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Dosage Forms (12):
Recent article
Dosage Forms
Nursing Times (107)32-33 2011
Abstract
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Abstract
Intranasal administration of dopamine (0.3; 3 and 30 microg/kg) on anxious behaviour of mice was studied using elevated plus-maze and open fields tests and the pinch-induced catalepsy on parallel bars test. Dopamine was introduced as nose drops or inhalation of nanoparticles of the c...
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PMID: 21961293
PDF is available here.
PDF is available here.
Abstract
We assessed apoptosis in the hepatocellular carcinoma (HCC) cell line HepG2 induced by an injectable extract from the seed of Coix lacryma-jobi (Semen coicis, SC), and monitored the expression of Bcl-2 and caspase-8.
Injectable SC was applied to HepG2 cells at different concentration...
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PMID: 21669575
PDF is available here.
PDF is available here.
Drug Safety (34)4 2011
Abstract
NSAIDs, particularly ibuprofen, are commonly prescribed for children but there is limited published research on real-life prescribed doses for this class of drugs.
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PMID: 21417503
PDF is available here.
PDF is available here.
Abstract
A latent structure analysis of pharmaceutical formulations was performed using Kohonen's self-organizing map (SOM) and a Bayesian network. A hydrophilic matrix tablet containing diltiazem hydrochloride (DTZ), a highly water-soluble model drug, was used as a model formulation. Nonlinear relationship c...
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PMID: 21355105
PDF is available here.
PDF is available here.
Abstract
We demonstrate that machine learning of multiple CPIs can not only assess drug polypharmacology but can also efficiently identify novel bioactive scaffold-hopping compounds. Through a machine-learning technique that uses multiple CPIs, we have successfully identified novel lead compounds for two pha...
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PMID: 21364574
PDF is available here.
PDF is available here.
Abstract
This study describes development and subsequent validation of a reversed phase high performance liquid chromatographic (RP-HPLC) method for the estimation of nandrolone phenylpropionate, an anabolic steroid, in bulk drug, in conventional parenteral dosage formulation and in prepared nanoparticle dosa...
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PMID: 21485287
PDF is available here.
PDF is available here.
Abstract
Evaluation of in vitro-in vivo correlation (IVIVC) plays important role in securing therapeutic effect if a dosage form undergoes technological modifications. Similarity (closeness) of dissolution profiles of the original and modified dosage forms has been traditionally considered to be sufficient fo...
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PMID: 21648197
PDF is available here.
PDF is available here.
Arerugi = [Allergy] (60)1 2011
Abstract
We had searched a substance that inactivated sweat antigen adopting histamine release test. And we found that tannic acid which selected by screening various natural products inactivated sweat antigen....
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PMID: 21346405
PDF is available here.
PDF is available here.
Abstract
Two spectrophotometric methods, derivative and multivariate methods, were applied for the determination of binary, ternary, and quaternary mixtures of the water-soluble vitamins thiamine HCI (I), pyridoxine HCI (II), riboflavin (III), and cyanocobalamin (IV). The first method is divided into first de...
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PMID: 21563680
PDF is available here.
PDF is available here.
Abstract
A simple, rapid, and selective HPLC-diode array detector method was developed for the simultaneous determination of lidocaine hydrochloride (LD) and cetylpyridinium chloride (CPC) in two combined pharmaceutical formulations. Effective chromatographic separation was achieved on a Zorbax SB-C8 (4.6 x 2...
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PMID: 21563684
PDF is available here.
PDF is available here.
Abstract
A stability-indicating HPLC method with diode array detection for the determination of paricalcitol, a synthetic vitamin D2 analog, was developed. Analytical parameters were studied according to International Conference on Harmonization guidelines. A C18 column (250 x 4.6 mm, 5 microm particle size)...
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PMID: 21563689
PDF is available here.
PDF is available here.
Abstract
With HPLC using a diode array detector (DAD), a method of substitution for reference substances in impurity profiling control was developed that combined peak tracking by the correlation of spectra with application of correction factors for determination of each impurity. For qualitative analysis, tw...
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PMID: 21563687
PDF is available here.
PDF is available here.
Abstract
To study preliminarily on the relationship between properties of the mixture composed of Tongsaimai extract and different excipients and pellet molding.
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PMID: 21473149
PDF is available here.
PDF is available here.
Abstract
To study the effectiveness of the granules of eliminating phlegm and removing blood stasis (GEPRB) on glucose metabolism for diabetic rats induced by streptozotocin and that on early diabetic rats cochlear histopathology.
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PMID: 21506425
PDF is available here.
PDF is available here.
Abstract
Ziprasidone is known as a novel "atypical" or "second-generation" antipsychotic drug. A sensitive and reproducible method was developed and validated for determination of ziprasidone and its major impurities, which are significantly different in polarity. The separation is performed...
