Abstract
We expressed an Escherichia coli nitroreductase (Ntr) gene in the male germ line of zebrafish. The Ntr gene encodes an enzyme that can convert prodrugs such as metronidazole (Met) to cytotoxins. A fusion protein eGFP:Ntr (fusing Ntr to eGFP) under control of approximately 2 kb putative promoters of...
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PMID: 19936986
PDF is available here.
Abstract
Loco-regional treatments play a key role in the management of hepatocellular carcinoma (HCC). Image-guided tumor ablation is recommended in patients with early-stage HCC when surgical options are precluded. Radiofrequency ablation has shown superior anticancer effects and greater survival benefit wi...
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PMID: 20564355
PDF is available here.
Abstract
We investigated natural and lesion-induced apoptosis in the developing rat dorsal lateral geniculate nucleus (dLGN). These lesions involved: i) monocular enucleation, and ii) unilateral ablation of the visual cortex at different postnatal ages before eye opening. We identified dying cells as apoptot...
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PMID: 20471376
PDF is available here.
Abstract
Of 614 patients with DTC during our period, 504 (83%) underwent total thyroidectomy and 104 (17%) underwent lesser surgery. Radioiodine administration was reported for 394 patients who underwent total thyroidectomy with a dose range of 24 to 297 mCi (mean of 116 mCi). Ten-year survival was higher fo...
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PMID: 20479583
PDF is available here.
Abstract
All study outcomes improved within all groups. Comparison between medical and surgical groups showed higher improvement in both perennial and seasonal, respectively, in nasal obstruction, sneezing, rhinomanometry, and rhinomanometry after NPT. Itching improved only in perennial allergen type. Rhinoe...
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PMID: 20502756
PDF is available here.
Abstract
We propose an original treatment strategy that combines ultrasound imaging and therapy using a dual-mode transducer rotating at 8 revolutions per second. Real-time B-mode imaging was interrupted to emit high-intensity ultrasound over a selected therapy aperture. A full 360 degrees image was taken ev...
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PMID: 20442018
PDF is available here.
Abstract
We also found that, on average, elastic modulus imaging can more accurately depict thermal ablation zones, when compared to strain imaging (14.7% versus 22.3% absolute percent error in area measurements, respectively). Furthermore, elastic modulus imaging also provides higher (more than a factor of...
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PMID: 20354279
PDF is available here.
Abstract
We have exploited a novel gold nanoshell-based complex (nanocomplex) for targeting, dual modal imaging, and photothermal therapy of HER2-overexpressing and drug-resistant ovarian cancer OVCAR3 cells in vitro. The nanocomplexes are engineered to simultaneously provide contrast as fluorescence optical...
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PMID: 20371708
PDF is available here.
Abstract
We show the possibilities of laser-induced breakdown spectroscopy (LIBS) as a nearly nondestructive tool in anthropology and paleontology for the measurement of the presence and distribution of trace elements in teeth. We applied LIBS to the determination of strontium and magnesium in dentin and ena...
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PMID: 20223067
PDF is available here.
Abstract
We present the case of a 17-year-old boy who developed severe dysphagia and subsequent weight loss as a result of lingual tonsil hypertrophy. He was successfully treated with plasma-mediated radiofrequency-based ablation (Coblation). In the past, traditional surgical procedures for lingual tonsil hy...
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PMID: 20229480
PDF is available here.
Abstract
I lung cancer patients is surgery, a lot of patients have a high comorbidity and are medically inoperable. Bronchoscopy, as a central technique in diagnosing lung cancer, has the potency to apply endoscopic therapy to small lung lesions in a minimally invasive way in patients with high risk for surg...
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PMID: 20203535
PDF is available here.
Abstract
While papillary and follicular thyroid cancer usually has an excellent prognosis, recurrent and aggressive forms of the disease do occur. The success of surgical excision and radioiodine therapy is evaluated by ultrasonography of the neck, and TSH-stimulated serum thyreoglobulin. Based on investigat...
