Abstract
We review the pathogenesis and current treatments of B-cell lymphoproliferative disorders and assess the role of rituximab for potential therapy in the setting of refractory CLH. We describe a case of CLH that was treated with intralesional rituximab. The patient had notable clinical improvement ove...
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PMID: 21658657
PDF is available here.
Abstract
We report a case of pancreatic acinar cell carcinoma associated with subcutaneous panniculitis together with a review of the English literature.
A 79-year-old woman, with a 13-month history of acute pancreatitis, asthenia, weight loss, and the CT finding of a mass in the pancreatic h...
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PMID: 21546712
PDF is available here.
Abstract
A 61-year-old man with a 12-year history of quiescent Crohn's disease on mesalamine presented to his gastroenterologist in April 2009, complaining of abdominal cramping, diarrhea, and a 25-lb weight loss over 6 weeks. He did not respond to prednisone 50 mg and 6-mercaptopurine 100 mg...
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PMID: 21675504
PDF is available here.
Abstract
To analyze cytokine gene expression in keratinocytes from patients with systemic lupus erythematosus (SLE).
Keratinocytes represent 95% of epidermal cells and can secrete several cytokines.
Keratinocytes were obtained by laser microdissection from 21 p...
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PMID: 21437440
PDF is available here.
Abstract
Molecular targeted therapies - particularly epidermal growth factor receptor inhibitors (EGFRi) and multi tyrosine kinase-inhibitors (MTKi) - continually gain importance in oncology treatment. Adverse events differ greatly from those of conventional chemotherapy; especially cutaneous adverse events...
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PMID: 21181615
PDF is available here.
Abstract
Recent years have seen a rise in the demand for dermatological herbal and plant products as well as products containing chamomile. Extracts and decoctions made from this plant are often recommended by laymen for treatment of a number of skin diseases e.g. inflammation, wounds and itching. This syste...
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PMID: 21156115
PDF is available here.
Abstract
We have proposed that AP1 factors function differently in basal versus suprabasal epidermis. To test this, we inactivated suprabasal AP1 factor function in mouse epidermis by targeted expression of dominant-negative c-jun (TAM67), which inactivates function of all AP1 factors. This produces increase...
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PMID: 20818430
PDF is available here.
Abstract
Systemic diseases may affect the oral tissues, i.e. oral mucosa, salivary glands, teeth or bone, and oral manifestations will frequently present early, i.e. in association with (non-fulminant) systemic disease. Thus, recognition and proper diagnosis is essential to initiate appropriate treatment sch...
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PMID: 21044560
PDF is available here.
Abstract
Graduated compression stockings are widely used for deep venous thrombosis (DVT) prophylaxis. Although below-knee stockings are used more often than thigh-length stockings, no reliable evidence indicates that they are as effective as thigh-length stockings.
To compare the effectiveness of thigh-leng...
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PMID: 20855784
PDF is available here.
Abstract
We describe a case of acquired perforating dermatosis presenting as the first symptom in a 64-year-old man who also was diagnosed to have mild obstructive jaundice due to a periampullary villous adenoma with high-grade dysplasia. In a patient with no other risk factors, the presence of an acquired p...
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PMID: 21214124
PDF is available here.
Abstract
The antimalarials chloroquine and hydroxychloroquine have been used for the treatment of inflammatory diseases for more than 60 years. Even today new indications evolve due to the complex mode of action of these compounds. Due to the fear of side effects, especially irreversible reti...
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PMID: 20678149
PDF is available here.
Abstract
We have seen are being made by dermatologists, skin biologists, and others who have come to appreciate the skin as an organ that is reflective of many important systemic mechanisms. In this commentary, I identify some of what I feel are the most important advances that will be the basis for many fut...
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PMID: 20872993
PDF is available here.
Abstract
Patients with urogenital complaints are frequently encountered by family practitioners, gynecologists, and dermatologists. This review article provides practical information regarding normal anatomy and embryology of the vulva, followed by a summary of procedural techniques. The new classifications...