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PMID: 21796998
PDF is available here.
PDF is available here.
Abstract
Two HPLC/MS/MS methods, one for determination of neomycin sulfate and the other for determination of oxytetracycline hydrochloride in the presence of their impurities, were developed and validated. Separations were achieved with gradient elution on a C18 column. All components were i...
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PMID: 21797002
PDF is available here.
PDF is available here.
Abstract
Abstract
Differences between phenazepam formulations were found in the clinical study of drug effects on the psychophysiological state in patients with anxiety disorder. Phenazepam did not cause negative changes of psychophysiological parameters. In patients with anxiety disorders, the most significant positi...
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PMID: 21809691
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)2 2011
Abstract
Two bioequivalence studies were carried out in healthy volunteers in order to compare the rate and extent of absorption of two dosage forms (film-coated tablet and orodispersible tablet) of oral olanzapine (CAS 132539-06-1) 10 mg test formulations and the respective brand formulation...
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PMID: 21428240
PDF is available here.
PDF is available here.
Abstract
We propose the use of a gamma-ray transmission technique to obtain the porosity of experimental formulation of tablets. The results of porosity were compared with those obtained by using conventional methodology (density and mercury intrusion). The experimental setup for gamma-ray transmission consi...
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PMID: 20580565
PDF is available here.
PDF is available here.
Abstract
The heated lidocaine/tetracaine patch (Synera; ZARS Pharma, Inc, Salt Lake City, UT) is among the local topical anesthetic formulations used to prevent procedural pain. This study was conducted to determine the depth and duration of anesthesia provided by the patch and to evaluate safety and tolerab...
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PMID: 20975464
PDF is available here.
PDF is available here.
Abstract
Excipients are, in the large majority of cases, not made specifically for pharmaceutical use. Most pharmaceutical excipient manufacturers supply less than 10% of the total production of that particular material for pharmaceutical use. Excipient product portfolio consists of hundreds of products diff...
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PMID: 21155382
PDF is available here.
PDF is available here.
Revista de Neurologia (51)6 2010
Abstract
Epilepsy is a condition characterized by signs and symptoms of neurological disorder. Lamotrigine has been widely used, mainly due to their greater tolerability and lower rate of drug interactions with other antiepileptic drugs however the newest antiepileptic drugs have high cost to patient. In Bra...
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PMID: 20839169
PDF is available here.
PDF is available here.
Clinical Cancer Research (16)21 2010
Abstract
The beneficial properties of β-glucans have been recognized for centuries. Their proposed mechanisms of action in cancer therapy occur via stimulation of macrophages and priming of innate neutrophil complement receptor 3 for eliciting complement receptor 3-dependent cellular cytotoxicity of iC3b-ops...
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PMID: 20855461
PDF is available here.
PDF is available here.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology (21)3 2010
Abstract
I (controls): bowel resection + oral total parenteral nutrition, Group II (oral liquid L-glutamine): Bowel resection + oral total parenteral nutrition + oral liquid L-glutamine, and Group III (i.v. L-glutamine): bowel resection + oral total parenteral nutrition + i.v. L-glutamine. On the postoperati...
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PMID: 20931426
PDF is available here.
PDF is available here.
Abstract
To establish a HPLC method for the determination of 11 essential compounds in Xuebijing injection.
Chromatogaphic analysis was performed on Aglient Zorbax SB-C18 (4.6 mm x 250 mm, 5 microm). The mobile phase 0. 5% acetic acid and methanol-acetonitrile-acetic acid (40: 60: 0.5). The flow rate was 1.0...
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PMID: 21141485
PDF is available here.
PDF is available here.
Abstract
A novel Eu-PB composite mercury film electrode (GC/Eu-PB/MFE) based on chemical modified was developed for the determination of baicalin and the investigation of its the electrochemical behavior.
Cyclic voltammetry and differential pulse voltammetry were used.
The adsorption characteristic of baical...
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PMID: 21141486
PDF is available here.
PDF is available here.
Abstract
To better address the need for developing stable formulations of plasmid DNA-based biopharmaceuticals, 37 compounds from a generally regarded as safe library were examined for their potential use as stabilizers. A plasmid DNA-based therapeutic vaccine, BHT-DNA, was used as a model system. Initial stu...
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PMID: 20740679
PDF is available here.
PDF is available here.
Abstract
This study examined the effects of step therapy for antidepressants on prescription drug and other medical utilization and spending. Step therapy is a type of pharmaceutical benefit design that requires that patients try certain specified medications (typically generic medications) prior to using alt...
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PMID: 20713497
PDF is available here.
PDF is available here.
Abstract
The purpose of this study was to evaluate the potential of new carboxylated multi-block copolymer of lactic acid and ethylene glycol (EL14) for nanoparticle (NP) formation and their ability to deliver high molecular weight hydrophobic drug--cyclosporine A (CsA). CsA-loaded EL14 NPs were compared wit...
