Abstract
Beliefs about medication may impact a woman's decision to take a needed medication during pregnancy. While many women will be faced with decisions regarding medication use during pregnancy, there is a paucity of research on this topic in the literature.
To study pregnant women's beliefs about medica...
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PMID: 20736425
PDF is available here.
Abstract
The response to treatment was the diagnostic mainstay in ancient times when diseases were poorly understood. Now that the bases of most diseases are known, appropriate diagnostic means are available. However, many physicians still rely on therapeutic tests to establish diagnoses. Since most illnesse...
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PMID: 20716691
PDF is available here.
Abstract
Comparative effectiveness studies of medications or, more appropriately, studies comparing the safety and efficacy of drugs have been conducted for decades, particularly for cancer chemotherapy. Research oncologists can stratify individuals participating in studies using prognostic criteria based on...
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PMID: 20730692
PDF is available here.
Abstract
This is a historical and social study about the symbolic effect of medication advertisements presented by women using object representations used by nurses, featured on Fon-Fon Magazine, which describes the medication advertisements featured on Fon-Fon Magazine; analyzes the object representations o...
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PMID: 20964063
PDF is available here.
Abstract
Pollutants such as human pharmaceuticals and synthetic hormones that are not covered by environmental legislation have increasingly become important emerging aquatic contaminants. This paper reports the development of a sensitive and selective multi-residue method for simultaneous determination and...
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PMID: 20851398
PDF is available here.
Abstract
We present major clinico-pathological entities, based on either the salient morphological features or the underlying etiologies....
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PMID: 19967418
PDF is available here.
Abstract
Druggability predictions are important to avoid intractable targets and to focus drug discovery efforts on sites offering better prospects. However, few druggability prediction tools have been released and none has been extensively tested. Here, a set of druggable and nondruggable cavities has been...
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PMID: 20684613
PDF is available here.
Abstract
We have found that these types of fingerprints have at least limited scaffold hopping ability including early enrichment of small numbers of active scaffolds at high database ranks. However, it has not been possible to derive Tanimoto coefficient value ranges for individual fingerprints that are gen...
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PMID: 20684607
PDF is available here.
Abstract
We have explored coarse-grained computer simulations (dissipative particle dynamics (DPD) and coarse-grained molecular dynamics using the MARTINI force field) of polymer-drug interactions to study the encapsulation of prednisolone (log p = 1.6), paracetamol (log p = 0.3) and isoniazid (log p = -1.1)...
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PMID: 20519214
PDF is available here.
Abstract
We reassessed the prevalence of iatrogenic admissions in a study of internists. Iatrogenic disease was defined as adverse drug reactions according to the World Health Organization Definition and complications induced by non-drug medical interventions. Subsequent admissions at the Departments of Medi...
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PMID: 20650043
PDF is available here.
Abstract
A morbidly obese individual's increased cardiac output requires administration of higher drug doses than would be required for a standard-size person to attain the same peak-plasma concentration. Lean body weight (LBW) is highly correlated with the increased cardiac output, more so than fat mass or...
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PMID: 20531173
PDF is available here.
Abstract
The majority of the published studies in this area were related to antibiotics and this will form the main focus of this review. A number of studies have focused on antibiotic concentrations at various target sites of infection or other tissue sites including cerebrospinal fluid, peritoneal fluid an...
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PMID: 20489605
PDF is available here.
Abstract
Species differences in microsomal binding were evaluated for 43 drug molecules in human, monkey, dog and rat liver microsomes, using a fixed concentration of microsomal protein. The dataset included 32 named drugs and 11 proprietary compounds encompassing a broad spectrum of physicoc...
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PMID: 20229604
PDF is available here.
Satish K Singh,
Nataliya Afonina,
Michel Awwad,
Karoline Bechtold-Peters,
Jeffrey T Blue,
Danny Chou,
Mary Cromwell,
Hans-Juergen Krause,
Hanns-Christian Mahler,
Brian K Meyer,
Linda Narhi,
Doug P Nesta and
Thomas Spitznagel
Abstract
Concern around the lack of monitoring of proteinaceous subvisible particulates in the 0.1-10 microm range has been heightened (Carpenter et al., 2009, J Pharm Sci 98: 1202-1205), primarily due to uncertainty around the potential immunogenicity risk from these particles. This article,...
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PMID: 20310025
PDF is available here.
Abstract
Recently, use of electrochemistry and combination of this method with spectroscopic and other analytical techniques are getting one of the important approaches in drug discovery and research as well as quality control, drug stability, determination of physiological activity, measurement of neurotran...
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PMID: 20402642
PDF is available here.
Abstract
We consider the need for human cardiomyocytes in drug-screening campaigns and review the strategies used to differentiate hPSCs towards the cardiac lineage. During early stages of differentiation, hPSC-cardiomyocytes display gene expression profiles, ultra-structures, ion channel functionality and p...
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PMID: 20659000
PDF is available here.
Abstract
Aptamers are single stranded DNA or RNA ligands which can be selected for different targets starting from a huge library of molecules containing randomly created sequences. Aptamers have been selected to bind very different targets, from proteins to small organic dyes. In the last years great progre...
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PMID: 20426747
PDF is available here.
Abstract
We have sequenced 42% of domain interacting with A3 and C2 domains of FVIII. Finally, it has been observed that normalized parameters, such as total peptide hits obtained by SEQUEST may be used for evaluation of the relative abundance of FVIII in different preparations.
Copyright 2010 Elsevier B.V....
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PMID: 20399057
PDF is available here.
Abstract
We have shown that transmission measurements in solution possess several advantages, such as quantitative analysis on the basis of Lambert-Beer's law, determination of identity and purity based on specifically developed identity criteria, characterization of protein structure and structural changes...
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PMID: 20381986
PDF is available here.
Abstract
Specific reversed-phase high-performance liquid chromatography conditions are reported for the analysis of recombinant and native human luteinizing hormone (hLH) and human chorionic gonadotropin (hCG) preparations. Heterodimeric hLH, hCG and their alpha- and beta-subunits migrated with significantly...
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PMID: 20395104
PDF is available here.
Abstract
Pharmacists made 36 visits from January to December 2009. During those visits they presented educational talks to 3,089 diners, and 12.4% of all diners spoke individually with pharmacists. Pharmacists addressed 581 questions or concerns from 384 diners. Significant issues were noted in 25.8% of indi...
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PMID: 20736159
PDF is available here.
Abstract
We demonstrate the use of a two-compartment organotypical model for monitoring drug biotransformation and the status of parent drugs or drug metabolites (reactive or stable metabolites).
The reader will gain knowledge of the importance of the two-compartment model with special reference to drug meta...
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PMID: 20367107
PDF is available here.