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Urea (10):
Recent article
Urea
Abstract
Aryl phenyl ureas with a 4-quinazolinoxy substituent at the meta-position of the phenyl ring are potent inhibitors of mutant and wild type BRAF kinase. Compound 7 (1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea hydrochloride) exhibits good pharmacokin...
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PMID: 21807507
PDF is available here.
PDF is available here.
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Abstract
Aryl phenyl ureas with a 4-quinazolinoxy substituent at the meta-position of the phenyl ring are potent inhibitors of mutant and wild type BRAF kinase. Compound 7 (1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea hydrochloride) exhibits good pharmacokin...
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PMID: 21807507
PDF is available here.
PDF is available here.
Abstract
These results revealed significant histological as well as ultrastructral lesions in the OTA treated group. The lesions included global congestion in the renal tissue and loss of demarcation between the cortex and medulla. The normal architecture of the renal corpuscles was destroyed and most of the...
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PMID: 21432769
PDF is available here.
PDF is available here.
Abstract
Organic Letters (13)6 2011
Abstract
The first class of bifunctional cinchona-alkaloid catalysts incorporating a urea moiety at C-5' has been developed. These materials catalyze the efficient and highly enantioselective 1,2-addition of nitromethane to trifluoromethylketones to form synthetically pliable products incorpo...
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PMID: 21338077
PDF is available here.
PDF is available here.
Liver Transplantation (17)2 2011
Abstract
Abstract
Over the last 40 years the technical obstacles which prevented a convective contribution to diffusive dialysis have been overcome. Hemodiafiltration represents a natural evolution of intermittent extracorporeal blood purification and the technology is now available to offer this as standard treatmen...
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PMID: 20938126
PDF is available here.
PDF is available here.
Abstract
We provide NMR and crystallographic evidence that the PucG protein from Bacillus subtilis catalyzes the transamination between an unstable intermediate ((S)-ureidoglycine) and the end product of purine catabolism (glyoxylate) to yield oxalurate and glycine. This activity enables soil and gut bacteri...
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PMID: 20852637
PDF is available here.
PDF is available here.
Abstract
We extend such work to flexible, multidomain proteins and one of the most widespread membrane transporter families, the major facilitator superfamily, thus showing that more complex membrane proteins can be successfully refolded to recover native substrate binding. We determine the unfolding free en...
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PMID: 20937906
PDF is available here.
PDF is available here.
Abstract
We have recently reported the discovery of pyrrolo[3,2-d]pyrimidine derivatives 1a and 1b as potent triple inhibitors of vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), and Tie-2 kinases. To identify compounds having strong inhibitory activity ag...
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PMID: 20833551
PDF is available here.
PDF is available here.
Abstract
We describe the in vitro and in vivo effects of AT9283 (1-cyclopropyl-3[5-morpholin-4yl methyl-1H-benzomidazol-2-yl]-urea), a potent inhibitor of several protein kinases, including Aurora A, Aurora B, Janus kinase 2 (JAK2), JAK3, and ABL on diverse imatinib-resistant BCR-ABL(+) cells. AT9283 showed...
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PMID: 20548094
PDF is available here.
PDF is available here.
Abstract
Solution conditions greatly affect the aggregation rate of a protein. Elucidating these influences provides insight into the critical factors governing aggregation. In this study, recombinant human botulinum protein antigen serotype C [rBoNTC (H(c))] was employed as a model protein. rBoNTC (H(c)) agg...
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PMID: 20862672
PDF is available here.
PDF is available here.
Kidney International (78)10 2010
Abstract
Chemmedchem (5)9 2010
Abstract
We investigated the binding site of ACT058362 and SB706375 in both hUT2R and rUT2R to explain the dramatically lower (approximately 400-fold) affinity of ACT058362 for rUT2R and the similar affinity (approximately 10 nM) of SB706375 for both UT2Rs. These studies used MembStruk and MSCDock to predict...
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PMID: 20683923
PDF is available here.
PDF is available here.
Abstract
To investigate the sequence dependence in the molecular mechanism of urea induced denaturation, molecular dynamics denaturing simulations of two beta-hairpin peptides, a fast folding peptide 1 (SESYINPDGTWTVTE) and a slow folding TRPZIP4 (GEWTWDDATKTWTWTE), were performed in urea aqueous solutions....