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PMID: 21125756
PDF is available here.
Abstract
A technique combining low-coherence reflectometry, laser ablation and microfluidics in a single microstructured fiber is developed. Experimental results demonstrate the possibility to ablate thin aluminum foil samples with fiber-guided Nd:YAG laser light, to collect liquid in the holes of the fiber...
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PMID: 20173832
PDF is available here.
Abstract
Irreversible thermal alterations in tissue function and structure are used in clinical applications to achieve diverse goals, from lower-temperature tumor ablation to higher-temperature tissue fusion and surgical cutting. The typical formulation in tumor hyperthermia studies, the thermal iso-effect...
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PMID: 21175400
PDF is available here.
Abstract
Thermotherapy is an attractive alternative to surgery and radiation therapy because of its ability to locally kill tumours while preserving surrounding normal tissues. An important part of successful thermotherapy is real-time temperature monitoring to control the area being heated while protecting...
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PMID: 20345268
PDF is available here.
Abstract
To evaluate exothermic permanganate redox chemistry for utility in tumour ablation.
Sodium permanganate (1-3 mL, 1 or 2 M) and glycerol (1 mL, 1 M) were injected in triplicate into a beaker using three injection orders: (1) simultaneous, (2) glycerol injection then permanganate injection, (3) perman...
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PMID: 20345271
PDF is available here.
Abstract
We still need new resources to achieve permanent destruction of abnormal tissues or suppression of pathological processes. Most of the physics-based (or energy-based) therapeutic principles at our disposal have been established a long time ago, but their actions on basic cellular and molecular mecha...
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PMID: 20176527
PDF is available here.
Abstract
We conclude that erbium lasers (Er:YAG and Er,Cr:YSGG) are most efficient and, with the right parameters, the thermal side effects are small. There is a substantial need for "gold standards", although this is difficult to establish in practice owing to different laser parameters (including pulse rep...
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PMID: 20011762
PDF is available here.
Abstract
In-vivo multicolor photoacoustic (PA) flow cytometry for ultrasensitive molecular detection of the CD44+ circulating tumor cells (CTCs) is demonstrated on a mouse model of human breast cancer. Targeting of CTCs with stem-like phenotype, which are naturally shed from parent tumors, was performed with...
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PMID: 19957272
PDF is available here.
Abstract
A method to estimate the boundary of a tumor using an interstitial microwave probe was evaluated in numerical and phantom models. This method utilizes time-domain signal reflection from the tumor/liver interface to provide information about tumor boundary in both radial and axial directions. Using c...
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PMID: 19567338
PDF is available here.
Abstract
Animal studies: Two antennas for 30 s provided the optimal ablation time, ablation width, mean size of largest vessel coagulated, and minimal bleeding when compared with other techniques. However, given that this is not an optimal technique for laparoscopic precoagulation, one antenna for 60 s was f...
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PMID: 19727958
PDF is available here.
Abstract
Women with CIN3 were significantly more likely to have spontaneous preterm deliveries (11% compared with 6%, odds ratio [OR] 1.52, 95% confidence interval [CI] 1.29-1.80, P<.001) and preterm PROM (8% compared with 6%, OR 1.27, 95% CI 1.09-1.48, P=.001) as compared with the unexposed population. Thes...
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PMID: 19888028
PDF is available here.
Abstract
Interventional techniques are divided into two categories: neuroablative and neuromodulatory procedures. Neuroablation is the physical interruption of pain pathways either surgically, chemically or thermally. Neuromodulation is the dynamic and functional inhibition of pain pathways either by adminis...
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PMID: 20127532
PDF is available here.
Abstract
Our meta-analysis suggests that a Maze surgical ablation procedure at the time of MV surgery is associated with a reduced postoperative AF risk. Our economic model further suggests that the surgical ablation strategy at the time of mitral valve surgery is likely a cost-effective intervention, provid...
