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Azides (1):
Recent article
Azides
Chemical Communications (46)40 2010
Abstract
A cross-linked hemoglobin bis-tetramer with oxygenation properties appropriate for a red cell substitute is produced by CuAAC conjugation of a dialkyne and two equivalents of an azide of β,β-cross-linked hemoglobin. The latter is formed efficiently by the aminolysis of the 3,5-dibromosalicylate es...
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PMID: 20852763
PDF is available here.
PDF is available here.
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Abstract
We have examined the influence of the gap junction opener trimethylamine (TMA) and the connexin 36 (Cx36) gap junctional blocker, quinine, on epileptiform activity induced by 4-aminopyridine (4-AP) in the rat entorhinal cortex (EC) and the CA1 hippocampal region. A cannula and surface electrodes wer...
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PMID: 20685138
PDF is available here.
PDF is available here.
Abstract
Myocardial infarction (MI) results in the death of cardiomyocytes (CM), which causes scar formation and pathological remodeling of the heart. The delivery of healthy myocytes or bone marrow cells reduces pathological remodeling after MI, however, current cell injection methods have l...
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PMID: 20540095
PDF is available here.
PDF is available here.
Abstract
The strain-promoted "double-click" (SPDC) reaction using Sondheimer diyne, a novel convergent method conjugating three molecules spontaneously, has enabled us to readily modify an azido-biomolecule with a small reporter azido-molecule.
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PMID: 20657923
PDF is available here.
PDF is available here.
Chemical Communications (46)34 2010
Abstract
A highly efficient silver triflate and N-heterocyclic carbene co-catalyzed three-component reaction of N'-(2-alkynylbenzylidene)hydrazide, methanol with alpha,beta-unsaturated aldehyde is described, which gives rise to the 2-amino-1,2-dihydroisoquinolines in good yield.
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PMID: 20697636
PDF is available here.
PDF is available here.
Kidney International (76) 2010
Abstract
Chemical Communications (46)31 2010
Abstract
A versatile and stable liposomal platform is developed for rapid optimization of its peripheral composition. The platform is based on polydiacetylene lipids terminated with alkynyl groups. Conditions for copper-catalyzed azide-alkyne cycloaddition (a "click" reaction) are optimized for rapid attachm...
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PMID: 20585691
PDF is available here.
PDF is available here.
Abstract
We describe a standardized approach for searching potent and selective inhibitors of glycosyltransferases by high throughput quantitative MALDI-TOFMS-based screening of focused compound libraries constructed by 1,3-dipolar cycloaddition of the desired azidosugar nucleotides with various alkynes. An...
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PMID: 20684602
PDF is available here.
PDF is available here.
Abstract
In a screening of saprotrophic, ectomycorrhizal and plant pathogen ascomycetes a frequent occurrence of laccase was observed. Lamprospora wrightii, the best producing organism, was chosen to elucidate the properties of a laccase from a moss-associated, saprotrophic ascomycete. The ex...
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PMID: 20652905
PDF is available here.
PDF is available here.
Abstract
We have demonstrated previously that sialic acid residues of CD44 negatively regulates its receptor function and CD44 plays an important role in the accumulation of T helper type 2 (Th2) cells in the airway of a murine model of acute asthma. Here we evaluated the role of sialidase in the hyaluronic...
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PMID: 20491786
PDF is available here.
PDF is available here.
Journal of Physical Chemistry A: Molecules, Spectroscopy, Kinetics, Environment and General Theory (114)28 2010
Abstract
Fluorosulfonyl azide, FSO(2)N(3), was characterized by IR (gas phase, Ar matrix), and Raman (liquid) spectroscopy. According to the matrix IR spectrum of (18)O-labeled FSO(2)N(3), its two oxygen atoms are nonequivalent. This assumption was confirmed by the X-ray crystal structure of FSO(2)N(3) at -1...
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PMID: 20578773
PDF is available here.
PDF is available here.
Abstract
We examined Drp1 regulation during tubular cell apoptosis following ATP depletion. Rat kidney proximal tubular cells (RPTC) were subjected to azide treatment or severe hypoxia in glucose-free medium to induce ATP depletion. During ATP depletion, Drp1 was shown to be dephosphorylated at serine-637. D...
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PMID: 20410216
PDF is available here.
PDF is available here.
