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Free Radicals (2):
Recent article
Free Radicals
Abstract
We also describe our experimental set-up for studying peroxynitrite-mediated degradation of hyaluronan, a system, which may be suitable for testing prospective pharmacological substances....
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PMID: 21952432
PDF is available here.
PDF is available here.
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Abstract
These results are consistent with a C3 α-hydroxyalkyl radical in which the p-orbital harboring the unpaired electron spin at C3 is periplanar with the C-H bonds at both C2 and C4....
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PMID: 21513273
PDF is available here.
PDF is available here.
Abstract
Disproportionation of dipyrrolylquinoxaline radical anions occurs via hydrogen atom transfer from the pyrrole moiety to the quinoxaline moiety to produce monodeprotonated dipyrrolylquinoxaline anions and monohydrodipyrrolylquinoxaline anions. In contrast, simple quinoxaline radical anions without pyr...
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PMID: 21510700
PDF is available here.
PDF is available here.
médecine/sciences (27)4 2011
Abstract
Oxidative stress is defined as an imbalance between the production of reactive oxygen species (ROS) and the antioxidant capacity of the cell. For long, ROS have been considered as harmful by-products of the normal aerobic metabolism process of the mitochondria, implicated in a large variety of diseas...
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PMID: 21524406
PDF is available here.
PDF is available here.
Abstract
A comparative H2O2-luminol- and Fe(II)-induced chemiluminescence analysis of extracts of two strains of marine oil oxidizing bacteria Actinetobacter calcoaceticus cultivated either in the presence or absence of oil was carried out. Effects of these extracts on E. coli MG1655 biosensor (pSoxS-lux) wer...
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PMID: 21950119
PDF is available here.
PDF is available here.
Abstract
Four bis-phenolate complexes [Zn(II)L], [Ni(II)L], [Cu(II)L] and [Co(II)L] (where [H(2)L = 2,2'-[2,2']bipyridinyl-6-yl-bis-4,6-di-tert-butylphenol] have been synthesized. The copper(II) and nickel(II) complexes have been characterized by X-ray diffraction, showing a metal ion within a square planar...
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PMID: 20820605
PDF is available here.
PDF is available here.
Abstract
We also report an updated G2(MP2) proton affinity of tryptophan (PA = 946 kJ mol(-1)) and hydrogen atom affinities of the tryptophan indole ring of relevance to electron-based peptide dissociations....
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PMID: 20830385
PDF is available here.
PDF is available here.
Abstract
Reductive elimination of a bridged chlorine from a diiridium(iii) core, [(dfpbo)(2)Ir(μ-Cl)](2) (dfpbo = 2-(3.5-difluorophenyl)benzoxazolato-N,C(2)), afforded an iridium dimer, [(fpbo)(2)Ir](2)(μ-Cl), showing an 18+δ structure with a bent bridge, which can release metalloradicals spontaneously in...
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PMID: 20820618
PDF is available here.
PDF is available here.
Free Radical Research (44)11 2010
Abstract
An increasing incidence of unresponsiveness to antimonials in Leishmaniasis has led to identification of plant-derived anti-leishmanial compounds like Artemisinin. Since iron-mediated generation of free radicals sustains the anti-malarial activity of Artemisinin, this study investigated whether simi...
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PMID: 20815780
PDF is available here.
PDF is available here.
Abstract
The extent to which deuterium can act as a protecting group to prevent unwanted 1,5-hydrogen atom transfer to aryl and vinyl radical intermediates was examined in the context of the generation of α-aminoalkyl radicals in a pyrrolidine ring. Intra- and intermolecular radical trapping following hydro...
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PMID: 20714669
PDF is available here.
PDF is available here.
Abstract
Free radicals (FRs) and oxidants (Os) have different vital activities in our bodies. Biological redox reactions are the major source for FRs-Os. In normal cases, they are under the control of our body's existing antioxidant (antiO) system. If their amounts exceeds a certain limit, they start to atta...
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PMID: 21105570
PDF is available here.
PDF is available here.
Food and Chemical Toxicology (48)10 2010
Abstract
Ninety female Balb/c mice were used. The animals were allocated to evenly six groups. While the first group was maintained as control, Groups 3, 4, 5, and 6 were administered 750 ppm, 1500 ppm, 3000 ppm, and 6000 ppm of N-acetylcysteine, respectively, for a period of 15 days. After day 15, Groups 2-...