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PMID: 20883910
PDF is available here.
Abstract
Colloidal oatmeal has a long history of beneficial use in dermatology. It is a natural product that has an excellent safety record and has demonstrated efficacy for the treatment of atopic dermatitis, psoriasis, drug-induced rash and other conditions. In recent years, in vitro and in...
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PMID: 20865844
PDF is available here.
W Miehsler,
G Novacek,
H Wenzl,
H Vogelsang,
P Knoflach,
A Kaser,
C Dejaco,
W Petritsch,
M Kapitan,
H Maier,
W Graninger,
H Tilg,
W Reinisch and
Austrian Society of Gastroenterology and Hepatology
Abstract
Infliximab (IFX) has tremendously enriched the therapy of inflammatory bowel diseases (IBD) and other immune mediated diseases. Although the efficacy of IFX was undoubtedly proven during the last decade numerous publications have also caused various safety concerns. To summarize the...
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PMID: 21122513
PDF is available here.
Abstract
Over the past three years the British Skin foundation has awarded over £2.2 million to research projects looking at a huge/multitude of different skin diseases in the UK. It is a lot of money but research is expensive and there remains a long way to go before many of these skin diseases are fully u...
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PMID: 20852522
PDF is available here.
Abstract
We will discuss a case of cutaneous focal mucinosis arising from the chin of a 27-year-old man....
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PMID: 20856067
PDF is available here.
Abstract
We are born, our skin is exposed to an unknown environment. Its development is predominantly based on characteristics which are inherent to the various age phases of life. Totally covering a human being, it acts as a protector throughout its lifetime, without ever being protected itself....
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PMID: 20963974
PDF is available here.
Abstract
The range of care provided to patients by the dermatology nursing team is wide. Alleviation of pain and itching, improvement of skin integrity through hygiene care and local treatments, the cleaning of wounds and the changing of dressings, psychological treatment and therapeutic education are the ma...
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PMID: 20963980
PDF is available here.
Abstract
Frequent or rare, minor or serious, numerous skin conditions exist. Allergic, inflammatory, infectious or bullous, dermatoses may also reveal underlying pathologies.
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PMID: 20963975
PDF is available here.
Abstract
Skin diseases may be treated locally or generally. Skin can also be affected by treatments that are used for healing other diseased organs; thus opening the field of drug eruptions.
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PMID: 20963979
PDF is available here.
Abstract
We report an unusual case of a 76-year-old woman with primary cutaneous amyloidosis who initially presented with features of asteatotic eczema that was unresponsive to topical corticosteroid treatment. Histological examination revealed amyloid deposits involving the superficial and deep dermis. Thes...
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PMID: 20938601
PDF is available here.
Abstract
I and VI; the DC protein bound only to collagens I and VI; however, no binding of BJ-PI to these proteins was detected. N-deglycosylation caused loss of structural stability of bothropasin and BJ-PI but HF3 remained intact, although its haemorrhagic and fibrinogenolytic activities were partially imp...
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PMID: 20664911
PDF is available here.
Abstract
We report the case of a 66-year-old white woman who presented with reddish brown to violaceous macules and plaques restricted to the extremities. The histopathologic findings, laboratory data, and systemic studies led us to the diagnosis of cutaneous plasmacytosis....
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PMID: 21049732
PDF is available here.
Philippe Ratajczak,
Anne Janin,
Regis Peffault de Latour,
Christophe Leboeuf,
Allison Desveaux,
Keyvan Keyvanfar,
Marie Robin,
Emmanuel Clave,
Corine Douay,
Anne Quinquenel,
Claire Pichereau,
Philippe Bertheau,
Jean Yves Mary and
Gérard Socié
Abstract
We studied the correlation between the presence of Th17 cells with histologic and clinical parameters. We first analyzed a cohort of 40 patients with GVHD of the gastrointestinal tract. Tumor necrosis factor (TNF), TNF receptors, and Fas expression, and apoptotic cells, CD4(+)IL-17(+) cells (Th17),...
