Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Nitroso Compounds (5):
Recent article
Nitroso Compounds
Abstract
We tested whether the pure and long acting HNO donor, 1-nitrosocyclohexyl acetate (NCA), affects contractile force in normal and pathological ventricular myocytes (VMs) as well as in isolated hearts. VMs were isolated from mice either subjected to isoprenaline-infusion (ISO; 30 μg/g per day) or to...
|
PMID: 20946877
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
Chiral N-heterocyclic carbenes were found to be efficient catalysts for the formal [2+2] cycloaddition reaction of alkyl(aryl)ketenes and nitroso compounds to give the corresponding 1,2-oxazetidin-3-ones in moderate to good yields with high enantioselectivities. Reductive ring-opening of the oxazeti...
|
PMID: 20820659
PDF is available here.
PDF is available here.
Tumor Biology (31)4 2010
Abstract
We herein gradually adapted four human breast adenocarcinoma cell lines (BT-20, Hs578T, T-47D, and MCF-7) to increasing concentrations of the NO donor DETA-NONOate up to 600 muM. The resulting model system consisted of a set of fully adapted high nitric oxide ("HNO") cell lines that are biologically...
|
PMID: 20480412
PDF is available here.
PDF is available here.
Abstract
We present three crystal structures of NtcA from the cyanobacterium Anabaena: the apoform, and two ligand-bound forms in complex with either 2-OG or its analogue 2,2-difluoropentanedioic acid. All structures assemble as homodimers, with each subunit composed of an N-terminal effector-binding domain...
|
PMID: 20616047
PDF is available here.
PDF is available here.
Abstract
The cell parameters of Ba3[Cr(CN)5NO]2.8H2O were determined from powder X-ray diffraction using the autoindexing program TREOR, and refined by the Le Bail methods with the FULLPROF program. An orthorhombic cell was determined with cell parameters a = 15.0324(2) A, b = 12.9542(9) A, and c = 7.5094(5)...
|
PMID: 20449888
PDF is available here.
PDF is available here.
Abstract
We tested this hypothesis among 545,770 participants in the prospective NIH-AARP Diet and Health Study, which assessed dietary intake at baseline (1995-1996) with a comprehensive food frequency questionnaire, and at ages 12 to 13 years with an abbreviated food frequency questionnaire....
|
PMID: 20570910
PDF is available here.
PDF is available here.
Abstract
We developed a means to study cellular heme insertion into apo-protein targets over a 3-h period and then investigated how nitric oxide (NO) released from a chemical donor (NOC-18) might influence heme (protoporphyrin IX) insertion into seven targets that present a range of protein structures, heme...
|
PMID: 20211245
PDF is available here.
PDF is available here.
Abstract
We disclose a novel aminooxygenation of oxindoles with nitrosobenzene catalyzed by a newly designed quinidine dimer to afford the desired products in good yields with enantioselectivities up to 96%. These reactions allow one to construct a C-O bond at the C(3) position of oxindoles with the creation...
|
PMID: 20356308
PDF is available here.
PDF is available here.
Abstract
Ring opening with organometallic reagents of [2.2.2]-acylnitroso cycloadducts, including an enantioselective kinetic resolution of these compounds, has been accomplished for the first time. By the careful choice of reaction conditions, it was possible to obtain new cyclohexenyl hydroxamic acids with...
|
PMID: 20232855
PDF is available here.
PDF is available here.
Chemical Communications (46)14 2010
Abstract
A novel HOTf-catalyzed three-component one-pot cycloaddition of alpha-diazo ester, nitrosobenzene and electron deficient alkene has been developed. This catalysis is very simple to operate and tolerant to moisture/oxygen to afford the product with high to excellent diastereoselectivity in good to ex...
|
PMID: 20309476
PDF is available here.
PDF is available here.
Pharmacology (85)4 2010
Abstract
I (an active metabolite of erdosteine) containing a pharmacologically active sulphydryl group, by means of electron paramagnetic resonance (EPR) spectroscopy which has not previously been used to characterize the antiradical activity of Met I. The effects of concentrations of 20, 10, 5, 2.5, 1.25 an...
|
PMID: 20215809
PDF is available here.
PDF is available here.
Journal of Physiology and Pharmacology (60 Suppl 7) 2009
Abstract
Inducible nitric oxide synthase (iNOS) and interleukin-8 (IL-8) mediate gastric inflammation. Nitric oxide (NO) produced by iNOS may activate oxidant-sensitive transcription factors. There are the binding sites for NF-kappaB, AP-1, and C/EBP (CCAAT/enhancer binding protein) in the promoter regions o...
|
PMID: 20388952
PDF is available here.