Inorganic Chemistry (49)13 2010
Abstract
Reaction of 1-adamantyl azide with iron(I) diketiminate precursors gives metastable but isolable imidoiron(III) complexes LFe=NAd (L = bulky beta-diketiminate ligand; Ad = 1-adamantyl). This paper addresses (1) the spectroscopic and structural characterization of the Fe=N multiple bond in these inte...
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PMID: 20524625
PDF is available here.
PDF is available here.
Food Microbiology (27)4 2010
Abstract
We obtained a dynamic range of greater than 3 logs for differentiating viable vs. dead cells. The viability and morphological characteristics of the stressed cells after one-week incubation at 25 degrees C, in air, and under nutrient-poor conditions were investigated. Our results indicated that, ove...
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PMID: 20417391
PDF is available here.
PDF is available here.
Nucleic Acids Research (38)11 2010
Abstract
We engineered Escherichia coli cells with a translation system orthogonal to the E. coli tyrosyl-tRNA synthetase (TyrRS)-tRNA(Tyr) pair, to use E. coli TyrRS variants for non-natural amino acids in the cells without interfering with tyrosine incorporation. We showed that the E. coli TyrRS-tRNA(Tyr)...
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PMID: 20159998
PDF is available here.
PDF is available here.
Chemical Communications (46)18 2010
Abstract
Unsymmetrical phosphites react efficiently in a Staudinger reaction with p-azido-phenylalanine, which can be applied for the biotinylation of proteins, thereby expanding the scope of the chemoselective Staudinger-phosphite reaction of aryl azides with symmetrical phosphites to the corresponding phos...
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PMID: 20424765
PDF is available here.
PDF is available here.
Abstract
It has been shown that various pyrido-, quinolino-, pyrazino-, and quinoxalinotetrazoles can be used efficiently as azide components in Cu-catalyzed click reaction with alkynes. This method allows for efficient synthesis of a wide variety of N-heterocyclic derivatives of 1,2,3-triazoles.
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PMID: 20380424
PDF is available here.
PDF is available here.
Abstract
N-heterocyclic carbene catalyzed oxidative amidations of various aldehydes to the corresponding hexafluoroisopropylesters by using the readily available organic oxidant A are described. The hexafluoroisopropylesters prepared in situ are shown to be highly useful active esters for amide bond formatio...
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PMID: 20359171
PDF is available here.
PDF is available here.
Abstract
Cube-octameric silsesquioxane (POSS) based conjugation scaffolds for copper catalysed azide-alkyne [3+2] cycloaddition are reported. The synthetic route to octaazido and octaalkyno functionalised POSS templates without cage rearrangements is described. A set of click couplings is conducted including...
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PMID: 20401398
PDF is available here.
PDF is available here.
Abstract
We have used the orthogonal carbodiimide condensation and copper-catalyzed azide-alkyne "click" cycloaddition (CuAAC) reactions to prepare self-assembled monolayers that present distinct peptides to stem cells in a bioinert background. The approach involved first forming mixed SAMs with three compon...
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PMID: 20353153
PDF is available here.
PDF is available here.
Bioconjugate Chemistry (21)4 2010
Abstract
We demonstrate here that copper-free click chemistry, between strained cyclooctyne functionalized QD and azido-biomolecules, leads to highly luminescent conjugates. In addition, we show that QD-cyclooctyne can be used at previously unreported low concentration (250 nM) for imaging the incorporation...
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PMID: 20222737
PDF is available here.
PDF is available here.
Bioconjugate Chemistry (21)4 2010
Abstract
We used the copper-catalyzed azide-alkyne cycloaddition to synthesize two series of derivatives in which thymidine is functionalized at either the C3' or N3 position with chelating systems suitable for the M(CO)(3) core (M = (99m)Tc, Re). The click chemistry approach enabled complexes with different...
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PMID: 20359195
PDF is available here.
PDF is available here.
Abstract
We recently found that the azido group could be used as an amino protecting group in the peptide condensation by the thioester method. In this study, we synthesized the glycosylated mouse pro-opiomelanocortin (1-74) by the thioester method. The N-terminal peptide thioester segment, whose Lys side ch...
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PMID: 20449504
PDF is available here.
PDF is available here.
Abstract
Our work takes advantage of the rigid nature of CNCs, the unique nanopattern etched on their surface in the form of regularly spaced primary OH groups, and the fact that these materials have all reducing end groups located on one end. In this communication, a method for the grafting of amine-termina...
