Abstract
Our aim was to evaluate the potential use of zirconium oxide (zirconia) as a blood journal bearing material in the DexAide right ventricular assist device. The DexAide titanium stator was replaced by a zirconia stator in several blood pump builds, without changing the remaining pump hardware compone...
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PMID: 19821816
PDF is available here.
Abstract
Computational fluid dynamic simulations of the flow in the Kyoto-NTN (Kyoto University, Kyoto, Japan) magnetically suspended centrifugal blood pump with a 16-straight-bladed impeller were performed in the present study. The flow in the pump was assumed as unsteady and turbulent, and...
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PMID: 19817732
PDF is available here.
Abstract
The extracorporeal carbon dioxide removal (ECCO(2)R) concept, used as an integrated tool with conventional ventilation, plays a role in adjusting respiratory acidosis consequent to tidal volume (Vt) reduction in a protective ventilation setting. This concept arises from the extracorporeal membrane o...
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PMID: 20427969
PDF is available here.
Abstract
We propose a new, low-cost pulsatile ventricular assist device (VAD) for short-term applications. The new device could prove very useful in emergency ventricular failure in which patient survival is not assured. In these cases, the device allows ventricular function to be maintained as the patient's...
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PMID: 19817728
PDF is available here.
Abstract
Computational fluid dynamic simulations of the flow in the Kyoto-NTN (Kyoto University, Kyoto, Japan) magnetically suspended centrifugal blood pump with a 16-straight-bladed impeller were performed in the present study. The flow in the pump was assumed as unsteady and turbulent, and...
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PMID: 19817732
PDF is available here.
Abstract
Calcium channel blockers continue to be used for the management of a wide variety of adult and pediatric conditions including hypertension, angina pectoris, atrial arrhythmias, Raynaud phenomenon, and migraine headaches. With increased use comes increased potential for misuse and abuse. This article...
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PMID: 19687715
PDF is available here.
John B O'Connell,
Patrick M McCarthy,
George Sopko,
Gerasimos S Filippatos,
Ileana L Piña,
Marvin A Konstam,
James B Young,
Leslie W Miller,
Mandeep R Mehra,
Edmond Roland,
John E A Blair,
David J Farrar and
Mihai Gheorghiade
Abstract
Mechanical circulatory support (MCS) devices are a guideline-recommended treatment option for a small subset of advanced heart failure patients. MCS has the potential to become more prominent in the management of Acute Heart Failure Syndromes (AHFS) as device technology advances and as clinical tria...
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PMID: 18548344
PDF is available here.
Abstract
The clinical outcomes of patients with LMT disease requiring PCPS is not satisfactory. In order to improve clinical outcomes of these patients, a strategy involving a timely insertion of LVAS before the onset of complications might be necessary....
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PMID: 19471222
PDF is available here.
Valentin Izraelev,
William J Weiss,
Bryan Fritz,
Raymond K Newswanger,
Eric G Paterson,
Alan Snyder,
Richard B Medvitz,
Joshua Cysyk,
Walter E Pae,
Dennis Hicks,
Branka Lukic and
Gerson Rosenberg
Abstract
The design and initial test results of a new passively suspended Tesla type left ventricular assist device blood pump are described. Computational fluid dynamics (CFD) analysis was used in the design of the pump. Overall size of the prototype device is 50 mm in diameter and 75 mm in length. The pump...
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PMID: 19770799
PDF is available here.
Abstract
This article reports on the most significant developments in the field of heart failure in the past year. Principal innovations in the management of chronic heart failure are explained, including the most important features of new management models for patients with chronic heart failure and the mai...
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PMID: 19174053
PDF is available here.
Abstract
A higher grade cardiac failure is associated with poor prognosis. In addition to medical conservative treatment and traditional cardiac surgery, in the past years different forms of an assisted circulation evolved. Short-term devices serve to bridge an acute life-threatening situation. The chosen sy...
