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Ketones (14):
Recent article
Ketones
Cell Cycle (10)8 2011
Abstract
We showed that high-energy metabolites (lactate and ketones) "fuel" tumor growth and experimental metastasis in an in vivo xenograft model, most likely by driving oxidative mitochondrial metabolism in breast cancer cells. To mechanistically understand how these metabolites affect tumor cell behavior...
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PMID: 21512313
PDF is available here.
PDF is available here.
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Organic Letters (13)6 2011
Abstract
The first class of bifunctional cinchona-alkaloid catalysts incorporating a urea moiety at C-5' has been developed. These materials catalyze the efficient and highly enantioselective 1,2-addition of nitromethane to trifluoromethylketones to form synthetically pliable products incorpo...
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PMID: 21338077
PDF is available here.
PDF is available here.
Lab On a Chip (10)23 2010
Abstract
Oxygen tension is critical in a number of cell pathways but is often overlooked in cell culture. One reason for this is the difficulty in modulating and assessing oxygen tensions without disturbing the culture conditions. Toward this end, a simple method to generate oxygen-sensitive microwells was d...
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PMID: 20938500
PDF is available here.
PDF is available here.
Abstract
A new series of 4-aryl-2,6-dimethyl-1,4-dihydropyridines, characterized by ester or ketone functions at positions 3 and 5, has been synthesized. Structural and conformational properties, concerning the dihydropyridine ring and the orientation (synplanar/antiperiplanar) of the substituents have been...
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PMID: 20877784
PDF is available here.
PDF is available here.
Abstract
The asymmetric Friedel-Crafts alkylation reaction of indoles with α,β-unsaturated ketones catalyzed by chiral phosphoric acid is reported. A wide range of indoles and 4,7-dihydroindoles were allowed to react with α,β-unsaturated ketones to give the corresponding 1,4-adducts in good to high chemi...
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PMID: 20877865
PDF is available here.
PDF is available here.
Abstract
Biomaterials (31)35 2010
Abstract
Poly(ether-ether-ketone) (PEEK) has been used as a load bearing orthopaedic implant material with clinical success. All of the orthopaedic applications contain stress concentrations (notches) in their design; however, little work has been done to examine the fatigue behavior of PEEK in the presence...
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PMID: 20864160
PDF is available here.
PDF is available here.
Chemical Communications (46)42 2010
Abstract
An efficient Michael-ketone aldol-dehydration domino reaction has been developed to afford spiro[cyclohex-2-enone-oxindole] motifs with high yields (up to 99%), excellent diastereoselectivities (dr >20 : 1) and enantioselectivities (up to 96% ee).
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PMID: 20865203
PDF is available here.
PDF is available here.
Abstract
We studied the aqueous photochemistry of 4-chlororesorcinol (1), which combines the conformational properties of both types of derivatives, using nanosecond transient absorption spectroscopy and photoproduct analysis. The absorption spectra obtained upon pulsed laser excitation of 1 showed the occur...
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PMID: 20859579
PDF is available here.
PDF is available here.
Abstract
Chiral N-heterocyclic carbenes were found to be efficient catalysts for the formal [2+2] cycloaddition reaction of alkyl(aryl)ketenes and nitroso compounds to give the corresponding 1,2-oxazetidin-3-ones in moderate to good yields with high enantioselectivities. Reductive ring-opening of the oxazeti...
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PMID: 20820659
PDF is available here.
PDF is available here.
Anti-Cancer Drugs (21)10 2010
Abstract
I and II studies in MBC identified neutropenia as the dose-limiting toxicity and a maximum tolerated dose of 1.4 mg/m2 on days 1 and 8 of a 21-day cycle. An encouraging response rate of 11.5% in refractory MBC led to the launch of the phase III Eisai Metastatic Breast Cancer Study Assessing Physic...
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PMID: 20838209
PDF is available here.
PDF is available here.
Chemical Communications (46)40 2010
Abstract
Transketolase mutants have been identified that accept aromatic acceptors with good stereoselectivities, in particular benzaldehyde for which the wild type enzyme showed no activity.
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PMID: 20835425
PDF is available here.
PDF is available here.
Abstract
The direct synthesis of α-bromoketones from alkylarenes by aerobic photooxidation with hydrobromic acid is reported. The key success for this direct oxidative reaction is due to control of bromination with acetic acid and ethanol, which are generated in situ by solvolysis of ethyl acetate in the co...
