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Tamoxifen (2):
Recent article
Tamoxifen
Genes & Development (25)16 2011
Abstract
We have determined the cistrome and transcriptome for the nuclear receptor liver receptor homolog-1 (LRH-1) in exocrine pancreas. Chromatin immunoprecipitation (ChIP)-seq and RNA-seq analyses reveal that LRH-1 directly induces expression of genes encoding digestive enzymes and secretory and mitochon...
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PMID: 21852532
PDF is available here.
PDF is available here.
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Abstract
We investigated the clinical relevance of β-arrestin-1 in breast cancer and elucidated a potential link between β-arrestin-1 expression and CCND1 amplification. β-Arrestin-1 protein expression was evaluated in two breast cancer patient cohorts, comprising 179 patients (cohort I) and 500 patients...
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PMID: 21497294
PDF is available here.
PDF is available here.
Clinical Breast Cancer (11)1 2011
Abstract
The purpose of this study is to assess the impact of adjuvant therapy on survival in males with non-metastatic breast cancer.
A retrospective analysis of male breast cancers treated between 1990 and 2003 was performed. Age, estrogen and progesterone receptor (ER/PgR)...
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PMID: 21421521
PDF is available here.
PDF is available here.
Translational Research (157)2 2011
Abstract
Tamoxifen, a selective estrogen receptor (ER) modulator (SERM), is widely used therapeutically for the treatment and prevention of breast cancer, but its use is associated with an increased risk of thrombosis. The mechanism of this adverse effect is still unclear. Arterial thromboses...
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PMID: 21256460
PDF is available here.
PDF is available here.
Cancer Biology & Therapy (11)2 2011
Abstract
We show that curcumin does induce apoptosis in A375 and the relatively resistant G361 malignant human melanoma cell lines at higher doses. Tamoxifen is an estrogen receptor (ER) blocker that is used for ER positive breast cancer treatment. Recently, tamoxifen has been shown to directly target the mi...
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PMID: 21088500
PDF is available here.
PDF is available here.
Medicine (Baltimore) (90)1 2011
Abstract
The term "chronic periaortitis" (CP), proposed by Mitchinson in 1984, comprises 3 main entities: idiopathic retroperitoneal fibrosis (IRF), inflammatory abdominal aortic aneurysms (IAAAs), and perianeurysmal retroperitoneal fibrosis (PRF).The presence of constitutional symptoms, high acute-phase rea...
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PMID: 21200184
PDF is available here.
PDF is available here.
Neural Development (6)1 2011
Abstract
We studied the temporal generation and diversity of Neurog2-positive precursor progeny using an inducible genetic fate mapping approach. We show that all subtypes of glutamatergic neurons derive from Neurog2 positive progenitors during development of the OB. Projection neurons, that is, mitral and t...
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PMID: 21466690
PDF is available here.
PDF is available here.
Abstract
We constructed a mouse line in which the CAR gene could be disrupted at any chosen time point in a broad spectrum of cell types and tissues. All knockouts examined displayed a dilated intestinal tract and atrophy of the exocrine pancreas with appearance of tubular complexes characteristic of acinar-...
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PMID: 21674029
PDF is available here.
PDF is available here.
Abstract
We report a case of t-ALL with t(11;19)(q23;p13.3) and MLL-MLLT1 (alias ENL) gene rearrangement confirmed by cytogenetic analysis, multiplex reverse transcription-PCR (multiplex RT-PCR), and DNA sequencing in a patient who had undergone treatment for breast cancer. A 40-yr-old woman developed acute...
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PMID: 21239865
PDF is available here.
PDF is available here.
Abstract
We present here a new ES cell line, SS-ES-1, established from the left thoracic tumor of a 16-year-old female patient. The SS-ES-1 cells retained genotype, morphology, and growth rate for over 150 passages. Immunocytochemical staining showed the strong immunoreactivity for cytokeratin, epithelial me...
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PMID: 20962673
PDF is available here.
PDF is available here.
