Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Stilbenes (8):
Recent article
Stilbenes
Biochemistry (Washington) (50)36 2011
Abstract
We previously identified a novel Jak2 inhibitor named G6. We showed that G6 specifically inhibits Jak2 kinase activity and suppresses Jak2-mediated cellular proliferation. To elucidate the molecular and biochemical mechanisms by which G6 inhibits Jak2-mediated cellular proliferation, we treated Jak2...
|
PMID: 21823612
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
We aimed at investigating (i) whether a daily dose of 300 mg resveratrol/kg body weight in healthy male Wistar rats for a period of 8 wk affects the selected parameters of glucose and lipid metabolism and (ii) whether the resulting plasma concentrations of resveratrol metabolites were effective...
|
PMID: 21732533
PDF is available here.
PDF is available here.
Abstract
We have analyzed differential miRNA expression in PCa cells treated with Res.
Using miRNA microarrays we found that 23 miRNAs were significantly down-regulated and 28 miRNAs were significantly up-regulated after Res treatment. The down-regulated miRs included miR-17-92 and miR-106ab...
|
PMID: 21714127
PDF is available here.
PDF is available here.
Abstract
We show that [(3)H]-resveratrol enters colon cancer cells (SW480, SW620, HT29) and leukemia U937 cells through a monensin (5-20 μmol/L) -sensitive process that suggests clathrin-independent endocytosis. Uptake of the molecule can be prevented by methyl-β-cyclodextrin (2-12 mg/mL), nystatin (12 ng/...
|
PMID: 21467134
PDF is available here.
PDF is available here.
Abstract
We discuss specificities of SIRT1 effects in the liver versus pancreatic β-cells, ultimately converging towards metabolic homeostasis at the organism level....
|
PMID: 21483037
PDF is available here.
PDF is available here.
Abstract
The immune system is balanced with cells that respond to microbes by developing into effector cells and cells that regulate the activity of effector cells. In many immune responses a subset of effector T cells termed Th17 are necessary for complete immunity because the cytokine IL-17...
|
PMID: 20708723
PDF is available here.
PDF is available here.
DNA and Cell Biology (30)3 2010
Abstract
We aimed at investigating the role of spleen tyrosine kinase (Syk) in the proliferation and phenotypes in rat pulmonary arterial VSMCs. Our results demonstrate that PDGF-BB or Syk-adenovirus led to a substantial increase of proliferation of VSMCs and cytoskeleton rearrangement in rat VSMCs. Consiste...
|
PMID: 21189061
PDF is available here.
PDF is available here.
Abstract
We hypothesize that SIRT1 is responsible for the upregulation of insulin-suppressed gluconeogenic genes through the deacetylation of FOXO1. Treatment of primary cultured hepatocytes with resveratrol increased insulin-repressed PEPCK and G6Pase mRNA levels, which depend on SIRT1 activity. We found th...
|
PMID: 21078299
PDF is available here.
PDF is available here.
Biomedical Chromatography (24)12 2010
Abstract
A rapid HPLC method was developed and validated for the quantification of oxyresveratrol analog trans-2,4,3',5'-tetramethoxystilbene (oxyresveratrol tetramethyl ether, OTE) in rat plasma. Chromatographic separation was achieved on an RP-HPLC column, which was protected by a guard column through a 12...
|
PMID: 21077256
PDF is available here.
PDF is available here.
Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents.
Abstract
The synthesis and antiproliferative activity of a new series of rigid analogues of combretastatin A-4 are described which contain the 1,4-diaryl-2-azetidinone (β-lactam) ring system in place of the usual ethylene bridge present in the natural combretastatin stilbene products. These novel compounds...
|
PMID: 21080725
PDF is available here.
PDF is available here.
Abstract
We review the evidence for a protective role of resveratrol in respiratory disease. Mechanisms of resveratrol action that may be relevant to respiratory disease are described. We conclude that resveratrol has potential as a therapeutic agent in respiratory disease, which should be further investigat...
|
PMID: 20214495
PDF is available here.
PDF is available here.
Fertility and Sterility (94)6 2010
Abstract
To analyze oxidative stress markers and seminal standard parameters after using resveratrol (0.1, 1.0, and 10.0 mM), an important antioxidant, in the cryopreservation of human semen.
In vitro prospective study.
Institutional study.
