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Aged, 80 and over (0):
Recent article
Aged, 80 and over
Abstract
Dementia is associated with increased rates and often poorer outcomes of hospitalization, including worsening cognitive status. New evidence is needed to determine whether some admissions of persons with dementia might be potentially preventable.
To determine whether...
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PMID: 22235087
PDF is available here.
PDF is available here.
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Abstract
Clinical practice guidelines recommend maintaining serum potassium levels between 4.0 and 5.0 mEq/L in patients with acute myocardial infarction (AMI). These guidelines are based on small studies that associated low potassium levels with ventricular arrhythmias in the pre-β-blocker...
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PMID: 22235086
PDF is available here.
PDF is available here.
Abstract
We present the first analysis of age-at-onset in the NIMH LOAD sample that allows for both a multilocus trait model and genetic heterogeneity among the contributing sites, while at the same time accommodating age censoring, effects of known genetic covariates, and full pedigree and marker informatio...
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PMID: 21812099
PDF is available here.
PDF is available here.
Abstract
Although extensive evidence support the key role of adipokines in cartilage homeostasis, contradictory data have been found for their expression and their effects in chondrocytes. This study was then undertaken to determine whether a phenotypic modulation may affect the expression of adipokines and t...
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PMID: 21935928
PDF is available here.
PDF is available here.
Abstract
Comparison of surgical results on obese patients undergoing hysterectomy by robot-assisted laparoscopy or laparotomy.
University hospital.
All women (n=114) with a BMI ≥30 kg/m(2) who underwent a simple hysterectomy as the main surgical procedure bet...
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PMID: 21854364
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to examine the factorial validity of the Job Expectations Questionnaire (Cuestionario de Expectativas Laborales CEL) in a sample of Mexican workers. Following a cross validation approach, two samples were used in the study. The first sample consisted of 380...
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PMID: 22059344
PDF is available here.
PDF is available here.
Abstract
We find that the infant human subventricular zone and RMS contain an extensive corridor of migrating immature neurons before 18 months of age but, contrary to previous reports, this germinal activity subsides in older children and is nearly extinct by adulthood. Surprisingly, during this limited win...
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PMID: 21964341
PDF is available here.
PDF is available here.
Abstract
We have modified the original apparatus for organ bioassay in order to minimize foaming and to increase analytical performance. By using this modified bioassay we investigated the vasodilatory potency of various endogenous RSNOs in the presence of physiologically relevant concentrations of albumin a...
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PMID: 21827780
PDF is available here.
PDF is available here.
Abstract
Attempts to determine the clinical significance of BRCA1/2 mutations in ovarian cancer have produced conflicting results.
To determine the relationships between BRCA1/2 deficiency (ie, mutation and promoter hypermethylation) and overall survival (OS), progression-free...
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PMID: 21990299
PDF is available here.
PDF is available here.
MMW Fortschritte der Medizin (153)41 2011
Abstract
MMW Fortschritte der Medizin (153)41 2011
Abstract
Abstract
We analyzed self-reported computer use, demographic variables, psychosocial variables, and health and well-being variables collected from 460 ethnically diverse, community-dwelling elders to investigate the relationship computer use has with demographics, well-being, and other key psychosocial varia...
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PMID: 22046718
PDF is available here.
PDF is available here.
Abstract
We examined the growth of tissue proven renal oncocytoma on serial imaging to improve our understanding of its natural history.
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PMID: 21849182
PDF is available here.
PDF is available here.
Abstract
A novel platform was developed that fuses pre-biopsy magnetic resonance imaging with real-time transrectal ultrasound imaging to identify and biopsy lesions suspicious for prostate cancer. The cancer detection rates for the first 101 patients are reported.
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PMID: 21849184
PDF is available here.
PDF is available here.
Abstract
We compared the rates of postoperative complications and failure to rescue (the fatality rate in patients with a complication) in patients treated with laparoscopic vs open radical nephrectomy....
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PMID: 21849185
PDF is available here.
