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Thioacetamide (0):
Recent article
Thioacetamide
Abstract
We elucidated the mechanism by which adiponectin modulates hepatic stellate cell activation and fibrogenesis. Adiponectin-overexpressing transgenic mice receiving thioacetamide were resistant to fibrosis, compared with controls. In contrast, adiponectin-null animals developed severe fibrosis. Expres...
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PMID: 21641391
PDF is available here.
PDF is available here.
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Abstract
We have demonstrated that Gas6 and its receptor Axl are expressed in macrophages, progenitor cells, and myofibroblasts and that Gas6 deficiency reduced inflammation and myofibroblast activation, causing delayed liver repair in response to acute injury. All these data suggest a role of Gas6/Axl signa...
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PMID: 21350191
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of iPSC transplantation on thioacetamide- (TAA-) induced acute/fulminant hepatic failure (AHF) in mice. Firstly, we demonstrated that iPSCs had the capacity to differentiate into hepatocyte-like cells (iPSC-Heps) that expressed various hepatic markers, including albumin,
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PMID: 21808596
PDF is available here.
PDF is available here.
Abstract
A series of N-aryl-2-arylthioacetamide derivatives (2-4) designed as non-nucleoside reverse transcriptase inhibitors was synthesized and evaluated for their inhibitory activity against HIV-1 (IIIB) replication in MT-4 cell cultures. The compounds 2-4 were performed by the reaction of thiols and 2-ch...
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PMID: 20731670
PDF is available here.
PDF is available here.
Abstract
We postulated that, in liver fibrosis, a reversal of LSEC function from tolerogenic to proinflammatory and immunogenic may contribute to both the heightened inflammatory milieu and altered intrahepatic immunity. We found that, after fibrotic liver injury from hepatotoxins, LSECs become highly proinf...
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PMID: 20639479
PDF is available here.
PDF is available here.
Abstract
OBT is sensitive for potentially evaluating liver function in rat models of acute hepatitis and thioacetamide-induced liver cirrhosis but not in cholestatic liver injury. The MBID test may be better for evaluation of cholestatic liver disease in this model....
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PMID: 19731033
PDF is available here.
PDF is available here.
Abstract
Hepatic fibrogenesis, a complex process that involves a marked accumulation of extracellular matrix components, activation of cells capable of producing matrix materials, cytokine release, and tissue remodeling, is regulated by matrix metalloproteinases (MMPs) and tissue inhibitors of metalloprotein...
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PMID: 20358000
PDF is available here.
PDF is available here.
Toxicology (268)3 2010
Abstract
The present study investigated the preventive effect of eugenol, a naturally occurring food flavouring agent on thioacetamide (TA)-induced hepatic injury in rats. Adult male Wistar rats of body weight 150-180 g were used for the study. Eugenol (10.7 mg/kg b.w./day) was administered to rats by oral i...
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PMID: 20036707
PDF is available here.
PDF is available here.
BMC Gastroenterology (10) 2010
Abstract
The index is composed of 4 serum variable including total proteins, gamma-GT, bilirubin and reduced glutathione (GSH), measured in diseased, treated and normal mice. These parameters were highly correlated with both the histological stage and the grade. They were combined in a logarithmic formula, w...
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PMID: 20515488
PDF is available here.
PDF is available here.
Abstract
We aimed to investigate the role of carnosine on the development of TAA-induced cirrhosis. 200mg TAA/kg body weight has been given i.p. twice a week for three months to female wistar rats. Another group received same dose of TAA in the same pattern plus 2g carnosine/L of drinking water for three mon...
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PMID: 19958806
PDF is available here.
PDF is available here.
Abstract
We verified if a solution of HF (glucose, vitamins, salts, amino acids, glucagon, insulin, and triiodothyronine) can revert liver cirrhosis and how some extracellular matrices are affected. Cirrhosis was induced for 14 weeks in 45 female Wistar rats (200 mg) by intraperitoneal injections of thioacet...
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PMID: 19784507
PDF is available here.
PDF is available here.
Abstract
We have investigated the ability of the combination of PPAR gamma ligand rosiglitazone (RSG) and of ATRA to prevent liver fibrosis. In vivo treatment with RSG or ATRA reduced fibrotic nodules, spleen weight, and hydroxyproline levels in rat model of thioacetamide-induced liver fibrosis. The combinat...
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PMID: 18594976
PDF is available here.
PDF is available here.