Abstract
We discuss the well established data with SERMs, SERDs and AIs, mechanisms underlying resistance and rationale for recycling endocrine compounds and for simultaneously targeting different pathways.
Copyright © 2010 Elsevier Ltd. All rights reserved....
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PMID: 21129614
PDF is available here.
PDF is available here.
Abstract
We aimed to develop a protocol for tamoxifen-induced gene inactivation with minimal effects on gene transcription and in vivo cardiac function, allowing studies of acute loss of the targeted gene. In mRNA microarrays, 35% of the 34,760 examined genes were significantly regulated in MCM(+/0) compared...
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PMID: 20802136
PDF is available here.
PDF is available here.
British Journal of Cancer (103)8 2010
Abstract
We explored whether BCAR4 is predictive for tamoxifen resistance and prognostic for tumour aggressiveness, and studied its function.
BCAR4 mRNA levels were measured in primary breast tumours, and evaluated for association with progression-free survival (PFS) and clinical benefit in patients with oes...
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PMID: 20859285
PDF is available here.
PDF is available here.
Abstract
We describe the generation of an inducible Cre transgenic line allowing conditional mutagenesis in ovarian granulosa cells. We have expressed the tamoxifen inducible CreER(T)² fusion protein from a Bacterial Artificial Chromosome (BAC) containing the regulatory elements of the hydroxysteroid (17-be...
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PMID: 20715176
PDF is available here.
PDF is available here.
Abstract
Ductal carcinoma in situ (DCIS) is a premalignant condition that, if left untreated, may progress to invasive breast cancer. After lumpectomy, DCIS can recur, and about half of recurrences are invasive. In 4 randomized trials, radiation has been shown to decrease the local recurrence...
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PMID: 20971843
PDF is available here.
PDF is available here.
Abstract
We report a female patient, aged 12 years and 6 months, suffering from juvenile breast hypertrophy, who presented at the third month of symptoms and benefited from tamoxifen treatment.
In experienced clinics, use of tamoxifen in the treatment of juvenile breast hypertrophy during the brisk growth pe...
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PMID: 20813327
PDF is available here.
PDF is available here.
Journal of Clinical Oncology (28)28 2010
Abstract
We compared gene expression profiles of pairs of fine-needle (stroma-poor) and core-needle (stroma-rich) biopsies from 37 cancers to identify stroma-associated genes. We defined stromal metagenes and tested their prognostic values in 684 node-negative patients who received no systemic adjuvant thera...
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PMID: 20805453
PDF is available here.
PDF is available here.
Abstract
We have demonstrated notable stability of this cell population under physiologic and inflammatory conditions. Our results suggest that self-renewal of mature T(reg) cells serves as a major mechanism of maintenance of the T(reg) cell lineage in adult mice....
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PMID: 20929851
PDF is available here.
PDF is available here.
Abstract
We earlier reported a significant association between the cytochrome P450 2D6 (CYP2D6) genotype and the clinical outcome in 282 Japanese breast cancer patients receiving tamoxifen monotherapy. Although many research groups have provided evidence indicating the CYP2D6 genotype as one of the strongest...
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PMID: 20574415
PDF is available here.
PDF is available here.
Abstract
We evaluated the effect of estrogen antagonist, raloxifene (Ral), on the prevention and treatment of BPH by investigating its effect on the proliferation of two different prostate cell lines: a stromal cell line, WPMY-1, and a benign prostatic hyperplasia epithelial cell line, BPH-1. We additionally...
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PMID: 20473319
PDF is available here.
PDF is available here.
Anticancer Research (30)9 2010
Abstract
MCF7(TAM) cells expressed EGFR, HER2 and WT1 at higher levels compared to tamoxifen-sensitive parental MCF7 cells. MCF7(TAM) cells responded weakly to estrogen stimulation, grew rapidly in the absence of estrogen and were insensitive to tamoxifen. We also established stable cell lines from MCF7(TAM)...
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PMID: 20944147
PDF is available here.
PDF is available here.
