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Aged (2):
Recent article
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Abstract
Dementia is associated with increased rates and often poorer outcomes of hospitalization, including worsening cognitive status. New evidence is needed to determine whether some admissions of persons with dementia might be potentially preventable.
To determine whether...
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PMID: 22235087
PDF is available here.
PDF is available here.
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Abstract
Abstract
Clinical practice guidelines recommend maintaining serum potassium levels between 4.0 and 5.0 mEq/L in patients with acute myocardial infarction (AMI). These guidelines are based on small studies that associated low potassium levels with ventricular arrhythmias in the pre-β-blocker...
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PMID: 22235086
PDF is available here.
PDF is available here.
Abstract
We present the first analysis of age-at-onset in the NIMH LOAD sample that allows for both a multilocus trait model and genetic heterogeneity among the contributing sites, while at the same time accommodating age censoring, effects of known genetic covariates, and full pedigree and marker informatio...
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PMID: 21812099
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
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PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine) in subjects with ALS in a two-part, double-blind safety and tolerability study, with a preliminary assessment of its effects on functional decline and mortality. In...
|
PMID: 22101764
PDF is available here.
PDF is available here.
Aging and Mental Health (15 Suppl 1) 2011
Abstract
Abstract
Although extensive evidence support the key role of adipokines in cartilage homeostasis, contradictory data have been found for their expression and their effects in chondrocytes. This study was then undertaken to determine whether a phenotypic modulation may affect the expression of adipokines and t...
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PMID: 21935928
PDF is available here.
PDF is available here.
Abstract
Although feeling bothered by the sexual unresponsiveness of an intimate partner was significantly associated with both women's and men's depressive symptoms, the moderating effect of the partner's supportiveness was significant only for women. Discussion. The results suggest that gender is a key d...
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PMID: 21918124
PDF is available here.
PDF is available here.
Abstract
Comparison of surgical results on obese patients undergoing hysterectomy by robot-assisted laparoscopy or laparotomy.
University hospital.
All women (n=114) with a BMI ≥30 kg/m(2) who underwent a simple hysterectomy as the main surgical procedure bet...
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PMID: 21854364
PDF is available here.
PDF is available here.
Abstract
We analyzed the ability of each management strategy to control anemia and neutropenia and the percentage of subjects who achieved a successful treatment outcome according to the different management strategies.
During treatment, 43 subjects developed anemia (human erythropoietin, n =...
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PMID: 21876446
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to examine the factorial validity of the Job Expectations Questionnaire (Cuestionario de Expectativas Laborales CEL) in a sample of Mexican workers. Following a cross validation approach, two samples were used in the study. The first sample consisted of 380...
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PMID: 22059344
PDF is available here.
PDF is available here.
Abstract
The present study tests the relationships between the three frequently used personality models evaluated by the Temperament Character Inventory-Revised (TCI-R), Neuroticism Extraversion Openness Five Factor Inventory - Revised (NEO-FFI-R) and Zuckerman-Kuhlman Personality Questionnai...
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PMID: 22059312
PDF is available here.
PDF is available here.
Abstract
We have explored the psychometric properties and construct validity of the Turkish adaptation of the Mathematics Teacher Efficacy Belief Instrument developed by Enochs, Smith, & Huinker (2000) for in-service mathematics teachers. The instrument distinguishes between two dimensions of efficacy belief...
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PMID: 22059339
PDF is available here.
PDF is available here.
Abstract
We the adaptation and testing of the psychometric properties of the Running Addiction Scale (RAS) in Spanish. To this end, we conducted two independent studies. The aim of the first was to present the first preliminary psychometric data (pilot sample of 174 marathon runners). Explained the process o...
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PMID: 22059340
PDF is available here.
PDF is available here.
Abstract
A minimally toxic nonmyeloablative regimen was developed for allogeneic hematopoietic cell transplantation (HCT) to treat patients with advanced hematologic malignancies who are older or have comorbid conditions.
To describe outcomes of patients 60 years or older afte...
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PMID: 22045765
PDF is available here.
PDF is available here.
Abstract
Solid organ transplant recipients have elevated cancer risk due to immunosuppression and oncogenic viral infections. Because most prior research has concerned kidney recipients, large studies that include recipients of differing organs can inform cancer etiology.
To d...
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PMID: 22045767
PDF is available here.
PDF is available here.
Abstract
Pemetrexed is an antifolate agent approved for the treatment of advanced lung cancer. Major side effects include myelosuppression and neutropenia. Three patients developed kidney disease while being treated with maintenance pemetrexed. Kidney biopsy specimens showed tubulointerstitia...
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PMID: 21849225
PDF is available here.
PDF is available here.
Abstract
Pemetrexed is an antifolate agent approved for the treatment of advanced lung cancer. Major side effects include myelosuppression and neutropenia. Three patients developed kidney disease while being treated with maintenance pemetrexed. Kidney biopsy specimens showed tubulointerstitia...
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PMID: 21849225
PDF is available here.
PDF is available here.
Presse Medicale (40)11 2011
Abstract
The prevalence of peritoneal dialysis in France remains one of the lowest in Europe in spite of official recommendations in 2008. Progress in peritoneal catheter placement and a good knowledge of the management of catheter complications are essential. A more frequent use of biocompatible solutions sh...
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PMID: 21924862
PDF is available here.
PDF is available here.
Transplantation (92)8 2011
Abstract
We examined 10 stable kidney transplant patients (mean estimated glomerular filtration rate 51±10 mL/min/1.73 m(2)) who received cinacalcet daily for persistent hyperparathyroidism. Urine specimens were collected at baseline and every 2 hr for a total study period of 6 hr after ingestion of 30 mg c...
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PMID: 21876476
PDF is available here.
PDF is available here.
Orvosi Hetilap (152)45 2011
Abstract
Incidence of the JAK2 mutation in their patients with chronic myeloproliferative neoplasia subgroups mainly corresponds to the literary data. Thrombosis ensued both in JAK positive polycythemia vera and essential thrombocythemia cases occurred nearly in the same number, but the incidence of thrombos...
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PMID: 22011365
PDF is available here.
PDF is available here.
Abstract
Smoking is a major risk factor for both cancer and chronic obstructive pulmonary disease (COPD). Computed tomography (CT)-based lung cancer screening may provide an opportunity to detect additional individuals with COPD at an early stage.
To determine whether low-dose...
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PMID: 22028353
PDF is available here.
PDF is available here.
Abstract
Abstract
As the proportion of persons in the United States older than 65 years increases, the prevalence of dementia will increase as well. Risk factors for dementia include age, family history of dementia, apolipoprotein E4 genotype, cardiovascular comorbidities, chronic anticholinergic use,...
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PMID: 22010769
PDF is available here.
PDF is available here.
Abstract
We have modified the original apparatus for organ bioassay in order to minimize foaming and to increase analytical performance. By using this modified bioassay we investigated the vasodilatory potency of various endogenous RSNOs in the presence of physiologically relevant concentrations of albumin a...
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PMID: 21827780
PDF is available here.
PDF is available here.
Abstract
We find that the infant human subventricular zone and RMS contain an extensive corridor of migrating immature neurons before 18 months of age but, contrary to previous reports, this germinal activity subsides in older children and is nearly extinct by adulthood. Surprisingly, during this limited win...
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PMID: 21964341
PDF is available here.
PDF is available here.
MMW Fortschritte der Medizin (153)41 2011
Abstract
MMW Fortschritte der Medizin (153)41 2011
Abstract
MMW Fortschritte der Medizin (153)41 2011
Abstract