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PMID: 19807289
PDF is available here.
Abstract
The mean waiting time on HU list was 18.3+/-17.7 days in HTx group and 12.5+/-9.4 days in D group (p=0.075). The average weekly allocation rate from the active HU list was 27.7%, and the mean weekly waiting-list mortality was 12.1%. The use of intra-aortic balloon pumping (p=0.005), mechanical venti...
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PMID: 18701314
PDF is available here.
Abstract
A propeller pump has the pressure-flow characteristics and minimal risk of hemolysis and venous pathway obstruction which make it ideal for temporary cavopulmonary assist. This type of device has the potential to provide a new therapeutic option for patients with failing univentricular Fontan physio...
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PMID: 18805191
PDF is available here.
Abstract
Preoperative plasma B-type natriuretic peptide concentration predicted ventricular dysfunction, hospital stay, and mortality in univariate and multivariable analyses. Logistic regression demonstrated preoperative B-type natriuretic peptide to independently predict ventricular dysfunction (odds ratio...
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PMID: 18692657
PDF is available here.
Abstract
Several treatment options are available for HLHS and related malformations. The appropriate treatment strategy must be matched to the individual patient, taking into consideration anatomic variables as well as other patient-specific characteristics. The majority of patients with HLHS and related mal...
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PMID: 18442568
PDF is available here.
Abstract
A simple technique of left ventricular assistance, offering the advantages of both cardiopulmonary bypass and off-pump revascularization, was adopted for high-risk patients. It was used in 56 patients with critical left main stenosis and occluded right coronary artery, severely reduced ejection frac...
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PMID: 18381879
PDF is available here.
Abstract
This article discusses the most important developments in heart failure reported during the last year. It contains a review of new findings on chronic heart failure, acute heart failure, cardiac resynchronization therapy, heart transplantation, with particular emphasis on the situation in Spain, and...
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PMID: 18341935
PDF is available here.
Abstract
Since severe and rapid hemodynamic compromise is typical of fulminant myocarditis, an immediate decision must be made about whether to initiate MCS. We attribute the excellent results and favorable long-term prognosis of our patients to the early initiation of MCS....
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PMID: 18751940
PDF is available here.
Abstract
Heart failure (HF) is a major public health problem in the United States, and its prevalence is likely to increase with the aging U.S. population. Mechanical circulatory support (MCS) utilizing bladder-based blood pumps generating pulsatile flow has been reserved for patients with severe HF failing...
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PMID: 18647112
PDF is available here.
Abstract
The present experimental study compared the effectiveness of counterpulsation provided by the intra-aortic balloon pump (IABP) versus that of a nonpulsatile, radial-flow centrifugal pump (CFP) in rapidly worsening acute heart failure (HF). Eighteen pigs were included in the study. After the inductio...
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PMID: 19033773
PDF is available here.
Abstract
We present a review of the technological advances of mechanical circulatory support in the pediatric population, including the recent emergence of a new class of circulatory support devices for pediatric patients with single ventricle physiology. The National Heart, Lung, and Blood Institute pediatr...
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PMID: 18812740
PDF is available here.
Abstract
Research on pulsatile blood pumps for extracorporeal life support has been widely performed because of the proven advantageous effects of blood pulsation. However, studies on the use of pulsatile blood pumps for hemodialysis are limited, although available evidence demonstrates that pulsatile blood...
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PMID: 18356654
PDF is available here.
Yoshio Ootaki,
Diyar Saeed,
Chiyo Ootaki,
Masatoshi Akiyama,
Hideyuki Fumoto,
Tetsuya Horai,
Raymond Dessoffy,
Jacquelyn Catanese,
Alex Massiello,
David Horvath,
Ji-Feng Chen,
Stephen Benefit,
Leonard A R Golding and
Kiyotaka Fukamachi
Abstract
Cannula design and cannulation site can pose major limitations to chronic pump implantations in animal studies. The aim of this study was to evaluate the biocompatibility of various inflow cannula designs for the DexAide right ventricular assist device (RVAD). The DexAide RVAD was implanted for inte...
