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Glycosylation End Products, Advanced (0):
Recent article
Glycosylation End Products, Advanced
Abstract
We investigated whether heparin interferes with HMGB1/RAGE interaction and prevents the cytokine activity. We used fluorescence spectrometry, circular dichroism spectrometry and SPR biosensor technique to evaluate the effect. After treatment of HMGB1 with different concentrations of heparin (0, 50,...
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PMID: 21095260
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
We investigated whether heparin interferes with HMGB1/RAGE interaction and prevents the cytokine activity. We used fluorescence spectrometry, circular dichroism spectrometry and SPR biosensor technique to evaluate the effect. After treatment of HMGB1 with different concentrations of heparin (0, 50,...
|
PMID: 21095260
PDF is available here.
PDF is available here.
Abstract
We investigated whether heparin interferes with HMGB1/RAGE interaction and prevents the cytokine activity. We used fluorescence spectrometry, circular dichroism spectrometry and SPR biosensor technique to evaluate the effect. After treatment of HMGB1 with different concentrations of heparin (0, 50,...
|
PMID: 21095260
PDF is available here.
PDF is available here.
Clinical Science (120)2 2011
Abstract
The sRAGE [soluble RAGE (receptor for advanced glycation end-products)] lack the transmembrane and cytoplasmic domain of the full-length receptor and can function as a decoy for RAGE ligands. Recent evidence suggests that sRAGE may be a potential biomarker of RAGE-mediated pathology. The present stu...
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PMID: 20726839
PDF is available here.
PDF is available here.
Abstract
We investigated whether the biological functions of human basophils can be influenced by AGEs.
We analyzed the effects of AGEs on various functions and markers of human basophils, including CD11b expression, apoptosis, degranulation, and cytokine production.
Flow cyto...
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PMID: 21646798
PDF is available here.
PDF is available here.
Abstract
Oxidative stress and resultant accumulation of advanced glycation end products (AGEs) are closely related to the development of cardiovascular disease, which is the major cause of death among end-stage renal disease patients. Several markers of oxidative stress, such as malondialdehyde, oxidized low...
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PMID: 20938133
PDF is available here.
PDF is available here.
Abstract
Persistently elevated oxidative stress and inflammation precede or occur during the development of type 1 or type 2 diabetes mellitus and precipitate devastating complications. Given the rapidly increasing incidence of diabetes mellitus and obesity in the space of a few decades, new...
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PMID: 21610689
PDF is available here.
PDF is available here.
Abstract
We investigated the possible mechanisms underlying AGE-related suppression of insulin synthesis. In the rat pancreatic β-cell line INS-1, we found that AGEs induced dephosphorylation of Foxo1 and increased its accumulation in the nucleus. The translocation of Foxo1 subsequently inhibited pancreatic...
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PMID: 21533167
PDF is available here.
PDF is available here.
Abstract
Skin autofluorescence (SAF) is a new method to noninvasively assess accumulation of advanced glycation endproducts (AGEs) in a tissue with low turnover. Recent progress in the clinical application of SAF as a risk marker for diabetic nephropathy as well as cardiovascular disease in nondiabetic end-s...
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PMID: 20844429
PDF is available here.
PDF is available here.
Laboratory Investigation (90)10 2010
Abstract
We evaluated the efficacy of the PPAR-γ agonist rosiglitazone (RSG) in ameliorating peritoneal membrane damage in a mouse PD model, and we analyzed the mechanisms underlying the protection offered by RSG. Exposure of the peritoneum to PD fluid resulted in AGEs accumulation, an inflammatory response...
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PMID: 20531289
PDF is available here.
PDF is available here.
Abstract
The effects of anaerobic (lens) vs aerobic (skin) environment on carbonyl and oxidant stress are compared using de novo and existing data on advanced glycation and oxidation products in human crystallins and collagen. Almost all modifications increase with age. Methylglyoxal hydroimidazolones, carbo...
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PMID: 20541005
PDF is available here.
PDF is available here.
Abstract
We successfully isolated approximately 24 mg/L 3-O-rhamnosyl quercetin and 12.9 mg/L 3-O-rhamnosyl kaempferol upon feeding of 0.2 mM of the respective flavonoids and were also able to isolate 3-O-allosyl quercetin. Thus, this study reveals a method that might be useful for the biosynthesis of rhamno...
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PMID: 20506539
PDF is available here.
PDF is available here.
