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Nitro Compounds (9):
Recent article
Nitro Compounds
Organic Letters (13)6 2011
Abstract
The first class of bifunctional cinchona-alkaloid catalysts incorporating a urea moiety at C-5' has been developed. These materials catalyze the efficient and highly enantioselective 1,2-addition of nitromethane to trifluoromethylketones to form synthetically pliable products incorpo...
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PMID: 21338077
PDF is available here.
PDF is available here.
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Natural Product Reports (28)1 2011
Abstract
Naturally-occurring nitro compounds display great structural diversity, and a wide range of biological activities. This review summarizes current information on the structures of naturally-occurring nitro compounds and on the biosynthesis of the nitro group.
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PMID: 21127810
PDF is available here.
PDF is available here.
Journal of Hazardous Materials (184)1-3 2010
Abstract
1,1-Diamino-2,2-dinitroethylene (C(2)H(4)N(4)O(4), FOX-7) quasi-three-dimensional (3D) grids, a promising high-energy-density material with superior sensitivity properties, were synthesized by a spray freeze-drying technique. The FOX-7 3D grids were constructed from one-dimensional nanostructures. T...
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PMID: 20846790
PDF is available here.
PDF is available here.
Abstract
The discovery of sulfoxaflor [N-[methyloxido[1-[6-(trifluoromethyl)-3-pyridinyl]ethyl]-λ(4)-sulfanylidene] cyanamide] resulted from an investigation of the sulfoximine functional group as a novel bioactive scaffold for insecticidal activity and a subsequent extensive structure-activity relationship...
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PMID: 21105655
PDF is available here.
PDF is available here.
Abstract
Resistance development and limited lepidopteran activities call for the discovery of "super-neonicotinoids" solving these problems. Compounds with the cis-configuration offer an opportunity for further optimization. Fixing the nitro group in the cis-configuration provided a new approach for neonicoti...
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PMID: 21043520
PDF is available here.
PDF is available here.
Chemical Communications (46)38 2010
Abstract
A spiropyran photoswitch is activated using UV light and protons from a form that shows no interaction with DNA to a form that binds to DNA by intercalation. This scheme is interpreted as a biologically relevant logic AND gate with potential applications as a dually controlled anticancer drug.
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PMID: 20820507
PDF is available here.
PDF is available here.
Journal of Antibiotics (63)10 2010
Abstract
We isolated a novel compound, arabilin, with two structural isomers, spectinabilin and SNF4435C, produced by Streptomyces sp. MK756-CF1. Structure elucidation on the basis of the spectroscopic properties showed that arabilin is a novel polypropionate-derived metabolite with a p-nitrophenyl group and...
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PMID: 20736953
PDF is available here.
PDF is available here.
Abstract
The physicochemical properties of candidate compounds play important roles in the design of new pesticides. Pesticides must be absorbed by pests, be transported to the target site, and then interact with proteins. Hydrophobicity is very important for these processes. Log P, where P is the partition c...
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PMID: 20879794
PDF is available here.
PDF is available here.
Abstract
A third strategy for cross-dehydrogenative coupling reaction has been reported via platinum-catalyzed sp(3) C-H and sp(3) C-H coupling reaction in the absence of oxidant. Nitroalkanes as well as dialkyl malonate derivatives, beta-keto esters and malononitrile are active participants in this coupling...
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PMID: 20664883
PDF is available here.
PDF is available here.
Toxicology (276)1 2010
Abstract
The essence of the Druckrey-Küpfmüller equation dtn = constant (where d = daily dose and t = exposure time-to-effect, with n > 1) for chemical carcinogens is that the total dose required to produce the same effect decreases with decreasing exposure levels, even though the exposure times required t...
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PMID: 20803795
PDF is available here.
PDF is available here.
Abstract
Abstract
We show that activation of amines and nitroalkanes with an electrophilic iodine source can lead directly to amide products. Preliminary observations support a mechanism in which the polarities of the two reactants are reversed (German, umpolung) during carbon-nitrogen bond formation relative to trad...
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PMID: 20577205
PDF is available here.
PDF is available here.
Journal of Hazardous Materials (178)1-3 2010
Abstract
In this work, a reliable simple method has been introduced for predicting enthalpy of melting of nitroaromatic energetic compounds through their molecular structures. This method can be used for a wide range of nitroaromatics including halogenated nitroaromatic compounds. The contribution of hydroge...
