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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Placebos (0):
Recent article
Placebos
New England Journal of Medicine (365)13 2011
Abstract
We conducted a single-center, randomized, double-blind, placebo-controlled trial. Participants were randomly assigned to receive cytisine or matching placebo for 25 days; participants in both groups received a minimal amount of counseling during the study. The primary outcome measure was sustained,...
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PMID: 21991893
PDF is available here.
PDF is available here.
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Abstract
Abstract
Hepatic encephalopathy (HE) is a common and serious complication of liver disease. Minimal HE has major impact on all aspects of a patient's life. The aim of this study was to asses the efficacy of probiotics in minimal hepatic encephalopathy in patients with cirrhosis of the liver.
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PMID: 21922877
PDF is available here.
PDF is available here.
Abstract
Our objectives were to: (1) characterize the response of serum 24,25VD(3) to vitamin D(3) (VD(3)) supplementation; (2) test the hypothesis that a higher 24,25VD(3) to 25VD(3) ratio (24,25:25VD(3)) predicts 25VD(3) response. Serum samples (n=160) from wk 2 and wk 6 of a placebo-controlled, randomized...
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PMID: 21605672
PDF is available here.
PDF is available here.
Abstract
In all subjects, SJW had no effect on the total area under the plasma concentration-time curve from time zero to infinity (AUC(∞)), the peak plasma concentration (C(max)) or the elimination half-life (t(frac12;)) of repaglinide. In addition, SJW had no significant effect on the blood glucose-lower...
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PMID: 21827215
PDF is available here.
PDF is available here.
Abstract
Our 3-month study in nondiabetic hypertensive patients showed a decrease in biomarkers of IR and chronic systemic inflammation with the PIO monotherapy and the PIRA combination only, which may help to explain some findings in other cardiovascular outcome trials.
© 2011 Diabetes Tech...
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PMID: 21880242
PDF is available here.
PDF is available here.
Abstract
Our 3-month study in nondiabetic hypertensive patients showed a decrease in biomarkers of IR and chronic systemic inflammation with the PIO monotherapy and the PIRA combination only, which may help to explain some findings in other cardiovascular outcome trials.
© 2011 Diabetes Tech...
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PMID: 21880242
PDF is available here.
PDF is available here.
Abstract
We undertook a double-blinded randomized controlled trial to examine the effectiveness of fish oil supplementation on the incidence of postsurgical AF after CABG and valve procedures. The primary end point was incidence of AF in the first 6 days after surgery. Two hundred patients were randomized to...
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PMID: 21762871
PDF is available here.
PDF is available here.
Abstract
We therefore also review dropout models that are used in the development of models for treatment effects and in the optimization of clinical trials by simulation approaches. The use of an appropriate modelling strategy that is capable of identifying the potential sources of variable placebo response...
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PMID: 21651312
PDF is available here.
PDF is available here.
Revue medicale suisse (7)301 2011
Abstract
Over the past twenty years, neuroscience has changed our understanding of placebo analgesia. Often perceived by researchers as a response bias adding noise to the assessment of efficacy, in the patients' view, it is associated with charlatanism. The origin of the word, qualifying a p...
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PMID: 21815494
PDF is available here.
PDF is available here.
Abstract
We performed this study to evaluate the hemostatic efficacy of the FAST Dressing in treating a grade V liver injury in noncoagulopathic swine.
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PMID: 21817977
PDF is available here.
PDF is available here.
Abstract
Acute ST-segment elevation myocardial infarction (STEMI) is a leading cause of morbidity and mortality. In experimental models of MI, erythropoietin reduces infarct size and improves left ventricular (LV) function.
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PMID: 21558517
PDF is available here.
PDF is available here.
Abstract
Military Medicine (176)5 2011
Abstract
To investigate the effects of 6 weeks of quercetin supplementation on energy, fatigue, and sleep quality in young persons conducting military physical training.
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PMID: 21634303
PDF is available here.
PDF is available here.
Abstract
Creative experimental efforts are needed to assess rigorously the clinical significance of placebo interventions and investigate the component elements that may contribute to the therapeutic benefit.
Copyright © 2011 Elsevier Inc. All rights reserved....