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PMID: 20571679
PDF is available here.
PDF is available here.
Abstract
We therefore conclude that urea interacts favorably with the whole protein surface and that all parts of the protein are important in urea-induced denaturation....
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PMID: 20563326
PDF is available here.
PDF is available here.
Abstract
We propose explanations for the specific observed differences based on differential insulin insufficiency/resistance and mitochondrial dysfunction in T1DM versus T2DM.
© 2010 Diabetes Technology Society....
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PMID: 20920426
PDF is available here.
PDF is available here.
Abstract
Enamel surface microhardness significantly decreased after bleaching with nonenhanced 10% CP (WHI). The chemical analyses suggest F uptake promoted by high-concentrate F bleaching gels (CPF, OPA, and PN) and a F loss with nonenhanced 10% CP bleaching gels (PLA, WHI). CP agent enhanced with Ca (CPCa)...
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PMID: 20657849
PDF is available here.
PDF is available here.
Abstract
Chronic kidney disease is one of the most common disorders in dogs and cats. The plasma urea nitrogen (P-UN) and creatinine (P-Cre) concentrations are not sufficiently sensitive for early diagnosis of renal dysfunction. Although urine and plasma clearance methods allow earlier detection of reduction...
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PMID: 20410678
PDF is available here.
PDF is available here.
Journal of Dairy Science (93)9 2010
Abstract
The effect of the method of conservation of forage on endogenous N (EN) secretion was studied using a 15N isotope dilution technique in 4 lactating Holstein cows selected from a replicated 3x3 Latin square. Cows were equipped with ruminal, duodenal (n=4), and ileal (n=2) cannulas. Diets comprised 44...
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PMID: 20723698
PDF is available here.
PDF is available here.
Journal of Dairy Science (93)9 2010
Abstract
Our results revealed changes in intestinal growth after soy protein feeding that were associated with effects on intestinal RNA and protein synthesis but that were not ameliorated by AA supplementation.
Copyright (c) 2010 American Dairy Science Association. Published by Elsevier Inc. All rights rese...
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PMID: 20723691
PDF is available here.
PDF is available here.
Journal of Dairy Science (93)9 2010
Abstract
Feed management is one of the principal levers by which the production and composition of milk by dairy cows can be modulated in the short term. The response of milk yield and milk composition to variations in either energy or protein supplies is well known. However, in practice, dietary supplies of...
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PMID: 20723688
PDF is available here.
PDF is available here.
Abstract
We interrogated the folding landscape of a model beta-rich protein, cellular retinoic acid-binding protein I (CRABP I), in the presence of an inert crowding agent (Ficoll 70). Urea titrations revealed a crowding-induced change in the water-accessible polar amide surface of its denatured state, based...
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PMID: 20662522
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of different polyol compounds, e.g. glycerol, mannitol and PEG-6000 on the in vitro stability of purified hPAH produced in a heterologous prokaryotic expression system. The recombinant human enzyme was stored in the presence of the studied stabilizing agents at different t...
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PMID: 19937396
PDF is available here.
PDF is available here.
Journal of Neurosurgery (113)2 2010
Abstract
A very rare case of continuous hypertension and tachycardia after excision of a cerebellar hemangioblastoma at the dorsal medulla oblongata is presented. This 21-year-old man was admitted to the authors' hospital with a headache and dizziness. Radiological examination revealed a tumor located behind...
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PMID: 19911894
PDF is available here.
PDF is available here.
Abstract
Nightguard vital bleaching (NGVB) has been applied as a safe and effective bleaching procedure with a wide variety of commercial products consisting of carbamide peroxide-based gels, but there have been few reports on tooth bleaching for tetracycline-stained teeth. The purpose of this study was to e...
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PMID: 20652791
PDF is available here.
PDF is available here.
Nature Chemistry (2)7 2010
Abstract
We now report the first synthesis and crystallographic characterization of dioxasiliranes stabilized by N-heterocyclic carbenes that feature a three-membered SiO(2)-peroxide ring, isolable at room temperature. Unexpectedly, these can undergo internal oxygen transfer in toluene solution at ambient te...
