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Piracetam (0):
Recent article
Piracetam
Abstract
We aimed to investigate the effects of levetiracetam on oxidative stress which is one of the new antiepileptic drugs in epileptic patients.
The study consisted of 21 patients with cryptogenic partial epilepsy. We determined the urinary 15F-2t-isoprostane levels of the 30 patients which is a marker o...
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PMID: 20692184
PDF is available here.
PDF is available here.
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Abstract
A simple and rapid high-performance liquid chromatographic method for the separation and determination of piracetam and its four impurities, 2-oxopyrrolidin-1-yl)acetic acid, pyrrolidin-2-one, methyl (2-oxopyrrolidin-1-yl)acetate, and ethyl (2-oxopyrrolidin-1-yl)acetate, was developed. The separatio...
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PMID: 20819285
PDF is available here.
PDF is available here.
Abstract
Continuous administration of levetiracetam, valproate or phenobarbital is effective in preventing recurrent febrile convulsions in rats. Phenobarbital appears to be more effective than levetiracetam and valproate. There were no significant differences in the prophylactic efficacy between levetiracet...
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PMID: 20637159
PDF is available here.
PDF is available here.
Epileptic Disorders (12)2 2010
Abstract
We present a patient with cryptogenic focal epilepsy and another with Dravet syndrome, who experienced seizure aggravation and negative myoclonus, associated with continuous spikes and waves during slow sleep, induced by levetiracetam. For both patients levetiracetam was discontinued, and there was...
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PMID: 20483715
PDF is available here.
PDF is available here.
Epileptic Disorders (12)2 2010
Abstract
We report two patients with LOMEDS and cognitive decline, aged 52 and 44 years. Continuous video-EEG recording showed generalised spike and slow wave complexes as an ictal correlate of the myoclonic jerks in both patients. Low dose levetiracetam resulted in rapid, sustained seizure freedom in both p...
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PMID: 20483713
PDF is available here.
PDF is available here.
Abstract
This multicenter, double-blind, placebo-controlled, 2-arm, parallel-group study was carried out to determine the effectiveness and safety of the novel anticonvulsant levetiracetam for the treatment of generalized social anxiety disorder (GSAD).
After a 1-week, single-blind, placebo run-in period, 21...
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PMID: 20021997
PDF is available here.
PDF is available here.
Abstract
We have established the safety, tolerability, and dosage of intravenous levetiracetam in children. This prospective study included 30 children (6 months to <15 years of age). Patients were administered a single dose of intravenous levetiracetam (50 mg/kg, maximal dose 2500 mg) over 15 minutes. A blo...
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PMID: 20413804
PDF is available here.
PDF is available here.
Abstract
In the past decade, most studies on levetiracetam were conducted on patients aged > or = 4 years of age. The authors sought to assess the efficacy and safety of levetiracetam as an adjunctive treatment of children <4 years of age with refractory epilepsy. The mean levetiracetam dosag...
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PMID: 19779208
PDF is available here.
PDF is available here.
Abstract
We examined drug effects cross-sectionally at baseline, 6 months, and 12 months. There were no significant differences in efficacy among the three AEDs. LEV caused fewer adverse events than the other AEDs. PB produced persistent negative cognitive side effects. LEV was associated with improved cogni...
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PMID: 20188634
PDF is available here.
PDF is available here.
Abstract
LEV as adjunctive therapy is effective and well-tolerated in children younger than 4 years with refractory epilepsy, suggesting that it represents a valid option for the treatment of refractory epilepsy in this age group....
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PMID: 20416214
PDF is available here.
PDF is available here.
Der Nervenarzt (81)4 2010
Abstract
We evaluated factors possibly influencing serum concentrations of levetiracetam (LEV-SC). The study included 163 patients with epilepsy (91 men, 72 women; mean age 39.6 years). The duration of treatment on first analysis was 226 days; the mean daily dose amounted to 2,434 mg. In each patient between...
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PMID: 20111854
PDF is available here.
PDF is available here.
Abstract
Peak concentration occurred 0.6 hours after administration of the first dose, with an absorption half-life of 0.06 hours. Minimal accumulation occurred over the 7 days, with only a slight increase in total area under the concentration-versus-time curve from 268.52 +/- 56.33 h x microg/mL (mean +/- S...
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PMID: 20187836
PDF is available here.
PDF is available here.
Abstract
We conducted a prospective, uncontrolled, phase 4, open label, 12-week study of levetiracetam to better profile its efficacy, safety, and impact on cognitive/behavioral status in 24 cognitively impaired, elderly individuals. In total, 69% were seizure free for the duration of the study; the remainin...
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PMID: 19001351
PDF is available here.
PDF is available here.
