflavin in combined neurometabolic therapy of acute cerebral insufficiency significantly reduced severity of metabolic disorders. Specific...
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PMID: 21105475
PDF is available here.
PDF is available here.
Klinicheskaia meditsina (88)5 2010
Abstract
Examination and treatment of 66 patients severely intoxicated with neurotropic poisons showed that inclusion of reamberin in combined therapy decreased the degree of tissue hypoxia as apparent from increased oxygen consumption, oxygen utilization index, and arteriovenous oxygen difference. This in t...
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PMID: 21089461
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (60)1 2010
Abstract
A series of new 3-hydroxy-6-hydroxymethyl-2-substituted 4H-pyran-4-one derivatives were synthesized as potential anticonvulsant compounds. Mannich compounds were prepared by the reaction of appropriate substituted piperazine derivatives with kojic acid and formaline. The structure of the synthesized...
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PMID: 20184223
PDF is available here.
PDF is available here.
Abstract
Because of the risk of severe encephalopathy, we conclude that patients who have previously received cisplatin or who receive ifosfamide at doses >or=9 g/m(2) require strict monitoring....
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PMID: 20151259
PDF is available here.
PDF is available here.
BMC Neurology (10) 2010
Abstract
This case demonstrates a significant role of vasospasm in the pathway of cyclosporine-induced neurotoxicity. Transcranial Doppler ultrasound is an effective tool for the diagnosis and follow-up of cyclosporine-induced vasospasm....
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PMID: 20459819
PDF is available here.
PDF is available here.
Galanin protects amyloid-beta-induced neurotoxicity on primary cultured hippocampal neurons of rats.
Abstract
We further found that galanin inhibited the activation of p53, Bax, and caspase-3 induced by Abeta(25-35) in the cultured hippocampal neurons. Moreover, galanin reversed the down regulation of Bcl-2 induced by Abeta(25-35) in the cultured neurons. Interestingly, in the Morris water maze task we foun...
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PMID: 20413891
PDF is available here.
PDF is available here.
Abstract
Synthesising data from multiple routine sources improved estimates of HCV prevalence and sequelae in dialysis patients and drug users, although prevalence validity should be assessed in survey and sequelae need a well-defined longitudinal approach....
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PMID: 20403169
PDF is available here.
PDF is available here.
Molecular Vision (16) 2010
Abstract
At a concentration of 0.1 microM or higher, brimonidine increased survival of purified rat RGCs in the presence of glutamate neurotoxicity, oxidative stress, and hypoxia. The neuroprotective effect of brimonidine is mediated via alpha2-adrenergic receptors at the RGC level....
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PMID: 20161817
PDF is available here.
PDF is available here.
Abstract
Little is known regarding the relationship between neurotoxicity symptoms and injury, particularly among adolescent farmworkers. This pilot study utilized logistic regression to analyze injury prevalence in relation to self-reported symptoms of neurotoxicity among adolescent farmworkers along the US...
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PMID: 20465058
PDF is available here.
PDF is available here.
Renal Failure (32)9 2010
Abstract
We report the case of a 55-year-old male on chronic hemodialysis who developed confusion and agitation after receiving ioversol during abdominal angiography. Although hemodialysis was performed his healing took 15 days. Patients with end-stage renal disease may be at an increased risk of adverse eff...
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PMID: 20863223
PDF is available here.
PDF is available here.
Abstract
A series of 4-aryl substituted semicarbazones of pyridyl carbaldehyde and pyridyl methyl ketone were designed and synthesized to meet the structural requirements essential for anticonvulsant activity. The structure of synthesized compounds were confirmed by IR spectroscopy, PMR spectroscopy and nitr...
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PMID: 20021362
PDF is available here.
PDF is available here.
Anesthesiology (111)6 2009
Abstract
Abstract
A number of new 8-substituted-4-(2/4-substituted phenyl)-2H-[1,3,5]triazino[2,1-b][1,3]benzothiazole-2-thiones (4a-t) were synthesized and evaluated for their anticonvulsant, anti-nociceptive, hepatotoxic, and neurotoxic properties. The titled compounds (4a-t) were obtained by cyclization of N-{[6-s...
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PMID: 19912067
PDF is available here.
PDF is available here.
Biochemical Journal (424)2 2009
Abstract
Scorpion venom, containing highly toxic, small polypeptides that diffuse rapidly within the patient, causes serious medical problems. Nanobodies, single-domain antigen-binding fragments derived from dromedary heavy-chain antibodies, have a size that closely matches that of scorpion toxins. Therefore...
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PMID: 19732033
PDF is available here.
PDF is available here.
Abstract
We examined the possible neurotoxicity of multiple doses of intrathecal ropivacaine in rats. Rats received 0.12 ml/kg body weight ropivacaine in normal saline at concentrations of 0.25%, 0.5%, 0.75% and 1.0% at 90-minute intervals via an implanted intrathecal catheter (ID 0.12 mm, OD 0.35 mm) for 48...
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PMID: 20014599
PDF is available here.
PDF is available here.
Neurotoxicology (30)6 2009
Abstract
Vojnosanitetski pregled (66)9 2009
Abstract
We described a patient with massive white matter damage which led to vigil coma and lethal outcome. CASE REPORT: A 56-year old woman ingested about 500 mL of herbicide containing glyphosate isopropylamine salt. The most prominent manifestation of poisoning included hypotension, coma, hyperkaliemia,...
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PMID: 19877558
PDF is available here.
PDF is available here.
Abstract
These results also provided evidence supporting the hypothesis that carvedilol and melatonin can be useful for treating neurodegenerative diseases, such as Huntington's disease....
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PMID: 20119823
PDF is available here.
PDF is available here.
Acta Neurologica Belgica (109)3 2009
Abstract
We report the case of a 35-year-old man presenting with a delayed and prolonged coma due to an intentional overdose with disulfiram without simultaneous alcohol ingestion. The clinical features--comprising a severe toxic encephalopathy with coma and convulsions, in combination with a quadriparesis o...
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PMID: 19902819
PDF is available here.
PDF is available here.
Abstract
Abstract
We investigated the effects of Tbeta4 on ethanol-induced neurotoxicity in cultured cerebral cortical astrocytes and the underlying mechanisms. Primarily cultured astrocytes were treated with 1 microg/ml Tbeta4 2 h prior to administration of 100 mM ethanol for 0.5, 1, 3 and 6 days, respectively. The...
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PMID: 19688260
PDF is available here.
PDF is available here.
Abstract
We present a systematical analysis of study design and methodological differences between 66 studies where estrogens' impact on ischemic brain damage in rat models has been investigated, providing evidence that the differences in results may be explained by high estrogen doses produced by slow-relea...
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PMID: 19458604
PDF is available here.
PDF is available here.
Drug and Alcohol Review (28)4 2009
Abstract
Alcohol-related neurotoxicity and dysregulation of hypothalamic-pituitary-adrenal axis and serotonergic systems may underlie certain offender characteristics consistently correlated with heightened DWI risk, persistence and intervention resistance. Their markers are less vulnerable to sources of bia...
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PMID: 19594795
PDF is available here.
PDF is available here.
Abstract
We doubt that quercetin possesses any significant efficacy in neurodegenerative disorders. Instead, therapeutic trials should focus more on the quercetin efficacy in cerebrovascular insults rather than neurodegeneration....
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PMID: 19538101
PDF is available here.
PDF is available here.