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Carboxylic Acids (8):
Recent article
Carboxylic Acids
Abstract
We demonstrate that a functional reversal of the β-oxidation cycle can be used as a metabolic platform for the synthesis of alcohols and carboxylic acids with various chain lengths and functionalities. This pathway operates with coenzyme A (CoA) thioester intermediates and directly uses acetyl-CoA...
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PMID: 21832992
PDF is available here.
PDF is available here.
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Chemmedchem (6)8 2011
Abstract
We previously screened a library of analogues based on the ubiquitous PTP substrate para-nitrophenylphosphate (pNPP) and found that incorporation of a 3-phenyl substituent to give 6-nitro-[1,1'-biphenyl]-3-yldihydrogen phosphate (1) enhanced affinity. Herein we report the conversion of 1 from a subs...
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PMID: 21671403
PDF is available here.
PDF is available here.
Abstract
A novel triazole carboxylic acid, penipanoid A (1), two new quinazolinone alkaloids, penipanoids B (2) and C (3), and a very recently reported quinazolinone derivative (4) were isolated from the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated by spectroscopic...
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PMID: 21495659
PDF is available here.
PDF is available here.
Abstract
GPR40, a G-protein-coupled receptor has been well established to play a crucial role in regulating blood glucose levels. Hence, GPR40 is a potential target for future antidiabetic agents. The present 3D QSAR study is aimed at delineating structural parameters governing GPR40 agonisti...
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PMID: 21352503
PDF is available here.
PDF is available here.
Abstract
Organically-modified hydroxyapatite materials were synthesized through the addition of oxalic, succinic, adipic and citric acids to a calcium hydroxide solution before neutralization by ammonium dihydrogenphosphate. All carboxylic acids have a significant influence on apatite crystallinity and nanop...
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PMID: 20886132
PDF is available here.
PDF is available here.
Journal of Antibiotics (63)12 2010
Abstract
We isolated a small compound from the fermentation broth of Penicillium verruculosum CR37010. This compound, named decalpenic acid, bears a decalin moiety with a tetraenoic acid side chain. Treatment of C3H10T1/2 cells with decalpenic acid alone induced the expression of early osteoblast markers, su...
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PMID: 20940725
PDF is available here.
PDF is available here.
Abstract
From Mitrephora maingayi, a new C21-type Annonaceous acetogenin (1) has been isolated, along with a biogenetically related known compound, oropheic acid (2). Their structures were elucidated on the basis of extensive spectroscopic analysis. The insecticidal activity of 1 was also assessed.
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PMID: 21213983
PDF is available here.
PDF is available here.
Abstract
The hexaazamacrocycles [28](DBF)(2)N(6) {cyclo[bis(4,6-dimethyldibenzo[b,d]furaniminoethyleneiminoethylene]} and [32](DBF)(2)N(6) {cyclo[bis(4,6-dimethyldibenzo[b,d]furaniminopropyleneiminopropylene]} form stable dinuclear copper(ii) complexes suitable to behave as receptors for several anionic subs...
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PMID: 20820604
PDF is available here.
PDF is available here.
Abstract
Three strains of fructophilic lactic acid bacteria were isolated from flowers in South Africa. The isolates formed a subcluster in the Lactobacillus buchneri phylogenetic group, closely related to Lactobacillus fructivorans, Lactobacillus homohiochii, Lactobacillus lindneri and Lactobacillus sanfran...
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PMID: 19965998
PDF is available here.
PDF is available here.
Abstract
We systematically investigated cellular internalization, toxicity, and innate immune response of HNPs in human breast cancer (SK-BR-3) and mouse alveolar macrophage (J774A.1) cells. Size- and surface functionality-dependent cellular uptake of HNPs was investigated by fluorescence labeling (fluoresce...
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PMID: 20698555
PDF is available here.
PDF is available here.
Abstract
Metabolite profiling of Cheonggukjang inoculated with different Bacillus strains including Bacillus amyloliqueciens CH86-1, Bacillus licheniformis 58, and Bacillus licheniformis 67 during fermentation, was performed using gas chromatography-time of flight-mass spectrometry after derivatization, comb...
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PMID: 20834151
PDF is available here.
PDF is available here.
Abstract
A series of novel dibenzo[b,d]furan mono-carboxylic acid derivatives were synthesized, characterized and evaluated for their ability to inhibit Protein Tyrosine Phosphatase 1B (PTP1B) in vitro in order to use them as potential anti-diabetic agents. Structure-activity relationship study led to the id...