PDF is available here.
Abstract
Two reactive oxygen species (ROS), nitric oxide (NO(.)) and superoxide ((.)O2), contribute to persistent pain. Using three different animal models where ROS mediate pain, this study examined whether NO(.) and (.)O2 converge to peroxynitrite (ONOO(-)) or whether each has an independent signaling path...
|
PMID: 19794317
PDF is available here.
PDF is available here.
Inorganic Chemistry (48)18 2009
Abstract
Transformations of dinitrosyl iron complex (DNIC) [(NO)(2)Fe(SEt)(2)](-) and the anionic Roussin's red ester (RRE) [(NO)(2)Fe(mu-SEt)(2)Fe(NO)(2)](-) into [2Fe-2S] clusters facilitated by HSCPh(3)/Me(2)S(3) and [Fe(SEt)(4)](-), respectively, via an intermediate anionic mixed thiolate-sulfide-bridged...
|
PMID: 19705817
PDF is available here.
PDF is available here.
Abstract
We show the design and synthesis of new perfluorinated nitrosopyrazolone-based ligands and the original method employed for their complexation of erbium ions in the presence of the co-ligand perfluorotriphenylphosphine oxide; the resulting chelate is non-hygroscopic, solution processable and possess...
|
PMID: 20448960
PDF is available here.
PDF is available here.
Abstract
Nitric oxide (NO) generation in the biological cells and tissues is a cause of the production of some nitro and nitroso compounds that differ in their physiological significance and toxicity. The resultant problem in the estimation of the content of all nitro and nitroso compounds totally and singly...
|
PMID: 19882863
PDF is available here.
PDF is available here.
Abstract
Abstract
We assessed the effect of administrating recently developed nitrosothiol compounds acting as nitric oxide (NO) donors on the production of cytokines and other markers of acute inflammatory reaction in an experimental model of warm (I/R), and in a model of cold ischemia and transplant in rats. Warm i...
|
PMID: 19514843
PDF is available here.
PDF is available here.
Abstract
Crude and energy-adjusted N-nitroso compounds intakes were significantly higher in the FFQ than the 7-day food records (P<0.001). Spearman correlations for crude and energy-adjusted N-nitroso intakes ranged from 0.004 to 0.48. By tertiles of N-nitiroso compounds, there was moderate agreement (kappa>...
|
PMID: 19559134
PDF is available here.
PDF is available here.
Abstract
This review is based on the proceedings from the Second Lebow Conference, held in Chicago in 2007. The conference concentrated on developing a framework for innovative studies in the epidemiology of environmental exposures, focusing specifically on the potential relationship with brain tumors. Resear...
|
PMID: 19466671
PDF is available here.
PDF is available here.
Free Radical Research (43)6 2009
Abstract
I dysfunction identical to traumatic spinal cord mitochondrial impairment and that this is mainly due to tyrosine nitration. Consistent with that, the protection of mitochondrial respiratory function by tempol is associated with a decrease in 3-NT levels in mitochondrial proteins also similar to the...
|
PMID: 19513907
PDF is available here.
PDF is available here.
Abstract
We further investigated PDI effects on vascular NADPH oxidase. VSMC transfected with wild-type PDI (wt-PDI) or PDI mutated in all four redox cysteines (mut-PDI) enhanced (2.5-fold) basal cellular ROS production and membrane NADPH oxidase activity, with 3-fold increase in Nox1, but not Nox4 mRNA. How...
|
PMID: 19402212
PDF is available here.
PDF is available here.
Abstract
We sought to determine the relationship between iNOS and WISP-1 in colitis. By analyzing human colonic biopsy samples, we showed that the expression of mRNA for both iNOS and WISP-1 was significantly higher in ulcerative colitis samples compared with control tissue. The upregulation of WISP-1 was po...
|
PMID: 19238344
PDF is available here.
PDF is available here.
Nature Medicine (15)3 2009
Abstract
We have identified a structural and functional defect in the ryanodine receptor (RyR1), a sarcoplasmic reticulum Ca2+ release channel, in the mdx mouse model of muscular dystrophy that contributes to altered Ca2+ homeostasis in dystrophic muscles. RyR1 isolated from mdx skeletal muscle showed an age...
|
PMID: 19198614
PDF is available here.
PDF is available here.