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PMID: 18204313
PDF is available here.
Abstract
We show how post-cardiotomy heart failure can be successfully treated by proactive use of biventricular assist devices (BIVAD)....
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PMID: 18269116
PDF is available here.
Abstract
We report our experience using the Lund University Cardiac Arrest System (LUCAS, Jolife, Lund, Sweden) which is a gas-driven sternal compression device that incorporates a suction cup for active decompression. During the last 13 months LUCAS has been used in our catheterisation laboratory to maintai...
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PMID: 17618034
PDF is available here.
Abstract
OBJECTIVES: One of the most popular palliative procedures performed to increase pulmonary blood flow in children with congenital heart defects is a shunt operation (Blalock-Taussig graft or Glenn procedure), which creates the new blood channel to the pulmonary artery. The main problem with this kind...
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PMID: 18203068
PDF is available here.
Abstract
Mechanical cardiac support represents a large spectrum of devices. The duration of assistance may vary from a few hours in the cath lab to several weeks. The goals for a temporary support by percutaneus assistance are: improve end-organ perfusion; decrease pulmonary capillary wedge pressure; decreas...
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PMID: 17988644
PDF is available here.
Abstract
The objective of this study was to analyze the early predictive factors for successful weaning from a percutaneous cardiopulmonary support system (PCPS) in patients with low cardiac output syndrome after cardiovascular surgery. A total of 938 patients underwent cardiovascular surgery with cardiopulm...
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PMID: 18160766
PDF is available here.
Abstract
Surgical therapy for the treatment of heart failure is a relatively young solution to a problem that has overwhelmed civilizations dating back to the First Dynasty. Despite centuries of enormous multidisciplinary medical and technological advance, nearly 2000 people in the USA died o...
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PMID: 18035942
PDF is available here.
Abstract
The results of MCSS therapy for patients with severe heart failure are improving, and there are increasing numbers of implants as device therapy enters the era of permanent use (i.e., destination therapy). Device-related infection of implanted pumps and sepsis remain important risk factors for death...
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PMID: 17918120
PDF is available here.
Abstract
Peripheral vasomotion, interstitial liquid exchange, and cardiovascular system behaviour are investigated by means of a lumped parameter model of the systemic and peripheral circulation, from the aortic valve to the venules. This modelling work aims at combining arterial tree hemodynamics descriptio...
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PMID: 17011809
PDF is available here.
Abstract
The reliability and simplicity of rotor bearing are vital to the success of long-term implantation of rotary blood pumps. This article describes both numerical and in vitro studies of the pressure rise in a 5-cm-diameter spiral groove bearing. Results show that the simplified analytical model overpr...
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PMID: 17537055
PDF is available here.
Abstract
In this study, the performances of the TinyPump (priming volume 5 mL) system including the pediatric cannulae (Stöckert Pediatric Arterial Cannulae 2.6, 3.0, and 4.0 mm, Stöckert Instruments GmbH, Munich, Germany; Polystan 20-Fr Venous Catheter, MAQUET GmbH, Rastatt, Germany) and an oxygenator (Te...
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PMID: 17470213
PDF is available here.
Abstract
Despite being technically challenging and carrying a higher periprocedural risk, the performance of revascularization in patients who have heart failure of ischemic origin can provide substantial clinical benefits. Although several studies have demonstrated a benefit of the performance of coronary a...
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PMID: 17643923
PDF is available here.
Abstract
The mean age and risk profile of patients referred for cardiac surgery is constantly increasing. Surgeons are now inclined to accept high-risk patients because interventional cardiology provides less invasive alternatives for an overlapping patient cohort. As risk profile increases so does hospital...
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PMID: 17643920
PDF is available here.