Abstract
We studied the efficacy of urine bile acids (UBA) in a rat model of liver disease. Thioacetamide (TAA)-treated rats were used in this study. Single intraperitoneal administration of high-dose TAA induces severe damage to the liver, and thus is used as a model of acute hepatitis. Continuous administr...
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PMID: 19182433
PDF is available here.
PDF is available here.
Abstract
The similar pattern found between the effect of cannabinoids and their antagonists on brain and liver indicated that the therapeutic effect might be directed by the improvement in both organs through CB2 receptors and/or TRPV1 receptors. Modulation of these systems may have therapeutic potential....
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PMID: 19086956
PDF is available here.
PDF is available here.
Hepatology (48)4 2008
Abstract
We aimed to modulate hyperammonemia in three rodent models by administration of wild-type Lactobacillus plantarum, a genetically engineered ammonia hyperconsuming strain, and a strain deficient for the ammonia transporter. Wild-type and metabolically engineered L. plantarum strains were administered...
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PMID: 18697211
PDF is available here.
PDF is available here.
Hepatology (48)4 2008
Abstract
Our aim was to determine the feasibility of functional magnetic resonance imaging (fMRI) during hypercapnia and hyperoxia for monitoring liver pathology. Liver fMRI images were acquired in rodents following acute bleeding, partial hepatectomy, and fibrosis. Results were quantitated and confirmed by...
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PMID: 18629804
PDF is available here.
PDF is available here.
Journal of Gene Medicine (10)9 2008
Abstract
This is the first study to demonstrate that knockdown of hepatic SPARC expression ameliorates thioacetamide-induced liver fibrosis in rats with chronic liver injury. SPARC is a potential target for gene therapy in liver fibrosis.
(c) 2008 John Wiley & Sons, Ltd....
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PMID: 18615449
PDF is available here.
PDF is available here.
Metabolic Brain Disease (23)3 2008
Abstract
Our in vitro and in vivo findings suggest that alterations in AChE and Mg(2+)-ATPase activities are not involved in the pathophysiology of the adult-onset fulminant hepatic encephalopathy, while the observed Na(+),K(+)-ATPase inhibition could be a result of the oxidative stress, neurotransmission de...
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PMID: 18665440
PDF is available here.
PDF is available here.
Biochemistry (Washington) (47)34 2008
Abstract
We now show that while a large fraction of the methionine residues in brain PrP (Sc) are present as methionine sulfoxides this modification could not be found on brain PrP (C) as well as on its recombinant models. In particular, the pattern of oxidation of M213 with respect to the glycosylation at N...
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PMID: 18680312
PDF is available here.
PDF is available here.
Toxicology (250)1 2008
Abstract
We explored the possibility of applying a toxicogenomics approach by using comprehensive gene expression data in rat liver treated with various compounds. As prototypic non-genotoxic hepatocarcinogens, thioacetamide (TAA) and methapyrilene (MP) were selected and 349 commonly changed genes were extra...
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PMID: 18619722
PDF is available here.
PDF is available here.
Cancer Research (68)16 2008
Abstract
We determined the expression of leptin receptors in normal and malignant human cholangiocytes. Effects on intrahepatic cholangiocarcinoma (HuH-28) cell proliferation, migration, and apoptosis of the in vitro exposure to leptin, together with the intracellular pathways, were then studied. Moreover, c...
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PMID: 18701500
PDF is available here.
PDF is available here.
Abstract
Thioacetamide (TAA) has been used extensively in the development of animal models of acute liver injury. Frequently, TAA is administered intraperitoneally to induce liver damage under anaesthesia. However, it is rarely administered by intravenous injection in conscious rats. The experiments in this...
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PMID: 18422601
PDF is available here.
PDF is available here.
Laboratory Investigation (88)6 2008
Abstract
We showed that heparanase, a heparan sulfate-degrading enzyme, and vascular endothelial growth factor (VEGF) play an important role during liver development and remodeling. In this communication, we investigated the relationship between heparanase and VEGF in thioacetamide-induced liver fibrosis in...
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PMID: 18458672
PDF is available here.
PDF is available here.
Abstract
The structure and electrical properties of self-assembled monolayers of cyclic aromatic and aliphatic dithioacetamides (1,4-bis(mercaptoacetamido)benzene and 1,4-bis(mercaptoacetamido)cyclohexane) and of mixed dithioacetamide/alkanethiol monolayers are characterized by X-ray photoelectron spectrosco...