Infertile and fertile men.
None.
Levels of thiobarbituric acid-react...
|
PMID: 20189559
PDF is available here.
PDF is available here.
Abstract
These results suggest that resveratrol acts by distinct and overlapping signaling pathways and mechanisms in HAECs and HPAECs, further supporting the notion that the cardioactive activities and effects of this grape polyphenol are contingent upon or influenced by the vascular bed of origin....
|
PMID: 20878097
PDF is available here.
PDF is available here.
Abstract
The metabolic syndrome is associated with increased risk for development of both cardiovascular disease and type 2 diabetes in humans. Because experimental data and clinical experience have shown that metabolic syndrome and caloric restriction have, at least partly, opposite pathophysiological pathw...
|
PMID: 20823772
PDF is available here.
PDF is available here.
Abstract
To investigate the role of spleen tyrosine kinase (Syk) in rat pulmonary vascular smooth muscle cells (PVSMCs) proliferation induced by platelet-derived growth factor-BB (PDGF-BB).
|
PMID: 21083985
PDF is available here.
PDF is available here.
Harvard Heart Letter (21)3 2010
Abstract
Current Eye Research (35)11 2010
Abstract
To investigate potential inhibitory effects of three polyphenolic agents, epigallocatechin gallate (EGCG; from green tea), resveratrol (from red wine), and curcumin (from turmeric), on the proliferation of human retinal pigment epithelial (RPE) cells and to elucidate unwanted effects.
ARPE19 cells a...
|
PMID: 20958191
PDF is available here.
PDF is available here.
Analyst (Cambridge UK) (135)11 2010
Abstract
We have developed a nanoparticle (NP)-conjugated FRET probe based on the human estrogen receptor α (ER) ligand-binding domain (LBD) to detect phytoestrogens. The NP-conjugated FRET probe showed fluorescence signals for genistein, resveratrol and daidzein compounds with Δ ratios of 1.65, 2.60 and 1...
|
PMID: 20877819
PDF is available here.
PDF is available here.
Analyst (Cambridge UK) (135)11 2010
Abstract
Herein, a sensitive and selective sensor for mercury(II) and glutathione based on the aggregation-induced emission (AIE) of a tetraphenylethene derivative stimulated by Hg(2+)-DNA complexes is reported. Aggregation complexes of AIE probes, quaternized tetraphenylethene salt and anti-Hg(2+) aptamer s...
|
PMID: 20877906
PDF is available here.
PDF is available here.
Nutrition and Cancer (62)7 2010
Abstract
We discuss merits of two such naturally occurring dietary agents-curcumin and resveratrol-for chemoprevention of CRC....
|
PMID: 20924971
PDF is available here.
PDF is available here.
Nutrition and Cancer (62)7 2010
Abstract
Head and neck squamous cell carcinoma (HNSCC) is one of the most fatal cancers worldwide. Despite advances in the management of HNSCC, the overall survival for patients has not improved significantly due to advanced stages at diagnosis, high recurrence rate after surgical removal, and second primary...
|
PMID: 20924973
PDF is available here.
PDF is available here.
Abstract
We investigated the roles of RV-induced SirT1 activation in endothelial cells under oxidative stress.
SirT1 mRNA expression levels were examined in the endothelium layer (endothelial cells) of cardiac coronary vessels from patients receiving coronary artery bypass graft surgery (CABG) surgery and ag...
|
PMID: 20644332
PDF is available here.
PDF is available here.
Experimental Dermatology (19)10 2010
Abstract
We investigated whether resveratrol would activate p66Shc in human immortalised keratinocytes (HaCaT cells), a well known and largely used model for skin keratinocytes. HaCaT cells were treated with resveratrol (10-150 μm) for different times. The effect of resveratrol on the proliferation of HaCaT...
|
PMID: 20626463
PDF is available here.
PDF is available here.
Abstract
Vinyl-substituted (Z)-stilbenes are stereoselectively synthesised on treatment of 4-arylbuta-2,3-dien-1-ols with arylboronic acids in the presence of a rhodium(i) catalyst. The reaction proceeds through the regioselective addition of organorhodium(i) species across the aryl-substituted carbon-carbon...
|
PMID: 20661491
PDF is available here.
PDF is available here.