Abstract
We conducted a prospective, uncontrolled, phase 4, open label, 12-week study of levetiracetam to better profile its efficacy, safety, and impact on cognitive/behavioral status in 24 cognitively impaired, elderly individuals. In total, 69% were seizure free for the duration of the study; the remainin...
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PMID: 19001351
PDF is available here.
PDF is available here.
Abstract
There is an increasing interest in nootropic drugs for the treatment of CNS disorders. Since the last meta-analysis of the clinical efficacy of piracetam, more information has accumulated. The primary objective of this systematic survey is to evaluate the clinical outcomes as well as the scientific...
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PMID: 20166767
PDF is available here.
PDF is available here.
Abstract
We review our experience with high-dose intravenous levetiracetam (IV-LEV) for acute seizure exacerbations in nine children with medically intractable epilepsy. All children had acute repetitive seizures-while on chronic antiepileptic drugs-that either led to hospitalization (eight) or occurred duri...
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PMID: 20163437
PDF is available here.
PDF is available here.
Abstract
We report on LEV therapy in 32 children (mean age: 10.6 years, range: 4-14) with RE or variants like atypical benign idiopathic partial epilepsy of childhood (ABIPEC), Landau-Kleffner syndrome (LKS), and continuous spikes and waves during sleep (CSWS) and in children with benign idiopathic focal epi...
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PMID: 20045383
PDF is available here.
PDF is available here.
Abstract
We outline how levetiracetam was discovered, the animal and human data showing its antiepileptic activity, its potential use in other neurological conditions and the significant adverse events. We also discuss the direction antiepileptic drug development will take in the future....
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PMID: 20136375
PDF is available here.
PDF is available here.
Abstract
The current evidence shows that levetiracetam therapy is effective for childhood epilepsy. However, it needs to be proved by the multi-centre, large sample RCTs....
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PMID: 20199730
PDF is available here.
PDF is available here.
Abstract
Levetiracetam is an anticonvulsant drug used to treat partial seizures, myoclonic seizures of juvenile myoclonic epilepsy and primary generalized tonic-clonic seizures. A review of the literature with an evidence-based medicine method highlighted parameters (age, renal failure, pregnancy, combinatio...
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PMID: 20205999
PDF is available here.
PDF is available here.
Abstract
The principle of the pharmacopoeial heavy metals test is detection and estimation of the metallic impurities colored by sulfide ion by comparison against lead standard. The test suffers from a loss of analytes upon ashing and from having varied responses for various metals. An inductively coupled pl...
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PMID: 20187573
PDF is available here.
PDF is available here.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov (110)12 2010
Abstract
We studied the efficacy of akatinol memantine compared to that of piracetam in the treatment of 41 patients with posttraumatic cognitive disturbances (20 patients were treated with akatinol memannine and 21 patients with piracetam) during 24 weeks. Ten patients had a severe traumatic brain injury (T...
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PMID: 21311490
PDF is available here.
PDF is available here.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov (110)1 2010
Abstract
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov (110)9 2010
Abstract
We conducted an open study on efficacy and safety of vinpotropile in patients with initial signs of chronic brain ischemia. Twenty patients, aged from 50 to 78 years, were examined. Seven patients had the diagnosis of discirculatory encephalopathy (DE), I stage, and 13 patients were diagnosed with D...
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PMID: 21183904
PDF is available here.
PDF is available here.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov (110)9 2010
Abstract
Abstract
We investigated the effect of LEV on differentiated NG108-15 neurons. In these cells treated with dibutyryl cyclic AMP, the expression level of the K(V)3.1 mRNA was elevated. With the aid of patch clamp technology, we found that LEV could suppress the amplitude of delayed rectifier K(+) current (I(K...
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PMID: 20065495
PDF is available here.
PDF is available here.
Abstract
While waiting for large, controlled studies, our data suggest that IV levetiracetam might be an alternative for the treatment of status epilepticus, especially in elderly patients with vascular status epilepticus and concomitant medical conditions....
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PMID: 19845418
PDF is available here.
PDF is available here.
Epilepsy & Behavior (16)2 2009
Abstract
These results suggest that adjunctive LEV XR may be associated with a lower incidence of nervous system, psychiatric, and nutritional and metabolic TEAEs as compared with LEV IR. However, this difference was observed at a broad scale and not at a specific TEAE level except for headache....
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PMID: 19699156
PDF is available here.
PDF is available here.
Abstract
We report a 17-year-old female patient with Lance-Adams syndrome caused by anoxic encephalopathy during a severe attack of bronchial asthma. She had difficulty in writing because of action myoclonus in her arms. She also exhibited freezing gait and was unable to walk without cane. Although her gait...
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PMID: 19764456
PDF is available here.
PDF is available here.
Abstract
A new ion chromatography method with non-suppressed conductivity detection has been developed for the quantification of residual phase transfer catalyst-tetrabutylammonium bromide (TBAB) in an active pharmaceutical drug, Levetiracetam. Separation conditions are optimized to get a clear separation of...