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PMID: 20740242
PDF is available here.
PDF is available here.
Abstract
Active and selective catalysts for the asymmetric reduction of ketones, under transfer hydrogenation conditions, were obtained by combining [RhCl(2)Cp*](2), with a series of l-amino acid thioamide ligands functionalized with 1,2,3-triazoles. The obtained secondary alcohol products were formed with u...
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PMID: 20721379
PDF is available here.
PDF is available here.
Abstract
Carboxylesterases (CEs) are a family of ubiquitous enzymes with broad substrate specificity, and their inhibition may have important implications in pharmaceutical and agrochemical fields. One of the most potent inhibitors both for mammalian and insect CEs are trifluoromethyl ketones (TFMKs), but th...
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PMID: 20676708
PDF is available here.
PDF is available here.
Abstract
A third strategy for cross-dehydrogenative coupling reaction has been reported via platinum-catalyzed sp(3) C-H and sp(3) C-H coupling reaction in the absence of oxidant. Nitroalkanes as well as dialkyl malonate derivatives, beta-keto esters and malononitrile are active participants in this coupling...
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PMID: 20664883
PDF is available here.
PDF is available here.
Abstract
We review recent developments and applications of aldolase-type organocatalytic direct transformations in aqueous media without addition of organic solvent.
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PMID: 20617260
PDF is available here.
PDF is available here.
Abstract
Benzoyl radicals are generated directly from (hetero)aromatic aldehydes upon tetrabutylammonium decatungstate ((n-Bu(4)N)(4)W(10)O(32)), TBADT) photocatalysis under mild conditions. In the presence of alpha,beta-unsaturated esters, ketones and nitriles radical conjugate addition ensues and gives the...
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PMID: 20661511
PDF is available here.
PDF is available here.
Behavioural Processes (85)1 2010
Abstract
In ungulates the process of chemical communication by urinary scent marking has been directly related to reproductive dominance, territorial defense and proximity to resources. The differences in the frequency of urine marking and chemical composition of urine of males Antelope cervicapra before, du...
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PMID: 20547215
PDF is available here.
PDF is available here.
Abstract
Methodology toward the stereoselective 1,2-cis glycoside linkage using intramolecular aglycon delivery (IAD) has been extensively developed. In the last two decades, progress has been made using various mixed acetal linkages and a number of glycosyl donor moieties to develop novel IAD strategies, ma...
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PMID: 20585666
PDF is available here.
PDF is available here.
Abstract
To develop a GC-MS method for the determination of methyl nonyl ketone in the volatile oil from the herbs of Houttuynia cordata.
The sample was split in the 240 degrees C injection port, with 20:1 split ratio, and separated on a DB-5 (30 m x 0.25 mm, 0.25 microm film thickness) fused silica column w...
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PMID: 20931852
PDF is available here.
PDF is available here.
Abstract
The responses suggested a preference for the images representing PEEK instrumentation as being associated with superior clinical outcomes, the least pain, the most comfort, and the least likelihood of required revision surgery. CONCLUSION: PEEK rods possess radiolucent properties that can alter pati...
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PMID: 20628327
PDF is available here.
PDF is available here.
Abstract
Al-containing helical mesoporous silicas have been synthesized and characterised by different techniques, showing outstanding activities (comparable to those obtained with sulfuric acid) in the oxathioacetalization of cyclohexane.
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PMID: 20526517
PDF is available here.
PDF is available here.
Abstract
Beta-ketoesters, which have widely been employed as nucleophiles, are also useful electrophiles in organocatalytic quinine mediated cascade reactions, leading to the formation of products bearing multiple stereocenters in high stereoselectivity.
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PMID: 20532297
PDF is available here.
PDF is available here.
Abstract
We report an efficient biocatalytic process to replace a recently implemented rhodium-catalyzed asymmetric enamine hydrogenation for the large-scale manufacture of the antidiabetic compound sitagliptin. Starting from an enzyme that had the catalytic machinery to perform the desired chemistry but lac...
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PMID: 20558668
PDF is available here.
PDF is available here.
Abstract
Two cytosolic NADPH-dependent carbonyl reductases from Gluconobacter oxydans 621H, Gox0644 and Gox1615, were heterologously produced in Escherichia coli. The recombinant proteins were purified to homogeneity and characterized. Gox0644 and Gox1615 were dimers with native molecular masses of 66.1 and...
