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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Skin and Connective Tissue Diseases (2):
Recent article
Skin and Connective Tissue Diseases
Abstract
This article describes the scanning electron microscopic (SEM) features of the ovine interdigital sinus. The lumen was filled with a dense secretory material and quite a number of hairs embedded in the luminal content. For SEM purposes, the sinus was divided into three parts: base, body and neck. At...
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PMID: 18277701
PDF is available here.
PDF is available here.
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Abstract
We explored the occurrence of clusterin in young, aged, and sun-exposed human skin. Immunohistochemical analysis showed that clusterin is constantly associated with altered elastic fibers in aged human skin. Elastotic material of sun-damaged skin (solar elastosis), in particular, revealed a strong s...
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PMID: 17872975
PDF is available here.
PDF is available here.
Abstract
There appears to be a correlation between a slowly progressive clinical course of MPA and the depth of dermal involvement and the severity of neutrophilic infiltration in biopsy specimens. Based on these results, we believe that these characteristic patterns may help clinicians establish an earlier...
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PMID: 17939936
PDF is available here.
PDF is available here.
Climacteric (10 Suppl 2) 2007
Abstract
A fairly consistent finding in work on the menopause and hormone replacement therapy is the positive effect of estrogen on connective tissue and its turnover. The menopause has been shown repeatedly to have a negative effect on the connective tissue in the dermis of the skin. Such an effect is preve...
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PMID: 17882680
PDF is available here.
PDF is available here.
Der Hautarzt (58)10 2007
Abstract
Systemic sclerosis (SSc) belongs to the family of autoimmune connective tissue diseases and is still a challenge to every practicing physician. The disorder is characterized by progressing fibrosis of the skin and internal organs, abnormal activation of the immune system, and distinct changes in mic...
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PMID: 17726594
PDF is available here.
PDF is available here.
Der Hautarzt (58)10 2007
Abstract
Systemic sclerosis is a complex multi-systemic disease with a mostly unresolved pathogenesis. Following an inflammatory reaction, overproduction of collagen and other extra-cellular matrix components leads to a characteristic fibrosis. It remains unclear why this overproduction by fibroblasts and my...
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PMID: 17786395
PDF is available here.
PDF is available here.
Abstract
I collagen arginine-to-cysteine (R-to-C) substitutions were found in three middle-aged adults suffering from spontaneous dissection of medium-size arteries. This disorder enters the heterogeneous spectrum of the Ehlers-Danlos syndrome (EDS). Despite similar genetic mutation and arterial alterations,...
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PMID: 17890912
PDF is available here.
PDF is available here.
Abstract
We used the impaired wound-healing process in obese/obese (ob/ob) mice to investigate the impact of obesity-mediated systemic inflammation on cutaneous wound-healing processes. Systemic administration of neutralizing monoclonal antibodies against tumor necrosis factor (TNF)alpha (V1q) or monocyte/ma...
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PMID: 17460730
PDF is available here.
PDF is available here.
Abstract
We report on previously undescribed ultrastructural changes in the elastic fibers found in the skin of 22 of 29 patients suffering from the hypermobile type of EDS. They existed in variable combinations of a fragmented appearance with frayed contours, internal microcavities, some elastotic-like chan...
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PMID: 17667170
PDF is available here.
PDF is available here.
Laboratory Investigation (87)8 2007
Abstract
We hypothesized that a de-regulation of vascular sprouting occurs in the absence of endogenous fibulin-5. To test this hypothesis, vascular sprouts from the long thoracic artery were quantified and polyvinyl alcohol sponges were implanted subcutaneously in wild-type and fbln5(-/-) mice to assess fib...
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PMID: 17607303
PDF is available here.
PDF is available here.
Abstract
Recognition of microvascular proliferation as a not uncommon feature, congenital arteriovenous malformations provide new insight into the growth behaviour and vascular composition of these lesions....
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PMID: 16816171
PDF is available here.
PDF is available here.
Abstract
Connective tissue sum scores did not differ between the sCAD group (mean 2.37 +/- 2.1, median 2) and the control group (mean 1.95 +/- 1.9, median 2, p = 0.34). One sCAD patient had osteogenesis imperfecta (2.3%) and exhibited the highest sum score of 8. The diameter of the CCA and VA and the prevale...
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PMID: 17562832
PDF is available here.
PDF is available here.