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PMID: 20235575
PDF is available here.
PDF is available here.
Abstract
Our results indicate that, instead of a highly organized secondary structure, hydrophobic hydration is critical for the elasticity of EMPs....
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PMID: 20235503
PDF is available here.
PDF is available here.
Chemical Communications (46)13 2010
Abstract
Oligonucleotides that contain a 5-iodo-2'-deoxyuridine in the sequence can be applied for a postsynthetic "click"-type modification with ethynyl-modified nile red as a fluorescent label by in situ formation of the intermediate azide.
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PMID: 20234915
PDF is available here.
PDF is available here.
Chemical Communications (46)13 2010
Abstract
Chimeras of poly(n-isopropyl acrylamide) and immunogenic peptides from the cancer-associated glycoprotein MUC1 were synthesised using a combination of solid-phase peptide synthesis, RAFT polymerisation and copper-catalysed alkyne-azide cycloaddition reactions.
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PMID: 20234901
PDF is available here.
PDF is available here.
Abstract
The reactivity of the trigonal bipyramidal iron(I) complex [SiP(iPr)(3)]Fe(N(2)) ([SiP(iPr)(3)] = (2-iPr(2)PC(6)H(4))(3)Si(-)) toward organoazides has been examined. 1-Adamantylazide was found to coordinate the iron center to form stable [SiP(iPr)(3)]Fe(eta(1)-N(3)Ad). Aryl azides instead afforded u...
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PMID: 20199026
PDF is available here.
PDF is available here.
Methods in Molecular Biology (607)607 2010
Abstract
We prepared an unnatural CaM molecule carrying a 3-azidotyrosine residue at the predetermined position 80. The synthesized CaM containing 3-azidotyrosine was site-specifically modified via azido group with a fluorescent alkyne derivative by click chemistry. This method will be useful to prepare not...
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PMID: 20204861
PDF is available here.
PDF is available here.
Abstract
We assessed the lipid peroxidation induced by the reaction of ferritin with H2O2. When linoleic acid micelles or phosphatidyl choline liposomes were incubated with ferritin and H2O2, lipid peroxidation increased in the presence of ferritin and H2O2 in a concentration-dependent manner. The hydroxyl r...
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PMID: 20356464
PDF is available here.
PDF is available here.
Abstract
We compared the abilities of EMA and PMA, together with real-time PCR, to specifically distinguish dead Legionella cells from viable cells. Several experiments showed that PMA or EMA treatment could specifically prevent the PCR amplification of DNA from dead Legionella cells in water samples. Howeve...
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PMID: 20332575
PDF is available here.
PDF is available here.
Abstract
A series of new and novel coumarin-6-sulfonamides with a free C4-azidomethyl group have been synthesized as antimicrobials in three steps starting from 7-methyl-4-bromomethylcoumarin 1. The reaction of 1 with chlorosulfonic acid was found to yield the corresponding 6-sulfonylchloride 2, which when t...
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PMID: 20047777
PDF is available here.
PDF is available here.
Abstract
Four coordination polymers of different transition metal ions with azide and the zwitterionic dicarboxylate ligand 1,2-bis(N-carboxymethyl-4-pyridinio)ethane (bcpe) were synthesized, and structurally and magnetically characterized. They are formulated as [M(2)(bcpe)(N(3))(4)].H(2)O (M = Mn, 1; Co, 2...
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PMID: 20449431
PDF is available here.
PDF is available here.
Abstract
The persistence of naturally occurring campylobacteria in aerobic compost constructed of manure from beef cattle that were administered chlortetracycline and sulfamethazine (AS700) or from cattle not administered antibiotics (control) was examined. Although there were no differences in population si...
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PMID: 20023098
PDF is available here.
PDF is available here.
Abstract
We hypothesized that manipulations of this receptor subtype would influence processing of rewards. Voltage-clamp recordings from NAcc medium spiny neurons of mice with alpha2 gene deletion showed reduced synaptic GABA(A) receptor-mediated responses. Behaviorally, the deletion abolished cocaine's abi...
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PMID: 20133874
PDF is available here.
PDF is available here.
Abstract
We explore an alternative bioorthogonal reaction, the 1,3-dipolar cycloaddition of azides and cyclooctynes, also known as "Cu-free click chemistry," for labeling biomolecules in live mice. Mice were administered peracetylated N-azidoacetylmannosamine (Ac(4)ManNAz) to metabolically label cell-surface...