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PMID: 19772723
PDF is available here.
PDF is available here.
Abstract
CNS Spectrums (14)5 2009
Abstract
Body dysmorphic disorder (BDD) is an often severe disorder, but few treatment studies have been conducted.
This pilot study explored the efficacy and safety of the antiepileptic medication levetiracetam for BDD.
Seventeen subjects with Diagnostic and Statistical Manual of Mental Disorders, Fourth Ed...
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PMID: 19407724
PDF is available here.
PDF is available here.
Abstract
This study showed that LEV might be a well-tolerated and effective treatment for lumbar radiculopathy. A large randomized placebo-controlled trial is recommended and comparative studies with alternative agents should be sought....
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PMID: 19627916
PDF is available here.
PDF is available here.
Medicina Clínica (132)9 2009
Abstract
Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine (11)1 2009
Abstract
A 67-year-old woman abruptly developed acute pulmonary oedema, severe bradycardia and then cardiac arrest while in hospital 6 days after an elective hernia repair. She was resuscitated, intubated and transferred to the intensive care unit. Within 24 hours, she began to display repetitive, generalise...
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PMID: 19281443
PDF is available here.
PDF is available here.
Acta Neurologica Belgica (109)1 2009
Abstract
We report the case of a CBS disappearing completely with successive monotherapies of carbamazepine and valproic acid but worsening with levetiracetam....
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PMID: 19402573
PDF is available here.
PDF is available here.
Abstract
Of 188 patients screened, 158 were randomized (intention-to-treat population): LEV XR (n = 79) or placebo (n = 79). Seventy-one (89.9%) LEV XR and 72 (91.1%) placebo patients completed the trial. Median POS-frequency/week reduction was 46.1% on LEV XR and 33.4% on placebo. Estimated reduction with L...
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PMID: 19317886
PDF is available here.
PDF is available here.
Abstract
In control tissue, presynaptic SV2A was expressed in all hippocampal subfields, with strongest expression in mossy fiber terminals. SV2A positive puncta were distributed in a patchy pattern over the somata and dendrites of neurons. SV2A decreased throughout the hippocampus of TLE patients with hippo...
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PMID: 18717715
PDF is available here.
PDF is available here.
Abstract
Improvement with lamotrigine relative to levetiracetam was observed for mean +/- SD (standard deviation) change from baseline to the end of the maintenance phase (week 20) on the Anger-Hostility subscale (lamotrigine -2.0 +/- 8.2, levetiracetam -0.3 +/- 8.4; p = 0.024) (the primary endpoint); the An...
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PMID: 19016830
PDF is available here.
PDF is available here.
Abstract
Eleven patients with a median age of 60 years were included in the per protocol analysis. Five were diagnosed as generalized-convulsive SE, five as partial-convulsive SE, and one as a nonconvulsive SE. The median time from hospital admission to ivLEV was 36 min. No serious side effects could be rela...
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PMID: 19054418
PDF is available here.
PDF is available here.
Benefit of combination therapy in epilepsy: a review of the preclinical evidence with levetiracetam.
Abstract
Levetiracetam (Keppra) is an antiepileptic drug (AED) characterized by a novel mechanism of action, unique profile of activity in seizure models, and broad-spectrum clinical efficacy. The present report critically reviews several preclinical studies focused on combination therapy with levetiracetam...
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PMID: 18627416
PDF is available here.
PDF is available here.
Abstract
LEV significantly decreased weekly partial-onset seizure frequency over placebo by 26.8% (p < 0.001). Median percentage reductions in weekly partial-onset seizure frequency from historical baseline were 55.9% for LEV and 13.7% for placebo (p < 0.001). The >or=50% responder rates were 55.9% for LEV,...
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PMID: 18657175
PDF is available here.
PDF is available here.
Abstract
Abstract
The objective of this study was to investigate the utility of levetiracetam (LEV) in children with refractory status epilepticus (RSE). Records of children with RSE who received LEV as adjunctive therapy were reviewed. Over a 7-year period, 11 children had received LEV for RSE. Age ranged from 2 day...
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PMID: 18926926
PDF is available here.
PDF is available here.
Clinical Drug Investigation (29)11 2009
Abstract
We describe a case of pancytopenia and multiple infections observed in the context of levetiracetam treatment. A 65-year-old woman who underwent surgical removal of a meningioma developed progressive pancytopenia complicated by pneumonia and multiple liver abscesses after starting levetiracetam ther...
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PMID: 19813778
PDF is available here.
PDF is available here.
Abstract
For the four treatment groups, in the pre-and post-treatment (10th day) evaluation of the treatment efficiency made by calculation of the hearing thresholds in 250-8000 Hz frequencies, no significant difference between the groups was determined (p>0.05). CONCLUSION: No additional benefit was obtaine...