Abstract
I collagen gene expression and in the development of fibrosis, demonstrated both in vitro and in animal models with a targeted deletion of Smad3, is of critical importance because it may lead to novel therapeutic strategies against these diseases. This review focuses on the mechanisms underlying Sma...
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PMID: 17589920
PDF is available here.
PDF is available here.
Abstract
We report a case occurring in a 25-year-old male with approximately 40 nodules and smaller papules distributed in a zosteriform fashion on the right lower lumbar region and upper gluteal region. The identification of the lesion by deep biopsy excluded the important differential diagnosis of segmenta...
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PMID: 17519633
PDF is available here.
PDF is available here.
Abstract
We describe herein two cases of coexisting PXE and cutaneous lupus and discuss a possible association. Although a fortuitous association cannot be excluded, the calculated prevalence of the association in our area was much less than in our observation. Given the ocular and vascular complications of...
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PMID: 17550565
PDF is available here.
PDF is available here.
Abstract
We evaluated the long-term maintenance of regenerated axons in an experimental nerve amputee model. The sciatic nerve of adult rats was transected and repaired with a silicone tube leaving a short gap; the distal nerve segment was again transected 10 mm distally and the distal stump either introduce...
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PMID: 17565536
PDF is available here.
PDF is available here.
Abstract
Needle insertion in soft tissue has attracted considerable attention in recent years due to its application in minimally invasive percutaneous procedures such as biopsies and brachytherapy. This paper presents a survey of the current state of research on needle insertion in soft tissue. It examines...
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PMID: 16938481
PDF is available here.
PDF is available here.
Abstract
We indicated that SKL-2841 also exerts anti-chemotactic activity for MIP-1 beta in mouse spleen cells. In the early stages of bleomycin-induced skin lesions, immunohistochemical analysis showed the expression of both MCP-1 and MIP-1 beta in dermal inflammatory cells. Moreover, intraperitoneal admini...
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PMID: 17147981
PDF is available here.
PDF is available here.
Clinical Anatomy (20)3 2007
Abstract
A method of intact postmortem removal of the pelvic floor for imaging correlation studies, with minimal access disfigurement, is described. This consists of subcutaneous removal of both ischiopubic rami with division of the obturator membrane cranial to the origin of the levator ani muscles. The ana...
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PMID: 17072874
PDF is available here.
PDF is available here.
Matrix Biology (26)2 2007
Abstract
PRELP is a member of the small leucine-rich repeat proteoglycan family that is abundantly expressed in many cartilages compared to other connective tissues. To study the consequence of PRELP overexpression in tissues where it is normally expressed at low abundance, transgenic mice were generated in...
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PMID: 17123807
PDF is available here.
PDF is available here.
Hawaii medical journal (66)3 2007
Abstract
Eosinophilic fasciitis (EF) is a rare connective tissue disorder characterized by symmetrical sclerodermatous skin changes primarily affecting the extremities and histologically, by thickening of the fascia with chronic inflammatory infiltrate containing eosinophils. EF is associated with peripheral...
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PMID: 17472044
PDF is available here.
PDF is available here.
Abstract
We show that mice deficient in the transcription factor T-box expressed in T cells (T-bet), a master regulator of type 1 immunity, display increased sensitivity to bleomycin-induced dermal sclerosis. Despite the well-established role of T-bet in adaptive immunity, we also show that RAG2(-/-) mice, w...
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PMID: 17307869
PDF is available here.
PDF is available here.
Clinical Science (112)4 2007
Abstract
We have described previously a dysregulation of collagen synthesis in cultured smooth muscle cells from saphenous veins and in dermal fibroblasts from the skin of patients with varicose veins, suggesting a systemic defect in their connective tissue. The present study describes comparative morphologi...
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PMID: 17020541
PDF is available here.
PDF is available here.
Abstract
We present a case with classical clinicopathologic findings of JHF and features of ISH, and we describe a novel mutation in CMG2....
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PMID: 17284973
PDF is available here.
PDF is available here.
Abstract
We used Affymetrix DNA microarrays representing >14,000 mouse genes to characterize global gene expression in skin during development of Scl GVHD in lethally irradiated BALB/c (H-2d) mice transplanted with B10.D2 (H-2d) bone marrow and spleen cells. These mice develop skin thickening, whereas contro...
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PMID: 16917493
PDF is available here.
PDF is available here.