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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Drugs, Investigational (0):
Recent article
Drugs, Investigational
Abstract
Using market exclusivity to promote pharmaceutical innovation can lead to positive outcomes, but the practice is also characterized by waste and collateral effects. Certain practices, such as mechanisms for reevaluation and closer ties of incentives programs to public health outcomes, can help addre...
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PMID: 21933276
PDF is available here.
PDF is available here.
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Oncotarget (2)6 2011
Abstract
Despite recent advances in the field, the treatment of patients with acute myeloid leukemia (AML) remains challenging and difficult. Although chemotherapeutic agents induce remissions in a large number of patients, many of them eventually relapse and die. A major goal for the develop...
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PMID: 21680954
PDF is available here.
PDF is available here.
Seminars in Oncology (38) 2011
Abstract
Many cytotoxic therapies are available for patients with metastatic breast cancer, but response rates are low and acquired or de novo resistance is virtually universal. Among the agents that are used in the treatment of pretreated metastatic breast cancer are vinorelbine, gemcitabine...
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PMID: 21600380
PDF is available here.
PDF is available here.
Seminars in Oncology (38) 2011
Abstract
Tumor resistance remains a major clinical challenge. Numerous pathways are under investigation to determine how best to target therapies to specific mutations in tumor biology and circumvent resistance. Agents in development include inhibitors of the poly(adenosine diphosphate [ADP]-...
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PMID: 21600381
PDF is available here.
PDF is available here.
Abstract
Abstract
We discuss the pharmacology of new parenteral anticoagulants, the results of clinical studies, the newly planned or ongoing clinical trials with these compounds, and their potential advantages and drawbacks over existing therapies....
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PMID: 21045018
PDF is available here.
PDF is available here.
Abstract
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) may be involved in several abnormalities associated with the metabolic syndrome. This study evaluated the antihypertensive efficacy and safety of two 11β-HSD1 inhibitors, MK-0736 and MK-0916, in overweight-to-obese hypertensive pa...
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PMID: 21419745
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)2 2011
Abstract
We provide an up-to-date synopsis of BCR-ABL signaling pathways, highlight new findings on mechanisms underlying BCR-ABL mutation acquisition and disease progression, discuss the use of nilotinib and dasatinib in a first-line capacity, and evaluate ponatinib, DCC-2036, and other ABL kinase inhibitor...
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PMID: 21098337
PDF is available here.
PDF is available here.
Abstract
The European Respiratory Society Congress, held in Barcelona, included topics covering new therapeutic developments in the field of respiratory health and disease. This conference report highlights selected presentations on therapies targeting inflammatory cells, with a focus on therapeutic agents f...
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PMID: 21046521
PDF is available here.
PDF is available here.
Abstract
The Japan Biotech Forum, held in London, included topics covering new licensing developments in the Japanese pharma and biotech industries. This conference report highlights selected presentations on licensing opportunities from several Japanese companies, including CanBas, LivTech, REGiMMUNE, D Wes...
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PMID: 21046519
PDF is available here.
PDF is available here.
Abstract
The 50th annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), held in Boston, included topics covering new therapeutic developments in the field of infectious disease. This conference report highlights selected presentations on research with novel antimicrobial agents. In...
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PMID: 21046516
PDF is available here.
PDF is available here.
Abstract
The 50th annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), held in Boston, included topics covering new therapeutic developments in the field of infectious disease. This conference report highlights selected presentations on research with novel antimicrobial agents. In...
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PMID: 21046515
PDF is available here.
PDF is available here.
Abstract
The Metastasis and the Tumor Microenvironment Conference, held in Philadelphia, included topics covering new research developments in the field of metastasis and tumor microenvironment. This conference report highlights selected presentations on translation targets from a clinical perspective, antib...
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PMID: 21046523
PDF is available here.
PDF is available here.
Abstract
The XXIst International Symposium on Medicinal Chemistry from the European Federation of Medicinal Chemistry (EFMC-ISMC), held in Brussels, included topics covering new therapeutic developments in the field of medicinal research. This conference report highlights selected presentations on therapies...
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PMID: 21046517
PDF is available here.
PDF is available here.