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PMID: 18507407
PDF is available here.
PDF is available here.
Abstract
These results reveal that CYP2E1 mediates TAA-induced hepatotoxicity in wild-type mice as a result of increased oxidative stress....
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PMID: 18374380
PDF is available here.
PDF is available here.
Abstract
Both NOS inhibitors developed a clear pro-fibrotic effect in the liver. Aminoguanidine was more fibrotic than L-NAME. Our data suggest a significant anti-fibrotic role for iNOS rather than for eNOS. L-Arginine did not show any anti-fibrotic properties in the TAA-model used....
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PMID: 18380797
PDF is available here.
PDF is available here.
Abstract
Green fluorescent protein was observed in the cytoplasms of liver cells under immunofluorescence microscopy 24 h after transfection with EGFP/VEGF plasmid in vitro. Staining with polyclonal antibodies against VEGF illustrated that hepatocytes expressed immunodetectable VEGF both in vitro and in vitr...
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PMID: 18416461
PDF is available here.
PDF is available here.
Behavioural Brain Research (188)1 2008
Abstract
These results reveal a double dissociation in spatial reference memory and spatial working memory between the PCS and PH groups, which would be of great interest to study about cerebral causes and substrates of the alterations accompanying HE....
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PMID: 18063138
PDF is available here.
PDF is available here.
Abstract
The results indicate some disturbances in the opioid system in cirrhotic rats. However, the low response to opioid therapy suggests that the opioid system may have only be partly involved in the development of the observed increased alcohol drinking in the rats with liver cirrhosis....
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PMID: 18441391
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of carnosine treatment on TAA-induced oxidative stress and hepatotoxicity. Rats were injected intraperitoneally with TAA (500 mg/kg) and carnosine (250 mg/kg, intraperitoneal) was co-administered with TAA. All animals were killed 24 h after injections. TAA administration r...
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PMID: 18164100
PDF is available here.
PDF is available here.
Toxicology (243)1-2 2008
Abstract
We report the development of HCC in wild type as well as HCV core protein (HCP)-transgenic zebrafish upon treatment with a hepatotoxin, thioacetamide (TAA). Two-fold accelerated HCC development could be achieved in the TAA-treated transgenic fish, that is, the progression of the disease in TAA-treat...
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PMID: 17997003
PDF is available here.
PDF is available here.
Abstract
A variety of nearly monodisperse semiconductor nanocrystals, such as CdS, ZnS, and ZnS:Mn, with controllable aspect ratios have been successfully prepared through a facile synthetic process. These as-prepared nanocrystals were obtained from the reactions between metal ions and thioacetamide by emplo...
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PMID: 18491306
PDF is available here.
PDF is available here.
Food and Chemical Toxicology (45)11 2007
Abstract
We tested the effects of TS leaf on TAA-induced liver injury. TAA (200mg/kg Bwt/3 days, i.p.) treated rats were orally administrated with TS leaf extract (1g/kg Bwt/10 days) three times. After 30 days treatment, the morphological data showed that TS leaf extract given to TAA-treated rats had less li...
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PMID: 17629604
PDF is available here.
PDF is available here.
Abstract
Selenium reduction in cirrhosis is frequently reported. The known beneficial effect of selenium supplementation on cirrhosis is probably obtained from nutritionally selenium-deficient subjects. Whether selenium supplementation truly improves cirrhosis in general needs additional experimental investi...
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PMID: 17643461
PDF is available here.
PDF is available here.
Liver International (27)6 2007
Abstract
Cirrhosis was induced by intraperitoneal injection of 50 mg thioacetamide twice a week for 14 weeks. In portal vein, mesenteric artery and aorta of normal and cirrhotic rats, mRNA for the five known SSTR was measured by quantitative reverse transcriptase-polymerase chain reaction. SSTR subtypes 1, 2...
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PMID: 17617126
PDF is available here.
PDF is available here.
Abstract
Efficacy of a herbal product of E. officinalis (fruit) (EO) has been evaluated against carbon tetrachloride (CCl4) and thioacetamide (TAA) induced changes in rat liver. Chronic treatment of CCl4 and TAA revealed abnormal histopathology indicative of pre-fibrogenic events. EO reversed such alteration...
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PMID: 17821859
PDF is available here.
PDF is available here.
