Abstract
We used activated EL-4 murine T-lymphoma cells, which produce interleukin (IL)-4 and IL-5, but not interferon (IFN)-γ, as T(H)2 cell-like cells and treated them with PMA+cAMP to investigate the effects of shikonin on T(H)2 cytokines, transcriptional factors, and the related mitogen-activated protei...
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PMID: 21806999
PDF is available here.
Abstract
To investigate the in vitro effects and the primary mechanisms of Changweiqing (, CWQ) on antimetastasis and antiinvasion of hypoxic colon carcinoma cells. In addition, to provide experimental evidence for the Chinese medicinal theory of "strengthening the body's resistance to elimin...
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PMID: 21725877
PDF is available here.
Abstract
We first explored the antiangiogenic activities of 5-formylhonokiol on proliferation, migration and tube formation of human umbilical vein endothelial cells (HUVECs) for the first time in vitro. Then we investigated the in vivo antiangiogenic effect of 5-formylhonokiol on zebrafish angiogenesis mode...
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PMID: 21297378
PDF is available here.
Abstract
Based on the phenomenon that hydrophilic acetonitrile can be separated from water by adding a hydrophobic solvent, a phase transition extraction (PTE) method for isolation of phytochemical compositions was developed. The isolation efficiency of the proposed method was assessed in com...
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PMID: 21268259
PDF is available here.
Abstract
I collagen and osteocalcin mRNA and the ratio of osteoprotegerin/receptor activator of NF-κB ligand mRNA, and suppressed the increase in IL-6 mRNA induced by OVX in the femur of mice. The present results indicate that the optimal dosage of the TF fraction of HEP for the improvement of bone properti...
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PMID: 20815976
PDF is available here.
Abstract
Hepatic veno-occlusive disease (HVOD) is a clinical syndrome characterized as hepatomegaly, ascites, jaundice and elevation of hepatic enzymes as an outcome from fibrous obliteration of small centrilobular hepatic venules. It is recognized as a rare but life-threatening complication...
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PMID: 21830430
PDF is available here.
Abstract
To explore the effect of Bushen Huoxue Decoction (BHD) on the orphan receptor (Nurr1) and tyrosine hydroxylase (TH) in the brain of rats with Parkinson's disease (PD).
One hundred and twenty SD rats were divided into 100 in the model group and 20 in the normal control...
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PMID: 21258896
PDF is available here.
Abstract
A rapid, sensitive and selective liquid chromatography/tandem mass spectrometry method (LC-MS/MS) was developed and validated for simultaneous determination of albiflorin and paeoniflorin in rat plasma using geniposide as an internal standard. Plasma samples were extracted by solid-phase extraction....
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PMID: 21077251
PDF is available here.
Guangyan Yan,
Yinglan Zhao,
Pengchi Deng,
Lei Lv,
Yanli Wang,
Qian Bu,
Bin Liu,
Chunyan Hu,
Yanqiang Zhuo,
Xunning Yang,
Li Wang and
Xiaobo Cen
Abstract
These results collectively indicate that SHL injection has the potential to cause hemolytic anemia. Metabonomic analysis showed increases in serum lactate, choline and phosphocholine but a decrease in taurine in treated groups and these findings may underlie the toxicological mechanism of SHL inject...
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PMID: 20864460
PDF is available here.
Abstract
The conversional synthesis of taxoids by the BAC sequence from the C(19)-diterpenoid alkaloids, 14-acetyltalatisamine (1), yunaconitine (12), and 14-acetylchasmanine (19), was designed and explored. Two aconane-type diterpenes 17 and 28, the advanced intermediates for our conversional synthesis, wer...
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PMID: 21061219
PDF is available here.
Abstract
Two new compounds 1 and 2 have been isolated from the aerial parts of Urena lobata L. The structures of the two new compounds were established as ceplignan-4-O-β-d-glucoside (1) and 2,5-dihydroxy benzoic acid-7-(2,6-dimethyl-6-hydroxy-2,7-octadienoic acid) anhydride-5-O-β-d-apiofuranosyl(1 → 2...
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PMID: 21061218
PDF is available here.
Abstract
Two new lignan glycosides, 2'-hydroxyl asarinin 2'-O-β-D-glucopyranoside (cuscutoside C, 1) and 2'-hydroxyl asarinin 2'-O-β-D-apiofuranosyl-(1 → 2)-[β-D-glucopyranosyl-(1 → 6)]-β-D-glucopyranoside (cuscutoside D, 2), were isolated from the seeds of Cuscuta chinensis Lam., along with six...
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PMID: 21061214
PDF is available here.