Abstract
We have evaluated the pro-oncogenic function of AGR2 in anti-hormone therapeutic responses. We show that AGR2 expression promotes cancer cell survival in clonogenic assays and increases cell proliferation and viability in a range of cancer cell lines. Chromatin immunoprecipitation and reporter assay...
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PMID: 20531310
PDF is available here.
PDF is available here.
Abstract
Blunted GH response to stimulation occurring in the face of reduced IGF-I feedback inhibition with tamoxifen indicates that GH secretion was suppressed by estrogen receptor antagonism. Because circulating estradiol was unaffected, these data indicate a significant role of local estrogen in the centr...
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PMID: 20444909
PDF is available here.
PDF is available here.
Ron receptor tyrosine kinase activation confers resistance to tamoxifen in breast cancer cell lines.
Abstract
We evaluated the role of Ron receptor activation in conferring resistance to tamoxifen in human and murine breast cancer cell lines. Activation of Ron by its ligand, hepatocyte growth factor-like protein (HGFL) was associated with partial rescue from tamoxifen-induced growth inhibition in Ron-expres...
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PMID: 20689759
PDF is available here.
PDF is available here.
Oncology Reports (24)2 2010
Abstract
We have recently identified a 28-gene expression signature that predicts, with high accuracy, the clinical course in a large population of breast cancer patients. This prognostic gene signature also accurately predicts response to chemotherapy commonly used for treating breast cancer, including CMF,...
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PMID: 20596637
PDF is available here.
PDF is available here.
Abstract
Journal of Clinical Oncology (28)21 2010
Abstract
Journal of Clinical Oncology (28)21 2010
Abstract
We hypothesized that anastrozole may be more effective in women with a high body mass index (BMI). PATIENTS AND METHODS: The Arimidex, Tamoxifen Alone or in Combination (ATAC) study was a double-blind randomized clinical trial in which postmenopausal women with early-stage breast cancer were randoml...
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PMID: 20547990
PDF is available here.
PDF is available here.
Abstract
We report the generation and initial characterization of a mouse line expressing tamoxifen-inducible improved Cre (iCre) recombinase (iCre-ER(T2)) under the regulation of NPHS2 (podocin) gene promoter. The resulting transgenic mouse line was named podocin-iCreER(T2) mice. The efficiency of iCre acti...
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PMID: 20641128
PDF is available here.
PDF is available here.
Abstract
We have performed pelvic magnetic resonance imaging (MRI) in patients undergoing breast cancer surgery before and after adjuvant drug therapy. Our purpose was to detect any radiographic uterine changes induced by various types of adjuvant therapy on pre- and postmenopausal patients by evaluating pro...
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PMID: 20661693
PDF is available here.
PDF is available here.
Abstract
We show that the transcription factor Bcl11b was expressed in all T cell compartments and was indispensable for T lineage development. When Bcl11b was deleted, T cells from all developmental stages acquired NK cell properties and concomitantly lost or decreased T cell-associated gene expression. The...
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PMID: 20538915
PDF is available here.
PDF is available here.
Abstract
Multi-spectroscopic methods including resonance light scattering (RLS), ultraviolet spectra (UV), fluorescence spectra, (1)H NMR spectroscopy, coupled with thermo-denaturation experiments were firstly used to study the interaction of antitumor drug tamoxifen (TMX) with calf thymus (ctDNA) in acetate...
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PMID: 20392665
PDF is available here.
PDF is available here.
Abstract
Distinct differences between two selective estrogen receptor modulators on lipids were observed. Toremifene improved lipid profiles, particularly as an enhancer of high-density lipoprotein cholesterol. To a large extent, tamoxifen improved low-density lipoprotein cholesterol levels. The impact of th...
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PMID: 20382637
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (90)25 2010
Abstract
To explore the pattern of benign gynecologic diseases in patients treated with tamoxifen for breast cancer.
A total of 163 cases with breast cancer were followed up by gynecologists. The incidence rates of several benign gynecologic conditions were determined and were compared among women receiving...
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PMID: 20979888
PDF is available here.
PDF is available here.