Gastroenterology (133)1 2007
Abstract
We conclude that single or repeated EPC transplantation halts established liver fibrosis in rats by suppressing activated hepatic stellate cells, increasing matrix metalloproteinase activity, and regulating hepatocyte proliferation....
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PMID: 17631135
PDF is available here.
PDF is available here.
European Journal of Pharmacology (564)1-3 2007
Abstract
These results indicated that the necrotic process was initiated at about 12 h and developed thereafter. By co-administration of dimethyl sulphoxide (DMSO, 18 and 1 h before, and 8 h after administration of thioacetamide: each time, 2.5 ml/kg body weight, p.o.), plasma GOT and GPT were significantly...
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PMID: 17395177
PDF is available here.
PDF is available here.
Brain Research (1153) 2007
Abstract
Acetylcholinesterase (AchE) is an important peripheral membrane-bound enzyme, crucial for cholinergic neurotransmission. Changes in AchE activity, kinetic and thermotropic properties were studied in hepatic encephalopathy (HE) associated with acute liver failure induced experimentally by the adminis...
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PMID: 17482580
PDF is available here.
PDF is available here.
Abstract
S-adenosylmethionine (SAMe) has been shown to protect hepatocytes from toxic injury, both experimentally-induced in animals and in isolated hepatocytes. The mechanisms by which SAMe protects hepatocytes from injury can result from the pathways of SAMe metabolism. Unfortunately, data documenting the...
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PMID: 17650956
PDF is available here.
PDF is available here.
Abstract
We conclude that aspirin and enoxaparin hold promise as a useful therapy for patients with extensive fibrosis....
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PMID: 17372820
PDF is available here.
PDF is available here.
Clinica Chimica Acta (380)1-2 2007
Abstract
Leakage into and clearance from the circulation of OCT are influenced by whether Kupffer cells are activated or not. OCT alone or in combination with other markers may be a useful indicator for Kupffer cell activation as well as mitochondrial damage in hepatic cells....
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PMID: 17350606
PDF is available here.
PDF is available here.
Virchows Archiv (450)5 2007
Abstract
We tested the applicability of precision-cut liver slices (PCLS) to study the early activation of the two main liver fibrogenic cell subpopulations: hepatic stellate cells (HSC) and portal fibroblasts (PF). PCLS were treated with thioacetamide or acetaminophen to induce HSC activation. In PCLS cultu...
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PMID: 17431675
PDF is available here.
PDF is available here.
Abstract
In primary cultured rat stellate cells and the LX-2 human stellate cell line, induction of BMP-7 by Ad-BMP-7 infection decreased the expression of collagen 1A2 mRNA and smooth muscle alpha-actin in the presence or absence of TGFbeta, via Smad 1/5/8 phosphorylation. BMP-7 triggered the mRNA expressio...
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PMID: 17127702
PDF is available here.
PDF is available here.
Toxicology (232)3 2007
Abstract
Liver injury initiated by non-lethal doses of CCl(4) and thioacetamide (TA) progresses to hepatic failure and death of type 2 diabetic (DB) rats due to failed advance of liver cells from G(0)/G(1) to S-phase and inhibited tissue repair. Objective of the present study was to investigate cellular sign...
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PMID: 17298859
PDF is available here.
PDF is available here.
Journal of Surgical Research (138)2 2007
Abstract
The mechanism of resolution from cirrhosis can be extensively investigated using the presented model which, for example, showed GST isoforms performing their roles at different time phases....
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PMID: 17292413
PDF is available here.
PDF is available here.
Liver International (27)3 2007
Abstract
Curcumin inhibited the development of TAA-induced liver cirrhosis mainly due to its anti-inflammatory activities and not by a direct anti-fibrotic effect. As curcumin ingestion is safe in humans, it may be reasonable to assess in clinical studies the beneficial effect of curcumin in slowing the deve...
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PMID: 17355460
PDF is available here.
PDF is available here.
Cell and Tissue Research (328)1 2007
Abstract
We have used transcriptional profiling to evaluate the effect of halofuginone on gene expression during the progression of thioacetamide (TAA)-induced liver fibrosis in the rat and have focused on genes that are associated with TGF-beta. TAA treatment causes alterations in the expression of 7% of li...
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PMID: 17180598
PDF is available here.
PDF is available here.
Abstract
In vitro study: 5, 10 or 25 microg/mL of tetrandrine-induced activation of caspase-3 in t-HSC/Cl-6 cells occurred dose-dependently. In vivo study: tetrandrine treatment as well as interferon-r significantly ameliorated the development of fibrosis as determined by lowered serum levels of aspartate am...