Abstract
Melatonin is easily nitrosated via various mechanisms at the nitrogen atom of the indole ring to give N-nitrosomelatonin (NOMela). This mini-review provides a comprehensive view of this N-nitroso compound. With an improved procedure NOMela can now economically synthesized with low laboratory expendi...
|
PMID: 19141085
PDF is available here.
PDF is available here.
Chemico-Biological Interactions (178)1-3 2009
Abstract
We report that treatment of recombinant human AR (AKR1B1) by a non-thiol-based NO-donor (DEANO) results in activation and S-nitrosylation of the protein. The nitrosylated (ARSNO), but not the reduced (ARSH), protein reacted with reduced glutathione (GSH) and this reaction resulted in the formation o...
|
PMID: 19061876
PDF is available here.
PDF is available here.
Nitric Oxide (20)1 2009
Abstract
Treatment of TRAIL-resistant tumor cells with the nitric oxide donor DETANONOate sensitizes the tumor cells to TRAIL-induced apoptosis concomitantly with DR5 upregulation. The mechanism of sensitization was examined based on the hypothesis that DETANONOate inhibits a transcription repressor Yin Yang...
|
PMID: 18778787
PDF is available here.
PDF is available here.
Journal of Parasitology (95)1 2009
Abstract
We searched the National Cancer Institute (NCI) compound library for structures related to the antitumor quinoline NSC3852 (5-nitroso-8-quinolinol) and used a computer algorithm to predict the antiprotozoan activity for each of 13 structures. Half of these compounds inhibited Toxoplasma gondii tachy...
|
PMID: 18837587
PDF is available here.
PDF is available here.
European Journal of Pharmacology (602)2-3 2009
Abstract
We have previously shown that the nitrosylated flurbiprofen derivative HCT1026 inhibits bone resorption, both in vivo and in vitro, and that its mechanism of action is independent of nitric oxide release and prostaglandin synthesis inhibition. Here we describe the effects of HCT1026 on osteoclast fo...
|
PMID: 19046964
PDF is available here.
PDF is available here.
Abstract
We observed that nitrosonifedipine was converted to radical form by reaction with cultured ECs. The cumene hydroperoxide mediated cytotoxity was reduced by nitrosonifedipine in cultured human glomerular ECs (HGECs). Also nitrosonifedipine suppressed the expression of TNF-alpha-induced intercellular...
|
PMID: 19151535
PDF is available here.
PDF is available here.
Abstract
The appropriate choice of chiral catalyst and starting materials leads to the synthesis of 1,2-oxazetidin-3-ones by cycloadditions of ketenes with nitroso compounds with very good regioselectivity and enantioselectivity. In addition to serving as potentially bioactive target molecules, the products...
|
PMID: 19226588
PDF is available here.
PDF is available here.
Abstract
An overview of the use of 2H-azirines, conjugated nitrosoalkenes and conjugated azoalkenes bearing phosphorus substituents in addition and cycloaddition reactions is presented, focused on strategies for the synthesis of aminophosphonate and aminophosphine oxide derivatives.
|
PMID: 19924050
PDF is available here.
PDF is available here.
Abstract
NO supplementation with S-NO-HSA after LPS administration prevents induction of iNOS, protects against endotoxin-induced acute lung injury, and reduces early mortality in endotoxic rats. The results of the study support a therapeutic role of S-NO-HSA in the treatment of endotoxemia....
|
PMID: 19776691
PDF is available here.
PDF is available here.
Bulletin for the history of chemistry / Division of the History ofChemistry of the American Chemical Society (34)2 2009
Abstract
Abstract
We tested the hypothesis that a nitric oxide donor, DETA-NONOate, up-regulates stromal cell-derived factor-1 (SDF1) and angiopoietin 1 (Ang1) in the ischemic brain and their respective receptors chemokine CXC motif receptor 4 (CXCR4) and Tie2 in the subventricular zone (SVZ) and thereby promote SVZ...
|
PMID: 18711749
PDF is available here.
PDF is available here.
Inorganic Chemistry (47)24 2008
Abstract
One-electron oxidation of phenol, 2,4,6-trimethylphenol, and 2,6-dimethylphenol by [IrCl(6)](2-) in aqueous solution has a simple pH dependence, indicating slow bimolecular oxidation of ArOH and faster oxidation of ArO(-). H/D kinetic isotope effects as large as 3.5 for oxidation of ArOH support con...
|
PMID: 19006385
PDF is available here.
PDF is available here.