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PMID: 20504806
PDF is available here.
PDF is available here.
Abstract
The feasibility of preparing microparticles with high insulin loading suitable for needle-free ballistic drug delivery by spray-freeze-drying (SFD) was examined in this study. The aim was to manufacture dense, robust particles with a diameter of around 50 microm, a narrow size distribution and a hig...
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PMID: 20519207
PDF is available here.
PDF is available here.
Abstract
We have explored coarse-grained computer simulations (dissipative particle dynamics (DPD) and coarse-grained molecular dynamics using the MARTINI force field) of polymer-drug interactions to study the encapsulation of prednisolone (log p = 1.6), paracetamol (log p = 0.3) and isoniazid (log p = -1.1)...
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PMID: 20519214
PDF is available here.
PDF is available here.
Abstract
A simple, reliable and selective differential pulse (DP) and square wave (SW) voltammetric methods at glassy carbon (GC) and boron-doped diamond (BDD) electrodes of lornoxicam in pharmaceutical dosage form and in spiked human serum samples have been developed and evaluated. The possible oxidation me...
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PMID: 20402638
PDF is available here.
PDF is available here.
Abstract
To compare the acute toxicity and the pharmacological effect of Huoxiang Zhengqi microemulsion and Huoxiang Zhengqi tincture.
The acute toxicities of Huoxiang Zhengqi microemulsion and Huoxiang Zhengqi tincture were observed by the test of maximum dose in mice and the antidiarrheal effects of them w...
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PMID: 20931856
PDF is available here.
PDF is available here.
Analytical Biochemistry (404)1 2010
Abstract
Xenobiotica (40)8 2010
Abstract
Difluprednate (DFBA; 6alpha,9-difluoro-11beta,17,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-acetate 17-butyrate) is an effective anti-inflammatory agent derived from prednisolone. The present study aimed to evaluate the metabolite profile of DFBA in rabbit ocular tissues after instillation of DFBA...
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PMID: 20509750
PDF is available here.
PDF is available here.
Abstract
Abstract
Mean VAS scores for daily ease of administration of MCT oil and film strips were significantly higher than scores for gelatin capsules at all time points, except on days 2, 4, and 7. There was no difference between MCT oil and film strip formulation scores. Mean VAS scores were 8.8 (MCT oil), 8.9 (f...
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PMID: 20513174
PDF is available here.
PDF is available here.
Abstract
A fixed-dose pediatric formulation of artesunate and mefloquine (Artequin Pediatric) has been developed. In this open, non-comparative study in Cameroonian children with uncomplicated falciparum malaria, the safety and efficacy of this formulation was tested, with a particular emphasis on the risk o...
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PMID: 20519597
PDF is available here.
PDF is available here.
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia (16)1 2010
Abstract
In a randomized controlled trial of sealing with a sheet-type collagen vs. a combined approach of fixing a collagen sponge, using fibrin glue for closure of air leaks, the use of Integran, a sheet-type absorbable topical collagen hemostat, is feasible to prevent pulmonary fistula after lung surgery....
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PMID: 20190704
PDF is available here.
PDF is available here.
Abstract
The objective of this study was to assess the efficacy of pantoprazole in infants with gastroesophageal reflux disease (GERD).
Infants ages 1 through 11 months with GERD symptoms after 2 weeks of conservative treatment received open-label (OL) pantoprazole 1.2 mg x kg(-1) x day(-1) for 4 weeks follo...
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PMID: 20400912
PDF is available here.
PDF is available here.
Joint Commission perspectives. Joint Commission on Accreditation of Healthcare Organizations (30)6 2010
Abstract
Abstract
This study evaluated a biodegradable drug delivery system for local cancer radiotherapy consisting of a thermally sensitive elastin-like polypeptide (ELP) conjugated to a therapeutic radionuclide. Two ELPs (49 kDa) were synthesized using genetic engineering to test the hypothesis that injectable biop...
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PMID: 20117157
PDF is available here.
PDF is available here.
Abstract
We utilized water-miscible organic solvents such as acetone and ethanol, which are considered safe class 3 solvents according to the ICH guideline. We deemed such an approach suitable for safe scale up and for enteric coating application to other compounds of a similar lipophilicity.
The resulting m...
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PMID: 19929567
PDF is available here.
PDF is available here.
Abstract
The construction and performance characteristics of dextromethorphan (DXM) carbon paste (CPEs) and polyvinyl chloride (PVC) electrodes are described. Different modes for electrode modification, including incorporation of ion pairs (IPs), ion pairing agent or soaking the plain electrode in IPs suspen...
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PMID: 20188955
PDF is available here.
PDF is available here.