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PMID: 21524568
PDF is available here.
PDF is available here.
Abstract
Estimates adjusted for publication biases made independently for each drug were very uncertain using both the journal and FDA data. Adjusted estimates were much more precise when borrowing strength across meta-analyses. Reassuringly, adjustments in this way made to the journal data agreed closely wi...
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PMID: 21530169
PDF is available here.
PDF is available here.
Abstract
Outstanding progress regarding the pathophysiology of Crohn's disease (CD) has led to the development of innovative therapeutic concepts. Numerous controlled trials have been performed in CD. This review concentrates on the results of randomized, placebo-controlled trials, and meta-analyses when avai...
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PMID: 21528051
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
The purpose of this study was to examine the effects of a 6-wk intervention that used guided relaxation and exercise imagery (GREI) to increase self-reported leisure-time exercise behavior among older adults. A total of 93 community-dwelling healthy older adults (age 70.38 ± 8.15 yr, 66 female) were...
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PMID: 21558568
PDF is available here.
PDF is available here.
Acta Cardiologica (66)2 2011
Abstract
Early clinical studies have suggested that administration of granulocyte-colony stimulating factor (G-CSF) may improve the clinical condition of patients suffering from myocardial infarction (MI).This prospective, randomized, double-blind, placebo-controlled single-centre trial aims to assess the saf...
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PMID: 21591581
PDF is available here.
PDF is available here.
Clinical Nephrology (75)4 2011
Abstract
The purpose of this study was to examine the efficacy of sodium 2-mercaptoethanesulfonate (MESNA), a reactive oxygen scavenger, in at-risk patients given radiographic contrast agents. Contrast-induced nephropathy (CIN) is a common complication of radiographic procedures; reactive oxygen species (ROS)...
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PMID: 21426884
PDF is available here.
PDF is available here.
Abstract
Greater exposure to retinol (vitamin A) may prevent prostate cancer, although under some conditions it could promote cell growth and de-differentiation. The authors prospectively examined prostate cancer risk and serum retinol levels, measured by using high-performance liquid chromatography, at basel...
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PMID: 21389041
PDF is available here.
PDF is available here.
Abstract
The medical community lacks results from prospective controlled multicenter studies of the diagnostic efficacy of 5-aminolevulinic acid (5-ALA) cystoscopy on tumor recurrence in patients with superficial bladder tumors.
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PMID: 21351082
PDF is available here.
PDF is available here.
Abstract
We performed a retrospective review of patients undergoing vertebroplasties and those patients who were referred for but did not receive vertebroplasties before and after the recently published placebo-controlled vertebroplasty trials....
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PMID: 21349971
PDF is available here.
PDF is available here.
Abstract
Our post hoc analysis assessed the baseline BP influence on the antiproteinuric effect in the Aliskiren in the Evaluation of Proteinuria in Diabetes (AVOID) study. Design, setting, participants, & measurements In the AVOID study, 599 hypertensive type 2 diabetic patients with nephropathy received 6...
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PMID: 21350110
PDF is available here.
PDF is available here.
Oral Oncology (47)2 2011
Abstract
The objective of this study was to assess the efficacy of a novel visible-light therapy (VLT) device for the prevention of oral mucositis in hematopoietic stem cell transplantation (HSCT) patients. A VLT-device suitable for intra-oral use was applied to 20 patients undergoing HSCT. The study design...
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PMID: 21163686
PDF is available here.
PDF is available here.
Abstract
Our findings indicate that in patients with hemorrhagic stroke, early anticoagulation is associated with a significant reduction in PE, a non significant reduction in mortality, with the trade-off of a non significant increase in hematoma enlargement. These results must be taken with caution and s...
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PMID: 21324058
PDF is available here.
PDF is available here.
Abstract
This was a prospective, randomised, placebo-controlled, double-blind multicentre trial to analyse the efficacy of choline citrate in patients with postoperative ileus (POI) after elective colorectal surgery.
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PMID: 21234579
PDF is available here.
PDF is available here.
Abstract
To investigate the relationship between low-dose aspirin-induced small bowel mucosal damage and blood flow, and the effect of rebamipide.
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PMID: 21245996
PDF is available here.
PDF is available here.