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PMID: 20627471
PDF is available here.
PDF is available here.
Abstract
Our best QSAR model reveals the polarizability, mass as the most influencing atomic properties in the structures of the carboxylic acid derivatives.
Crown Copyright 2010. Published by Elsevier Masson SAS. All rights reserved....
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PMID: 20561721
PDF is available here.
PDF is available here.
Dental Materials Journal (29)4 2010
Abstract
Hydroxyapatite formation was examined at the surface of self-assembled monolayers (SAMs) modified with four functional groups, -COOH, -NH(2), -CH(3), and -OH. For COOH-SAM and NH(2)-SAM, scanning electron spectroscopic observation showed that flake-like sheet crystals covered the whole wafer and sma...
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PMID: 20657151
PDF is available here.
PDF is available here.
Abstract
To isolate and purify gallic acid and brevifolincarboxylic acid simultaneously by high-speed counter-current chromatography (HSCCC) from a crude extract of Polygonum capitatum.
The biphasic solvent system composed of ethyl acetate-n-butanol-0.44% acetic acid (3:1:5) was used at a flow rate of 2.0 mL...
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PMID: 20931845
PDF is available here.
PDF is available here.
Abstract
Sugarcane bagasse and chicken manure were anaerobically fermented to carboxylic acids using a mixed culture of marine microorganisms at 55 degrees C. Using the MixAlco process--an example of consolidated bioprocessing--the resulting carboxylate salts can be converted to mixed alcohol fuels or gasoli...
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PMID: 19711199
PDF is available here.
PDF is available here.
Bioresource Technology (101)15 2010
Abstract
The work described in this paper demonstrated that acetylation of pine wood up to 16.4 weight percent gain has a positive effect on the compression strength. Higher modification levels resulted in a reduction of the compression strength of wood, compared to the untreated wood. A comprehensive invest...
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PMID: 20231093
PDF is available here.
PDF is available here.
Abstract
Ion chromatography has been proposed for the determination of three common inorganic anions (chloride, nitrate, and sulfate) in nine weak acids (tartaric acid, citric acid, formic acid, acetic acid, metacetonic acid, butyric acid, butanedioic acid, hexafluorophosphoric acid, and salicylic acid) usin...
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PMID: 20819280
PDF is available here.
PDF is available here.
Abstract
A series of novel 2,4,6-trisubstitutedpyrimidine-5-carboxylic acid derivatives were designed and synthesized with the intent of producing a peroxisome proliferator-activated receptor gamma (PPARgamma) partial agonist for antidiabetic agents. A pharmacophore-driven approach of in-house screening iden...
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PMID: 20527969
PDF is available here.
PDF is available here.
Abstract
ADP-induced platelet aggregation decreased (mean +/- SD 93 +/- 6% and 80 +/- 22% of baseline values, respectively) after 72 hours in dogs in both 3-day treatment groups; duration of effect ranged from > 3 to > 7 days. Platelet mapping TEG and impedance aggregometry yielded similar results. Citrated...
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PMID: 20594086
PDF is available here.
PDF is available here.
Abstract
This study was performed to investigate the effects of adding a dual starter on the chemical and sensory characteristics of red wine made of Campbell Early grape. The yeast starter, Saccharomyces cerevisiae, and lactic acid bacteria (LAB) starter, Oenococcus oeni, were used for inoculation in the wi...
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PMID: 20668406
PDF is available here.
PDF is available here.
Chemmedchem (5)7 2010
Abstract
The tautomerism and corresponding transition states of four authentic HIV-1 integrase (IN) inhibitor prototype structures, alpha,gamma-diketo acid, alpha,gamma-diketotriazole, dihydroxypyrimidine carboxamide and 4-quinolone-3-carboxylic acid, were investigated at the B3LYP/6-311++G(d...
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PMID: 20533499
PDF is available here.
PDF is available here.
Abstract
Halogen derivatives of selected 3-benzofurancarboxylic acids were prepared using 6-acetyl-5-hydroxy-2-methyl-3-benzofuranocarboxylic acid as starting material. (1)H-NMR spectra were obtained for all of the synthesized structures, and for compound VI, an X-ray crystal structure was also obtained. All...
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PMID: 20657389
PDF is available here.
PDF is available here.
Abstract
The aim of this work is to devise an efficient enzymatic process for the production of linear alkyl esters in aqueous miniemulsion systems. The esterification reactions of linear alcohols and carboxylic acids were performed with three different enzymes, commercial Amano lipase PS fro...