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PMID: 20117881
PDF is available here.
PDF is available here.
Abstract
Bifenthrin, chlorfenapyr, fipronil, and thiamethoxam were evaluated for activity against the red imported fire ant, Solenopsis invicta Buren (Hymenoptera: Formicidae). Mobility impairment and lethal times were determined after topical treatments. Both immobilization and mortality occurred most quick...
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PMID: 20568621
PDF is available here.
PDF is available here.
Abstract
We determined the impact of imidacloprid (Premise) on colonies of Reticulitermes spp. (Isoptera: Rhinotermitidae) through soil applications in the field. We selected 11 houses in the Raleigh, NC, area with active termite infestations. In-ground monitoring stations (mean = 75.9 stations) were install...
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PMID: 20568625
PDF is available here.
PDF is available here.
Abstract
Novel reaction of tetranitromethane (TNM) with electrophilic alkenes in the presence of triethylamine yielding substituted 3-nitroisoxazoles was found and studied. Triethylamine increases the reactivity of TNM toward electrophilic alkenes promoting their heterocyclization, and the reactions proceed...
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PMID: 20384287
PDF is available here.
PDF is available here.
Neurotoxicity Research (17)4 2010
Abstract
We investigated the roles of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the dysregulation of transcription factors and histone modifying enzymes induced by 3-NP in primary cortical neurons. BDNF prevented the 3-NP-induced decrease in cAMP response-element binding prote...
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PMID: 19779956
PDF is available here.
PDF is available here.
Neurobiology of Disease (38)2 2010
Abstract
We tested whether phosphodiesterase 5 (PDE5) inhibitors, sildenafil and vardenafil, would afford protection against 3-nitropropionic acid (3NP), which produces striatal lesions that closely mimic some of the neuropathological features of Huntington's Disease (HD). The neurotoxin was given over 5 day...
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PMID: 20109548
PDF is available here.
PDF is available here.
Abstract
An enantioseparation study of nitro-substituted aryloxyaminopropanols was performed using HPLC on a teicoplanin chiral stationary phase and TLC impregnated with L-aspartic and L-tartaric acid as chiral selectors. The type of substituent on the nitrogen in the hydrophilic part of molecule is essentia...
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PMID: 20503935
PDF is available here.
PDF is available here.
Chemosphere (79)8 2010
Abstract
The development of a new quantitative structure-property relationship (QSPR) model to predict aqueous solubility (S(w)) accurately for compounds of military interest is presented. The ability of the new model to predict solubility is assessed and compared to available experimental data. A large set...
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PMID: 20233619
PDF is available here.
PDF is available here.
Abstract
A 90 days oral toxicity study of imidacloprid was conducted in female rats with doses of 0, 5, 10, 20mg/kg/day. Decrease in the body weight gain was observed at 20mg/kg/day and at necropsy the relative body weights of liver, kidney and adrenal was also significantly increased at this dose level. No...
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PMID: 20146932
PDF is available here.
PDF is available here.
Chemical Communications (46)16 2010
Abstract
A new FRET-based, photoswitchable fluorescent dyad derived from a spiropyran-polythiophene conjugate was developed and applied to the detection of cyanide anion.
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PMID: 20369207
PDF is available here.
PDF is available here.
Abstract
The biocatalytic activity of nitroreductase from Salmonella typhimurium (NRSal) was investigated for the reduction of alpha,beta-unsaturated carbonyl compounds, nitroalkenes, and nitroaromatics. The synthesized gene was subcloned into a pET28 overexpression system in E.coli BL21 strain, and the corr...
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PMID: 20449486
PDF is available here.
PDF is available here.
Abstract
Vascular inflammatory disorders are often associated with both decreased NO bioavailability and a lack of responsiveness to NO, a consequence of impaired NO biosynthesis, dysregulated l-arginine metabolism, endothelial nitric oxide synthase (eNOS) uncoupling and NO consumption induced by redox react...
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PMID: 20080062
PDF is available here.
PDF is available here.
Abstract
We were interested in its therapeutic efficacy in human lung cancer cells. 4EGI-1, as a single agent, inhibited the growth and induced apoptosis of human lung cancer cells.When combined with the death ligand tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), enhanced apoptosis-induced...