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PMID: 20571577
PDF is available here.
PDF is available here.
Diabetes Care (33)7 2010
Abstract
We developed a 24-h euglycemic clamp in patients who received an average of 2,200 calories in a standardized three-meal and two-snack regimen per day, adjusted to body size and sex. Intravenous insulin was adjusted every 30 min to achieve 5.5 +/- 1.1 mmol/l glycemia over 24 h prehemodialysis, during...
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PMID: 20215452
PDF is available here.
PDF is available here.
Abstract
We investigated whether and by which mechanisms free heme [Fe(III)-protoporphyrin IX (FP)] might contribute to the dysregulation of L-arginine (L-Arg) metabolism and bioavailability. Carrier systems "y+" [or cationic amino acid transporter (CAT)] and "y+L" transport L-Arg into red blood cells (RBC),...
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PMID: 20357184
PDF is available here.
PDF is available here.
Abstract
Pathways and densities of descending vasa recta (DVR) and ascending vasa recta (AVR) in the outer zone of the inner medulla (IM) were evaluated to better understand medullary countercurrent exchange. Nearly all urea transporter B (UT-B)-positive DVR, those vessels exhibiting a continuous endothelium...
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PMID: 20392798
PDF is available here.
PDF is available here.
Abstract
The outer zone of the renal inner medulla (IM) is spatially partitioned into two distinct interstitial compartments in the transverse dimension. In one compartment (the intercluster region), collecting ducts (CDs) are absent and vascular bundles are present. Ascending vasa recta (AVR) that lie withi...
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PMID: 20392799
PDF is available here.
PDF is available here.
Abstract
Blood passing the renal medulla enters a strongly hypertonic environment challenging functional properties and survival of blood cells. In erythrocytes, exposure to hyperosmotic shock stimulates Ca(2+) entry and ceramide formation with subsequent cell membrane scrambling, an effect p...
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PMID: 20237147
PDF is available here.
PDF is available here.
Environmental Research (110)5 2010
Abstract
Arsenic (As) is one of the most abundant hazards in the environment and it is a human carcinogen. Related to excretory functions, the kidneys in humans, animal models or naturally exposed fauna, are target organs for As accumulation and deleterious effects. Previous studies carried out using X-ray f...
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PMID: 20170908
PDF is available here.
PDF is available here.
Environmental Research (110)5 2010
Abstract
We investigated here if the dose-related accumulation of arsenic in the liver was related to the expression of aquaglyceroporin 9 (AQP9) in the same organ. CD1 male mice were treated with different concentrations (0, 2.5, 5 or 10mg/kg/day) of sodium arsenite during 1, 3 or 9 days. A significant dose...
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PMID: 19733843
PDF is available here.
PDF is available here.
Abstract
We studied its activity in a number of Jak2-dependent systems. AT9283 potently inhibited proliferation and Jak2-related signalling in Jak2-dependent cell lines as well as inhibiting the formation of erythroid colonies from haematopoietic progenitors isolated from MPD patients with Jak2 mutations. Th...
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PMID: 20507304
PDF is available here.
PDF is available here.
Medicine (Baltimore) (89)4 2010
Abstract
We prospectively compared the predictive value of renal function and serum urea on clinical outcome in patients with HF. Patients hospitalized with definite clinical diagnosis of HF (n = 355) were followed for short-term (1 yr) and long-term (mean, 6.5 yr) survival and HF rehospitalization. Increasi...
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PMID: 20616658
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1804)7 2010
Abstract
The stability of bovine lactoperoxidase to denaturation by guanidinium-HCl, urea, or high temperature was examined by differential scanning calorimetry (DSC) and tryptophan fluorescence. The calorimetric scans were observed to be dependent on the heating scan rate, indicating that lactoperoxidase st...
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PMID: 20298816
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1804)7 2010
Abstract
We now demonstrate that the FlgM protein from the thermophile Aquifex aeolicus exhibits a more ordered conformation at 20 degrees C than the previously characterized FlgM protein from Salmonella typhimurium. FlgM is an inhibitor of the RNA transcription factor sigma28, which is involved in regulatio...