Abstract
A new lycopodane-type Lycopodium alkaloid, 6α-hydroxy-5,15-oxide-lycopodane (1), and seven known alkaloids were isolated from the whole plants of Huperzia serrata. Their structures were elucidated by means of spectroscopic methods. 12-Deoxyhuperzine O (2) was reported as a naturally occurring alkal...
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PMID: 21061224
PDF is available here.
Abstract
An investigation of the n-BuOH-soluble fraction from the aerial parts of Artemisia frigida has led to the isolation of two new flavonoid glycosides, named friginoside A and friginoside B. Their structures were characterized as 5,7-dihydroxy-3',4',5'-trimethoxy flavone 7-O-β-d-glucuronide (1) and 5,...
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PMID: 21061216
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Abstract
We present a case of a woman, who developed a mixed cholestatic/hepatocellular liver injury due to herbal products. Firstly, she was admitted to Division of Surgery for right upper abdominal pain and jaundice and, for the suspect of biliary obstruction, she underwent to cholecystectomy. For persiste...
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PMID: 21222373
PDF is available here.
Abstract
We determined the effect of Radix Salviae Miltiorrhizae (Danshen) injection on apoptosis and NF-κB P65 protein expression in the intestinal mucosa of rats with SAP or OJ, and explored the protective mechanism of Danshen in their mucosa.
Sprague-Dawley rats were used in the SAP and OJ experiments. T...
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PMID: 20943465
PDF is available here.
Abstract
To evaluate the anti-proliferation and anti-angiogenesis effect of curcumin-K30 solid dispersion (Cur-K30) on tumors in vivo.
Growth inhibition rates of the tumor cells was measured with MTT method. Tumor inhibition was detected by tumors transplanted subcutaneously i...
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PMID: 21051827
PDF is available here.
Abstract
To investigate the effect of Qingre Quyu Granule (清热祛瘀颗粒, QRQYG) on stabilizing vulnerable plaques in apolipoprotein E (ApoE) deficient mice.
Seventy-two male ApoE deficient mice were given a high-fat diet from 6 weeks of age. At the 16th week, all the mic...
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PMID: 20872119
PDF is available here.
Abstract
An ultra performance liquid chromatography tandem TOF mass spectrometric (UPLC-DAD-TOF-MS) fingerprinting method was developed for the quality control and source discrimination of Cortex magnoliae officinalis produced in Zhejiang Province (Wen-Hou-Po). Twelve samples of Wen-Hou-Po collected from two...
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PMID: 21121263
PDF is available here.
Abstract
We believe that metabonomic approach is helpful to further understanding and clinical diagnosis of traditional Chinese medicine (TCM) induced nephrotoxicity.
Copyright (c) 2010 Elsevier Ltd. All rights reserved....
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PMID: 20678537
PDF is available here.
Abstract
To objectively evaluate the clinical effect of acupoint injection therapy for chronic gastritis of gastric blood stasis type.
One hundred and two cases arranged by registration order were randomly divided into an acupoint injection group and a medicine group, 51 cases in each group. The acupoint inj...
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PMID: 21058475
PDF is available here.
Abstract
To develop a RP-HPLC method for the simultaneous determination of five components including ligustrazine, ferulic acid, butylphthalide, ligustilide and butene-NBP in Rhizoma Chuanxiong, a Chinese herbal medicine.
The chromatographic analysis was carried out by using a grace smart RP C18 column with...
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PMID: 21246821
PDF is available here.
Abstract
To develop a reversed-phase high performance liquid chromatographic method (RP-HPLC) for the simultaneous analysis of nine isoflavonoids in Huangqi Gegen decoction.
HPLC determination was performed on a Kromasil C18 column(4.6 mm x 250 mm, 5 microm) and detected at 250 nm. The mobile phase was consi...
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PMID: 21246819
PDF is available here.
Abstract
To unveil the mechanism of sleep-improving effect of lyophilized powder of Sini powder on drosophila.
Drosophila melanogaster whose strain were wild Canton S, unmated, were collected daring 12 h after their emergencing, then they were anaesthetized by small flow of CO2 and divided into different tub...
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PMID: 21246833
PDF is available here.
Abstract
To investigate the objectivity and authenticity of the difference of the Cold and Hot nature between Mahuang decoction and Maxingshigan decoction based on the cold/hot plate differentiating assay.
The measuring time and dosage of Mahuang decoction and Maxingshigan decoction were investigated before...
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PMID: 21246831
PDF is available here.
Abstract
Cordyceps sinensis is a medicinal fungus of Traditional Chinese Medicine. There are a wide range of reported uses of Cordycep sinensis in the literature. However, the production of Cordyceps sinensis is so limited that can not be widely used. Cultured Cordyceps sinensis (Bailing Capsule) and natural...