Abstract
We demonstrate that most of the anti-inflammatory pharmacology of heparin is unrelated to anticoagulant activity. ODSH has low affinity for anti-thrombin III, low anti-Xa, and anti-IIa anticoagulant activities and does not activate Hageman factor (factor XII). Unlike heparin, ODSH does not interact...
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PMID: 20375277
PDF is available here.
PDF is available here.
Intensive Care Medicine (36)7 2010
Abstract
We examined the content of GDPs in commercially available glucose-containing infusion fluids and investigated whether GDPs are found in patients' blood.
The content of GDPs was examined in infusion fluids by high-performance liquid chromatography (HPLC) analysis. To investigate wheth...
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PMID: 20397009
PDF is available here.
PDF is available here.
Abstract
We demonstrate that most of the anti-inflammatory pharmacology of heparin is unrelated to anticoagulant activity. ODSH has low affinity for anti-thrombin III, low anti-Xa, and anti-IIa anticoagulant activities and does not activate Hageman factor (factor XII). Unlike heparin, ODSH does not interact...
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PMID: 20375277
PDF is available here.
PDF is available here.
Abstract
We demonstrate that most of the anti-inflammatory pharmacology of heparin is unrelated to anticoagulant activity. ODSH has low affinity for anti-thrombin III, low anti-Xa, and anti-IIa anticoagulant activities and does not activate Hageman factor (factor XII). Unlike heparin, ODSH does not interact...
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PMID: 20375277
PDF is available here.
PDF is available here.
Abstract
We demonstrate that most of the anti-inflammatory pharmacology of heparin is unrelated to anticoagulant activity. ODSH has low affinity for anti-thrombin III, low anti-Xa, and anti-IIa anticoagulant activities and does not activate Hageman factor (factor XII). Unlike heparin, ODSH does not interact...
|
PMID: 20375277
PDF is available here.
PDF is available here.
Abstract
We demonstrate that most of the anti-inflammatory pharmacology of heparin is unrelated to anticoagulant activity. ODSH has low affinity for anti-thrombin III, low anti-Xa, and anti-IIa anticoagulant activities and does not activate Hageman factor (factor XII). Unlike heparin, ODSH does not interact...
|
PMID: 20375277
PDF is available here.
PDF is available here.
Abstract
We demonstrate that most of the anti-inflammatory pharmacology of heparin is unrelated to anticoagulant activity. ODSH has low affinity for anti-thrombin III, low anti-Xa, and anti-IIa anticoagulant activities and does not activate Hageman factor (factor XII). Unlike heparin, ODSH does not interact...
|
PMID: 20375277
PDF is available here.
PDF is available here.
Abstract
We demonstrate that most of the anti-inflammatory pharmacology of heparin is unrelated to anticoagulant activity. ODSH has low affinity for anti-thrombin III, low anti-Xa, and anti-IIa anticoagulant activities and does not activate Hageman factor (factor XII). Unlike heparin, ODSH does not interact...
|
PMID: 20375277
PDF is available here.
PDF is available here.
Abstract
We demonstrate that most of the anti-inflammatory pharmacology of heparin is unrelated to anticoagulant activity. ODSH has low affinity for anti-thrombin III, low anti-Xa, and anti-IIa anticoagulant activities and does not activate Hageman factor (factor XII). Unlike heparin, ODSH does not interact...
|
PMID: 20375277
PDF is available here.
PDF is available here.
Abstract
We demonstrate that most of the anti-inflammatory pharmacology of heparin is unrelated to anticoagulant activity. ODSH has low affinity for anti-thrombin III, low anti-Xa, and anti-IIa anticoagulant activities and does not activate Hageman factor (factor XII). Unlike heparin, ODSH does not interact...
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PMID: 20375277
PDF is available here.
PDF is available here.
Annals of Surgery (252)1 2010
Abstract
Clinical calcium (20)7 2010
Abstract
Abstract
Abstract
We developed an immunoelectron microscopic (IEM) detection method using anti-CML monoclonal antibody 6D12 in conjunction with computer-assisted image analysis. Antibody was pre-absorbed with purified AGE-bovine serum albumin to assure specificity. Antigen-antibody (ag-ab) complexes were individually...
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PMID: 20490536
PDF is available here.
PDF is available here.
Experimental Gerontology (45)6 2010
Abstract
A common biochemical characteristic of aging is proteotoxicity i.e. the accumulation of altered proteins. While many studies have shown that NAD(+) is important when lifespan is modulated by dietary means, it is uncertain whether or how NAD(+) affects either formation or elimination of altered prote...
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PMID: 20226237
PDF is available here.
PDF is available here.