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PMID: 20298817
PDF is available here.
PDF is available here.
Abstract
We show that the GSK-3 inhibitor AR-A014418 regulated alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)-induced GluR1 and GluR2 internalization via phosphorylation of kinesin light chain 2 (KLC2), the key molecule of the kinesin cargo delivery system. Specifically, AMPA stimulation trigg...
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PMID: 20534517
PDF is available here.
PDF is available here.
Cancer Research (70)12 2010
Abstract
We have combined a Chk1/2-targeted agent, AZD7762, currently in phase I clinical trials, with gemcitabine and ionizing radiation in preclinical pancreatic tumor models. We found that in vitro AZD7762 alone or in combination with gemcitabine significantly sensitized MiaPaCa-2 cells to radiation. AZD7...
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PMID: 20501833
PDF is available here.
PDF is available here.
Abstract
We found that the AOA population size increased significantly and AOA community changed greatly in the urea only treatment. However, HA could inhibit the increase of AOA population, moreover, HA could buffer the change in AOA community showed by canonical correspondence analysis (CCA) result. On the...
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PMID: 20687344
PDF is available here.
PDF is available here.
Plant, Cell & Environment (33)11 2010
Abstract
We used a molecular approach to characterize ureide accumulation under drought stress in Phaseolus vulgaris. Accumulation of ureides, mainly allantoate, was found in roots, shoots and leaves, but only a limited transient increase was observed in nodules from drought-stressed plants. We show that ure...
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PMID: 20545885
PDF is available here.
PDF is available here.
Animal Science Journal (81)3 2010
Abstract
The effects of adding beet pulp or wheat bran to urea-treated potato pulp (PP) in order to reduce moisture of PP silage and flake density of corn grain on digestibility and ruminal fermentation in beef steers were studied in a split-plot design experiment. The whole-plot treatments were PP silage mi...
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PMID: 20597888
PDF is available here.
PDF is available here.
Atrial natriuretic peptide enhances recovery from ischemia/reperfusion-induced renal injury in rats.
Abstract
We therefore examined whether human ANP enhances recovery from I/R-induced renal injury by reducing damage to EGF-producing kidney cells in a rat model. Male Wistar rats weighing 200-240 g were observed for 48 h after reperfusion following 45-min renal ischemia. Rats were intravenously administered...
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PMID: 20471588
PDF is available here.
PDF is available here.
The Journal of Pain (11)6 2010
Abstract
These results suggest for the first time that hypocretin receptors in rat PnO modulate nociception. PERSPECTIVE: Widely distributed and overlapping neural networks regulate states of sleep and pain. Specifying the brain regions and neurotransmitters through which pain and sleep interact is an essent...
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PMID: 20015707
PDF is available here.
PDF is available here.
Abstract
G5 exhibited the greatest penetration, while G2 and G3 produced the lowest values. All bleaching agents penetrated from the pulp chamber to the external root surface. There was a direct correlation between the presence of oxidative agents and penetration potential. Sodium perborate in distilled wate...
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PMID: 20718216
PDF is available here.
PDF is available here.
Biotechnology Letters (32)6 2010
Abstract
We developed a cryopreservation method using an organotypical sandwich model in a flat membrane bioreactor (FMB). We measured albumin secretion rate, urea synthesis rate and 7-ethoxy coumarin (ECOD) in long-term cultures of cryopreserved cells (up to 14 days). The albumin secretion rate was 62% that...
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PMID: 20213529
PDF is available here.
PDF is available here.
Abstract
I (cTnI) was performed using an immunochromatographic test. The concentrations of cortisol and insulin were determined using commercial radioimmunoassay kits. Increases in serum cortisol levels in experimental group animals coincided with hyperglycaemia and was probably a response to pain. Increased...
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PMID: 20060404
PDF is available here.
PDF is available here.
Abstract
Two series of novel diaryl ureas have been designed and synthesized, with their in vitro antitumor effect screened on human non-small cell lung cancer (NSCLC) cell line A549 and human breast cancer cell line MDA-MB-231. Some target compounds demonstrated significant inhibitory activities against bot...
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PMID: 20181414
PDF is available here.