Abstract
Based on the potential of resveratrol as a colon cancer chemopreventive agent, a set of 26 stilbenes were synthesized and tested against the colon cancer cell lines HT-29 and Caco-2. (Z)-4-(3,5-Dimethoxystyryl)aniline (4), (Z)-methyl-4-(3,5-dimethoxystyryl)benzoate (6), and (Z)-1,3-dimethoxy-5-(4-me...
|
PMID: 20627379
PDF is available here.
PDF is available here.
Abstract
A series of 5-(3',4',5'-trimethoxyphenyl)pyrrolo[3,4-a]carbazole-1,3(2H,10H)-diones was designed as cis-restricted analogues of 3-aroylindoles, arylthioindoles and 3-benzylidoneindolin-2-ones derived from combretastatin A4 (CA-4). Starting from various indoles, compounds were synthesized by means of...
|
PMID: 20538383
PDF is available here.
PDF is available here.
Abstract
The silent information regulator (SIR) genes (sirtuins) comprise a highly conserved family of proteins, with one or more sirtuins present in virtually all species from bacteria to mammals. In mammals seven sirtuin genes - SIRT1 to SIRT7 - have been identified. Emerging from research on the sirtuins...
|
PMID: 21155626
PDF is available here.
PDF is available here.
Abstract
Natural products can exhibit many beneficial effects on human health. As far as cancer is concerned, naturally occurring compounds have been reported to prevent tumorigenesis and also to suppress the growth of established tumors. As cancer cells have evolved multiple mechanisms to resist the inducti...
|
PMID: 20486070
PDF is available here.
PDF is available here.
Abstract
We show that resveratrol inhibited cholera toxin (CT)-induced cyclic AMP accumulation in Vero cells. Resveratrol suppressed the CT activity by suppressing the internalization of CT and traffic to the Golgi apparatus without affecting CT binding to cells. Further, resveratrol partially precipitated C...
|
PMID: 20307562
PDF is available here.
PDF is available here.
Abstract
We hypothesized that high-dose resveratrol would improve native angiogenesis in a swine model of metabolic syndrome and chronic myocardial ischemia.
Yorkshire swine were fed a normal diet (Control, n = 7), hypercholesterolemic diet (HCD, n = 7), or hypercholesterolemic diet with supplemental resvera...
|
PMID: 20570307
PDF is available here.
PDF is available here.
Future Oncology (6)8 2010
Abstract
Combretastatin A4 phosphate (CA4P) is the lead compound of a relatively new class of agents termed vascular disrupting agents that target existing tumor blood vessels. Rapid tumor blood flow shutdown has been demonstrated in preclinical models and patients by various techniques such as dynamic contr...
|
PMID: 20799867
PDF is available here.
PDF is available here.
Abstract
This study tested the hypothesis that resveratrol supplementation would lower oxidative stress in exercised muscles of aged mice. Young (3 months) and aged (27 months) C57BL/6 mice received a control or a 0.05% trans-resveratrol-supplemented diet for 10 days. After 7 days of dietary intervention, 20...
|
PMID: 20507922
PDF is available here.
PDF is available here.
Molecular Carcinogenesis (49)8 2010
Abstract
We further demonstrated that long-term ethanol-treated E40 cells develop drug resistance in response to mitomycin C (MMC) treatment (>8 microM). Immunoblot analysis revealed that caspase-8-mediated mitochondrial apoptotic signals (such as Bad) were inactivated in the MMC-resistant E40 cells. Immunop...
|
PMID: 20623640
PDF is available here.
PDF is available here.
Molecular Carcinogenesis (49)8 2010
Abstract
We report our observation that resveratrol can also promote the growth of certain human cancer cells when they are grown either in culture or in athymic nude mice as xenografts. At relatively low concentrations (
PDF is available here.
PDF is available here.
Abstract
We tested the ability of resveratrol and its metabolites to modulate the function of some known targets in vitro. In the present study, we have shown that COX-1, COX-2 and QR2 are potently inhibited by resveratrol, and that COX-1 and COX-2 are also inhibited by the resveratrol 4'-O-sulfate metabolit...
|
PMID: 20450491
PDF is available here.
PDF is available here.