Abstract
We demonstrated for the first time that AGE could evoke inflammatory and fibrogenic reactions in MRC-5 cells via aldosterone production, which were blocked by the MR antagonistic activity of nifedipine. Our present study provides a unique beneficial aspect of nifedipine on tissue damage and remodeli...
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PMID: 20438710
PDF is available here.
PDF is available here.
Abstract
In an ongoing project directed toward the discovery of novel treatments for diabetic complications from traditional herbal medicines, fifteen compounds, apigenin (1), apigenin-7-O-beta-D: -glucopyranoside (2), apigenin-7-O-(6''-O-acetyl)-beta-D: -glucopyranoside (3), luteolin (4), luteolin-7-O-beta-...
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PMID: 20607492
PDF is available here.
PDF is available here.
Abstract
Nucleobases and DNA react non-enzymatically with sugars, and generate DNA-advanced glycation end products (DNA-AGEs). Incubation of plasmid pBr322 with ribose for 3-7 days caused the transformation of the supercoiled plasmid to the open circular and linear forms. Removal of sugar after an initial 24...
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PMID: 20653285
PDF is available here.
PDF is available here.
Abstract
We are still far from understanding them completely and maybe even farther from developing effective therapeutic approaches. Nevertheless, the present article attempts to offer an overview of known associations between AGEs and vascular complications, in order to draw attention to a less known subje...
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PMID: 20467929
PDF is available here.
PDF is available here.
Abstract
We investigated the protective role of resveratrol against the AGE-induced impairment on macrophage lipid homeostasis. In THP-1-derived macrophages, RAGE was dose-dependently induced by AGE and played a key role in the AGE-induced cholesterol accumulation. Resveratrol markedly reduced RAGE expressio...
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PMID: 20372816
PDF is available here.
PDF is available here.
Abstract
Abstract
We review the role of the AGE-RAGE axis in diabetic macroangiopathy....
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PMID: 20446573
PDF is available here.
PDF is available here.
Abstract
BACKGROUND/AIMS Skin autofluorescence (AF) is a non-invasive marker for advanced glycation endproducts (AGE) in tissues, making use of their characteristic AF pattern. The aim of this study was to investigate whether skin AF is increased in patients with neovascular age-related macular degeneration...
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PMID: 19726430
PDF is available here.
PDF is available here.
Abstract
Our findings showed that grape seed, Cat's whiskers and Sweetleaf extract were the most effective pancreatic alpha-amylase, intestinal maltase, and sucrase inhibitor with IC(50) values of 0.29 +/- 0.01 mg/ml, 0.97 +/- 0.10 mg/ml and 0.86 +/- 0.01 mg/ml, respectively. All extracts (1 mg/ml) markedly...
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PMID: 20109131
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of puerarin against advanced glycation end products (AGEs)-induced inflammation in mouse mesangial cells. Puerarin acts by inducing the expression of heme oxygenase-1 (HO-1) in a dose- and time-dependent manner. Puerarin was able to enhance phosphorylation of protein kinas...
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PMID: 20060010
PDF is available here.
PDF is available here.
Abstract
We were looking for an in vitro BBB model expressing these receptors and studied the alteration of transport of Abeta peptides across this model under the influence of immunoglobulins. Cell line ECV304 was found to be suitable for our experiments. We found evidence for involvement of an improved cle...
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PMID: 20432623
PDF is available here.
PDF is available here.
Abstract
D-galactose induced mouse aging model was developed as described before. As expected, salidroside blocked D-galactose induced increase of serum AGEs levels. It also reversed D-galactose induced aging effects in neural and immune system, as evidenced by improving motor activity, increasing memory lat...
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PMID: 20514993
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1804)4 2010
Abstract
We investigated the effects of kynurenines on AGE synthesis in HLP. We found that incubation with 5 mM ribose or 5 mM ascorbate produced significant quantities of pentosidine, and this was further enhanced in the presence of two different kynurenines (200-500 microM): N-formylkynurenine (Nfk) and ky...
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PMID: 20026434
PDF is available here.
PDF is available here.
Diabetes & Metabolism (36)2 2010
Abstract
On age-adjusted analyses, diabetes duration, retinopathy, nephropathy and neuropathy were significantly associated with skin AF levels (all P<0.001). AF levels increased significantly with severity in both retinopathy and nephropathy (P<0.001). After adjusting for age, diabetes duration, HbA(1c), sm...
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PMID: 20137994
PDF is available here.
PDF is available here.
