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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Pharmaceutical Preparations (21):
- Nostrums
- Drugs, Chinese Herbal
- Veterinary Drugs
- Street Drugs
- Drug Combinations
- Xenobiotics
- Prescription Drugs
- Plant Extracts
- Dosage Forms
- Placebos
- Solutions
- Prodrugs
- Pharmaceutical Preparations, Dental
- Nonprescription Drugs
- Drugs, Investigational
- Drugs, Generic
- Materia Medica
- Drugs, Essential
- Designer Drugs
- Vaginal Creams, Foams, and Jellies
- Pharmaceutic Aids
Recent article
Pharmaceutical Preparations
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Abstract
Abstract
We describe the potential of estimating melting temperature (T(m)) for nonstandard oligonucleotides by using the correlation of the experimental T(m) with the calculated duplex binding energy (BE) for oligonucleotides of a given length. This method has been automated into a standardized molecular dy...
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PMID: 21702481
PDF is available here.
PDF is available here.
Abstract
We present a data mining approach that enables the identification of alternative analog series with different core structures, corresponding substitution patterns, and comparable potency progression. Scaffolds can be exchanged between these series and new analogs suggested that incorporate preferred...
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PMID: 21774471
PDF is available here.
PDF is available here.
Abstract
We present an extension of the activity cliff concept by introducing "activity ridges" that are formed by overlapping "combinatorial" activity cliffs between participating compounds, giving rise to ridge-like structures in activity landscapes. Activity ridges are rich in SAR information. In a system...
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PMID: 21761918
PDF is available here.
PDF is available here.
Abstract
A large-scale similarity search investigation has been carried out on 266 well-defined compound activity classes extracted from the ChEMBL database. The analysis was performed using two widely applied two-dimensional (2D) fingerprints that mark opposite ends of the current performanc...
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PMID: 21728295
PDF is available here.
PDF is available here.
Abstract
Abstract
Bioanalysis (3)10 2011
Abstract
The recent Montreux Symposium on LC-MS held in 2010 provided an insight into the key areas of present achievements and future developments in LC-MS. This domain is rapidly changing from a technology- to an application-driven enterprise. New demands for advanced options are coming fro...
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PMID: 21585298
PDF is available here.
PDF is available here.
Abstract
Prescrire international (20)114 2011
Abstract
Prescrire international (20)114 2011
Abstract
Abstract
Drug disposition, metabolism and drug-drug interactions are important considerations for most drugs. Cytokines are integral to the successful resolution of many diseases. Data are emerging on a role for cytokines in regulation of the expression and activity of drug transporters and drug metabolising...
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PMID: 21299442
PDF is available here.
PDF is available here.
Abstract
Companion diagnostics and stratified medicines will be increasingly used over the next ten years. Current market leaders who have created diagnostic divisions with a focus on biomarker identification will benefit, notably Abbott, AstraZeneca, Novartis, and GlaxoSmithKline. Pricing incentives and impr...
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PMID: 21469770
PDF is available here.
PDF is available here.
Current Protocols in Toxicology (Chapter 20) 2011
Abstract
The Caco-2 cell system, a well characterized intestinal in vitro model, makes it possible to evaluate the ability of chemicals to cross the intestinal barrier, as well as to study their transport mechanisms. Permeability values estimated with this model correlate well with human in v...
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PMID: 21400683
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
A general toxicity of basic drugs is related to phospholipidosis in tissues. Therefore, it is essential to predict the tissue distribution of basic drugs to facilitate an initial estimate of that toxicity. The objective of the present study was to further assess the original prediction method that c...
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PMID: 21034759
PDF is available here.
PDF is available here.
Abstract
Abstract
We have used cytochrome c and model peptides to view adduction profiles of quinone-thioether metabolites, and have determined by MALDI-TOF analysis that these electrophiles target specific residues within these model systems....
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PMID: 20972761
PDF is available here.
PDF is available here.
Abstract
Flow cytometry-based assays serve as valuable tools for various aspects of the drug development process ranging from target discovery and characterization to evaluation of responses in a clinical setting. The integrity of the samples and the appropriate selection and characterization of the reagents...
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PMID: 20946898
PDF is available here.
PDF is available here.
Seton Hall law review (41)2 2011
Abstract
Pharmocoepigenetics: a new approach to predicting individual drug responses and targeting new drugs.
Abstract
Epigenetics is the study of heritable changes in genes and gene expression that do not involve DNA nucleotide sequences. Epigenetic modifications include DNA methylation, several forms of histone modifications, and microRNA expression. Because of its dynamic nature, epigenetics provi...
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PMID: 21602587
PDF is available here.
PDF is available here.