Abstract
With the proper choice of numerical parameters, the computer simulations and the oil film method demonstrated good correlation. Improper generation of the simulation grid did lead to divergent results between the numerical simulation and the experiment. For the pump impeller as well as for the inflo...
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PMID: 17520575
PDF is available here.
Abstract
The ability to abstain from fluoroscopy and the feasibility of inserting the afferent cannula across the interatrial septum guided by TEE allows for application of this system in intensive care units, saving precious time as well as financial and human resources....
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PMID: 17597046
PDF is available here.
Abstract
The pediatric TandemHeart pump is being developed for short-term circulatory support of patients varying in size from 2 to 40 kg. The pump withdraws blood from the left atrium via cannula inserted percutaneously, either through the right internal jugular vein or transhepatically, and pumps the blood...
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PMID: 18043160
PDF is available here.
Abstract
The TinyPump is a miniature centrifugal blood pump with an extremely small priming volume of 5 ml, allowing blood transfusion free cardiopulmonary bypass as well as extracorporeal membrane oxygenation in pediatric patients. In this study, a new pump housing with the angled inlet port (25 degrees tow...
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PMID: 18043159
PDF is available here.
Abstract
We hypothesize that a folding propeller blood pump would function optimally in this cavopulmonary circulation. The hydraulic performance of a two-bladed propeller prototype was characterized in an experimental flow loop using a blood analog fluid for 0.5-3.5 lpm at rotational speeds of 3,600-4,000 r...
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PMID: 18043158
PDF is available here.
Abstract
Patients suffering from acute cardiac graft rejection can die because of hemodynamic collapse while being treated with vigorous immunosuppressive therapies. There is little pediatric data on the use of mechanical circulatory support (MCS) in patients with acute cardiac graft rejection accompanied by...
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PMID: 18043151
PDF is available here.
Abstract
We have developed a miniaturized semiclosed cardiopulmonary bypass (CPB) circuit incorporating a centrifugal blood pump (TinyPump) with a volume of 5 ml. The current study was undertaken to evaluate the hemolytic performance of the TinyPump in comparison with the BioPump and to investigate the impac...
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PMID: 18043145
PDF is available here.
Abstract
We describe a novel approach to endocardial and epicardial mapping and ablation of hypotensive VT using a percutaneous left ventricular assist device in the electrophysiology laboratory, permitting near-surgical access to cardiac structures....
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PMID: 17229307
PDF is available here.
Abstract
In adult patients, mechanical circulatory support (MCS) devices are part of the standard of care for heart failure. There are several options available that clinicians may use to provide support for their patients and thus the choice of devices can be tailored to their individual needs. Unfortunatel...
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PMID: 17356354
PDF is available here.
Abstract
We hypothesized that this was primarily due to a left ventricular (LV) effect. This study compared BiV, LV, and right ventricular (RV) assists in terms of hemodynamic and energetic response. Ten sheep underwent instrumentation and device implantation at least 1 week prior to study. HF (50% reduction...
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PMID: 17209959
PDF is available here.
Abstract
Continuous flow pump support has emerged as an alternative therapy in patients with congestive heart failure. For long-term applications, it is important to have a control system that changes the pump function according to the physiological conditions of the patient, thereby preventing risk situatio...
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PMID: 17295191
PDF is available here.
Stavros G Drakos,
Abdallah G Kfoury,
Edward M Gilbert,
James W Long,
James C Stringham,
Elizabeth H Hammond,
Kent W Jones,
David A Bull,
MaryBeth E Hagan,
Jan W Folsom,
Benjamin D Horne and
Dale G Renlund
Abstract
Certain pretransplant characteristics clearly predispose a patient to the development of CRD or increased mortality after heart transplantation. Interestingly, the risk of CRD after heart transplantation is greater for patients bridged to transplant with inotropes than with mechanical circulatory su...
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PMID: 17184631
PDF is available here.