Journal of Cell Biology (183)6 2008
Abstract
We uncover a new mechanism through which PSD-95 regulates synaptogenesis. We find that PSD-95 overexpression affected spine morphology but also promoted the formation of multiinnervated spines (MISs) contacted by up to seven presynaptic terminals. The formation of multiple contacts was specifically...
|
PMID: 19075115
PDF is available here.
PDF is available here.
Abstract
We demonstrate the effect of NO donors and soluble guanylyl cyclase (sGC) activators in differentiation of ES cells into myocardial cells. Our results with mouse and human ES cells demonstrate an increase in Nkx2.5 and myosin light chain (MLC2) mRNA expression on exposure of cells to NO donors and a...
|
PMID: 19020077
PDF is available here.
PDF is available here.
Abstract
Our data suggest significant levels of oxidative DNA damage occur in OA chondrocytes that accumulates with OA progression. Additionally, DNA damage induced by NO and ONOO(-) in non-OA chondrocytes does not undergo full endogenous repair....
|
PMID: 18720406
PDF is available here.
PDF is available here.
Inorganic Chemistry (47)22 2008
Abstract
An electron-rich nickel(I) beta-diketiminate cleaves the E-NO bond of O-, S-, and N-organonitroso species to give the nickel nitrosyl [Me 3NN]NiNO along with dimeric nickel(II) alkoxide or thiolate complexes {[Me 3NN]Ni} 2(mu-E) 2 or the mononuclear nickel(II) amide [Me 3NN]NiNPh 2. This diamagnetic...
|
PMID: 18928271
PDF is available here.
PDF is available here.
Abstract
We synthesized hetero-Diels-Alder cycloadducts from acyl nitroso derivatives and 9,10-dimethylanthracene, to be photo-inducible HNO-releasing agents and found that introduction of conjugated nitroaromatic groups effectively enhanced the responsiveness of HNO release to UV-A irradiation; we confirmed...
|
PMID: 18956051
PDF is available here.
PDF is available here.
European Journal of Pharmacology (596)1-3 2008
Abstract
We tested the relationship between CGRP and ADMA in spontaneously hypertensive rats (SHRs). For the in vivo study, SHRs were treated with or without L-arginine for 2 weeks, and Wistar Kyoto (WKY) rats were used as controls. Systolic arterial pressure was measured, and the levels of CGRP, ADMA, and N...
|
PMID: 18782573
PDF is available here.
PDF is available here.
Abstract
Photodynamic efficacy of chlorin p6, a potential candidate of photodynamic therapy (PDT), has been studied at pH 5.0, 6.0 and 7.6 in aqueous and lipid environment. Increased chlorin p6 mediated photodynamic bleaching of N,N-dimethyl-4-nitrosoaniline (RNO), a measure of singlet oxygen yield, was obta...
|
PMID: 18682329
PDF is available here.
PDF is available here.
Abstract
A cleaner and simple spectrophotometric method using microflow analysis (muFA) was performed. It consisted of a T-junction with microcoil on a polymethyl methacrylate (PMMA) chip which was fabricated by laser ablation and a molded polydimethylsiloxane (PDMS) as top plate. The fabricated PMMA chip wa...
|
PMID: 18065259
PDF is available here.
PDF is available here.
Psychopharmacology (200)2 2008
Abstract
Our findings suggest that exogenous NO benefits chronic stress-induced depression by stimulating hippocampal neurogenesis and may represent a novel approach for the treatment of depressive disorders....
|
PMID: 18512047
PDF is available here.
PDF is available here.
Neuroscience (156)1 2008
Abstract
We tested the hypothesis that combination treatment upregulates angiopoietin-1 and its receptor Tie2 in the ischemic brain and bone marrow stromal cells, thereby enhancing cerebral neovascularization after stroke. Adult wild type male C57BL/6 mice were i.v. administered PBS, bone marrow stromal cell...
|
PMID: 18691637
PDF is available here.
PDF is available here.
Abstract
We report a novel, transition-metal-free oxidative C-C bond cleavage process for a broad range of ester and dicarbonyl compounds involving carbanion addition to nitrosobenzene. ReactIR experiments on the nitrosobenzene-mediated oxidative decarboxylation of esters indicate the reaction proceeds via f...
|
PMID: 18722431
PDF is available here.
PDF is available here.
Cancer Research (68)18 2008
Abstract
We report novel independent mechanisms governing Cdc25A in response to nitrosative insult. We observed direct and rapid inhibition of Cdc25A phosphatase activity after in vitro treatment with the low molecular mass cell-permeable S-nitrosothiol S-nitrosocysteine ethyl ester (SNCEE). In addition, tre...
|
PMID: 18794133
PDF is available here.