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PMID: 20637250
PDF is available here.
PDF is available here.
Abstract
Chemoenzymatic dynamic kinetic resolution (DKR) of amines involving sulfanyl radical-induced racemization happened to be the very first switchable DKR process allowing the synthesis of either (R)- or (S)-amides, in good yield and high enantiomeric excess, depending on the nature of the enzyme; the d...
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PMID: 20661510
PDF is available here.
PDF is available here.
Abstract
Benzoyl radicals are generated directly from (hetero)aromatic aldehydes upon tetrabutylammonium decatungstate ((n-Bu(4)N)(4)W(10)O(32)), TBADT) photocatalysis under mild conditions. In the presence of alpha,beta-unsaturated esters, ketones and nitriles radical conjugate addition ensues and gives the...
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PMID: 20661511
PDF is available here.
PDF is available here.
Abstract
Three new complexes of the general formula L[RuCl(3)(DMSO)(3)] (1-3), where L = chlorpromazine hydrochloride, trifluoroperazine dihydrochloride or thioridazine hydrochloride, were prepared and characterized by elemental analysis and spectroscopic methods (FT-IR, UV-Vis, (1)H NMR and (13)C NMR). In a...
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PMID: 20684856
PDF is available here.
PDF is available here.
Abstract
We recently developed a technique for free radical and oxidative stress monitoring using the ex vivo electron spin resonance (ESR) spin trapping method in patients with neuroemergency. Blood samples were collected by catheterization of the internal jugular bulb. The alkoxyl radical level was measure...
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PMID: 19812971
PDF is available here.
PDF is available here.
Abstract
Administration of reamberin leads to rapid reduction of the intoxication symptoms, improves general condition, and reduces fever stage duration. The dynamics of inflammatory symptoms is characterized by decreasing duration of hemocolitis in comparison that in patients receiving glucose-salt solution...
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PMID: 21086650
PDF is available here.
PDF is available here.
Abstract
Using periodic DFT calculations, it is concluded that the stable radiation-induced alanine radical most probably is the result of reductive deamination and protonation of the detached amino group, yielding an NH(4)(+) ammonium ion and a negatively charged radical.
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PMID: 20559598
PDF is available here.
PDF is available here.
Abstract
Abstract
This paper details the study of applicability of microwave initiated synthesized polyacrylamide grafted guar gum (GG-g-PAM) as matrix for controlled release of 5-amino salicylic acid (a drug used for the treatment of ulcerative colitis). In vitro release of this drug from various grades of GG-g-PAM...
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PMID: 20471416
PDF is available here.
PDF is available here.
Abstract
The photophysical and photochemical properties of violanthrone (V1) and two 16,17-R derivatives with R = OC(8)H(17) and OCOC(17)H(35) (V2 and V3, respectively) in solution were examined. The fluorescence quantum yield of V3 is Phi(f) = 0.2, while that of V1 is low (0.01) and V2 even lower. A radical...
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PMID: 20508892
PDF is available here.
PDF is available here.
Circulation Journal (74)8 2010
Coadministration of carvedilol attenuates nitrate tolerance by preventing cytochrome p450 depletion.
Abstract
Long-term administration of nitroglycerin (NTG) causes tolerance secondary to increased vascular formation of reactive oxygen species. Carvedilol, which has potent antioxidant activity in addition to functioning as an adrenergic blocker, prevents nitrate tolerance by a still to be elucidated mechani...
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PMID: 20574135
PDF is available here.
PDF is available here.
Circulation Journal (74)8 2010
Abstract
Oxidative stress and pulmonary veins (PVs) play critical roles in the pathophysiology of atrial fibrillation. The purpose of the present study was to investigate whether oxidative stress and antioxidant agents can change the electrophysiological characteristics of the left atrium (LA) and PVs.
Conve...
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PMID: 20562495
PDF is available here.
PDF is available here.
Abstract
The existence of different redox pools within the humate was confirmed, with the quinoid-centered redox entities showing the fastest kinetics. The results pertained to all size and polarity fractions....
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PMID: 20354802
PDF is available here.
PDF is available here.
Abstract
These results show that as oxidative radicals induce high proportions of irreversible damages (polymerisation) centrin 2 is highly sensitive to ionising radiation. This could have important consequences on its biological functions....