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PMID: 19793043
PDF is available here.
PDF is available here.
Abstract
VPA exposure resulted in a decrease in estradiol levels and a general downregulation of expression of genes encoding for enzymes early in steroidogenesis. No consistent changes were seen with LEV or CBZ exposure....
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PMID: 19566492
PDF is available here.
PDF is available here.
Abstract
Effective influence of the drug Cerebral and its micro- and macrofractions on the mean lifespan and degenerative process dynamics of Drosophila melanogaster have been investigated. No dose--effect dependence was detected when different concentrations of Cerebral were used. The administration of Cere...
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PMID: 19441721
PDF is available here.
PDF is available here.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov (109)7 2009
Abstract
An open 6 month clinical trial of efficacy of acatinol has been carried out in patients with mild cognitive disorder (MCD). Forty patients received acatinol and 20 patients of comparison group were treated with piracetam. Mean age of patients was 67,7+/-7,2 years. Patient's state was assessed with a...
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PMID: 19672236
PDF is available here.
PDF is available here.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov (109)6 2009
Abstract
Efficacy of omaron (a combination of piracetam 400 mg and cinnarizin 25 mg) has been studied 3 months after stroke in 90 post-stroke patients. Forty-five patients receiving the basic therapy (antihypertensive and antithrombotic drugs, statins) have been included in the control group and 45 patients...
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PMID: 19672226
PDF is available here.
PDF is available here.
Revista de Neurologia (49)1 2009
Abstract
Topiramate and valproic acid have demonstrated efficacy in migraine prevention. Lamotrigine is efficacious for the treatment of migraine aura. Even though new studies are necessary, zonisamide could be a good option for the preventive treatment of migraine....
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PMID: 19557697
PDF is available here.
PDF is available here.
Abstract
The study results confirm that general anaesthesia affects the memory function in children. Piracetam is effective for prevention of postoperative cognitive dysfunction after anaesthesia....
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PMID: 19517672
PDF is available here.
PDF is available here.
Revue medicale de Liege (64)1 2009
Abstract
We propose a diagnostic and therapeutic discussion on a common clinical problem. Due to the large number of available antiepileptic drugs, choosing the best treatment is not an easy task. One must take into consideration the type of epilepsy, the pharmacological properties of the antiepileptic drug,...
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PMID: 19317105
PDF is available here.
PDF is available here.
Abstract
Fragile X-associated tremor/ataxia syndrome is a recently discovered disorder affecting more of one third of older adult male carriers of premutation alleles of fragile X mental retardation 1 (FMR1 gene). There is no established treatment.The 66-year-old right-handed grandfather of a boy with fragil...
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PMID: 19471185
PDF is available here.
PDF is available here.
European Neurology (61)4 2009
Abstract
The 50% responder rate (the proportion of patients with a minimum of 50% reduction in partial seizure frequency) occurred in 46.4% of the LEV group, compared with 39.3% of the placebo group (p = 0.590). The median of the absolute weekly frequency reduction from baseline of partial seizures was 0.66...
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PMID: 19176965
PDF is available here.
PDF is available here.
European Journal of Pharmacology (601)1-3 2008
Abstract
We examined the effects of the two new, high affinity SV2A ligands, brivaracetam and seletracetam, in comparison to levetiracetam on the severity of dystonia in mutant hamsters. Seletracetam (50 and 75 mg/kg i.p.) and brivaracetam (75 mg/kg i.p.) reduced the severity of dystonia to a comparable exte...
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PMID: 19014930
PDF is available here.
PDF is available here.
Epileptic Disorders (10)4 2008
Abstract
Results of the present study suggest that long-term LEV treatment as add-on therapy does not interfere with cognitive function and improves quality of life....
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PMID: 19017572
PDF is available here.
PDF is available here.
Emergency Medicine Journal (25)12 2008
Abstract
Following a collapse at home, a previously well 24-year-old Ukrainian man living in Ireland was brought to the emergency department. He complained of neck pain and cervical spine radiographs revealed loss of lordosis, scalloping of the posterior vertebral bodies and widening of the neural exit foram...
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PMID: 19033517
PDF is available here.
PDF is available here.
Abstract
LEV monotherapy is effective and safe for the control of partial and generalized tonic-clonic seizures in children with epilepsy. LEV appears to be a promising anti-epileptic drug for monotherapy in children with epilepsy....
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PMID: 19102836
PDF is available here.
PDF is available here.
Pharmacotherapy (28)12 2008
Abstract
High-dose busulfan is frequently used in a variety of conditioning regimens for hematopoietic cell transplantation. In this setting, busulfan has marked neurotoxicity, specifically causing seizures that generally are tonic-clonic in character. Phenytoin has been the preferred drug to treat busulfan-...
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PMID: 19025431
PDF is available here.
PDF is available here.