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PMID: 21246839
PDF is available here.
Abstract
To determine the fungal populations in seven ochratoxin A contaminated root herbs in Jiangxi province, and investigate the mycoflora associated with mycotoxin contamination in the root herbs.
Single spore isolation was used to obtain the strains from root herb's surface. Fungi were identified accord...
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PMID: 21246810
PDF is available here.
Abstract
We searched potential AChE inhibitors from flavonoids, a group of naturally occurring compounds in plants or traditional Chinese medicines (TCM). Twenty-one flavonoids, covered different subclasses, were tested for their potential function in inhibiting AChE activity from the brain in vitro. Among a...
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PMID: 20452337
PDF is available here.
Abstract
These results demonstrate that HSE exerts anti-inflammatory effects by inhibiting both TNF-alpha-NO and cyclooxygenase II-PGE(2) pathways....
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PMID: 20706037
PDF is available here.
Abstract
With bioassay-guided fractionation, five new polyprenylated benzoylphloroglucinol derivatives, garcimultiflorone D (1), 18-hydroxygarcimultiflorone D (2), garcimultiflorone E (3), garcimultiflorone F (4), and isogarcimultiflorone F (5), and five known compounds, guttiferone E (6), guttiferone F (7),...
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PMID: 20681570
PDF is available here.
Abstract
Twenty-one highly oxygenated nortriterpenoids with a schisanartane skeleton were isolated from the stems of Schisandra propinqua var. propinqua. These nortriterpenoids featured a polycyclic framework composed of 7/8/5 consecutive carbocycles, which were organized by similar 5/5/7/5/7/5 rings A-F and...
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PMID: 20681569
PDF is available here.
Abstract
Three new flavonoids, oxytropisoflavans A (1) and B (2) and (6aR,11aR)-3,8-dihydroxy-9,10-dimethoxypterocarpan (3), together with 30 known flavonoids (4-33), were isolated from the aerial parts and roots of Oxytropis falcata. The absolute configurations of 3 and C-3 in 1 and 2 were deduced by circul...
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PMID: 20684529
PDF is available here.
Abstract
Eight new limonoids with four different structural frameworks, including gedunin (1, 2), havanensin (3, 4), mexicanolide (5, 6), and methyl angolensate types (7, 8), together with six known limonoids, were isolated from the leaves of Cipadessa baccifera. Compounds 2 and 5 exhibited moderate cytotoxi...
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PMID: 20666364
PDF is available here.
Abstract
Eight novel tirucallane-type alkaloids (1-8) and 11 known compounds were isolated from a methanol extract of the bark of Dysoxylum laxiracemosum. The structures of 1-8 were elucidated using extensive NMR spectrometric and mass spectroscopic methods. Compounds 1 and 5, named laxiracemosins A and E, s...
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PMID: 20669932
PDF is available here.
Abstract
Two new dimeric xanthone O-glycosides, puniceasides A (1) and B (2), a new trimeric O-glycoside, puniceaside C (3), and two new trimeric C-glycosides, puniceasides D (4) and E (5), together with 12 known xanthones were isolated from the entire plant of Swertia punicea. The structures of 1-5 were det...
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PMID: 20677781
PDF is available here.
Abstract
Two new iridoid glucosides, named diffusosides A and B, were isolated from the aerial part of Hedyotis diffusa Willd. Their structures were elucidated by 1D-, 2D-NMR spectroscopic analysis and HRESIMS. These two compounds showed no cytotoxic activity against SMMC-7721, SW480, SW620, Bel7402, and Hep...
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PMID: 20080156
PDF is available here.
Abstract
The seed of Cassia obtusifolia Linn have yielded three new compounds, 2-benzyl-4,6-dihydroxy benzoic acid (1), 2-benzyl-4,6-dihydroxy benzoic acid-6-O-beta-D-glucopyranoside (2) and 2-benzyl-4,6-dihydroxy benzoic acid-4-O-beta-D-glucopyranoside (3). Their structures were determined by spectroscopic...
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PMID: 20211226
PDF is available here.
Abstract
Two secolignan glycoside isomers, urticaside A (1) and urticaside B (2), were isolated from the roots of Urtica triangularis Hand.-Mazz. Their structures were elucidated by means of spectral analyses including 1D, 2D NMR and HR-EI-MS.
Copyright (c) 2010 Elsevier B.V. All rights reserved.
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PMID: 20211227
PDF is available here.