Abstract
Southern Medical Journal (103)9 2010
Abstract
Androgenetic alopecia (AGA) is the most common form of hair loss in men, and female pattern hair loss (FPHL) is the most common form of hair loss in women. Traditional methods of treating hair loss have included minoxidil, finasteride, and surgical transplantation. Currently there is a myriad of new...
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PMID: 20689478
PDF is available here.
PDF is available here.
Abstract
Abstract
The scarcity of new innovative drugs in the development pipeline for combating HIV replication may signal a change in direction for HIV researchers and drug developers. The model of introducing drugs with incremental improvements within existing drug classes is no longer commercially...
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PMID: 21072979
PDF is available here.
PDF is available here.
Abstract
Since the middle of 1990s, the development of combinatorial chemistry along with the high throughput screening have led to some lack of interest for natural products from the pharmaceutical industry. Moreover, purification and optimization of natural compounds are very often difficult and animal exp...
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PMID: 20637355
PDF is available here.
PDF is available here.
Abstract
Abstract
We have seen an increasing trend of foreign data as part of clinical trial data submitted in new drug applications (NDA) to US Food and Drug Administration (FDA). To understand the design and analysis characteristics, we studied schizophrenia multi-regional clinical trials (MRCTs). The schizophrenia...
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PMID: 20872622
PDF is available here.
PDF is available here.
Current Drug Targets (11)7 2010
Abstract
FMS-Like-Tyrosine kinase-3 (FLT3) mutations are found in about 30% of cases of acute myeloid leukemia and confer an increased relapse rate and reduced overall survival. Targeting this tyrosine kinase by direction inhibition is the focus of both preclinical and clinical research in AML. Several molec...
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PMID: 20370649
PDF is available here.
PDF is available here.
Drug Discovery Today (15)13-14 2010
Abstract
Extracellular nucleotides, such as ATP and UTP, have distinct signaling roles through a class of G-protein-coupled receptors, termed P2Y. The receptor ligands are typically charged molecules of low bioavailability and stability in vivo. Recent progress in the development of selective agonists and an...
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PMID: 20594935
PDF is available here.
PDF is available here.
Abstract
Abstract
IMPORTANCE OF THE FIELD: Melatonin is a major chronobiological regulator involved in circadian phasing, sleep, and numerous other functions including cyto-/neuroprotection, immune modulation, and energy metabolism. The suitability of melatonin as a drug is limited because of its short half-life. The...
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PMID: 20408738
PDF is available here.
PDF is available here.
Abstract
We have made impressive advances in identifying the major cell populations and many biochemical mediators that can drive this process. As a result, novel therapeutics are being developed based upon these discoveries. AREAS COVERED IN THIS REVIEW: This review examines the experimental therapies curre...
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PMID: 20443753
PDF is available here.
PDF is available here.
MMW Fortschritte der Medizin (152)20 2010
Abstract
Abstract
Since the discovery of cis-platinum, many transition metal complexes have been synthesized and assayed for antineoplastic activity. In recent years, ruthenium-based molecules have emerged as promising antitumor and antimetastatic agents with potential uses in platinum-resistant tumors or as alternat...
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PMID: 20213076
PDF is available here.
PDF is available here.
American Journal of Health-System Pharmacy (67)suppl_5 2010
Abstract
PURPOSE: To compare and contrast the pharmacology, efficacy, and safety of new, emerging, and established antiarrhythmic and anticoagulant medications and describe nonpharmacologic interventions for the treatment of atrial fibrillation (AF). SUMMARY: Shortcomings of established antiarrhythmic agents...
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PMID: 20410533
PDF is available here.
PDF is available here.
American Journal of Health-System Pharmacy (67)suppl_5 2010
Abstract
Drug Discovery Today (15)9-10 2010
Abstract
We briefly review current understanding of the inflammatory mechanisms involved in the pathogenesis of COPD. This understanding has enabled the identification of several therapeutic targets that might have great potential for the development of novel anti-inflammatory and anti-remodeling biologic th...
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PMID: 20223295
PDF is available here.
PDF is available here.
Drug Discovery Today (15)9-10 2010
Abstract
I and phase II anticancer clinical trials with first-generation inhibitors, although sometimes disappointing, have yet to report a forbidding side-effect inherent to the inhibition of this chaperone, which has a very complex and widespread role in cell biochemistry. Research in the field has started...