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PMID: 20503297
PDF is available here.
PDF is available here.
Abstract
We describe for the first time the molecular mechanism of resistance to a carboxylic acid amide (CAA) fungicide. We identified a family of four cellulose synthase (CesA) genes containing conserved domains that are found in all processive glycosyltransferases. Phylogenetic analysis revealed their clo...
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PMID: 20226261
PDF is available here.
PDF is available here.
Abstract
Currently, hepatitis C virus (HCV) antiviral therapy is characterized by long duration, a multitude of side effects, difficult administration and suboptimal success; clearly, alternatives are needed. Collectively, specifically targeted antiviral therapy for HCV (STAT-C) molecules achieve rapid viral...
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PMID: 20559582
PDF is available here.
PDF is available here.
Phytochemistry (71)8-9 2010
Abstract
We have targeted low molecular weight, cross-linked phenolic and indolic compounds that were released from wall preparations by alkaline hydrolysis at 70 degrees C and in a microwave bomb. Significantly higher concentrations of syringaldehyde, p hydroxybenzaldehyde and indole carboxylic acid were re...
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PMID: 20359727
PDF is available here.
PDF is available here.
Abstract
We show that embryonic stem cells are characterized by abundant metabolites with highly unsaturated structures whose levels decrease upon differentiation. By monitoring the reduced and oxidized glutathione ratio as well as ascorbic acid levels, we demonstrate that the stem cell redox status is regul...
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PMID: 20436487
PDF is available here.
PDF is available here.
Abstract
A number of 5-phenylisoxazole-3-carboxylic acid derivatives (5a-e, 11a-e) were synthesized and analyzed for their ability to inhibit xanthine oxidase. Most of the compounds exhibited potency levels in the micromolar/submicromolar range. The presence of a cyano group at the 3-position of phenyl moiet...
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PMID: 20189693
PDF is available here.
PDF is available here.
Abstract
We employed umbrella sampling molecular dynamics simulations in explicit water to study the binding of the Mg(2+) cofactor to ribonuclease H (RNase H) from three different organisms. We show that the enzyme can differentiate between different Mg(2+)-binding modes that are nearly equally stable by cr...
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PMID: 20397692
PDF is available here.
PDF is available here.
Abstract
We introduce a variant of coumarin-based photoactivatable protecting groups and use it exemplarily for caging of a carboxylic acid, an amine, a phenol, and a carbonyl compound. The caged compounds are efficiently photolyzed at long-wavelength UV/vis irradiation. Compared to the corresponding (6-brom...
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PMID: 20356068
PDF is available here.
PDF is available here.
Phytopathology (100)5 2010
Abstract
Four isolates of Peronophythora litchii with resistance to carboxylic acid amide (CAA) fungicides were selected on fungicide-amended agar. These isolates had various levels of resistance, as evidenced by their resistance factor (RF), which is the 50% effective concentration (EC(50)) value of a parti...
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PMID: 20373974
PDF is available here.
PDF is available here.
Abstract
We obtained the three-dimensional structure of OXA-46, which shows the overall fold of active serine beta-lactamases and a dimeric quaternary structure. Significant differences with currently available structures of class D beta-lactamases were found in the loops located close to the active site, wh...
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PMID: 20145076
PDF is available here.
PDF is available here.
Journal of Physical Chemistry B (114)16 2010
Abstract
X-irradiation of L-arginine hydrochloride monohydrate crystals at 66 K led to at least five radicals detectable with K-band Electron Paramagnetic Resonance (EPR), Electron-Nuclear DOuble Resonance (ENDOR) and ENDOR-induced EPR (EIE) techniques. Radicals R1a and R1b were identified as carboxyl-center...
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PMID: 20364864
PDF is available here.
PDF is available here.
Abstract
This work presents a new synthetic approach to aromatic and aliphatic polycarbonates by melt polycondensation of bisphenol A diacetates with alkylene- and arylenediphenyl dicarbonates. The diphenyl dicarbonates were prepared from phenyl chloroformate and the corresponding dihydroxy compounds. The pr...
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PMID: 20657506
PDF is available here.
PDF is available here.
Abstract
In this study, the flavor substances of soypaste were extracted by a simultaneous distillation method and identified by GC-MS. The characteristic aroma components of soypaste were determined by the GC-O technique and the FD value of the characteristic aroma components was determined by AEDA method....
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PMID: 20657491
PDF is available here.
PDF is available here.