Abstract
Five resveratrol sulfate metabolites were synthesized and assessed for activities known to be mediated by resveratrol: inhibition of tumor necrosis factor (TNF) alpha induced NFkappaB activity, cylcooxygenases (COX-1 and COX-2), aromatase, nitric oxide production in endotoxin-stimulated macrophages,...
|
PMID: 20527891
PDF is available here.
PDF is available here.
Abstract
We investigated the anti-invasive mechanism of resveratrol in lung cancer cells. HO-1 was shown to be elevated (approximately 4.7-fold) in lung cancer tumor samples as compared with matched normal tissues. After treatment of lung adenocarcinoma cell line A549 cells with resveratrol (50 microM) for 2...
|
PMID: 20461740
PDF is available here.
PDF is available here.
Abstract
We sought to identify the effects of resveratrol on fat cell biology and to elucidate whether Sirt1 is involved in resveratrol-mediated changes.
Human Simpson-Golabi-Behmel syndrome preadipocytes and adipocytes were used to study proliferation, adipogenic differentiation, glucose upt...
|
PMID: 20463039
PDF is available here.
PDF is available here.
Abstract
Carcinogenesis (31)7 2010
Abstract
We reported earlier that pterostilbene (trans-3,5-dimethoxy-4'-hydroxystilbene), a structurally related stilbene found in blueberries, was effective in reducing the incidence and multiplicity of aberrant crypt foci formation in the colon of rats injected with azoxymethane (AOM). Our present study wa...
|
PMID: 20061362
PDF is available here.
PDF is available here.
Abstract
We show that resveratrol (0-500 microM) inhibits the growth of a doxorubicin-resistant B16 melanoma cell subline (B16/DOX) (IC(50) = 25 microM after 72 h, P < 0.05). This was accomplished by imposing an artificial checkpoint at the G(1)-S phase transition, as demonstrated by cell-cycle analysis and...
|
PMID: 20564188
PDF is available here.
PDF is available here.
FEBS Letters (584)13 2010
Abstract
We found that PC12 (pheochromocytoma) cells expressed SIRT1 in the cytoplasm. Nerve growth factor (NGF)-induced neurite outgrowth of these cells was promoted by activators of SIRT1, while inhibitors of SIRT1 or SIRT1-siRNA significantly inhibited it. The overexpression of a mutant SIRT1 that localis...
|
PMID: 20434449
PDF is available here.
PDF is available here.
Abstract
We also previously found that the mitochondrial 18 kDa Translocator Protein (TSPO) is required for apoptosis induction by ErPC3. These previous studies also suggested involvement of reactive oxygen species (ROS). In the present study we further investigated the potential involvement of ROS generatio...
|
PMID: 20107899
PDF is available here.
PDF is available here.
Abstract
We also discovered that blockade of N-methyl-d-aspartate (NMDA) receptors reduces the fetal ACTH response to cerebral hypoperfusion. The present study was designed to test the hypothesis that PGHS-2 action and the downstream effect of HPA axis stimulation are stimulated by NMDA-mediated glutamatergi...
|
PMID: 20445154
PDF is available here.
PDF is available here.
Abstract
We found that in cultured coronary arterial endothelial cells, resveratrol, in a dose-dependent manner, significantly increases transcriptional activity of Nrf2. Accordingly, resveratrol significantly upregulates the expression of the Nrf2 target genes NAD(P)H:quinone oxidoreductase 1, gamma-glutamy...
|
PMID: 20418481
PDF is available here.
PDF is available here.
Abstract
Abstract
Synthetic routes have been established for the preparation of regio- and stereoisomerically pure samples of the mono-beta-d-glucuronic acid derivatives of combretastatin A-1, referred to as CA1G1 (5a) and CA1G2 (6a). Judicious choice of protecting groups for the catechol ring was required for the re...
|
PMID: 20496923
PDF is available here.
PDF is available here.
Abstract
We present an overview of the genetic origins and cellular consequences of this deficiency and discuss how these insights might aid future development of treatment strategies.
(c) 2010 Wiley-Liss, Inc....
|
PMID: 20818732
PDF is available here.
PDF is available here.
Poultry Science (89)6 2010
Abstract
Resveratrol, a polyphenol derived from red grapes, berries, and peanuts, exerts antiinflammatory, antioxidant, and immunomodulatory effects. The objective of this study was to investigate the effects of dietary resveratrol supplementation on performance and serum and egg yolk antioxidant status in q...
|
PMID: 20460666
PDF is available here.