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PMID: 20360945
PDF is available here.
PDF is available here.
Abstract
Contaminants, such as pesticides, can cause direct toxic effects when released into aquatic environments. Suitably sensitive species can help us understand and predict the impacts of such pollutants. Automated sediment toxicity testing and biomonitoring has grown rapidly, and biomonitoring instrumen...
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PMID: 20127481
PDF is available here.
PDF is available here.
Molecular and Cellular Biochemistry (337)1-2 2010
Abstract
We determined the effect of diazoxide on the suppression of post-ischemic myocardial tissue hyperoxygenation in vivo, superoxide (O(2)(-*)) generation in isolated mitochondria, and impairment of the interaction between complex II and complex III in purified mitochondrial proteins. It was observed th...
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PMID: 19851835
PDF is available here.
PDF is available here.
Phosphonylpyrazoles from Bestmann-Ohira reagent and nitroalkenes: synthesis and dynamic NMR studies.
Abstract
Application of diethyl 1-diazo-2-oxopropylphosphonate (Bestmann-Ohira reagent) as a cycloaddition partner with nitroalkenes has been extensively investigated. Base-mediated reaction of the Bestmann-Ohira reagent with various nitroalkenes such as beta-substituted, alpha,beta-disubstituted, and nitroe...
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PMID: 20218559
PDF is available here.
PDF is available here.
Abstract
The hemlock woolly adelgid, Adelges tsugae Annand (Hemiptera: Adelgidae), is an exotic insect species dramatically reducing populations of eastern hemlock, Tsuga canadensis (L.) Carrieré, throughout the eastern United States. Systemic imidacloprid is one of the primary chemicals used to successfull...
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PMID: 20429450
PDF is available here.
PDF is available here.
Mathematical Biosciences (224)2 2010
Abstract
Our proposed semiparametric model can simultaneously handle these problems in a unified framework. The framework accounts for heterogeneity by incorporating random effects and has two components. The parametric component of the model which deals with the linear effects of time invariant covariates a...
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PMID: 20085773
PDF is available here.
PDF is available here.
Abstract
A highly efficient, catalytic, diastereo- and enantioselective conjugate addition of alpha-ketoesters to nitroalkenes has been devised. The reaction was applicable to various substrates. Notably, the combination of endogenous and exogenous bases was effective, allowing a small amount of the catalyst...
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PMID: 20199025
PDF is available here.
PDF is available here.
Abstract
B-biotype Bemisia tabaci (Gennadius) has invaded China over the past two decades. To understand the risks and to determine possible mechanisms of resistance to thiamethoxam in B. tabaci, a resistant strain was selected in the laboratory. Cross-resistance and the biochemical mechanism...
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PMID: 19937914
PDF is available here.
PDF is available here.
Abstract
BNAs function as both formaldehyde and nitrite donors under physiologic conditions to cross-link collagenous tissue. Higher order BNAs are more effective than mono nitroalcohols, raising the possibility of using these agents for therapeutic corneoscleral cross-linking....
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PMID: 19797229
PDF is available here.
PDF is available here.
Abstract
Broadleaf plantain plant (Plantago major L.) was used in phytoremediation of imidacloprid insecticide in water and soils. For the Freundlich model the constant related to the biosorption capacity (Kf) of imidaclaprid were respectively, 7.94, 6.31, and 2.51 ug/g for dry roots, fruits (seeds with shel...
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PMID: 20734615
PDF is available here.
PDF is available here.
Abstract
We will focus on the past and present research of this molecule, to finally bring a perspective on what will be next in this promising field of study....
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PMID: 20335954
PDF is available here.
PDF is available here.
Abstract
We conducted field trials at five different locations over a period of 6 yr to investigate the efficacy of imidacloprid applied each spring as a basal soil drench for protection against emerald ash borer, Agrilus planipennis Fairmaire (Coleoptera: Buprestidae). Canopy thinning and emerald ash borer...
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PMID: 20214376
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)4 2010
Abstract
We demonstrate a role for D-serine in NMDA receptor-mediated neurotoxicity and stroke. Brain cultures of SR-deleted mice display markedly diminished nitric oxide (NO) formation and neurotoxicity. In intact SR knock-out mice, NO formation and nitrosylation of NO targets are substantially reduced. Inf...