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PMID: 20414648
PDF is available here.
PDF is available here.
Abstract
Our results confirm that intense aerobic bacterial degradative processes can introduce a bias in palaeotemperature reconstructions especially when there is evidence of substantial aerobic bacterial degradation of the deposited organic matter. The widespread occurrence of epoxyalkenones in the marine...
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PMID: 20491919
PDF is available here.
PDF is available here.
Abstract
CFR-PEEK (carbon fiber reforced-poly ether ether ketone) has been demonstrated to be excellent substitute titanium in orthopedic applications and can be manufactured with many physical, mechanical, and surface properties, in several shapes. The aim of this study was to compare, using the three-dimen...
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PMID: 20464460
PDF is available here.
PDF is available here.
Trends in Microbiology (18)7 2010
Abstract
We summarize and compare findings on AHK signaling in these bacteria. The L. pneumophila lqs (Legionella quorum sensing) and V. cholerae cqs (cholera quorum sensing) gene clusters synthesize and detect Legionella autoinducer 1 (3-hydroxypentadecan-4-one) or cholera autoinducer-1 (3-hydroxytridecan-4...
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PMID: 20382022
PDF is available here.
PDF is available here.
Abstract
We have recently described the synthesis of 1alpha,25-dihydroxy-19-norvitamin D3 analogs 2 and 3, possessing an additional ring connecting their 3beta-oxygen and C-2. Such structural constrains prevent the A-ring conformational flexibility and the analogs exist exclusively in the alpha-chair form wi...
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PMID: 20214980
PDF is available here.
PDF is available here.
Nature Chemistry (2)7 2010
Abstract
We describe the use of aldehyde auto-oxidation as a simple, clean and effective method for C-H activation, resulting in the generation of an acyl radical. This acyl radical can be used for carbon-carbon bond formation and herein we describe the application of this method for the hydroacylation of al...
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PMID: 20571580
PDF is available here.
PDF is available here.
Asymmetric epoxidation of 2-arylidene-1,3-diketones: facile access to synthetically useful epoxides.
Abstract
In this article the first enantioselective epoxidation reaction of acyclic and cyclic 2-arylidene-1,3-diketones is reported. Easily accessible or commercially available alpha,alpha-diaryl prolinols as the organocatalysts in the presence of tert-butyl hydroperoxide (TBHP) provide the corresponding ep...
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PMID: 20358125
PDF is available here.
PDF is available here.
Abstract
We quantify over 40 end-products (amines, acids, alcohols, aldehydes, or ketones) produced by malignant neuroblastoma under accelerated glycolysis (+glucose (GLU) supply 1-10 mM) +/- mitochondrial toxin; 1-methyl-4-phenylpyridinium (MPP(+)) to abate aerobic respiration to delineate differences betwe...
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PMID: 19784859
PDF is available here.
PDF is available here.
Neurochemical Research (35)6 2010
Abstract
We applied spectroscopy (circular dichroism, fluorescence) in a simplified model consisting in a peptide analogue (K156) of alpha4 helix involved in recognition of viral and cell DNA; an oligonucleotide corresponding to the U5' LTR DNA end; and an inhibitor (TB11) of the diketo acid (DKA) family. Re...
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PMID: 19937113
PDF is available here.
PDF is available here.
Abstract
We demonstrate the function of thread-based microfluidic devices in the context of five different colorimetric assays: detection of ketones, nitrite, protein, and glucose in artificial urine, and detection of alkaline phosphatase in artificial plasma....
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PMID: 20496913
PDF is available here.
PDF is available here.
Chemical Communications (46)20 2010
Abstract
Highly enantioselective Michael addition of malonates to beta,gamma-unsaturated alpha-ketoesters has been promoted by chiral N,N'-dioxide-Yttrium(iii) complexes, providing the corresponding products in excellent yields with 94-99% ee values.
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PMID: 20379595
PDF is available here.
PDF is available here.
Abstract
New modular chiral phosphines effective for two distinct Cu(I)-catalyzed asymmetric tetrasubstituted-carbon-forming reactions, namely, allylation and propargylation of ketones, were identified. The optimized phosphine 8 was readily synthesized on a gram scale in high yield via three facile transform...