PDF is available here.
Abstract
We investigated whether the exercise response varied by the prior duration of exposure to androgen suppression therapy, that is acute-less than 6 months vs later-6 months or greater....
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PMID: 21849187
PDF is available here.
PDF is available here.
Abstract
We investigated whether serum amino acid profiles are a potentially useful biomarker in patients with renal cell carcinoma....
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PMID: 21849193
PDF is available here.
PDF is available here.
Abstract
From the perspective of oncological and functional outcomes partial nephrectomy is considered standard surgery for small renal tumors 4 cm or less. However, radical nephrectomy is commonly done for small tumors. It is important to predict postoperative renal function in patients to choose the most op...
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PMID: 21849191
PDF is available here.
PDF is available here.
Abstract
Polidocanol sclerotherapy for hydrocele or spermatocele combines high efficiency with low morbidity, but the optimal dose is not known. We compared the efficacy and morbidity of 2 or 4 ml polidocanol sclerotherapy for hydrocele or spermatocele.
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PMID: 21849198
PDF is available here.
PDF is available here.
Abstract
Although there are several reports concerning gemcitabine-induced interstitial lung disease (ILD), the risk factors for ILD are not well known. In addition, data comparing the incidence and pattern of ILD associated with gemcitabine treatment in patients with non-small-cell lung cancer (NSCLC) versus...
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PMID: 21818557
PDF is available here.
PDF is available here.
Abstract
The incidence and mortality of gastric and colorectal cancers are among the highest malignant tumors in China. The aim of this study is to investigate whether variations of the human oxoguanine glycosylase 1 (hOGG1) gene are related to the risk of gastric and colorectal cancers in the Chinese populat...
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PMID: 21822670
PDF is available here.
PDF is available here.
Abstract
There is no standard second-line treatment for patients with unresectable advanced or recurrent gastric cancer (URGC) in the event that first-line treatment fails. Moreover, the benefits of second-line chemotherapy in elderly patients remain uncertain. The aim of this study was to identify the benefi...
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PMID: 21830159
PDF is available here.
PDF is available here.
Abstract
To evaluate the efficacy and toxicity of CHG regimen (low-dose cytarabine, homoharringtonine with G-CSF priming) as an induction chemotherapy for elderly patients with high-risk MDS or acute myeloid leukemia transformed from MDS (MDS-AML).
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PMID: 21845438
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to examine the role of Ki-67, a cellular proliferation marker, in the prognosis of goblet cell appendiceal carcinoid tumor.
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PMID: 21824598
PDF is available here.
PDF is available here.
Abstract
The outcomes after repeat pulmonary resection for colorectal cancer (CRC) and the factors associated with the prognosis of these patients remain uncharacterized.
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PMID: 21824604
PDF is available here.
PDF is available here.
Abstract
We have analyzed the Society for Cardiothoracic Surgery in Great Britain and Ireland audit database to look at changes in practice over time....
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PMID: 21924147
PDF is available here.
PDF is available here.
Abstract
The members of the claudin family are major integral transmembrane protein constituents of tight junctions. Normal and neoplastic tissues can be characterized by unique qualitative and quantitative distribution of claudin subtypes, which may be related to clinicopathological features. Differential di...
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PMID: 21832144
PDF is available here.
PDF is available here.
Abstract
: To estimate the association of age, medical comorbidities, functional status, and unintentional weight loss (as a marker of frailty) with postoperative complications in women undergoing major gynecologic surgery.
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PMID: 21934441
PDF is available here.
PDF is available here.
Abstract
Microvascular decompression is an etiological strategy for the therapy of trigeminal neuralgia (TN). Preoperative identification of neurovascular compression, therefore, could have an impact on the determination of appropriate treatment for TN.
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PMID: 21835888
PDF is available here.
PDF is available here.
Abstract
Increased venous contrast in ischemic stroke using susceptibility-weighted imaging has been widely reported, although few reports have compared increased venous contrast areas with perfusion change areas.