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PMID: 20484086
PDF is available here.
Abstract
We sought to review the current literature on the clinical and histologic aspects of onychoheterotopia.
A literature search was performed to evaluate peer-reviewed articles on the topic.
Detailed reports have characterized many features of onychoheterotopia. The various etiology and treatment option...
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PMID: 20724029
PDF is available here.
Abstract
The success of gene therapy mainly depends on the gene vector (GV) responsible for the efficient transport of genetic information. The qualities of a GV have a profound influence on the method of application, the efficiency of gene transfer in the target tissue, the amount and persistence of gene ex...
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PMID: 20408940
PDF is available here.
Abstract
We find that gene electrotransfer to skin is of particular interest; not only due to the easy accessibility of this organ, which renders both treatment and evaluation feasible, but also the capability of the skin to produce transgenes and elicit immunological responses. Up to now more than 40 papers...
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PMID: 20557284
PDF is available here.
Abstract
Statins, initially developed as antimicrobials, are primarily considered cholesterol-lowering agents. Recently, researchers discovered anti-inflammatory properties of statins. Studies on the effects of statins and the alterations noted include: bench work that supported a Th1/Th2 ske...
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PMID: 20684142
PDF is available here.
Abstract
All patients showed marked improvement after a few sessions of CO(2) laser. No-one had recurrence or noticeable side effects. CONCLUSION: The CO(2) laser is an option in adult and child patients with multiple milia lesions or milia en plaque, obtaining good cosmetic results with minimal side effects...
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PMID: 20590368
PDF is available here.
Abstract
We developed a mouse model of drug allergy induced by skin sensitization to amoxicillin (amox), a penicillin antibiotic frequently involved in delayed drug allergy.
Whereas wild-type mice could not be sensitized to amox, CD4+ T-cell-deficient mice developed an amox-specific allergic...
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PMID: 20121757
PDF is available here.
Abstract
BDD is relatively common in a dermatologic setting, especially among patients seeking cosmetic treatments. These patients have some different features compared with general dermatology patients. Dermatologists should be aware of the clinical characteristics of BDD to identify and refer these patient...
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PMID: 20561712
PDF is available here.
Abstract
Examination of patients for skin lesions of TSC could be improved by including inspection for longitudinal nail grooves, red comets, longitudinal leukonychia, and splinter hemorrhages in addition to ungual fibromas. The anatomic distribution of TSC ungual fibromas is not random and appears consisten...
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PMID: 20462663
PDF is available here.
Abstract
Our new challenge is to understand the mechanisms underlying more common, but less well-defined, mucocutaneous bleeding (MCB) disorders. Present diagnostic testing for platelet function disorders and von Willebrand's Disease often fails to identify the cause of bleeding in individuals with inherited...
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PMID: 20590875
PDF is available here.
Abstract
We report a 40-year old man in Uganda with ulcerated skins lesions, hypotension, and anaphylaxis caused by bites of safari ants. Treatment was successful. Physicians should be aware of anaphylaxis caused by ant bites.
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PMID: 20595468
PDF is available here.
Abstract
There was rare (0.5% of specimens) disagreement recorded between interpretations of the dermatologist and dermatopathologist. Permanent and frozen section pathology agreed with one another 90.4% of the time. Specimen processing was the most probable cause of discordance. Most discordance was not cli...
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PMID: 20653724
PDF is available here.
Abstract
The efficacy of EO was evaluated in 21 patients (16 pyogenic granulomas and 5 venous lakes). The diameters of the lesions ranged from 0.3 to 1.0 cm. The mean number of EO injections was 1.6 (range 1-4). A CR was achieved in 95% of the reactive vascular lesions (20 CR, 1 MI). Two episodes of transien...
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PMID: 20533938
PDF is available here.