British Journal of Nutrition (103)7 2010
Abstract
We tested two different honeys- a multiflora honey and UMF 20+, both produced by Comvita New Zealand Ltd (Te Puke, New Zealand). Multiflora honey or UMF 20+(20 g) was consumed daily for 4 weeks, with a 2-week 'washout' period in between. Blood samples were collected every week for each intervention...
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PMID: 20064284
PDF is available here.
PDF is available here.
Clinical calcium (20)4 2010
Abstract
We demonstrated in previous studies that physiologic levels of mechanical strain such as hypergravity, weight-bearing, and LIPUS induce the formation of bone-type collagenous matrix into a specific molecular packing arrangement through the formation of characteristic types of cross-links as minerali...
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PMID: 20354325
PDF is available here.
PDF is available here.
Immunology (129)3 2010
Abstract
Our data indicate that AGE-OVA may be more immunogenic/allergenic than regular OVA....
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PMID: 19922418
PDF is available here.
PDF is available here.
Immunology (129)3 2010
Abstract
Our data indicate that AGE-OVA may be more immunogenic/allergenic than regular OVA....
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PMID: 19922418
PDF is available here.
PDF is available here.
Immunology (129)3 2010
Abstract
Our data indicate that AGE-OVA may be more immunogenic/allergenic than regular OVA....
|
PMID: 19922418
PDF is available here.
PDF is available here.
Immunology (129)3 2010
Abstract
Our data indicate that AGE-OVA may be more immunogenic/allergenic than regular OVA....
|
PMID: 19922418
PDF is available here.
PDF is available here.
Immunology (129)3 2010
Abstract
Our data indicate that AGE-OVA may be more immunogenic/allergenic than regular OVA....
|
PMID: 19922418
PDF is available here.
PDF is available here.
Immunology (129)3 2010
Abstract
Our data indicate that AGE-OVA may be more immunogenic/allergenic than regular OVA....
|
PMID: 19922418
PDF is available here.
PDF is available here.
Immunology (129)3 2010
Abstract
Our data indicate that AGE-OVA may be more immunogenic/allergenic than regular OVA....
|
PMID: 19922418
PDF is available here.
PDF is available here.
Immunology (129)3 2010
Abstract
Our data indicate that AGE-OVA may be more immunogenic/allergenic than regular OVA....
|
PMID: 19922418
PDF is available here.
PDF is available here.
Immunology (129)3 2010
Abstract
Our data indicate that AGE-OVA may be more immunogenic/allergenic than regular OVA....
|
PMID: 19922418
PDF is available here.
PDF is available here.
Immunology (129)3 2010
Abstract
Our data indicate that AGE-OVA may be more immunogenic/allergenic than regular OVA....
|
PMID: 19922418
PDF is available here.
PDF is available here.
Immunology (129)3 2010
Abstract
Our data indicate that AGE-OVA may be more immunogenic/allergenic than regular OVA....
|
PMID: 19922418
PDF is available here.
PDF is available here.
Immunology (129)3 2010
Abstract
Our data indicate that AGE-OVA may be more immunogenic/allergenic than regular OVA....
|
PMID: 19922418
PDF is available here.
PDF is available here.
Journal of Hepatology (52)3 2010
Abstract
The demonstration of advanced glycation end product-induced reactive oxygen species generation in hepatic stellate cells unveils a potential new route through which advanced glycation end products induce liver fibrosis in the metabolic syndrome.
Copyright (c) 2010 European Association for the Study...
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PMID: 20133001
PDF is available here.
PDF is available here.
Abstract
Patients with NYHA II-IV stable HF for at least 3 months were eligible for this study. One hundred and two patients were included in the study and randomized to either 200 mg alagebrium twice daily or placebo for a period of 36 weeks. The mean age of patients was 60 +/- 11 years, 78% were male, and...
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PMID: 20100811
PDF is available here.
PDF is available here.
Abstract
Protective effects of caffeic acid (CA) and ellagic acid (EA) in kidney of diabetic mice were examined. CA or EA at 2.5 and 5% was mixed in diet and supplied to diabetic mice for 12 wk. Results showed that the intake of CA or EA increased renal content of these compounds, alleviated...
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PMID: 19885845
PDF is available here.
PDF is available here.
Abstract
Oxidative stress is defined as an overflow of oxidative metabolites either in the human body or in a compartment of the body. Today this chemical definition has been slightly modified and encompasses an elevation of oxidative metabolites or a relative deficiency of anti-oxidants. Molecular oxygen is...
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PMID: 20155652
PDF is available here.
PDF is available here.