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PMID: 21844118
PDF is available here.
PDF is available here.
Abstract
The p53 gene product is an attractive target for tumor immunotherapy. The present study aims to understand the potential of MVAp53 vaccine to induce expansion of p53-specific cytotoxic T lymphocyte ex vivo in cancer patients. The result indicated that 14 of 23 cancer patients demonstrated p53-specifi...
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PMID: 21843052
PDF is available here.
PDF is available here.
Abstract
Abstract
The diagnostic category of atypia of undetermined significance (AUS) in the Bethesda System for reporting the results of thyroid fine-needle aspirations (FNAs) is intended to encompass findings associated with a low risk of malignancy. It is unclear if there are patterns within this evolving, heterog...
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PMID: 21917679
PDF is available here.
PDF is available here.
Abstract
Gene expression profiles of paired hepatocellular carcinoma (HCC) and adjacent noncancerous liver tissue samples revealed preferential expression of midkine in HCC. This finding suggested the clinical usefulness of midkine measurement in serum for monitoring HCC treatment response, recurrence, and pr...
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PMID: 21917682
PDF is available here.
PDF is available here.
Abstract
When test scores were evaluated, almost all participants (96%) were found to have at least one impairment. The rates of impairment varied dramatically between tests from 3 percent (visual acuity) to 75 percent (visual search). Several average test scores were found to be different from the original...
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PMID: 21972855
PDF is available here.
PDF is available here.
Abstract
Low 25-hydroxyvitamin D (25[OH]D) levels are common in patients with non-dialysis-dependent chronic kidney disease (CKD). The associations between low 25(OH)D levels and mortality in non-dialysis-dependent patients with CKD are unclear.
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PMID: 21816525
PDF is available here.
PDF is available here.
Abstract
To ascertain if breast cancer subtypes had prognostic effect on breast cancer specific survival, distant metastases and local relapse rates in women affected by early stage breast cancer.
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PMID: 21824742
PDF is available here.
PDF is available here.
Otology & Neurotology (32)8 2011
Abstract
To establish a tissue engineering therapy for the treatment of large tympanic membrane perforation (TMP) without the need for conventional surgical therapy.
Randomized control trial.
General hospital.
A total of 63 chronic TMPs were ran...
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PMID: 21897328
PDF is available here.
PDF is available here.
Abstract
It is unclear if advance directives (living wills) are associated with end-of-life expenditures and treatments.
To examine regional variation in the associations between treatment-limiting advance directive use, end-of-life Medicare expenditures, and use of palliative...
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PMID: 21972306
PDF is available here.
PDF is available here.
Abstract
We studied Tregs in the pancreas and peripheral blood.
We recruited 44 patients with IgG4-related AIP. For comparison, we recruited 37 patients with other pancreatic diseases and 27 healthy subjects as controls. We studied infiltrating cells in the pancreas by immunohistochemistry an...
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PMID: 21926547
PDF is available here.
PDF is available here.
Journal of Hepatology (55)4 2011
Abstract
Multiple episodes of DILI in association with different drugs occur infrequently. In each individual, the type of injury was similar during the two DILI episodes, regardless of the causative drug. Second episodes of DILI are more likely to be associated with features of AIH. It remains uncertain if...
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PMID: 21338638
PDF is available here.
PDF is available here.
Abstract
We sought to determine the utility of this functional assay in assessing the risk of infection, rejection, and tumor recurrence in liver transplant recipients.
Immune function was determined by ImmuKnow assay that measures the amount of adenosine triphosphate (ATP) produced by CD4 (+...
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PMID: 21809031
PDF is available here.
PDF is available here.
New England Journal of Medicine (365)13 2011
Abstract
New England Journal of Medicine (365)13 2011
Abstract
We linked nationwide data from the Medicare Minimum Data Set and claims files from 2000 through 2007. We defined patterns of transition as burdensome if they occurred in the last 3 days of life, if there was a lack of continuity in nursing homes after hospitalization in the last 90 days of life, or...