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PMID: 20230904
PDF is available here.
PDF is available here.
Drug Discovery Today (15)9-10 2010
Abstract
Corticotropin releasing factor (CRF) receptor antagonists have been sought since the stress-secreted peptide was isolated in 1981. Although evidence is mixed concerning the efficacy of CRF(1) antagonists as antidepressants, CRF(1) antagonists might be novel pharmacotherapies for anxiety and addictio...
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PMID: 20206287
PDF is available here.
PDF is available here.
Drug Discovery Today (15)9-10 2010
Abstract
The unique properties of cancer- and metastasis-initiating cells endowed with a high self-renewal and aberrant differentiation potential (including their elevated expression levels of anti-apoptotic factors, multidrug transporters, and DNA repair and detoxifying enzymes) might be associated with the...
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PMID: 20338259
PDF is available here.
PDF is available here.
Abstract
We reviewed the IGF-1R pathway and its inhibitors. WHAT THE READER WILL GAIN: Approaches targeting IGF-1R include small-molecule IGF-1R tyrosine kinase inhibitors (TKIs), which are in preclinical and early clinical phases of development, and the mAbs, among which figitumumab is being investigated in...
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PMID: 20367288
PDF is available here.
PDF is available here.
Abstract
The 2010 American Academy of Allergy, Asthma and Immunology (AAAAI) meeting, held in New Orleans, included topics covering new therapeutic developments in the fields of allergy, asthma and immunological diseases. This conference report highlights selected presentations on potential treatments for fo...
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PMID: 20432184
PDF is available here.
PDF is available here.
Abstract
The Antibody Engineering & Design 2010 conference, held in Frankfurt, included topics covering new developments in the field of therapeutic antibodies. This conference report highlights selected presentations on 'fit for purpose' biologics, improving the pharmaceutical properties of antibodies, the...
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PMID: 20432182
PDF is available here.
PDF is available here.
Abstract
The American Chemical Society 239th National Meeting, held in San Francisco, included topics covering developments related to the chemical optimization of therapeutics. This conference report highlights selected presentations on agents under investigation for the treatment of neurological disorders,...
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PMID: 20432180
PDF is available here.
PDF is available here.
Abstract
The 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics, held in Atlanta, included topics covering disclosures of new data in the field of pharmacokinetics and drug interactions. This conference report highlights selected presentations on pharmacokinetic studies o...
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PMID: 20432179
PDF is available here.
PDF is available here.
Abstract
The 12th Annual Superbugs and Superdrugs conference, held in London, included topics covering new therapeutic developments in the field of antimicrobial research. This conference report highlights selected presentations on antimicrobial peptides, addressing bacterial resistance, and new treatments f...
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PMID: 20432187
PDF is available here.
PDF is available here.
Abstract
The American Chemical Society 239th National Meeting, held in San Francisco, included topics covering developments related to the chemical optimization of therapeutics. This conference report highlights selected presentations on second-generation cholesterol absorption inhibitors (CAIs), CCK2 recept...
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PMID: 20432181
PDF is available here.
PDF is available here.
Abstract
IMPORTANCE OF THE FIELD: Once prostate cancer becomes castration-resistant, bone metastases are a significant problem and treatment options are limited. As a result, there is a need for more effective therapies that have antitumor and anti-bone metastatic effects. Because Src and Src-family kinases...
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PMID: 20367532
PDF is available here.
PDF is available here.
Abstract
IMPORTANCE OF THE FIELD: The multikinase inhibitor sorafenib was the first agent to demonstrate a survival benefit for patients with locally advanced or metastatic hepatocellular carcinoma (HCC). Although sorafenib represents a landmark in the treatment of HCC and proved molecularly targeted therapy...
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PMID: 20374038
PDF is available here.
PDF is available here.
Abstract
We also comment on potential compounds such as resveratrol and melatonin. Despite the lack of information from clinical trials on these two compounds, they are attracting considerable attention because of their natural origin and antioxidant and antiapoptotic action. Furthermore, they do not show to...
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PMID: 20402598
PDF is available here.
PDF is available here.