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PMID: 20080615
PDF is available here.
PDF is available here.
Abstract
We describe the application of a model click reaction to the conjugation, in a single step of unprotected alpha-1-thiomannosyl ligands, functionalized with an azide group to liposomes containing a terminal alkyne-functionalized lipid anchor. Excellent coupling yields were obtained in the presence of...
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PMID: 20072887
PDF is available here.
PDF is available here.
Abstract
The use of the reaction of azide and alkyne cycloaddition for the synthesis of nucleic acid conjugates and DNA oligomer analogues is considered. The data on chemical and enzymatic techniques of azides and alkynes introduction into DNA are summarized.
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PMID: 20823915
PDF is available here.
PDF is available here.
Abstract
Our results indicate that the amphibian postcaval vein and aorta exhibit plasma membrane electron transport....
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PMID: 20093738
PDF is available here.
PDF is available here.
Biochemistry (Washington) (48)40 2009
Abstract
The early steps in the photocycle of sensory rhodopsin II mutant D75N are investigated in a comprehensive study using femtosecond visible pump/probe spectroscopy. An overall slower response dynamics after photoexcitation is observed compared to wild-type sensory rhodopsin II, which is assigned to ch...
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PMID: 19739678
PDF is available here.
PDF is available here.
Abstract
A new and easy method for synthesis of symmetric pyrrole-2,5-dicarboxylate derivatives via a simple titanium(IV)-mediated oxidative dimerization of 2-azidocarboxylic esters is described. The process involves a transformation of titanium(IV) enolates into nonisolated 2-iminoesters, which undergo an o...
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PMID: 19725550
PDF is available here.
PDF is available here.
Journal of Organic Chemistry (74)19 2009
Abstract
Direct synthesis of condensed triazoles from diverse sulfamidates by ring opening of sulfamidates with sodium azide followed by one-pot propargylation and cycloaddition furnished title compounds. The methodology in general has been demonstrated on diverse sulfamidates derived from amino acids, amino...
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PMID: 19725506
PDF is available here.
PDF is available here.
Abstract
A Mn(III)-mediated divergent synthesis of substituted pyridines and 2-azabicyclo[3.3.1]non-2-en-1-ol derivatives was exploited using readily available vinyl azides and cyclopropanols with a wide range of substituents. In short, the reactions of vinyl azides with monocyclic cyclopropanol provided pyr...
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PMID: 19722716
PDF is available here.
PDF is available here.
Abstract
Novel azido-functionalized POSS were synthesized, which could serve as nanoprecursors for higher-order molecular construction of organic-inorganic hybrids via"click" chemistry.
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PMID: 20448969
PDF is available here.
PDF is available here.
Inorganic Chemistry (48)17 2009
Abstract
New energetic inorganic materials composed of 1,3-diazido-2-(azidomethyl)-2-propylammonium salts have been fully characterized by IR, (1)H, (13)C, and (15)N NMR spectroscopy and by elemental analyses, as well as single crystal X-ray diffraction. In addition, the heats of formation and detonation pre...
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PMID: 19715373
PDF is available here.
PDF is available here.
Abstract
Phenyl azides with powerful electron-donating substituents are known to deviate from the usual photochemical behavior of other phenyl azides. They do not undergo ring expansion but form basic nitrenes that protonate to form nitrenium ions. The photochemistry of the widely used photoaffinity labeling...
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PMID: 19624129
PDF is available here.
PDF is available here.
Abstract
Iridium(I) catalyzes the intramolecular benzylic C-H bond amination of ortho-homobenzyl-substituted aryl azides to produce indolines at 25 degrees C.
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PMID: 19627144
PDF is available here.
PDF is available here.
Abstract
We designed a new RGD homodimeric peptide with two PEG(4) spacers (PEG(4) = 15-amino-4,7,10,13-tetraoxapentadecanoic acid) between the two monomeric RGD motifs and one PEG(4) linker on the glutamate alpha-amino group ((18)F-labeled PEG(4)-E[PEG(4)-c(RGDfK)](2), P-PRGD2), as a promising agent for non...
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PMID: 19296102
PDF is available here.
PDF is available here.