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PMID: 21991894
PDF is available here.
PDF is available here.
Orvosi Hetilap (152)40 2011
Abstract
Mutations in BRCA1 and BRCA2 genes account for the majority of hereditary breast and ovarian cancers. Approximately 10% of cases of ovarian cancer are due to germline mutations in BRCA1 and BRCA2. Ovarian cancer associated with BRCA1 and BRCA2 mutations has a distinct histological ph...
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PMID: 21945869
PDF is available here.
PDF is available here.
Abstract
The evaluation of peritoneal CT attenuation values in patients with peritonitis is simple and can be used for objective assessment of the severity of peritonitis.
Copyright © 2011 Elsevier Inc. All rights reserved....
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PMID: 21943948
PDF is available here.
PDF is available here.
New England Journal of Medicine (365)12 2011
Abstract
Abstract
To our knowledge, our findings provide novel evidence to support the hypothesis of a mild iron overload in patients with prediabetes and T2D. A cohort study concerned with the effect of the attenuation of excess iron on glucose metabolism in a prediabetic population is warranted....
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PMID: 21880847
PDF is available here.
PDF is available here.
Abstract
We conducted a large population-based study involving asymptomatic adults in Taiwan, a population with prevalent upper gastrointestinal lesions, to confirm this claim....
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PMID: 21810951
PDF is available here.
PDF is available here.
Abstract
We conducted an open-label study of BoNTA in men with BPH-related LUTS who were unsuitable for surgery as well as investigation of the effect of the toxin on in vitro growth of fibroblasts. In the clinical part, 5 patients aged from 75 to 88, suffering from BPH and UR were treated. Patients were pre...
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PMID: 21928723
PDF is available here.
PDF is available here.
Lakartidningen (108)32-33 2011
Abstract
Abstract
Abdominal computed tomography (CT) scans are frequently performed for a variety of abdominal complaints. Not infrequently, bowel wall thickening noted on these radiographic studies of the gastrointestinal (GI) tract prompt further endoscopic evaluation. It is unclear whether the costs and risks of en...
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PMID: 21932485
PDF is available here.
PDF is available here.
Abstract
The diagnosis of ulcerative colitis is based on combination of clinical, endoscopic and pathological findings. However cases have been reported showing atypical endoscopic and histological features in ulcerative colitis. Hence the objective of this study was to determine the atypical features of new...
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PMID: 21922873
PDF is available here.
PDF is available here.
Abstract
Irish Journal of Medical Science (180)S10 2011
Abstract
Missouri medicine (108)4 2011
Abstract
In elderly patients with established atrial fibrillation (AF) who are receiving thyroid replacement, regular testing for thyroid function is often not performed, placing the patient at risk for iatrogenic hyperthyroidism. Of 215 patients followed in an anticoagulation clinic, 41 were receiving thyroi...
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PMID: 21905446
PDF is available here.
PDF is available here.
Abstract
We compared plasma protein profiles of four mouse models of lung cancer with profiles of models of pancreatic, ovarian, colon, prostate, and breast cancer and two models of inflammation. A protein signature for Titf1/Nkx2-1, a known lineage-survival oncogene in lung cancer, was found in plasmas of m...
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PMID: 21907921
PDF is available here.
PDF is available here.
Abstract
We evaluated a novel liquid chromatography tandem mass spectrometry (LC-MS/MS) method, which utilizes aTRAQ reagents, for amino acid analysis in urine. aTRAQ reagents tag the primary and secondary amino groups of amino acids. Internal standards for each amino acid are also labeled with a modified aT...
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PMID: 21852206
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (124)11 Suppl 2011
Abstract
Evidence supporting the use of bioprostheses for heart valve replacement in young adults is accumulating. However, reoperation data, which may help guide clinical decision making in young patients, remains poorly defined in the literature.
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PMID: 21911822
PDF is available here.
PDF is available here.
Abstract