Journal of Ethnopharmacology (128)3 2010
Abstract
All doses of C. limetta aqueous extract, used in this assay, were safe and effective.
Copyright 2010 Elsevier Ireland Ltd. All rights reserved....
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PMID: 20149855
PDF is available here.
PDF is available here.
Journal of Ethnopharmacology (128)3 2010
Abstract
This experimental work reported for the first time the anticoagulant effect of leaf extracts from Croton zambesicus. These findings are of particular interest as the leaves from Croton zambesicus are commonly used in infusion by local population and may provide a new natural source for the developme...
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PMID: 20219668
PDF is available here.
PDF is available here.
Journal of Ethnopharmacology (128)3 2010
Abstract
The tested microbes Micrococcus flavus and Escherichia coli were highly susceptible to extract CE and antimicrobial activity of CB is comparable to that of extract CE against Escherichia coli and Staphylococcus faecalis while it is better than that of extract CE, against Klebsiella pneumoniae. Both...
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PMID: 20176098
PDF is available here.
PDF is available here.
Journal of Ethnopharmacology (128)3 2010
Abstract
The score for the primary and related symptoms of the menstruation was increased significantly among patients treated with the WJJ. The differences on the FSH, PRL, and E2 levels of patients were significant before and after the treatment with WJJ. Comparing the WJJ group and the placebo group, the...
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PMID: 20051257
PDF is available here.
PDF is available here.
Abstract
Most kidney diseases that ultimately lead to end-stage renal failure originate within the glomerulus and are associated with proteinuria. Treatment options are unspecific and offer partial cures at best because available therapies do not primarily treat glomerular cells but rather ac...
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PMID: 20130528
PDF is available here.
PDF is available here.
Applied Spectroscopy (64)4 2010
Abstract
Mid-infrared (mid-IR) analysis of solid biomaterials by the familiar KBr disc technique is all too often frustrated by water interference in the very important protein (amide) and carbohydrate (hydroxyl) regions of their spectra. A method was therefore devised that overcomes the difficulty and corre...
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PMID: 20412631
PDF is available here.
PDF is available here.
Applied Spectroscopy (64)4 2010
Abstract
We report on the local microenvironment surrounding three small fluorescent probe molecules (pyrene, [6-propionyl-2-(N,N-dimethylamino) naphthalene] (PRODAN), and [4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran] (DCM)) when they are sequestered at low concentration within thin biod...
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PMID: 20412618
PDF is available here.
PDF is available here.
Applied Spectroscopy (64)4 2010
Abstract
Solid dispersion formulations and drug in polymer matrices are increasingly being used by the pharmaceutical industry to enhance the solubility, or bio-availability, of active pharmaceutical ingredients (APIs). The degree of solubility or bio-availability enhancement, as well as properties such as c...
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PMID: 20412630
PDF is available here.
PDF is available here.
Abstract
Simple, accurate, sensitive and validated UV spectrophotometric, chemometric and HPTLC-densitometric methods were developed for determination of oxybutynin hydrochloride (OX) in presence of its degradation product and additives in its pharmaceutical formulations. Method A is the first derivative of...
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PMID: 20152446
PDF is available here.
PDF is available here.
Abstract
A noncontact/nondestructive air-coupled acoustic technique to be potentially used in mechanical property determination of bilayer tablets is presented. In the reported experiments, a bilayer tablet is vibrated via an acoustic field of an air-coupled transducer in a frequency range sufficiently high...
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PMID: 20063078
PDF is available here.
PDF is available here.
Abstract
Potential efficacy of zileuton, a 5-LOX inhibitor, was evaluated for the reduction of pulmonary adenomas in the A/J murine model when administered via nose-only inhalation. Development of pulmonary adenomas was induced with benzo(a)pyrene. Animals were treated with a zileuton solution (5 mg/mL in 85...
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PMID: 20101484
PDF is available here.
PDF is available here.
Abstract
The purpose of this study was to establish a calibration model to predict the hydrate content in powder materials consisting of anhydrate (theophylline anhydrate (THA)) and theophylline monohydrate (THM) by using various kinds of X-ray powder diffraction (XRPD) analytical methods. XRPD profiles were...
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PMID: 20127211
PDF is available here.
PDF is available here.
Abstract
An intravenous solution is a dosage forms intended for administration into the bloodstream. This route is the most rapid and the most bioavailable method of getting drugs into systemic circulation, and therefore it is also the most liable to cause adverse effects. In order to reduce the possibility...
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PMID: 20182828
PDF is available here.
PDF is available here.
Abstract
Valsartan orodispersible tablets have been developed at 40-mg dose, with the intention of facilitating administration to patients experiencing problems with swallowing and hopefully, improving its poor oral bioavailability. Work started with selecting drug compatible excipients depending on differen...
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PMID: 20112137
PDF is available here.
PDF is available here.