Abstract
The BEAUTIFUL Holter substudy explored the cardiac safety of the I(f) inhibitor ivabradine in patients with stable coronary artery disease and left ventricular systolic dysfunction receiving optimal background therapy. The Holter substudy included 840 patients (ivabradine 5 or 7.5 mg/day, n = 421; pl...
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PMID: 21247517
PDF is available here.
PDF is available here.
Abstract
CC chemokine receptor 2 (CCR2), expressed on the surface of circulating monocytes, and its ligand monocyte chemoattractant protein-1 (MCP-1; also known as CC-chemokine ligand 2) are present in atherosclerotic plaques and may have important roles in endothelial monocyte recruitment and activation. MLN...
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PMID: 21247529
PDF is available here.
PDF is available here.
Journal of Rheumatology (38)4 2011
Abstract
To determine the benefits and harm of surgery for shoulder osteoarthritis (OA).
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PMID: 21239751
PDF is available here.
PDF is available here.
Abstract
Clinical Cancer Research (17)5 2011
Abstract
Increased growth factor signaling may contribute to tamoxifen resistance. This randomized phase II trial assessed tamoxifen plus placebo or the epidermal growth factor receptor inhibitor gefitinib in estrogen receptor (ER)-positive metastatic breast cancer.
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PMID: 21220480
PDF is available here.
PDF is available here.
Abstract
This pharmacokinetic (PK) study was designed to investigate the maximum intranasal insulin dose that could be achieved by repeated doses in a single nostril of a nasal spray of recombinant regular human insulin 1% in combination with cyclopentadecalactone (CPE-215) 2%, a compound tha...
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PMID: 21303633
PDF is available here.
PDF is available here.
Abstract
We tested, in a pilot study, whether rosiglitazone (ROSI) restores normal glucose tolerance (NGT) in obese adolescents with IGT by improving insulin sensitivity and β-cell function. In a small randomized, double-blind, placebo (PLA)-controlled study, lasting 4 months, 21 obese adolescents with IGT...
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PMID: 20467418
PDF is available here.
PDF is available here.
Abstract
We investigated the impact of systemically applied neurotrophin-3 (NT-3) on long-term hearing loss and the survival of neurons....
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PMID: 21261959
PDF is available here.
PDF is available here.
Abstract
Previous studies have shown that in areas of seasonal malaria transmission, intermittent preventive treatment of malaria in children (IPTc), targeting the transmission season, reduces the incidence of clinical malaria. However, these studies were conducted in communities with low coverage with insect...
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PMID: 21304923
PDF is available here.
PDF is available here.
Abstract
This study needs to be reproduced and adapted. It nevertheless opens new perspectives for patients with PWS and perhaps other syndromes with behavioural disturbances and obesity. Trial registration: NCT01038570....
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PMID: 21702900
PDF is available here.
PDF is available here.
Journal of Urology (185)1 2011
Abstract
Abstract
Our group recently reported a reduction of infarct size by chloramphenicol treatment in a porcine in vivo model of acute MI, through a mechanism involving the induction of autophagy. Since 2005 several studies have implicated autophagy as a target for cardioprotection....
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PMID: 21187717
PDF is available here.
PDF is available here.
AIDS Alert (25)12 2010
Abstract
Abstract
Tranexamic acid can reduce bleeding in patients undergoing elective surgery. We assessed the effects of early administration of a short course of tranexamic acid on death, vascular occlusive events, and the receipt of blood transfusion in trauma patients.
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PMID: 21702233
PDF is available here.
PDF is available here.
Abstract
Some HIV protease inhibitors (PIs), including full-dose ritonavir (800 mg) and ritonavir-boosted lopinavir, acutely induce insulin resistance in the absence of HIV infection and changes in body composition. Boosting dose ritonavir (100-200 mg) is the most commonly prescribed PI, yet...
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PMID: 20595906
PDF is available here.
PDF is available here.
Abstract
: Bevacizumab is approved in combination with chemotherapy as first-line treatment for non-small cell lung cancer (NSCLC). Preclinical data suggest that enzastaurin and bevacizumab may have complementary effects in inhibiting angiogenesis.
: Eligibility criteria: ≥1...