Abstract
The traditional Chinese medicine formula Fuling Decoction (FD) has been clinically used for eczema treatment, but the unclear chemical distribution and the lack of quality control have strongly restricted its application. In this study, an analytical method incorporating ultra-fast liquid chromatogr...
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PMID: 20362035
PDF is available here.
Abstract
Phytochemical study on the ethanol extract of the rhizomes of Curculigo breviscapa led to the isolation of two new norlignans, breviscapin C (1) and breviscaside B (2), together with six known norlignans, curcapital (3), capituloside (4), pilosidine (5), curcapitoside (6), crassifoside H (7), and cr...
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PMID: 20079812
PDF is available here.
Abstract
Although the quinolizidine alkaloids and flavonoids, the main active components of the traditional Chinese medicine Sophora flavescens, have been largely investigated, a new matrine alkaloid derivative 9alpha-hydroxy-7,11-dehydromatrine (1) and a rare 1,4-diazaindan-type alkaloid flavascensine (17),...
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PMID: 20079811
PDF is available here.
Abstract
Two new bufadienolides, named tigencaoside A(1) and tigencaoside B(2), were isolated from the rhizomes of Helleborus thibetanus Franch., along with two known bufadienolides, hellebrigenin (3) and 5beta,14beta-dihydroxy-19-oxo-3beta-[(alpha-L-rhamnopyranosyl)oxy]bufa-20,22-dienolide (4). Their struct...
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PMID: 20230875
PDF is available here.
Abstract
A sensitive and specific HPLC method was developed to analyze baicalin in rat plasma. The author had compared the pharmacokinetics of baicalin after oral administration of HLJDT decoction or pure baicalin in MCAO and sham-operated rats. All the rats were divided into two groups, MCAO and sham-operat...
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PMID: 20093170
PDF is available here.
Abstract
We investigated the in-vitro and in-vivo anticancer effects of evodiamine on human colon lovo cells and their potential mechanisms. The 3-(4, 5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide assay showed that the in-vitro proliferation of lovo cells was inhibited by evodiamine of various con...
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PMID: 20647931
PDF is available here.
Abstract
Tissue engineering is a promising area with a broad range of applications in the fields of regenerative medicine and human health. The emergence of periodontal tissue engineering for clinical treatment of periodontal disease has opened a new therapeutic avenue. The choice of scaffold is crucial. Thi...
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PMID: 21125792
PDF is available here.
Abstract
Human skeletal stem cells (STRO-1 positive/STRO-1+) respond to different topographical features in various ways. On a flat surface these cells spread and tend to develop a fibroblast-like morphology. On a microgrooved surface enriched skeletal stem cell populations prefer to stretch...
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PMID: 20302977
PDF is available here.
Abstract
To study the basic prescriptions of drugs and points for point application in summer to treat the diseases with attacks in winter and the law governing their compatibility.
A database was set up by collecting and sorting out the relevant literature, and the analysis was made with the complex network...
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PMID: 21053623
PDF is available here.
Abstract
To observe the effects of Bushenyiqihexue Formula (Formula for Tonifying the Kidney, Replenishing qi and Harmonizing Blood, FTKRQHB) on the endometrial gland apoptosis in the mice with blastocyst implantation dysfunction.
The mice with the first-day pregnancy were divided into the control, model and...
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PMID: 21053626
PDF is available here.
Abstract
To assess the therapeutic effect and adverse reaction of Qufeng Zhidong Recipe (a recipe for dispelling wind to stop abnormal movement) used to treat children with tic disorder (TD).
The enrolled patients were randomized into a TCM group (31 cases) treated with Qufeng Zhidong Recipe and a Western me...
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PMID: 21053620
PDF is available here.
Abstract
To observe the effect of Yinian Jiangya Yin (Decoction for lowering blood pressure to prolong life) on patients with early hypertension and its mechanism on the function of vascular endotheliocytes.
The 79 patients with early primary hypertension belonging to the TCM syndrome of stagnation of phlegm...
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PMID: 21053621
PDF is available here.
Abstract
To observe the effects of Bushen Huoxue Formula (Formula for reinforcing the kidney and activating blood circulation) on the learning and memory function and the cerebral neurotransmitters in diabetic mice.
Forty ICR mice were randomized into the normal control group, model group, Nimotop group and...
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PMID: 21053627
PDF is available here.
Abstract
It is reported that Houttuynia cordata Thunb. (HCT), a traditional Chinese herbal medicine, has many biological properties such as antiviral, antibacterial and antileukemic activities. However, the molecular mechanisms of cytotoxicity and apoptosis in human primary colorectal cancer cells are not cl...
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PMID: 20944136
PDF is available here.