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PMID: 20107067
PDF is available here.
PDF is available here.
Abstract
Humans are exposed to pesticides as a consequence of their application in farming or their persistence in a variety of media, including food, water, air, soil, plants, animals, and smoke. The interaction of pesticides with environmental factors may result in the alteration of their physicochemical p...
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PMID: 20062955
PDF is available here.
PDF is available here.
Abstract
Occasional reports linking neonicotinoid insecticide applications to field population outbreaks of the spider mite have been a topic of concern for integrated pest management programs. To elucidate the impacts of a neonicotinoid insecticide on the carmine spider mite, Tetranychus cinnabarinus Boisdu...
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PMID: 20578884
PDF is available here.
PDF is available here.
Abstract
We investigated whether PMZ could protect against the neurotoxic effects induced by 3-nitropropionic acid (3-NP), an inhibitor of the succinate dehydrogenase, used to model Huntington's disease (HD) in rats. Lewis rats receiving chronic subcutaneous infusion of 3-NP were treated with PMZ. The findin...
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PMID: 19852992
PDF is available here.
PDF is available here.
Abstract
Cyclosporine A is a well-known immunosuppressant drug that is currently used for prevention of allograft rejection. The current study was conducted to explore the therapeutic potential of cyclosporine A against 3-nitropropionic acid (3-NP)-induced neurotoxicity, an animal model of Huntington disease...
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PMID: 20448265
PDF is available here.
PDF is available here.
Abstract
Catalytic asymmetric 1,4-addition of beta-keto esters to nitroalkenes is described. 2.5 mol % of a homobimetallic Lewis acid/Brønsted base bifunctional Co2-Schiff base complex smoothly promoted the reaction in excellent yield (up to 99%), diastereoselectivity, and enantioselectivity (up to >30:1 dr...
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PMID: 20110907
PDF is available here.
PDF is available here.
Abstract
The 1-methyl-2-quinolone (MeQone) framework is often found in alkaloids and recently attention was drawn to unnatural MeQone derivatives with the aim of finding new biologically active compounds, however, low reactivity of the MeQone framework prevents the syntheses of versatile derivatives. A nitro...
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PMID: 20714294
PDF is available here.
PDF is available here.
Abstract
We found that low doses of either toxin resulted in significant pathology in the mouse striatum. Signs of apoptosis were observed in both experimental groups, although apoptosis triggered by IOA treatment was independent from caspase-3 activation. Importantly, each toxin appears to produce cellular...
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PMID: 20440403
PDF is available here.
PDF is available here.
Experimental Neurology (221)1 2010
Abstract
We have investigated the electrophysiological effects of ZNS in a rat corticostriatal slice preparation. ZNS affected neither the resting membrane potential nor the input resistance of the putative striatal spiny neurons. In contrast, this drug depressed in a dose-dependent manner the current-evoked...
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PMID: 19913015
PDF is available here.
PDF is available here.
Abstract
The antiamyloidogenic capacity of water-soluble nitroderivatives of fullerene C60: methyl ester of LN-[(2-nitroglyceryl) fullerenyl] proline, methyl ester of LN-[(2,3-dinitroglyceryl) fullerenyl] proline, and 2 nitroxyethyl ether LN-([2-(nitroxy) ethyl] fullerenyl) proline has been studied in vitro...
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PMID: 20586318
PDF is available here.
PDF is available here.
Abstract
Deregulated translation initiation is implicated extensively in cancer initiation and progression. Several translation initiation factors cooperate with known oncogenes, are elevated in human tumors and have been implicated in drug resistance. Consequently, there is a great deal of i...
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PMID: 21425987
PDF is available here.
PDF is available here.
Abstract
The levels of serum gastrin-17 (G-17) and pepsinogen-1 (P-1) were studied in 54 patients with duodenal ulcerative disease (UD) who worked at chemical plants manufacturing nitrogenous compounds and in 15 healthy individuals (a control group). There are objective data on the time course of changes in...
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PMID: 20030266
PDF is available here.
PDF is available here.