Abstract
This paper provides a brief review of recent progress in the field of metal coordination polymers assembled from azole-containing carboxylic acids and gives a diagrammatic summary of the diversity of topological structures in the resulting infinite metal-organic coordination networks (MOCNs). Azole-...
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PMID: 20657495
PDF is available here.
PDF is available here.
Abstract
Females of the African malaria vector, Anopheles gambiae Giles sensu stricto, use human volatiles to find their blood-host. Previous work has shown that ammonia, lactic acid, and aliphatic carboxylic acids significantly affect host orientation and attraction of this species. In the current study, th...
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PMID: 20496580
PDF is available here.
PDF is available here.
Abstract
Fast and reproducible Capillary Zone Electrophoresis (CZE) method for the quantification of (+)-S clopidogrel carboxylic acid metabolite in human fluids was elaborated for the first time. Optimal buffer and CZE conditions were established to obtain the complete separation of clopidogrel, its metabol...
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PMID: 20346740
PDF is available here.
PDF is available here.
Chemical Communications (46)15 2010
Abstract
We describe the efficient and highly enantioselective kinetic resolution of trans-cycloalkane-1,2-diols utilizing an enantioselective Steglich reaction with a variety of carboxylic acids that form the corresponding anhydrides in situ.
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PMID: 20461855
PDF is available here.
PDF is available here.
Chemical Communications (46)14 2010
Abstract
The condensation of a Kemp's triacid derivative with a diamino resorcinarene yielded a cavitand with the deepest cavity prepared to date featuring an inwardly-directed carboxylic acid. The extended 6,7-diaminoquinoxaline wall bearing the acid allowed accommodation of large amines, such as 1-adamanta...
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PMID: 20379555
PDF is available here.
PDF is available here.
Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants and Agricultural Wastes (45)3 2010
Abstract
A series of novel N-alkyl substituted amides, synthesized by enzyme catalysis, were evaluated against root-knot nematode, Meloidogyne incognita and found to have potential antinemic activity. The corresponding amides were prepared by the condensation of equimolar amounts of carboxylic acids with dif...
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PMID: 20390959
PDF is available here.
PDF is available here.
Journal of Dentistry (38)4 2010
Abstract
The data confirms that the conversion of aluminium is a diffusion-controlled process at early stage less than 1h and it is largely complete between 1 and 6h. The comparison with the experimental data shows that the majority of aluminium cations do not form tricarboxylates but are coordinated with on...
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PMID: 20043973
PDF is available here.
PDF is available here.
Abstract
A new [(18)F] labeled amino acid anti-1-amino-2-[(18)F]fluoro-cyclobutyl-1-carboxylic acid 9 (anti-2-[(18)F]FACBC) was synthesized in 30% decay-corrected yield with high radiochemical purity over 99%. The cyclic sulfamidate precursor was very stable and highly reactive towards nucleophilic radiofluo...
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PMID: 20207538
PDF is available here.
PDF is available here.
Inorganic Chemistry (49)7 2010
Abstract
The comparison of two series of preorganized strapped porphyrins, derived from both the alphabetaalphabeta and alphaalphabetabeta conformers of meso-tetrakis(aminophenyl)porphyrin, and the coordination studies of their affinity for O(2) are reported. Both series of ligands bear a proximal built-in a...
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PMID: 20210347
PDF is available here.
PDF is available here.
Inorganic Chemistry (49)7 2010
Abstract
To further understand copper-promoted oxidation reactions, the Cu(I) complexes LCuX (L = N,N'-di-tert-butyl-N,N'-dimethylethylenediamine; X = benzoylformate (BF) or p-nitro-benzoylformate) were synthesized, fully characterized by X-ray crystallography and spectroscopy in solution, and their reactivi...
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PMID: 20218646
PDF is available here.
PDF is available here.
Abstract
Single electron transfer (SET)-photochemical decarboxylation of free carboxylic acids was performed in a polar solvent using several arenes such as phenanthrene, naphthalene, 1-methylnaphthalene, biphenyl, triphenylene, and chrysene in the presence of various electron acceptors such as 1,2-, 1,3-, a...
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PMID: 20428069
PDF is available here.
PDF is available here.
Abstract
We obtained a new prebiotic from defatted rice bran that was developed as an insoluble dietary fiber through amylase and hemicellulase treatment followed by removal of the soluble fraction. Containing approximately 70% hemicellulose, ERF is utilized by lactobacilli and subsequently converted to buty...
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PMID: 20198303
PDF is available here.
PDF is available here.