Abstract
We show that activated MAPK represses interaction of TAM-bound ERalpha with silencing mediator for retinoid and thyroid hormone receptors (SMRT) and inhibits the recruitment of SMRT by ERalpha to certain estrogen target genes. Blockade of MAPK signaling cascade with MEK inhibitor U0126 promotes the...
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PMID: 20406620
PDF is available here.
PDF is available here.
Abstract
We review molecular diagnostic tools focusing on breast cancer therapy....
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PMID: 20535965
PDF is available here.
PDF is available here.
Medical Oncology (27)2 2010
Abstract
We used a cellular model to evaluate the effects of autocrine expression of human growth hormone on responses of cells to tamoxifen. Our results imply for the first time that autocrine expression of growth hormone in human breast adenocarcinoma cell line, MCF-7, results in increase in cell prolifera...
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PMID: 19472088
PDF is available here.
PDF is available here.
The Lancet (375)9729 2010
Abstract
Abstract
We report that a PIK3CA mutation-associated gene signature (PIK3CA-GS) derived from exon 20 (kinase domain) mutations was able to predict PIK3CA mutation status in two independent datasets, strongly suggesting a characteristic set of gene expression-induced changes. However, in ER+/HER2- BC despite...
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PMID: 20479250
PDF is available here.
PDF is available here.
Harvard Mental Health Letter (26)12 2010
Abstract
Abstract
Tamoxifen was found to be used off-label in only 5.8% of the patients who received the drug in 2008 in this HMO, and only 18 patients (2.1%) received tamoxifen for a diagnosis that did not have some supporting evidence of efficacy. Since off-label prescribing of tamoxifen was found to be relatively...
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PMID: 20518588
PDF is available here.
PDF is available here.
Journal of Clinical Oncology (28)16 2010
Abstract
We are providing a guide for the use of medications that inhibit CYP2D6 in patients administered tamoxifen....
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PMID: 20439629
PDF is available here.
PDF is available here.
Anticancer Research (30)6 2010
Abstract
Neither OHT nor fulvestrant inhibited cell growth, nor did they induce apoptosis. Gefitinib, everolimus and perifosine inhibited proliferation in all cell lines. Only perifosine induced apoptosis. In PTEN-positive HEC1A cells, combined treatment of gefitinib plus OHT showed increased antiproliferati...
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PMID: 20651347
PDF is available here.
PDF is available here.
The Breast (19)3 2010
Abstract
Of 1020 new breast cancer patients, 918 (90%) were oestrogen receptor (OR) positive and were started on gT as part of their treatment. Of those, a total of 121 (13.2%) suffered with arthralgia. All 121 patients agreed to enter the study and swap treatment to Nolvadex for 6 months 114 patients (94.2%...
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PMID: 20347307
PDF is available here.
PDF is available here.
British Journal of Radiology (83)990 2010
Abstract
We describe a 45-year-old male patient with recurrent retroperitoneal fibrosis (RPF), in whom a pseudocyst in the peri-aortic fibrotic mantle was diagnosed. Without any intervention other than oral treatment with tamoxifen, the pseudocyst showed significant regression. Although rare, pseudocyst form...
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PMID: 20505023
PDF is available here.
PDF is available here.
Abstract
A mixture of the (Z)- and (E)-isomers of 4-hydroxy-N-desmethyltamoxifen was conveniently prepared in four steps. These geometrical isomers were then neatly separated by semi-preparative Reverse Phase High Performance Liquid Chromatography (RP-HPLC) using specified conditions. Additionally, the isola...
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PMID: 20400308
PDF is available here.
PDF is available here.
Journal of Membrane Biology (235)1 2010
Abstract
We have shown that mouse cholangiocytes have an intact RVD via VACC and K(+) conductance. However, such cell volume regulation was not studied in the normal human cholangiocyte. Volume measurement by Coulter counter and whole-cell patch clamp technique were used to characterize the RVD and VACC in h...
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PMID: 20411247
PDF is available here.
PDF is available here.