Abstract
We outline key PK concepts relevant to PD, and then consider real-life experiments to illustrate the importance to the medicinal chemist of data obtained by PKPD. Useful assumptions and potential pitfalls are described, providing a holistic view of the plethora of determinants behind in vitro-in viv...
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PMID: 21320067
PDF is available here.
PDF is available here.
Abstract
We apparently need compounds with low tissue binding. Our theoretical analysis and experimental data demonstrate that unbound plasma concentration is not determined by plasma protein binding but by hepatic intrinsic clearance after oral dose, and unbound tissue concentration is not determined by tis...
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PMID: 21320069
PDF is available here.
PDF is available here.
Abstract
Antibody-drug conjugates (ADCs), formed through the chemical linkage of a potent small molecule cytotoxin (drug) to a monoclonal antibody, have more complex and heterogeneous structures than the corresponding antibodies. This review describes the analytical methods that have been use...
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PMID: 21441786
PDF is available here.
PDF is available here.
Abstract
Metabolic activation of new chemical entities to reactive intermediates is routinely monitored in drug discovery and development. Reactive intermediates may bind to cellular macromolecules such as proteins, DNA and may eventually lead to cell death via necrosis, apoptosis or oxidativ...
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PMID: 21320068
PDF is available here.
PDF is available here.
Abstract
The use of in vitro metabolism in scaling to predict human clearance of new chemical entities has become a commonplace activity in the research and development of new drugs. The measurement of in vitro lability in human liver microsomes, a rich source of drug metabolizing cytochrome...
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PMID: 21320062
PDF is available here.
PDF is available here.
Nippon Jinzo Gakkai shi (53)2 2011
Abstract
We report a case of suspected pseudo-elevation of serum creatinine in a patient with rheumatoid arthritis, whose blood sample was obtained from his right cubital vein immediately after the intra-articular injection of 0.67 mg of a pharmaceutical preparation of dexamethasone (Decadron) containing cre...
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PMID: 21516707
PDF is available here.
PDF is available here.
Abstract
We have mined publicly available compound and bioactivity data for promiscuous chemotypes. For this purpose, a hierarchy of active compounds, atomic property based scaffolds, and unique molecular topologies were generated, and activity annotations were analyzed using this framework. Starting from ...
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PMID: 21070069
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Abstract
We propose the use of a gamma-ray transmission technique to obtain the porosity of experimental formulation of tablets. The results of porosity were compared with those obtained by using conventional methodology (density and mercury intrusion). The experimental setup for gamma-ray transmission consi...
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PMID: 20580565
PDF is available here.
PDF is available here.
Nature Medicine (16)12 2010
Abstract
Current Gene Therapy (10)6 2010
Abstract
We will show that both fields together are able to allow the next step towards successful prevention and therapy. Here we summarize the features of producing and modifying these non-viral gene vectors to ensure the required quality to modify cells and to treat human and animals....
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PMID: 21054244
PDF is available here.
PDF is available here.
Critical Care Medicine (38)12 2010
Abstract
We aimed to assess the impact of an automated dispensing system on the incidence of medication errors related to picking, preparation, and administration of drugs in a medical intensive care unit. We also evaluated the clinical significance of such errors and user satisfaction.
Preintervention and p...
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PMID: 20838333
PDF is available here.
PDF is available here.
Abstract
We aim to provide an overview of the current knowledge on the ABCB1 and ABCG2 transporter expression profiles in the placenta and fetal tissues in humans relative to other species.
The available information on ABCB1 and ABCG2 temporal expression profiles in placenta and fetus indicates rather good c...
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PMID: 20738225
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Drug-drug interactions caused by induction of metabolizing enzymes, particularly CYP3A, can impact the efficacy and safety of co-administered drugs. It is, therefore, important to understand a new compound's potential for enzyme induction and to understand how to use the induction data generated in...
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PMID: 20955108
PDF is available here.
PDF is available here.
Abstract
Enantioselective analysis of some pharmaceuticals during wastewater treatment has the potential to reveal significant insights regarding the effectiveness of biotransformation processes. Furthermore, enantioselective analysis of chiral pharmaceuticals in the aquatic environment may provide a useful...
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PMID: 21121459
PDF is available here.
PDF is available here.
Analyst (Cambridge UK) (135)11 2010
Abstract
We describe profiling of human plasma with liquid chromatography (LC) coupled to Fourier-transform mass spectrometry (FTMS). FTMS is a high-resolution mass spectrometer providing mass accuracy and resolution to discriminate thousands of m/z features, which are peaks defined by m/z, retention time an...
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PMID: 20838665
PDF is available here.
PDF is available here.
Toxicological Sciences (118)1 2010
Abstract
This article describes the first step toward full (that includes conditions for both absence and presence of metabolic activation) validation and drug discovery application of a 96-well, automated, high-content micronucleus (HCMN) assay. The current validation tests were performed using Chinese hams...