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PMID: 20420398
PDF is available here.
PDF is available here.
Abstract
In this work, 52 diphenyl-4,5-dihydroisoxazoles and -3-hydroxy ketones were prepared and their estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta) activities were explored in order to systematize and maximize their biological activity. The biological activity was firstly screened b...
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PMID: 20430632
PDF is available here.
PDF is available here.
Abstract
The combination of Pd(OAc)(2) with 1,3-bis(diphenylphosphino)propane (dppp) in ethylene glycol constitutes a high-performance catalytic system for highly regioselective arylation of a range of electron-rich vinyl ethers by aryl bromides to provide, upon hydrolysis, alkyl aryl ketones and cyclic keta...
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PMID: 20401375
PDF is available here.
PDF is available here.
Abstract
A one-pot synthesis of oxazolidinones was initiated via the allylation of alpha-dicarbonyl compounds, accompanying regio- and diastereo-controlled carbon-carbon bond formation on the side chains of the oxazolidinones.
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PMID: 20401374
PDF is available here.
PDF is available here.
Abstract
Systematic studies of reaction conditions and subsequent optimization led to the identification of important parameters for stereoselectivity in the asymmetric alpha-hydroxylation reaction of 1,3-ketoesters. Enantioselectivities of up to 98% can be achieved for cyclic substrates and 88% for acyclic...
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PMID: 20337468
PDF is available here.
PDF is available here.
Abstract
Novel reaction of tetranitromethane (TNM) with electrophilic alkenes in the presence of triethylamine yielding substituted 3-nitroisoxazoles was found and studied. Triethylamine increases the reactivity of TNM toward electrophilic alkenes promoting their heterocyclization, and the reactions proceed...
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PMID: 20384287
PDF is available here.
PDF is available here.
Abstract
A diastereoselective route to (+)-bakkenolide A is presented from the readily available optically active Wieland-Miescher ketone. This novel synthesis of this sesquiterpene lactone features the following as key stereoselective transformations: (i) the ring contraction reaction of a octalone mediated...
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PMID: 20377233
PDF is available here.
PDF is available here.
Abstract
We have found that a variety of alpha,beta-unsaturated ketones, even without other electron-withdrawing functional groups, could be reduced on the alkenic double bonds with high selectivities employing amido-rhodium hydride complex in aqueous media, and up to 100% chemoselectivity has been achieved....
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PMID: 20387856
PDF is available here.
PDF is available here.
Abstract
We observed an increase in IL-1beta-positive and active NF-kappaB-positive duodenal epithelial cells, a decrease in PCNA (proliferative cell nuclear antigen)-positive duodenal epithelial cells and an increase in degenerative changes in duodenum. On the other hand, Z-FA.FMK pretreatment inhibited all...
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PMID: 20128771
PDF is available here.
PDF is available here.
Biomaterials (31)13 2010
Abstract
The surface of polyetheretherketone (PEEK) was coated with a pure titanium (Ti) layer using an electron beam (e-beam) deposition method in order to enhance its biocompatibility and adhesion to bone tissue. The e-beam deposition method was a low-temperature coating process that formed a dense, unifor...
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PMID: 20153890
PDF is available here.
PDF is available here.
Molecular Diversity (14)2 2010
Abstract
A new, facile, and efficient procedure for conjugate addition of indole and pyrrole with Michael acceptors have been developed for pulverization-activation reaction catalyzed by wet cyanuric chloride (2,4,6-trichloro-[1,3,5]-triazine or TCT) through grinding under solvent-free conditions at room tem...
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PMID: 19662504
PDF is available here.
PDF is available here.
Abstract
Cyclodehydration of Bohlmann-Rahtz aminodienone intermediates using N-iodosuccinimide as a Lewis acid proceeds at low temperature under very mild conditions to give the corresponding 2,3,6-trisubstituted pyridines in high yield and with total regiocontrol.
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PMID: 20657473
PDF is available here.
PDF is available here.
Abstract
Catalytic hydrogenation under mild conditions of olefins, unsaturated aldeydes and ketones, nitriles and nitroarenes was investigated, using a supported rhodium complex obtained by copolymerization of Rh(cod)(aaema) [cod: 1,5-cyclooctadiene, aaema-: deprotonated form of 2-(acetoacetoxy)ethyl methacr...