Abstract
By using a neutral inner-salt-type dicarboxylate as coligand, a novel two-dimensional (2D) manganese(II) coordination polymer, [Mn(L)(N(3))]ClO(4) x 1/2 H(2)O (L = 1,3-bis(3-carboxylatopyridinium)propane), was synthesized, and characterized by X-ray crystallography and magnetic measurements. The com...
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PMID: 20449105
PDF is available here.
PDF is available here.
Abstract
Our results suggest that becatecarin is transported by ABCG2 and can induce ABCG2 expression in cancer cells....
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PMID: 19132374
PDF is available here.
PDF is available here.
Matrix elimination ion chromatography method for trace level azide determination in irbesartan drug.
Abstract
Ultra-trace analysis of azide in complicated Irbesartan sample matrix is achieved by the in-line sample preparation technique. Sodium azide is the precursor of Irbesartan, which is used as an anti-hypertensive drug. Due to the toxic nature of sodium azide, reliable determination of azide in Irbesart...
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PMID: 19772721
PDF is available here.
PDF is available here.
Journal of Organic Chemistry (74)14 2009
Abstract
The thermal, photochemical, and photochemical/CuI-mediated cascade cyclizations of a range of substituted 1-(2-azidophenyl)-3-alkenylallenes are described. These reactions provide both 1,2- and 2,3-cyclopentennelated indole products in varying ratios. In most cases, high regioselectivity for the 2,3...
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PMID: 19472993
PDF is available here.
PDF is available here.
Bioconjugate Chemistry (20)7 2009
Abstract
We report a versatile approach for the immobilization of unmodified monosaccharides onto iron oxide nanoparticles. Covalent coupling of the carbohydrate onto iron oxide nanoparticle surfaces was accomplished by the CH insertion reaction of photochemically activated phosphate-functionalized perfluoro...
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PMID: 19534519
PDF is available here.
PDF is available here.
Abstract
A general method is described to sequester peptides containing azides from complex peptide mixtures, aimed at facilitating mass spectrometric analysis to study different aspects of proteome dynamics. The enrichment method is based on covalent capture of azide-containing peptides by t...
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PMID: 19402736
PDF is available here.
PDF is available here.
Abstract
A simple addition with a large impact: Addition of aromatic amines such as phenanthroline and 4-DMAP (4-dimethylaminopyridine) increases copper(I)-catalyzed azide alkyne cycloaddition (CuAAC) catalytic activity of [CuCl(SIMes)] at a large range of temperatures in such a way that efficient catalysis...
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PMID: 19462382
PDF is available here.
PDF is available here.
Parasitology (90 ( Pt 3))03 2009
Abstract
The modified Kato technique has the advantages of reproducibility, simplicity and economy: the disadvantage is that it cannot be used in conjunction with traditional faecal preservatives. Sodium azide has been evaluated as a preservative for human faeces for subsequent Kato analysis. More than 400 f...
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PMID: 4011316
PDF is available here.
PDF is available here.
ChemBioChem (10)7 2009
Abstract
Two steps to click iodine: We have developed a two-step reaction for protein iodination using click chemistry. With this method, which is summarized in the scheme, covalent attachment of a stable iodine-containing aromatic azide moiety to an alkyne-containing protein was achieved.
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PMID: 19338033
PDF is available here.
PDF is available here.
Abstract
Pt(II) azido complexes [Pt(bpy)(N(3))(2)] (1), [Pt(phen)(N(3))(2)] (2) and trans-[Pt(N(3))(2)(py)(2)] (3) incorporating the bidentate diimine ligands 2,2'-bipyridine (bpy), 1,10-phenanthroline (phen) or the monodentate pyridine (py) respectively, have been synthesised from their chlorido precursors...
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PMID: 19290364
PDF is available here.
PDF is available here.
Biochemical Journal (419)1 2009
Abstract
In the blood plasma of humans and rats, ceruloplasmin is the major copper-binding protein and ferroxidase, accounting for 70% of the copper present in the plasma, with the rest binding primarily to albumin and a macroglobulin. Systematic studies with fresh plasma were carried out to compare what occ...
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PMID: 19076073
PDF is available here.
PDF is available here.
Journal of Antibiotics (62)5 2009
Abstract
We report the rapid discovery of a new and potent inhibitor of bacterial chitinases by the use of in situ click chemistry. We observed a target-templated formation of a potent triazole inhibitor of the chitinase-catalyzed chitin hydrolysis, through in situ click chemistry between a biologically acti...
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PMID: 19329983
PDF is available here.
PDF is available here.