Abstract
The in vitro activity of four 2-nitropropene derivatives, 1-(3-benzothienyl)-2-nitropropene (N1), 1-(3-thienyl)-2-nitropropene (N2), 1-(5-bromo-2-thienyl)-2-nitropropene (N3) and 1-(4-bromo-2-thienyl)-2-nitropropene (N4), were tested against cultures of the parasite Trypanosoma cruzi. Cytotoxicity s...
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PMID: 20027464
PDF is available here.
PDF is available here.
Journal of Organic Chemistry (74)19 2009
Abstract
Septet 2,4,6-trinitrenotoluene is the major paramagnetic product formed during the photolysis of 2,4,6-triazidotoluene in cryogenic matrices. This trinitrene displays different electron paramagnetic resonance (EPR) spectra in solid argon and in 2-methyltetrahydrofuran (2MTHF) glass, corresponding to...
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PMID: 19725551
PDF is available here.
PDF is available here.
Abstract
A one-pot reaction of nitroalkenes and enones was developed for the preparation of nitro-vinyl-substituted cyclohexanes, which could be simply converted into poly-N-heterocycles.
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PMID: 20448976
PDF is available here.
PDF is available here.
Organic Letters (11)17 2009
Abstract
An atom-economic organocatalytic asymmetric Michael reaction of alpha,beta,beta-trisubstituted olefins has been successfully developed. The reaction exhibits excellent enantioselectivities under low loading of catalysts, and the conjugate addition products are valuable for the synthe...
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PMID: 19653671
PDF is available here.
PDF is available here.
Abstract
Nitric oxide (NO) generation in the biological cells and tissues is a cause of the production of some nitro and nitroso compounds that differ in their physiological significance and toxicity. The resultant problem in the estimation of the content of all nitro and nitroso compounds totally and singly...
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PMID: 19882863
PDF is available here.
PDF is available here.
Abstract
These results also provided evidence supporting the hypothesis that carvedilol and melatonin can be useful for treating neurodegenerative diseases, such as Huntington's disease....
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PMID: 20119823
PDF is available here.
PDF is available here.
Biochemical Journal (422)2 2009
Abstract
Nitro-fatty acid products of oxidative inflammatory reactions mediate anti-inflammatory cell signalling responses. LNO2 (nitrolinoleic acid) induces expression of HO-1 (haem oxygenase-1), an enzyme that catabolizes haem into products exhibiting potent anti-inflammatory properties. In the present man...
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PMID: 19534727
PDF is available here.
PDF is available here.
Abstract
The pesticides isoproturon, imidacloprid and cyromazine, identified as groundwater pollutants, were incorporated in lignin-based formulations to obtain controlled release (CR) properties. The formulations were prepared by mixing the pesticide with a commercially available pine kraft...
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PMID: 19272698
PDF is available here.
PDF is available here.
Abstract
Huntington's disease (HD) is an inherited progressive neurodegenerative disorder in human characterized by progressive loss of movement and cognitive disturbances. 3-nitropropionic acid (3-NP; a mitochondrial toxin) produces age-dependent oxidative linked striatal damage, responsible for HD like sym...
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PMID: 19957883
PDF is available here.
PDF is available here.
Biochemistry (Washington) (48)34 2009
Abstract
This study examined how the quaternary organic ammonium ion, benzyltriethylamine (BTEA), binds to the Na,K-ATPase to produce membrane potential (V(M))-dependent inhibition and tested the prediction that such a V(M)-dependent inhibitor would display electrogenic binding kinetics. BTEA competitively i...
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PMID: 19621894
PDF is available here.
PDF is available here.
Abstract
We have identified a strong stereoelectronic effect on catalyst structure when a fluorine substituent is placed in the backbone. X-ray structure analysis provides evidence that hyperconjugative effects are responsible for a change in conformation in the azolium precatalyst. This new N-heterocyclic c...
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PMID: 19722669
PDF is available here.
PDF is available here.
Journal of Organic Chemistry (74)15 2009
Abstract
Starting from commercially available natural rosin derivatives, a class of bifunctional rosin-derived amine thiourea catalysts were designed and synthesized. The doubly stereocontrolled asymmetric addition of a variety of 1,3-dicarbonyl compounds to nitroalkenes was investigated. These rosin-derived...
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PMID: 19552379
PDF is available here.
PDF is available here.