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PMID: 20881647
PDF is available here.
PDF is available here.
Cancer Science (101)11 2010
Abstract
We conducted a multicenter, phase II, placebo-controlled, double-blind, randomized study in Japanese cancer patients who received cancer chemotherapy including cisplatin (≥70mg/m(2) ). Aprepitant was administered for 5days. A total of 453 patients were enrolled. In the three study groups, (i) stan...
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PMID: 20718754
PDF is available here.
PDF is available here.
Abstract
The Health Outcomes and Reduced Incidence with Zoledronic Acid Once Yearly-Pivotal Fracture Trial found one case of osteonecrosis of the jaw (ONJ) in a patient with postmenopausal osteoporosis (OP) treated with 5 milligrams of zoledronic acid (ZOL) once yearly and one case in a patient receiving a pl...
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PMID: 21037195
PDF is available here.
PDF is available here.
Abstract
Abstract
We compared the employment status among treatment responders, treatment nonresponders, and placebo groups of patients enrolled in MSH during the clinical trial and follow-up periods. Treatment with hydroxyurea did not significantly (p > .05) affect employment status, but there was a trend for more c...
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PMID: 21141286
PDF is available here.
PDF is available here.
Journal of Hypertension (28)11 2010
Abstract
To compare the efficacy and safety of the angiotensin II antagonist olmesartan medoxomil (O) and the ACE inhibitor ramipril (R) in elderly patients with essential arterial hypertension.
After a 2-week placebo wash-out 1102 treated or untreated elderly hypertensive patients aged 65-89 years (office s...
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PMID: 20829713
PDF is available here.
PDF is available here.
Ugeskrift for laeger (172)42 2010
Abstract
In aspirin-treated patients with acute coronary syndromes without ST-segment elevation unfractionated heparin (UFH) or low molecular weight heparin (LMWH) treatment < 7 days significantly reduce the risk of acute myocardial infarction (AMI), and LMWH furthermore reduces revascularisation. There is a...
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PMID: 21040659
PDF is available here.
PDF is available here.
Journal of Rheumatology (37)12 2010
Abstract
To develop a recommended measure of response for use in psoriatic arthritis (PsA) clinical trials and observational cohort studies reflecting joint involvement.
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PMID: 20952468
PDF is available here.
PDF is available here.
Abstract
Limitations of existing pharmacological treatments for opioid dependence include low adherence, medication diversion, and emergence of withdrawal symptoms.
To determine the efficacy of buprenorphine implants that provide a low, steady level of buprenorphine over 6 months for the treatment of opioid...
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PMID: 20940383
PDF is available here.
PDF is available here.
Abstract
We investigated the efficacy and safety of AIN457, a human antibody to IL-17A, in patients with psoriasis, rheumatoid arthritis, and chronic noninfectious uveitis. Patients with chronic plaque-type psoriasis (n = 36), rheumatoid arthritis (n = 52), or chronic noninfectious uveitis (n = 16) were enro...
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PMID: 20926833
PDF is available here.
PDF is available here.
Abstract
These results demonstrate that NP inhalations produce rapid increases in plasma nicotine concentrations, provide satisfaction and are well tolerated. At the 20 μg/puff dose, peak nicotine concentrations were higher than with the Nicotrol/Nicorette nicotine vapor inhaler cartridge. Further trials of...
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PMID: 20939642
PDF is available here.
PDF is available here.
Family medicine (42)9 2010
Abstract
We mailed a 22-question, confidential survey about placebo use and beliefs to a random sample of 1,000 members of the American Academy of Family Physicians.
A total of 412 of 970 (43%) eligible physicians responded, and 56% of respondents said they had used a placebo in clinical practice. Forty perc...
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PMID: 20927672
PDF is available here.
PDF is available here.
Abstract
Obese European adolescents' insulin sensitivity improved without weight change during placebo or metformin intervention in addition to lifestyle intervention. Most differences did not reach statistical significance, probably due to improved compliance with lifestyle intervention as a placebo effect....
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PMID: 20639355
PDF is available here.
PDF is available here.
New England Journal of Medicine (363)14 2010
Abstract
New England Journal of Medicine (363)14 2010
Abstract