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PMID: 19818194
PDF is available here.
Abstract
Twin pregnancies subsequent to LEEP had a significantly increased risk of overall subsequent spontaneous preterm delivery (43.4%) with an adjusted odds ratio of 1.58 (95% confidence interval 1.16-2.14) compared with pregnancies with no prior LEEP (32.5%). The association was consistent in various se...
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PMID: 19701028
PDF is available here.
Abstract
The hypothesis was tested that estradiol (E2) from the ovarian follicles controls time of luteolysis. Time of luteolysis was evaluated by multiple measures of corpus luteum (CL) structure (area, volume) and function (progesterone [P4], luteal blood flow). The hypothesis for experiment 1 was that rep...
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PMID: 19264702
PDF is available here.
Abstract
These results show that volumetric high-intensity focused ultrasound (HIFU) sonication allows for efficiently creating large thermal lesions while reducing treatment duration and also that the rapid multiplane MR thermometry improves the safety of the therapeutic procedure by monitoring temperature...
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PMID: 19746786
PDF is available here.
Abstract
Creation of a conduction block is the rationale behind arrhythmia surgery. The "cut-and-sew" technique provides complete conduction block and a line of conduction block prevents propagation of abnormal activation and interrupts reentrant circuits. Alternative ablation devices have been developed to...
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PMID: 20715692
PDF is available here.
L Bonaccorsi,
G Nesi,
F Nuti,
M Paglierani,
C Krausz,
L Masieri,
S Serni,
L Proietti-Pannunzi,
Y Fang,
S C Jhanwar,
C Orlando,
M Carini,
G Forti,
E Baldi and
L Luzzatto
Abstract
A TMPRSS2:ERG fusion gene was present and expressed, as demonstrated by RT-PCR, in 84% of patients in group A and in 54% of patients in group B (p=0.01). The presence of TMPRSS2:ERG transcripts and the levels of ERG RNA, measured by quantitative Real Time-PCR, did not correlate significantly with cl...
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PMID: 19494719
PDF is available here.
Abstract
Thermal and thermal-ablative procedures for treating prostate cancer have been investigated systematically since approximately 1980 (apart from some historical predecessors), and numerous experimental and clinical reports have been published on this subject. Various technologies have been used, incl...
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PMID: 19554305
PDF is available here.
Abstract
The interventions included: (1) Silver nitrate gland ablation, (2) cyst or abscess fenestration, ablation, or excision using carbon dioxide (CO(2)) laser, (3) marsupialization, (4) needle aspiration with or without alcohol sclerotherapy, (5) fistulization using a Word catheter, Foley catheter, or Ja...
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PMID: 19445813
PDF is available here.
Abstract
We were able to create large lesions (by producing overlapping lesions), and it was possible to monitor these lesions with MRI with excellent contrast. The length of the lesions in vivo brain was much higher than the length in vitro, indicating that the penetration in the in vitro brain is limited,...
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PMID: 19574126
PDF is available here.
Abstract
We measured the ex vivo electrical conductivity of eight human metastatic liver tumours and six normal liver tissue samples from six patients using the four electrode method over the frequency range 10 Hz to 1 MHz. In addition, in a single patient we measured the electrical conductivity before and a...
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PMID: 19349647
PDF is available here.
Abstract
Acute obstruction of the airway in the emergent situation results from a wide variety of malignant and benign disease processes. Acute management involves establishing a secure and patent route for adequate gas exchange. This requires rapid determination of the location of the obstruction and nature...
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PMID: 19447308
PDF is available here.
Abstract
We present successful chemical ablation of the gallbladder using pure alcohol, through a percutaneous gallbladder drainage tube, in a patient who developed intractable cholecystitis with obstruction of the cystic duct after receiving a biliary stent. Our results suggest that chemical ablation therap...
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PMID: 19399941
PDF is available here.