PDF is available here.
Abstract
We found a significant decrease for malondialdehyde and higher values of glutathione peroxidase measurements in the plasma and BAL during propofol anaesthesia. Significantly higher levels of malondialdehyde and lower concentrations of glutathione peroxidase in plasma and BAL were found during sevofl...
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PMID: 20442581
PDF is available here.
PDF is available here.
Lab On a Chip (10)10 2010
Abstract
We developed microfluidic-based pure chitosan microfibers (approximately 1 meter long, 70-150 microm diameter) for liver tissue engineering applications. Despite the potential of the chitosan for creating bio-artificial liver chips, its major limitation is the inability to fabricate pure chitosan-ba...
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PMID: 20445889
PDF is available here.
PDF is available here.
Abstract
We wanted to develop inhibitors of key proteins that form the invasion machinery of the malarial parasite. A critical feature of host-cell invasion by apicomplexan parasites is the interaction between the carboxy terminal tail of myosin A (MyoA) and the myosin tail interacting protein (MTIP). Using...
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PMID: 20426475
PDF is available here.
PDF is available here.
Abstract
Organolithiums add in an umpolung fashion to the beta-carbon of N-carbamoyl enamines (N-vinyl ureas). The reaction proceeds with syn diastereospecificity and provides urea-stabilized, configurationally defined organolithiums. Facilitated by coordinating solvents (THF or DMPU), these undergo intramol...
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PMID: 20411935
PDF is available here.
PDF is available here.
Abstract
We provide the first report that hind-limb dysfunction and extensive axonal damage can occur in mice 3weeks after acute dosing with a toxic compound, bromophenylacetylurea. Three weeks after acutely dosing mice with neuropathic OPs no clinical signs were observed, but distal lesions were present in...
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PMID: 20188121
PDF is available here.
PDF is available here.
The Journal of Chemical Physics (132)17 2010
Abstract
We developed a multiscale approach (MultiSCAAL) that integrates the potential of mean force obtained from all-atomistic molecular dynamics simulations with a knowledge-based energy function for coarse-grained molecular simulations in better exploring the energy landscape of a small protein under che...
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PMID: 20459186
PDF is available here.
PDF is available here.
Abstract
Diagnosis of HBoV primary infection can be strengthened by measurement of IgG avidity. HBoV secondary infections or anamnestic antibody responses occur ubiquitously in immunocompetent adults.
Copyright 2010 Elsevier B.V. All rights reserved....
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PMID: 20227338
PDF is available here.
PDF is available here.
Journal of Physical Chemistry B (114)16 2010
Abstract
Atomistic dynamics simulations of purely hydrophobic carbon nanotubes in 8 M urea are performed to dissect the role of dispersion interactions in the denaturing power of urea. The enhanced population of urea and a paucity of water in proximity of nanotubes suggest that the stronger dispersion intera...
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PMID: 20361766
PDF is available here.
PDF is available here.
Abstract
I served as control which received standard diet; group II received orally only K(2)Cr(2)O(7) (700 ppm equivalent to 67 mg/kgbw); group III received both K(2)Cr(2)O(7) and Se (0.5 mg/kg of diet); group IV received Se (0.5mg Na(2)SeO(3)/kg of diet). The exposure of rats to K(2)Cr(2)O(7) for 21 days p...
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PMID: 19913299
PDF is available here.
PDF is available here.
Biomaterials (31)13 2010
Abstract
We report a technique to induce hepatocyte aggregate formation using type-I collagen-coated poly(L-lactic acid) (PLLA) discrete aligned nanofibers (disAFs) by providing limited cell-substrate adhesion strength and restricting cell migration to uniaxial movement. Kinetics of aggregate formation, morp...
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PMID: 20149442
PDF is available here.
PDF is available here.
Biotechnology Letters (32)5 2010
Abstract
Mesenchymal stem cells (MSCs) are candidates for cell therapy of kidney diseases. However, the application of MSC derived from human umbilical cord (UC-MSC) in treating acute renal failure (ARF) has not been reported. UC-MSCs, 10(6), were transplantated via the left carotid artery into ARF rats whic...
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PMID: 20131083
PDF is available here.
PDF is available here.