PDF is available here.
Minerva ginecologica (62)3 2010
Abstract
During and after menopause the skin shows up clearly how the lack of estrogen affects tissues, and menopause can in fact be considered a "multisystemic" disorder of connective tissue. The low menopausal estrogen levels combined with age-related skin changes, accelerating skin aging. This affects bot...
|
PMID: 20595944
PDF is available here.
PDF is available here.
Abstract
Our results have shown that all oligomers, glucosides and trans-resveratrol-3-O-glucuronide exhibit stronger antioxidant activity than trans-resveratrol and that dimer of trans-4,4'-dihydroxystilbene is a stronger antioxidant than its monomer as well as that cis stereoisomers of piceid and epsilon-v...
|
PMID: 20199826
PDF is available here.
PDF is available here.
Abstract
Trans-resveratrol (3,5,4'-trihydroxy-trans-stilbene), a naturalpolyphenol, displays diversified bioactivities that are crucial in chemoprevention of cancer and cardiovascular diseases. Equally promising action is exerted by resveratrol analogues, mainly pterostilbene (3,5-dimethoxy-4'-hydroxy-trans-...
|
PMID: 20642113
PDF is available here.
PDF is available here.
Abstract
We investigated the protective effect of resveratrol on hepatic injury induced by dimethylnitrosamine (DMN) in rats. Oral administration of resveratrol (20 mg/kg daily for 4 weeks) remarkably prevented the DMN-induced loss in body and liver weight, and inhibited the elevation of serum alanine transa...
|
PMID: 20607498
PDF is available here.
PDF is available here.
Abstract
We evaluate the effect of a polyphenol-based grape extract (NE) obtained from Portuguese white-winemaking by-products, and Resveratrol in pure form, on adenovirus type 5 infection. For this purpose, recombinant adenovirus vectors (Ad-5) and a human-derived cell line (293) were used as models. The NE...
|
PMID: 20109126
PDF is available here.
PDF is available here.
Abstract
We evaluated the in vivo effects of DMMA against infection by wild-type and sortase A- and/or sortase B-deficient Staphylococcus aureus in Balb/c mice. With DMMA treatment, survival rates increased and kidney and joint infection rates decreased (p<0.01) in a dose-dependent manner. The rate of kidney...
|
PMID: 20433810
PDF is available here.
PDF is available here.
Journal of Surgical Research (161)1 2010
Abstract
Pterostilbene inhibits growth via apoptosis induction in vitro. Further in vitro mechanistic studies and in vivo experiments are warranted to determine the potential role for pterostilbene in lung cancer treatment or prevention.
Copyright (c) 2010 Elsevier Inc. All rights reserved....
|
PMID: 20031166
PDF is available here.
PDF is available here.
Abstract
DMF (N,N-dimethylformamide)/KOH was found to be an efficient hydrogen source in the Pd(OAc)(2)-catalyzed transfer semihydrogenation of various functionalized internal alkynes to afford cis-alkenes in good to high yields with excellent chemo- and stereoselectivity. This catalytic process was also app...
|
PMID: 20345142
PDF is available here.
PDF is available here.
Phytochemistry (71)7 2010
Abstract
Stilbenoids, syagrusins A-B (1-2), and a stilbenolignan, 5-hydroxyaiphanol (3), along with three known phenylpropanoids (4-6), were isolated from seeds of Syagrus romanzoffiana. Compounds 1 and 2 possess unusual 1,4,4a,9a-tetrahydrofluoren-9-one and bicyclo[3.3.0]octanedione skeletons, respectively,...
|
PMID: 20156629
PDF is available here.
PDF is available here.
Abstract
We investigated the protective role of resveratrol against the AGE-induced impairment on macrophage lipid homeostasis. In THP-1-derived macrophages, RAGE was dose-dependently induced by AGE and played a key role in the AGE-induced cholesterol accumulation. Resveratrol markedly reduced RAGE expressio...
|
PMID: 20372816
PDF is available here.
PDF is available here.
Abstract
We also comment on potential compounds such as resveratrol and melatonin. Despite the lack of information from clinical trials on these two compounds, they are attracting considerable attention because of their natural origin and antioxidant and antiapoptotic action. Furthermore, they do not show to...
|
PMID: 20402598
PDF is available here.
PDF is available here.