PDF is available here.
Circulation Research (103)6 2008
Abstract
The Journal of Chemical Physics (129)10 2008
Abstract
Heterodyne-detected electronic sum frequency generation (HD-ESFG) spectroscopy is newly developed to obtain complex electronic chi(2) spectra of interfaces for a simultaneous detection bandwidth broader than 100 nm. HD-ESFG provides linear chi(2) spectra that have unambiguous information on the "up"...
|
PMID: 19044899
PDF is available here.
PDF is available here.
Abstract
These results indicate that this new approach has the potential for improving carcinogenicity predictions based on the identification of structural alerts....
|
PMID: 18533217
PDF is available here.
PDF is available here.
Abstract
We describe a strategy for direct identification of protein S-nitrosylation sites in an electrospray ionization (ESI) quadrupole time-of-flight (QTOF) mass spectrometer without prior chemical derivatization of S-nitrosylated peptides. Both sample buffer composition and MS hardware parameters were ca...
|
PMID: 18635375
PDF is available here.
PDF is available here.
European Journal of Pharmacology (591)1-3 2008
Abstract
This study was designed to investigate the role of nitric oxide (NO) in bone marrow stem cells and their differentiation into endothelial cells in vitro. Adult mouse bone marrow multipotent progenitor cells (MAPCs) were used as the source of stem cells. Oct-4 expression (both mRNA and protein) was s...
|
PMID: 18616941
PDF is available here.
PDF is available here.
Abstract
We report a water-soluble and structurally well-characterized RRE [Fe(mu-SC2H4COOH)(NO)2]2 (DNIC-1) and a {Fe(NO)2}(10) DNIC [(PPh2(Ph-3-SO3Na))2Fe(NO)2] (DNIC-2), their NO-induced protein regulation, and their cellular uptake mechanism using immortalized vascular endothelial cells as a model. Compa...
|
PMID: 18661983
PDF is available here.
PDF is available here.
Molecular Cell (31)3 2008
Abstract
We show in cells and mice that beta-arrestin 2, a central element in GPCR trafficking, interacts with and is S-nitrosylated at a single cysteine by endothelial NO synthase (eNOS), and that S-nitrosylation of beta-arrestin 2 is promoted by endogenous S-nitrosogluthathione. S-nitrosylation after agoni...
|
PMID: 18691971
PDF is available here.
PDF is available here.
Inorganic Chemistry (47)15 2008
Abstract
The reaction of K 2[PtCl 4] and HO(H)NCMe 2CMe 2N(H)OH.H 2SO 4 ( BHA.H 2SO 4; 2) in a molar ratio 1:2 at 20-25 degrees C in water affords a mixture of [Pt(BHA) 2][PtCl 4] ( 5) and [Pt(BHA-H) 2] ( 6) ( BHA- H = anionic monodeprotonated form of BHA) which, upon heating at 80-85 degrees C for 12 h or o...
|
PMID: 18582029
PDF is available here.
PDF is available here.
Abstract
We developed a novel, simple, and specific detection method using an RP-HPLC at UV 285 nm for the separation and quantification of N-nitroso-bile acids. First, we found that N-nitroso-bile acids have a specific spectrophotometric absorbance at 285 nm. Using this 285 nm detection system, we could esp...
|
PMID: 18666179
PDF is available here.
PDF is available here.
Abstract
Rat liver microsomes attached to nanoparticles were used for LC-MS studies of CYP3A and 2E1 enzymes in metabolism of N-nitroso compounds. Using these biocolloids, turnover rates were measured within 2 min. Inhibitor IC(50) values for ketoconazole (KET) and 4-methylpyrazole (4-MEP) were estimated.
|
PMID: 19356087
PDF is available here.
PDF is available here.
Abstract
Protein S-nitrosylation in the heart tissue has been implicated in several patho (physiological) processes. However, specific protein targets for S-nitrosylation remain largely unknown. In this study, the rat cardiac proteins were incubated in vitro with S-nitrosoglutathione (GSNO), a biologically e...
|
PMID: 18670085
PDF is available here.
PDF is available here.
Abstract
We have overexpressed and purified the recombinant His-tagged SoxR protein. Upon treatment of the purified protein under anaerobic conditions with (1) NO solution, (2) S-nitrosothiol (RSNO), and (3) chemically synthesized low molecular weight DNICs (LMW-DNICs), we have observed enhancement of the EP...
|
PMID: 18449575
PDF is available here.
PDF is available here.