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PMID: 20586543
PDF is available here.
PDF is available here.
Inflammopharmacology (18)4 2010
Abstract
The methanol extract of Russelia equisetiformis (MRE), which exhibited significant antiinflammatory activity, was evaluated for the possible mode of action by studying its antioxidant potential in adjuvant- induced arthritic rats. 1, 1 diphenyl-2-picrylhydrazyl (DPPH) radical scavenging effect was d...
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PMID: 20119851
PDF is available here.
PDF is available here.
Abstract
We proposed that production of free radicals can be reduced by preventing high blood glucose levels and by the control of instabilities in blood glucose levels. A contributor to these instabilities in blood glucose is glycaemic control by using of fast blood sugar test. Furthermore, the earlier asse...
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PMID: 21850933
PDF is available here.
PDF is available here.
Abstract
Electromagnetic fields (EMFs) played a role in the initiation of living systems, as well as subsequent evolution. The more recent literature on electrochemistry is documented, as well as magnetism. The large numbers of reports on interaction with living systems and the consequences are presented. An...
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PMID: 20509751
PDF is available here.
PDF is available here.
Hawaii medical journal (69)8 2010
Abstract
Cells ability to evade cell death and to proliferate post geno-/cell-toxic stresses, likely leads to formation of cancer. Activation of p38MAPK and p53 following these stresses help protect cells against cancer development by initiating apoptosis. The duration of p38MAPK and p53 activation is regula...
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PMID: 20845286
PDF is available here.
PDF is available here.
Vojnosanitetski pregled (67)8 2010
Abstract
Plasma MDA concentration in the group S was significantly higher at 20 min ATR in comparison with the groups T and R (6.78 +/- 0.33 micromolL-1(-1) vs. 4.07 +/- 1.53 and 3.22 +/- 0.9. micromolL-1(-1), respectively). There was a significant difference in MDA concentration in erytrocythes between the...
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PMID: 20845670
PDF is available here.
PDF is available here.
Abstract
The influence of injection periods of 3-(1H-pyrrol-2-yl)-1H-indazole regarding vitamins A, E, C, selenium (Se), malondialdehyde (MDA) levels, and glutathione peroxidase (GSH-Px) activity in rats has been investigated. The substance was given by subcutaneous injection at 20 mg/kg every other day for...
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PMID: 19756400
PDF is available here.
PDF is available here.
Heart and Vessels (25)4 2010
Abstract
We sought to determine whether circulating oxidized low-density lipoprotein (ox-LDL) levels differ between subjects with isolated hypercholesterolemia and combined hyperlipidemia, as well as the effect of simvastatin on circulating ox-LDL according to the type of dyslipidemia. Twenty-five subjects w...
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PMID: 20676836
PDF is available here.
PDF is available here.
Abstract
Our data indicate that besides cold and osmotic stress adaptation roles, Csp family proteins also promote efficient host cell invasion and oxidative stress adaptation processes in L. monocytogenes....
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PMID: 20184451
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1804)7 2010
Abstract
We performed a proteomic study to understand how Saccharomyces cerevisiae adapts its metabolism during the exponential growth on three different concentrations of glucose; this information will be necessary to understand yeast carbon metabolism in different environments. We induced a natural diauxic...
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PMID: 20362699
PDF is available here.
PDF is available here.
Abstract
The vast majority of energy necessary for cellular function is produced in mitochondria. Free-radical production and apoptosis are other critical mitochondrial functions. The complex structure, electrochemical properties of the inner mitochondrial membrane (IMM), and genetic control from both mitoch...
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PMID: 20818734
PDF is available here.
PDF is available here.
Minerva Pediatrica (62)3 Suppl 1 2010
Abstract
Our goal is to identify reliable markers for the detection of OS in physiology and pathology. These biomarkers can be useful for several clinical purpose such as to monitor the response to any antioxidant intervention and then develop preventive strategies. The standardization and a large clinical u...
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PMID: 21089735
PDF is available here.
PDF is available here.
Minerva Pediatrica (62)3 Suppl 1 2010
Abstract
We investigated whether oxidative stress can play a role in this process. Here we resume our findings, that recall to a greater safeguard of babies from unjustified pain....
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PMID: 21089720
PDF is available here.
PDF is available here.