Abstract
We have been investigating approaches to treat systemic amyloidoses, conditions that show common features with some CNS (central nervous system) disorders. For TTR (transthyretin) amyloidosis, we are seeking small molecule compounds that stabilize the amyloidogenic protein and either prevent its str...
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PMID: 20298204
PDF is available here.
PDF is available here.
Chemical Communications (46)12 2010
Abstract
Site-specific pK(a) determination of the carboxylate-binding subunit in artificial peptide receptors is achieved by pH-dependent UV resonance Raman scattering with subsequent matrix factorization. This quantitative methodology allows to determine accurately the local acidity of a binding site based...
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PMID: 20221516
PDF is available here.
PDF is available here.
Abstract
Analogues of the antifungal marine natural product (E)-dysidazirine were prepared and evaluated in broth ro-dilution assays against a panel of fungal pathogens. A simple structure-activity relationship was developed which provides insight into the mechanism of action of long-chain 2H-azirine carboxy...
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PMID: 20171099
PDF is available here.
PDF is available here.
Abstract
Pyrrolyl-propionic and butyric-acid derivatives 1 and 2 were synthesized in order to study the effect of the variation of the methylene chain in comparison to the previously reported pyrrolyl-acetic acid compound I, which was found as potent aldose reductase inhibitor, while the pyrrolyl-tetrazole d...
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PMID: 20189816
PDF is available here.
PDF is available here.
Abstract
A library of oligomeric compounds was synthesized based on the imidazole-4,5-dicarboxylic acid scaffold along with amino acid esters and chiral diamines derived from amino acids. The final compounds incorporate nonpolar amino acids (Leu, Phe, Trp), polar amino acids (Ser, Asp, Arg), and neutral amin...
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PMID: 20170086
PDF is available here.
PDF is available here.
Abstract
The new steroidal 5,7-diene, 3beta-hydroxyandrosta-5,7-diene-17beta-carboxylic acid (17-COOH-7DA), was synthesized from 21-acetoxypregnenolone, with the oxidative cleavage of the side chain being dependent on the presence of oxygen. In human epidermal (HaCaT) keratinocytes, 17-COOH-7DA inhibited pro...
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PMID: 20025893
PDF is available here.
PDF is available here.
Abstract
Highly enantioselective phase-transfer-catalyzed alkylation of tert-butyl 2-benzoyloxy-3-oxobutanoate was realized by the use of an N-spiro chiral quaternary ammonium salt, as a complementary approach to the asymmetric hydroxylation of alpha-alkyl-beta-keto esters. The synthetic util...
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PMID: 20013997
PDF is available here.
PDF is available here.
Abstract
Aerobic biodegradation of linear alkylbenzene sulfonates (LAS) and sulfophenylcarboxylic acids (SPCs) in water, at different salinity values, has been studied. Three experiments have been carried out employing a staircase model system with continuous dosage of LAS to the system and using concentrati...
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PMID: 19238564
PDF is available here.
PDF is available here.
Abstract
The synthesis and structure-activity relationships of a series of new penems bearing ferrocenyl group attached to the C-2 position of the penem nucleus were described. The beta-lactanic derivatives obtained had been characterized as sodium salts, through (1)H NMR and IR, as well as through element a...
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PMID: 20053481
PDF is available here.
PDF is available here.
Dental Materials Journal (29)2 2010
Abstract
Camphorquinone (CQ) derivatives having acylphosphine oxide (APO) group are unknown. This study synthesized such a novel 7,7dimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carbonyldiphenyl phosphine oxide (DOHC-DPPO = CQ-APO). Ultraviolet and visible (UVVIS) spectra of CQ-APO, CQ, and APO were measured. Ph...
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PMID: 20379021
PDF is available here.
PDF is available here.
Abstract
Graphene-carbon nanotube nanocomposites that contain multitubular co-axial and hollow cavity microstructures are prepared. Nanometer-scale graphene sheets are anchored with oxalic acid and consequently linked to each other via oxalyl bonding, thereby self-assembling into numerous outer tubes with di...
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PMID: 20058294
PDF is available here.
PDF is available here.
Abstract
[Ag(CF(3)COO)(bpy)] (), [Ag(2)(C(2)F(5)COO)(2)(bpy)] () and [Ag(2)(C(3)F(7)COO)(2)(bpy)] () were prepared and characterized by MS-EI, (1)H, (13)C NMR, variable-temperature IR (VT-IR) spectroscopy (solid sample and evolved volatile species) and thermal analysis. Single-crystal X-ray diffraction data...
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PMID: 20449428
PDF is available here.
PDF is available here.