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PMID: 20657481
PDF is available here.
PDF is available here.
Abstract
The reactions of selected alpha,beta-unsaturated steroidal ketones with Lawesson's reagent (LR) in CH(2)Cl(2) and toluene under the standard reaction conditions and with a combination of phosphorus pentasulfide with hexamethyldisiloxane (P(4)S(10)/HMDO) in 1,2-dichlorobenzene (ODCB) under microwave...
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PMID: 20657494
PDF is available here.
PDF is available here.
Molecular Diversity (14)2 2010
Abstract
A new and efficient method for the preparation of 3-amino-2,5-dihydropyridazines from three-component reactions of (phenyl-hydrazono)-propan-2-one, aldehydes, and malononitrile or ethyl cyanoacetate in the presence of magnesium oxide (MgO) as a highly effective heterogeneous base catalyst is present...
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PMID: 19543800
PDF is available here.
PDF is available here.
Abstract
Highly enantioselective Diels-Alder reactions of alpha-halo-alpha,beta-unsaturated ketones with Lewis acid-activated chiral oxazaborolidine 1 are described. The reaction with alpha-fluoroenones provided the corresponding cyclohexane derivatives having a fluorinated quaternary stereogenic center with...
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PMID: 20373752
PDF is available here.
PDF is available here.
Chemical Communications (46)16 2010
Abstract
A facile, efficient and selective solvent-free synthesis of ketones from secondary alcohols with tert-butylhydroperoxide (TBHP) as the oxidant under microwave irradiation is achieved, where the copper(ii) 2,4-alkoxy-1,3,5-triazapentadienato complexes are efficient catalysts providing high yields (up...
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PMID: 20369176
PDF is available here.
PDF is available here.
Abstract
We report that a hard Lewis base substantially affects the reaction efficiency of direct catalytic asymmetric gamma-addition of allyl cyanide (1a) to ketones promoted by a soft Lewis acid/hard Brønsted base catalyst. Mechanistic studies have revealed that Cu/(R,R)-Ph-BPE and Li(OC(6)H(4)-p-OMe) ser...
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PMID: 20337453
PDF is available here.
PDF is available here.
Abstract
The BF(3).OEt(2)-promoted nucleophilic substitution of alpha-aryl-alpha-ketophosphates to afford alpha,alpha-diaryl ketone products is described. Electron-rich alpha-ketophosphates perform best, with electron-neutral and electron-poor substrates also tolerated. The reaction is tolerant of a range of...
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PMID: 20235527
PDF is available here.
PDF is available here.
Abstract
Prochiral ketones are reduced to enantioenriched, secondary alcohols using catecholborane and a family of air-stable, bifunctional thiourea-amine organocatalysts. Asymmetric induction is proposed to arise from the in situ complexation between the borane and chiral thiourea-amine organocatalyst resul...
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PMID: 20334398
PDF is available here.
PDF is available here.
Abstract
A convenient and efficient method for the synthesis of various arylketones by nickel-catalyzed addition of arylboronic acids to nitriles is described. A catalytic cycle involving Ni(II) species as the catalytic intermediates is proposed to account for the present catalytic reaction.
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PMID: 20334426
PDF is available here.
PDF is available here.
Abstract
In this paper, the development of a chiral phosphine-catalyzed formal [2 + 2] cycloaddition of aldehydes and ketoketenes that provides access to a variety of highly substituted beta-lactones (14 examples) is reported. The BINAPHANE catalytic system displays excellent enantioselectivity (seven exampl...
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PMID: 20337432
PDF is available here.
PDF is available here.
Abstract
A membraneless extraction module (MLEM) for the sample preparation of volatile compounds and its use for the chromatographic analysis of vicinal diketones in beer are reported. The extraction process is based on the same principles of gas diffusion (GD) and pervaporation (PV); however it does not us...
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PMID: 20188933
PDF is available here.
PDF is available here.
Biotechnology Letters (32)4 2010
Abstract
An anti-Prelog alcohol dehydrogenase from Oenococcus oeni that reduces 2-octanone to (R)-2-octanol was purified by 26-fold to homogeneity. The enzyme had a homodimeric structure consisting of 49 kDa subunits, required NADPH, but not NADH, as a cofactor and was a Zn-independent short-chain dehydrogen...
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PMID: 20035369
PDF is available here.
PDF is available here.