Abstract
We observed a statistically increased level of TBARS in plasma and isoprostanes in urine of patients with invasive breast cancer in comparison with a control group. The concentration of tested biomarkers in plasma or urine from patients with invasive breast cancer was also higher than in patients wi...
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PMID: 20577033
PDF is available here.
PDF is available here.
Abstract
We have used a xanthine oxidase/acetaldehyde system to generate tyrosyl radicals on sperm whale myoglobin in the presence of superoxide. Using mass spectrometry we found that superoxide prevented myoglobin dimer formation by repairing the protein tyrosyl radical. An addition product of superoxide at...
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PMID: 20211247
PDF is available here.
PDF is available here.
Abstract
Gas-phase guanine (G) radical cations were generated by electrospraying a solution of guanosine (L) and Cu(NO(3))(2). Collision-induced dissociation (CID) for guanine radical cations yielded five competing dissociation channels, corresponding to the elimination neutral molecules of NH(3), HCN, H(2)N...
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PMID: 20428546
PDF is available here.
PDF is available here.
Abstract
We propose that a different, but also effective, electron-transfer cascade is conserved among the class II photolyases. The existence of such electron transfer pathways is supported by the observation that the catalytically active fully reduced flavin state obtained by photoreduction is maintained e...
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PMID: 20227927
PDF is available here.
PDF is available here.
Abstract
Two low-molecular-weight polysaccharides, GLP(L)1 and GLP(L)2, purified from a crude Ganoderma lucidum polysaccharide preparation GLPP were investigated for their physicochemical properties, structure characterization and antioxidant activities. The results indicated that GLP(L)1 was a glucan with a...
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PMID: 20153767
PDF is available here.
PDF is available here.
Journal of Physical Chemistry B (114)16 2010
Abstract
X-irradiation of L-arginine hydrochloride monohydrate crystals at 66 K led to at least five radicals detectable with K-band Electron Paramagnetic Resonance (EPR), Electron-Nuclear DOuble Resonance (ENDOR) and ENDOR-induced EPR (EIE) techniques. Radicals R1a and R1b were identified as carboxyl-center...
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PMID: 20364864
PDF is available here.
PDF is available here.
Journal of Physical Chemistry B (114)16 2010
Abstract
Triplet-excited riboflavin ((3)RF*) was found by laser flash photolysis to be quenched by polyunsaturated fatty acid methyl esters in tert-butanol/water (7:3, v/v) in a second-order reaction with k approximately 3.0 x 10(5) L mol(-1) s(-1) at 25 degrees C for methyl linoleate and 3.1 x 10(6) L mol(-...
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PMID: 20377218
PDF is available here.
PDF is available here.
Abstract
Type 2 diabetes is a metabolic disease, which frequency increases substantially with age. Oxidative stress as a result of production and deactivation of free radicals unbalance, may play an important role in a complex pathogenesis of disease. Free radicals are by-products of metabolism, which in reg...
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PMID: 20568408
PDF is available here.
PDF is available here.
Journal of Physical Chemistry A: Molecules, Spectroscopy, Kinetics, Environment and General Theory (114)16 2010
Abstract
The CN radical has been implicated as an important contributor to the plasma deposition of amorphous carbon nitride. Here, laser-induced fluorescence and optical emission spectroscopy were used to explore in greater detail the gas phase energetics of CN in CH(3)CN, BrCN, and CH(4)/N(2) plasmas. Meas...
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PMID: 20359204
PDF is available here.
PDF is available here.
Abstract
We develop a method to separate the sources through minimizing a p-norm-like diversity measure under some mild assumptions which are generally valid for EPR signals. Simulations demonstrate that the proposed method performs well on EPR signal separation, with better robustness to noise compared to o...
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PMID: 20194039
PDF is available here.
PDF is available here.
Der Urologe (49)5 2010
Abstract
Chronic inflammation seems of importance in multiple types of cancer. Numerous reports have revealed a potential link between chronic prostatatic inflammation and prostate cancer. The aim of this paper is to review the epidemiological, moprphological, molecular and clinical aspects of prostattic inf...
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PMID: 20405276
PDF is available here.
PDF is available here.
Brain research (1328) 2010
Abstract
These results were supported by the immunohistochemical findings in the substantia nigra that has shown the protection of neurons by RES from deleterious effects of 6-OHDA. Thus, RES may be used to reduce the deterioration caused by free radicals thereby preventing subsequent behavioral, biochemical...