Seminars in Hematology (47 Suppl 1) 2010
Abstract
I (HTLV-1). The investigators in Japan have conducted several clinical trials on multi-agent chemotherapy and stem cell transplantation for patients with ATL. They have also initiated several new clinical trials with a number of agents: an anti-CCR4 antibody, KW-0761; forodesine, a purine nucleoside...
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PMID: 20359583
PDF is available here.
PDF is available here.
Seminars in Hematology (47 Suppl 1) 2010
Abstract
Though peripheral T-cell lymphoma (PTCL) is an area of significant unmet therapeutic need, a number of new treatment options are available for patients, especially those with relapsed or refractory disease. A plethora of drugs are now in development for PTCL, but drugs that truly target novel diseas...
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PMID: 20359580
PDF is available here.
PDF is available here.
Abstract
We recommend formally integrating the planning time for scenario analyses and to incentivize optimal designs (e.g., designs offering the highest information value per resource unit invested). Regardless of the trial design ultimately chosen, quantitatively comparing alternative trial design options...
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PMID: 20338900
PDF is available here.
PDF is available here.
Abstract
We report the design, implementation, and outcome of an innovative Bayesian, response-adaptive, dose-ranging trial of an investigational drug in patients with diabetes, incorporating a dose expansion approach to flexibly address both efficacy and safety.
The design was developed to a...
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PMID: 20338905
PDF is available here.
PDF is available here.
Abstract
Abstract
This article aims to review hepatitis B and C and influenza infections and to summarise the main characteristics of the antiviral drugs available to treat those infections in adults. The review of each drug focuses on dosage depending on treatment indication, dosage adjustment in renal or hepatic im...
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PMID: 20395018
PDF is available here.
PDF is available here.
Abstract
Recent advances in understanding the biologic mechanisms underlying cancer development have driven the design of new therapeutic approaches, termed 'targeted therapies', that selectively interfere with molecules or pathways involved in tumor growth and progression. Inactivation of growth factors and...
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PMID: 20199123
PDF is available here.
PDF is available here.
Abstract
CDC announces the availability of a new heptavalent botulinum antitoxin (HBAT, Cangene Corporation) through a CDC-sponsored Food and Drug Administration (FDA) Investigational New Drug (IND) protocol. HBAT replaces a licensed bivalent botulinum antitoxin AB and an investigational monovalent botulinum...
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PMID: 20300057
PDF is available here.
PDF is available here.
Abstract
We present the legacy of Lehman and colleagues in the context of past and present oncology drug development practices and focus on some of the current issues at the center of an evolving harmonization process that will generate a new safety guidance for oncology drugs, ICH S9. The purpose of this ne...
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PMID: 20045015
PDF is available here.
PDF is available here.
Abstract
Pharmacotherapy (30)3 2010
Abstract
We conducted a MEDLINE search restricted to English-language articles citing cethromycin or ABT-773 (its original designation) from 1990-May 2009. Additional data sources were identified from the references of selected articles. All published trials and available poster data citing cethromycin were...
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PMID: 20180612
PDF is available here.
PDF is available here.
Abstract
IMPORTANCE OF THE FIELD: Despite the improvement in survival of systemic lupus erythematosus (SLE), a cure for this chronic and disabling disease is still a myth. Refractory manifestations and treatment-related complications are still major causes for mortality and morbidity. More effective but less...
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PMID: 20148712
PDF is available here.
PDF is available here.
Abstract
We expect that more pathophysiology-based treatments, capable of curing and/or preventing narcolepsy and related diseases, will be available in near future. As cases of EDS, associated with other neurological conditions (i.e., symptomatic narcolepsy or narcolepsy due to medical conditions), are ofte...
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PMID: 20166851
PDF is available here.
PDF is available here.
Abstract
IMPORTANCE OF THE FIELD: Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death worldwide. Although patients with early-stage disease have a good prognosis, there has been no effective therapy available for those with advanced disease. Despite the death risk of patient...
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PMID: 20128706
PDF is available here.
PDF is available here.
Abstract
IMPORTANCE OF THE FIELD: The endothelin (ET) axis, which includes the biological functions of ETs and their receptors, has played a physiological role in normal tissue, acting as a modulator of vasomotor tone, tissue differentiation and development, cell proliferation and hormone production. Interes...
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PMID: 20102289
PDF is available here.
PDF is available here.