Abstract
A wide range of thermal and cryoablation methods is currently available for the curative eradication or palliative treatment of a variety of bone and soft-tissue tumors. Radiofrequency ablation has been developed as a multipurpose tool for the skeletal system. Cryoablation has the added advantages o...
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PMID: 19358439
PDF is available here.
Abstract
We describe a PCR-based method allowing non-lethal molecular characterization of single flies. Using this procedure, individual candidate recombinant animals can be genotyped and selected one generation earlier than with extant methodology and, importantly, before stocks are established. This advanc...
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PMID: 19450239
PDF is available here.
Abstract
Atrial fibrillation (AF) is the most frequent and sustained cardiac arrhythmia affecting humans. The electrical isolation by ablation of the pulmonary veins (PV) in the left atrium (LA) of the heart has proved to be an effective cure for the AF. The ablation consists mainly of the formation of a loc...
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PMID: 19411218
PDF is available here.
Abstract
Two months after the last treatment in group 1:7 patients were satisfied and 3 were very satisfied; in group 2: 6 patients were satisfied and 4 were very satisfied, in group 3: 4 patients were satisfied and 6 were very satisfied. LED was effective on improvement of skin texture and rhytidis reductio...
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PMID: 19839877
PDF is available here.
Abstract
We conclude that the fat content of small primary breast cancer could serve as a 'heat sink' and should be considered as a preventing factor of complete local tumor destruction by RF thermal ablation.
(c) 2008 S. Karger AG, Basel....
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PMID: 18987475
PDF is available here.
Abstract
A cutting waterjet to produce corneal flaps during refractive surgery or to slice donor corneas for corneal grafting was developed. Jets generated with several different nozzles were compared to determine the most appropriate nozzle geometry for this application. In this paper, it is also discussed...
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PMID: 19469663
PDF is available here.
Abstract
The management of varicose veins is evolving at pace but the speed of change often outstrips the evidence. Patients should expect to be offered the whole range of treatment options that are suitable for their particular circumstances. This range should include conservative management, surgery, endov...
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PMID: 19648987
PDF is available here.
Abstract
The effect of post-training treatment with L-histidine (LH) on the memory consolidation of inhibitory avoidance was investigated in Carassius auratus submitted to cerebellar ablation. The inhibitory avoidance procedure included 3 days: one habituation day, one training day (5 trials, T1-T5) and one...
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PMID: 19219307
PDF is available here.
Abstract
The presented approach introduces a method for estimating the potential benefit of a surgical assist system prior to its actual development or clinical use. The central research question is: What minimal requirements must a future system meet so that its use would be more advantageous than a convent...
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PMID: 19929296
PDF is available here.
Abstract
Diffuse hepatic uptake of I-131 either on diagnostic or post-therapeutic scans is a usual finding in patients with differentiated thyroid carcinoma. The aim of this study was to evaluate the frequency and clinical significance of diffuse hepatic uptake of radioiodine on post-therapeutic (PT) and pos...
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PMID: 19092374
PDF is available here.
Abstract
Microwave ablation is a relatively new technology under development and testing to treat the same types of cancer that can be treated with radiofrequency ablation. Microwave energy has several possible benefits over radiofrequency energy for tumor ablation but, because clinical microwave ablation sy...
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PMID: 19179193
PDF is available here.
Abstract
We present the above case of struma ovarii in a young patient and discuss the radiological characteristics of the disease....
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PMID: 19999326
PDF is available here.
Abstract
Different noninvasive or minimally invasive therapeutic ablation procedures can produce tissue necrosis associated with local-stiffness increase. Although elastography has been proved as a potential evaluation tool for many kinds of ablation-induced lesions, the application of subtraction technique...
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PMID: 19213631
PDF is available here.
Abstract
We describe and evaluate several novel beam sequencing schemes which, along with parallel-receive acquisition, are designed to reduce acquisition time and heating. These techniques reduce the total number of radiation force impulses needed to generate an image and minimize the time between successiv...
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PMID: 19213633
PDF is available here.