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PMID: 20167206
PDF is available here.
PDF is available here.
Anticancer Research (30)5 2010
Abstract
We measured the following WB selenium (Se) levels (Se-group vs. control group, U-test): begin RT 64.17+/-13.98 microg/l vs. 64.50+/-14.47 microg/l (p=0.869); mid RT 92.48+/-26.68 microg/l vs. 65.80+/-18.04 microg/l (p<0.001); end RT 93.78+/-25.90 microg/l vs. 64.06+/-17.54 microg/l (p<0.001); 6 week...
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PMID: 20592379
PDF is available here.
PDF is available here.
Abstract
Plants have been used for many years as a source of traditional medicine to treat various diseases and conditions. Many of these medicinal plants are also excellent sources for phytochemicals, many of which contain potent antioxidant and antiacetylcholinesterase activities. Chard (Beta vulgaris L. v...
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PMID: 20184938
PDF is available here.
PDF is available here.
Abstract
Methanolic extracts of six species of Salvia (S. hydrangea, S. lachnocalyx, S. macilenta, S. multicalis, S. sclarea and S. xanthocheila) were analyzed for their antioxidant properties, ability to prevent DNA damage by free radicals, and neuroprotective effects. Several biochemical assays were used t...
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PMID: 20197079
PDF is available here.
PDF is available here.
Abstract
We studied plasma fatty acids total profile (esterificated and non-esterificated) before hypoxia exposure, on 2nd, 5th, 10th, 20th minutes of acute hypoxia and on 5th and 15th minutes of recovery. It was shown that blood saturation value dropped to 52.1 +/- 7.1 % on 25th minute of hypoxia exposure....
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PMID: 20583568
PDF is available here.
PDF is available here.
Abstract
A competition experiment was designed so that the relative rates of anodic cyclization reactions under various electrolysis conditions can be determined. Reactions with ketene dithioacetal and enol ether-based substrates that use lithium methoxide as a base were shown to proceed through radical cati...
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PMID: 20302359
PDF is available here.
PDF is available here.
Abstract
Structures and electronic states of the HOO radical interacting with water molecules, expressed by HOO(H2O)n (n = 1 and 2), have been investigated by means of a direct ab initio molecular dynamics (MD) method. From the static ab initio calculation of HOO-H2O complex, two types of HOO radical were fo...
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PMID: 20358039
PDF is available here.
PDF is available here.
Abstract
We have examined the crystal and molecular structure of [1a](2) as a function of pressure. At ambient pressure the dimer consists of two radicals linked by a hypervalent 4-center 6-electron S...Se-Se...S sigma-bond into an essentially coplanar arrangement. The dimers are packed in cross-braced slipp...
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PMID: 20222662
PDF is available here.
PDF is available here.
Abstract
Effective oral delivery of proteins is impeded by steep pH gradients and proteolytic enzymes in the gastrointestinal tract, as well as low absorption of the proteins into the bloodstream because of their size, charge, or solubility. In this work, pH-responsive complexation hydrogels of poly(itaconic...
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PMID: 19536838
PDF is available here.
PDF is available here.
Annales de Dermatologie et de Vénéréologie (137 Suppl 1) 2010
Abstract
Hyaluronic acid, or hyaluronan, is a polymer made of the repetition of a unique disaccharidic unit, D-glucuronic acid and D-N-acetylglucosamine, that can reach a molecular mass of 10(7) daltons. This primitive polymer has emerged as a remarkable extracellular matrix component by its viscoelastic pro...
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PMID: 20435253
PDF is available here.
PDF is available here.
Abstract
We compared HT29R, an HT29-derived human colon cancer cell line refractory to butyrate-induced cell differentiation but highly sensitive to cell death, with the differentiation-positive HT29-12 and HT29-21 cell lines (exhibiting low sensitivity to butyrate-induced cell death), with respect to levels...
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PMID: 19434493
PDF is available here.
PDF is available here.
Abstract
The present study describes DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity and antimutagenic properties of the essential oil of myrtle (Myrtus communis L.). Plant samples were collected from the two distant localities (southernmost and northern point) of the Montenegro coastline. C...
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PMID: 20428077
PDF is available here.
PDF is available here.