Abstract
We have investigated this possibility in the case of the MCF-7 breast cancer cell line. The line was cultured for a prolonged period either in the presence of tamoxifen to block the action of oestrogen or in the absence of estrogen to mimic the action of oophorectomy or treatment with aromatase inhi...
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PMID: 20234184
PDF is available here.
PDF is available here.
Abstract
We reviewed 80 breast cancer cases that had been evaluated by the Oncotype DX assay and also underwent immunohistochemical staining for ER and PR. We found excellent correlation between ER and PR status determined qualitatively by each method. In addition, when hormone receptor expression measured q...
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PMID: 20186046
PDF is available here.
PDF is available here.
Abstract
Premenopausal women are at highest risk for papillary and follicular thyroid carcinoma, implicating a role for estrogens in thyroid cancer. The expression of estrogen receptors alpha and beta (ER), the effects of estradiol (E2), selective estrogen receptor modulators (SERMs) 4-hydroxytamoxifen and r...
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PMID: 20372779
PDF is available here.
PDF is available here.
Abstract
Those presented with absolute frequencies demonstrated greater accuracy in estimating 2 of 4 side effects, and of any side effect occurring, than those presented with frequency bands. Those presented with combined descriptors were more accurate at estimating the risk of pulmonary embolism than those...
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PMID: 19896321
PDF is available here.
PDF is available here.
Abstract
We suggest that the occurrence or aggravation of epilepsy, despite estrogen deficiency in the menopausal or post-menopausal period, is related to excessive accumulation of FSH and LH....
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PMID: 20063987
PDF is available here.
PDF is available here.
Abstract
We have investigated the role of AR expression in human breast cancer in response to treatment with the antiestrogen tamoxifen. Resistance to tamoxifen is a major problem in treating women with breast cancer. By gene expression profiling, we found elevated AR and reduced estrogen receptor (ER) alpha...
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PMID: 19533338
PDF is available here.
PDF is available here.
Abstract
We performed a population-based study in the county of North Jutland, Denmark, including 120 women aged <60 years who received adjuvant chemotherapy with seven cycles of cyclophosphamide, epirubicin and fluoruracil or adjuvant tamoxifen for 6 months for early breast cancer from 2004 to 2006. They we...
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PMID: 20306129
PDF is available here.
PDF is available here.
Abstract
We examined the prognostic and predictive value of CNF in two randomized clinical trials comparing chemoendocrine therapy with endocrine therapy alone in patients with node-negative breast cancer. A total of 1,850 patients randomly assigned to treatment groups comparing endocrine with chemoendocrine...
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PMID: 19280340
PDF is available here.
PDF is available here.
Abstract
We evaluated the ability of 4-hydroxytamoxifen (OHT) and epidermal growth factor (EGF) to regulate homotypic adhesion in MCF7 breast cancer cells. Our results demonstrate that OHT and EGF activate the E-cadherin promoter, increase E-cadherin mRNA and protein expression and enhance homotypic aggregat...
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PMID: 19593637
PDF is available here.
PDF is available here.
Annals of Internal Medicine (152)7 2010
Abstract
Abstract
We report 6 patients with SM involving the pancreas (mean age 43.2 y, 5 female), and review their clinical presentation, radiographic findings, pathology, and outcome. Five of these 6 patients were originally thought to have a primary pancreatic neoplasm. Initial presenting clinical information was...
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PMID: 20351487
PDF is available here.
PDF is available here.
Clinical Cancer Research (16)7 2010
Abstract
Increased coactivator mRNA levels seem to be an early response to tamoxifen without dose-response relationship in the 1- to 20-mg range. Clinical and molecular effects of low-dose tamoxifen should be further explored.
Copyright 2010 AACR....
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PMID: 20332317
PDF is available here.
PDF is available here.
Molecular Endocrinology (24)4 2010
Abstract
We investigated the effect of long-term (21 d) hormone replacement on ER signaling by whole-body in vivo imaging. Estrogens and selective ER modulators were administered daily at doses equivalent to those used in humans as calculated by the allometric approach. As controls, ER activity was measured...
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PMID: 20197311
PDF is available here.
PDF is available here.