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PMID: 17451202
PDF is available here.
PDF is available here.
Archives of Toxicology (81)3 2007
Abstract
We consider that the critical event in the onset of hepatotoxin-induced hypertyrosinemia is likely to be a reduction in hepatic tyrosine aminotransferase (TAT) activity. We discuss mechanisms by which TAT activity could be lost with special consideration given to pyridoxal 5'-phosphate (P5P) depleti...
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PMID: 16902803
PDF is available here.
PDF is available here.
Abstract
Thioacetamide (TA) undergoes saturation toxicokinetics in ad libitum (AL) fed rats. Diet restriction (DR) protects rats from lethal dose of TA despite increased bioactivation-mediated liver injury via CYP2E1 induction. While a low dose (50 mg TA/kg) produces 6-fold higher initial injury, a 12-fold h...
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PMID: 17234228
PDF is available here.
PDF is available here.
Toxicology (230)2-3 2007
Abstract
We have established that TA exhibits saturation toxicokinetics over a 12-fold dose range, which explains the lack of dose-response for bioactivation-based liver injury. In vivo and in vitro studies indicated that the second step (TASO-->TASO(2)) of TA bioactivation is less efficient than the first o...
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PMID: 17187915
PDF is available here.
PDF is available here.
Abstract
To obtain a new model of chronic portal hypertension in the rat, two classical methods to produce portal hypertension, partial portal vein ligation and the oral administration of thioacetamide (TAA), have been combined. Male Wistar rats were divided into four groups: 1 (control; n = 10), 2 [triple p...
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PMID: 17390171
PDF is available here.
PDF is available here.
Gastroenterology (132)2 2007
Abstract
Treatment with nitroflurbiprofen, an NO-releasing cyclooxygenase inhibitor, improves portal hypertension without major adverse effects in thioacetamide-induced cirrhotic rats by attenuating intrahepatic vascular resistance, endothelial dysfunction, and hepatic hyperreactivity to vasoconstrictors....
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PMID: 17258737
PDF is available here.
PDF is available here.
Fitoterapia (78)2 2007
Hepatoprotection of Phyllanthus maderaspatensis against experimentally induced liver injury in rats.
Abstract
The hexane extract of Phyllanthus maderaspatensis (200 and 100 mg/kg) showed significant hepatoprotection on carbon tetrachloride and thioacetamide induced liver damage in rats. The protective effect was evident from serum biochemical parameters and histopathological analysis. Rats treated with P. m...
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PMID: 17210231
PDF is available here.
PDF is available here.
Abstract
Fulminant hepatic failure (FHF) is a condition with a sudden onset of necrosis followed by degeneration of hepatocytes, without any previously established liver disease, generally occurring within hours or days. FHF is associated with a wide spectrum of neuropsychiatric alterations ranging from stup...
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PMID: 17169376
PDF is available here.
PDF is available here.
Abstract
The TAA group showed lower motor activity counts than the normal saline group. Hepatic eNOS, but not iNOS, mRNA and protein expressions were enhanced in the TAA group. In addition, hepatic eNOS mRNA expression was negatively correlated with total movement but positively correlated with ALT and AST....
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PMID: 17276928
PDF is available here.
PDF is available here.
Abstract
Metabonomics has already been used to discriminate different pathological states in biological fields. The metabolic profiles of chronic experimental fibrosis and cirrhosis induction in rats were investigated using (1)H NMR spectroscopy of liver extracts and serum combined with pattern recognition t...
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PMID: 17113614
PDF is available here.
PDF is available here.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques (10)3 2007
Abstract
Induced liver necrosis caused significant elevation of activity of liver enzymes, parameters of oxidative stress and marked changes in histopathology, like necrosis of hepatocytes, hepatocyte degeneration and infiltration of inflammatory cells. In TPA and ST pretreated rats histopathological changes...
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PMID: 17727797
PDF is available here.
PDF is available here.
Abstract
We investigated the antioxidative and antihyperproliferative potential of tannic acid against thioacetoamide (TAA), a potent hepatotoxic-substance-induced oxidative stress and hyperproliferation biomarker. We have shown here that the activities of hepatic antioxidant enzymes, phase II metabolizing e...
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PMID: 17725526
PDF is available here.
PDF is available here.