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PMID: 20631060
PDF is available here.
PDF is available here.
Water Environment Research (82)11 2010
Abstract
The occurrence of nine different types of pharmaceuticals and caffeine were analyzed in various units of three wastewater treatment plants (WWTPs) and their receiving rivers in Beijing, China. Analyte concentrations were determined using ultra performance liquid chromatograph-tandem quadruple mass s...
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PMID: 21141385
PDF is available here.
PDF is available here.
Chemical Communications (46)40 2010
Abstract
Fluorinated polysilsesquioxane (FPSQ) hollow spheres with a large empty interior were synthesized in an aqueous medium by using (trifluoropropyl)trimethoxysilane as the sole precursor. The drug release applications of these spheres were demonstrated, and the materials have great potential as fluorin...
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PMID: 20856943
PDF is available here.
PDF is available here.
Abstract
Abstract
White petrolatums of Japanese Pharmacopoeia grade and Sun white marketed as a cosmetic were characterized by measuring their physical properties and drug-releasing characteristics. White petrolatums of Japanese Pharmacopoeia grade available commercially in Japan were Perfecta, White 1S, Ultima, Snow...
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PMID: 21155385
PDF is available here.
PDF is available here.
Abstract
In advanced age, the tendency to fall increases, as does the severity of the over, falls cause substantial costs to the health and welfare systems. Among elderly people, most falls result from the concurrence of several risk factors and a trigger. Taking medication can significantly influence the te...
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PMID: 21166252
PDF is available here.
PDF is available here.
Annals of Neurology (68)5 2010
Abstract
Market exclusivity given to biologics puts burdens on healthcare and new development.
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PMID: 21031566
PDF is available here.
PDF is available here.
Abstract
A fully automated screening using liquid chromatography-mass spectrometric method applying data-dependent acquisition was developed to identify toxicologically relevant substances in serum and urine. A library including more than 405 spectra of about 365 compounds (main drugs and important metabolit...
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PMID: 20846915
PDF is available here.
PDF is available here.
Chemical Communications (46)38 2010
Abstract
A thermosensitive liposome with embedded AuNPs in a bilayer was prepared using supercritical CO(2). The AuNPs-liposome can absorb a certain wavelength light, convert optical energy into heat, induce phase transition, and release drug. The results show that drug release from the liposome is due to th...
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PMID: 20820547
PDF is available here.
PDF is available here.
Abstract
Droplet evaporation has been known to bias cascade impactor measurement of aerosols generated by jet nebulizers. Previous work suggests that vibrating mesh nebulizers behave differently from jet nebulizers. Unlike jet nebulizers, vibrating mesh nebulizers do not rely on compressed air to generate dr...
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PMID: 20455771
PDF is available here.
PDF is available here.
Abstract
We provide proof that drugs related by side effect similarity have in fact affinities for multiple common targets beyond their primary targets and set the basis for the use of comparative pharmacology to anticipate drug side effects.
Nomenclature issues to be able to identify and properly store drug...
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PMID: 20662552
PDF is available here.
PDF is available here.
Pharmacy World & Science (32)5 2010
Abstract
We developed a novel PRR (NPRR) method and compared it with the original PRR method for the purpose of a combined application of these two methods for ADR signal detection.
NPRR is also based on unbalanced proportions, in which the proportion for a given ADR is linked to a specific drug (or all othe...
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PMID: 20676936
PDF is available here.
PDF is available here.
Abstract
We undertook this study to standardise methods for estimation of nevirapine (NVP), lamivudine (3TC) and stavudine (d4T) in single tablets/capsules by HPLC and spectrophotometry and to compare the content of these drugs determined by both these methods.
Twenty tablets/capsules of NVP, 3TC and d4T eac...
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PMID: 20966516
PDF is available here.
PDF is available here.
Abstract
A spectrophotometric method was developed for the quantitative determination of doripenem in pharmaceutical dosage form (DORIBAX) in the presence of its degradation products. The first-derivative with or without the substration technique, depending on formed products degradation was applied (lambda=...
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PMID: 20634123
PDF is available here.
PDF is available here.
Abstract
An increasing number of examples in the literature suggest that the in vivo duration of drug action not only depends on macroscopic pharmacokinetic properties like plasma half-life and the time needed to equilibrate between the plasma and the effect compartments, but is also influenced by long-lasti...
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PMID: 20880390
PDF is available here.
PDF is available here.
Abstract
Adverse drug reactions are recognized as a significant public health issue. Pharmacogenetics (PGx) provides a potential means of preventing some adverse drug reactions by predicting the optimal medication dose for an individual; however, PGx is rarely used in clinical practice. Thus far, there have...
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PMID: 20813335
PDF is available here.
PDF is available here.