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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Biological Therapy (8):
Recent article
Biological Therapy
Abstract
We assessed the impact of diets controlled in calcium and oxalate contents on urinary and fecal analytes in healthy subjects who were naturally colonized with O. formigenes or not colonized with O. formigenes....
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PMID: 21575973
PDF is available here.
PDF is available here.
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Abstract
BACKGROUND: Endogenous uveitis is a sight-threatening disease. In addition to corticosteroids, immunosuppressive agents are commonly used to treat patients with severe course. Immunosuppressive drugs act nonspecifically, rather than providing a specific interaction with the critical pathogenetic pat...
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PMID: 20737162
PDF is available here.
PDF is available here.
Abstract
To review biological therapies as they pertain to the treatment of inflammatory eye diseases, especially uveitis.
Biological therapies including antibodies, soluble receptors, and cytokines are being tested increasingly for a variety of ocular inflammations. As a class, tumor necrosis factor inhibit...
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PMID: 20829688
PDF is available here.
PDF is available here.
Autoimmunity Reviews (9)12 2010
Abstract
Biologics including tumor necrosis factor α (TNF-α), interleukin-6 receptor (IL-6R), T and B cell inhibitors are very effective therapeutic agents for the treatment of arthritides. These compounds effectively improve articular symptoms and inhibit joint damage. In this respect, the...
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PMID: 20667515
PDF is available here.
PDF is available here.
Abstract
Hepatitis B virus (HBV) reactivation results from increased viral replication in inactive carriers or patients with prior infection with HBV. Reactivation may occur spontaneously or secondary to immunomodulating or immunosuppressive chemotherapy. Reactivation may manifest with no symptoms but on occ...
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PMID: 20883071
PDF is available here.
PDF is available here.
Abstract
This report summarises phase 2 trial results of biologic lung volume reduction (BioLVR) for treatment of advanced homogeneous emphysema. BioLVR therapy was administered bronchoscopically to 25 patients with homogeneous emphysema in an open-labelled study. Eight patients received low...
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PMID: 19926742
PDF is available here.
PDF is available here.
Abstract
Smoking was present in 45.5% in CD and 15.8% in UC. CD patients who underwent at least one bowel resection comprised 46.5%. In an univariate analysis, disease location, behavior, AZA, or AZA/biological use before surgery [odds ratio (OR): 0.26 and 0.22, P<0.001] and smoking (OR: 1.61, P = 0.03) were...
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PMID: 19648821
PDF is available here.
PDF is available here.
Biometrics (66)2 2010
Abstract
An outcome-adaptive Bayesian design is proposed for choosing the optimal dose pair of a chemotherapeutic agent and a biological agent used in combination in a phase I/II clinical trial. Patient outcome is characterized as a vector of two ordinal variables accounting for toxicity and...
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PMID: 19673865
PDF is available here.
PDF is available here.
Biometrics (66)2 2010
Abstract
An outcome-adaptive Bayesian design is proposed for choosing the optimal dose pair of a chemotherapeutic agent and a biological agent used in combination in a phase I/II clinical trial. Patient outcome is characterized as a vector of two ordinal variables accounting for toxicity and...
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PMID: 19673865
PDF is available here.
PDF is available here.
Abstract
T cells contribute to the initiation and perpetuation of autoimmunity in systemic lupus erythematosus (SLE), and seem to be directly involved in the development of related organ pathology. Defects associated with CD8(+) and T-regulatory (T(REG)) cell function manifest in parallel with the expanded C...
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PMID: 20458333
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)5 2010
Abstract
We aimed to review the current literature on the effects of IL-1 and TNF-alpha neutralization as a new OA therapy. In vitro and experimental models showed a reduction in cartilage destruction with IL-1 inhibition therapy by IL-1 receptor antagonists (IL-1Ra). Despite this favorable evidence in anima...
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PMID: 20108016
PDF is available here.
PDF is available here.
Neuromuscular Disorders (20)5 2010
Abstract
Abstract
We examined the therapeutic potential of phage Kpn5 in the treatment of Klebsiella pneumoniae B5055-induced burn wound infection in a mouse model. An experimental model of contact burn wound infection was established in mice employing K. pneumoniae B5055 to assess the efficacy of phage Kpn5 in vivo....
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PMID: 20519918
PDF is available here.
PDF is available here.
Journal of Immunotherapy (33)4 2010
Abstract
Cancers often arise as the end stage of inflammation in adults, but not in children. As such there is a complex interplay between host immune cells during neoplastic development, with both an ability to promote cancer and limit or eliminate it, most often complicit with the host. In...
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PMID: 20386472
PDF is available here.
PDF is available here.
Abstract
All marketed TNF inhibitors for compared to control RA appear to increase the risk of serious and nonserious infections compared with DMARDs. Although suggestive, data for abatacept and rituximab are less definitive and longer periods of patient exposure to these agents are needed before an assessme...
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PMID: 19117595
PDF is available here.
PDF is available here.
Orthopedics (33)4 2010
Abstract
Abstract
Rheumatoid arthritis (RA) is the most common inflammatory musculoskeletal disease and an important cause of diminished quality-of-life for the affected individuals and with a major impact on society because of decreased work-force participation. Treatment of RA has been advanced dramatically during...
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PMID: 20423676
PDF is available here.
PDF is available here.
Abstract
The median follow-up of the patients was 6.2 years, and median overall survival was 5.3 years. Twenty-four patients (5.3%) developed MDS with median time of onset of 4.2 years (range, 8 months to 7.5 years). An additional 5 patients developed clonal karyotypic abnormalities in the bone marrow withou...
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PMID: 20371446
PDF is available here.
PDF is available here.
Abstract
This study aimed to investigate the antitumor and antiangiogenic effects utilizing a novel therapy regimen of metronomic topotecan and pazopanib, a multireceptor tyrosine kinase inhibitor. In vitro (Western blot) and in vivo dose-finding experiments were done following pazopanib therapy in ovarian c...
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PMID: 20371710
PDF is available here.
PDF is available here.
Rheumatology (49)6 2010
Abstract
Abstract
Clinical Rheumatology (29)3 2010
Abstract
Clinical Rheumatology (29)3 2010
Abstract
Clinical Rheumatology (29)3 2010
Abstract
Journal of wound care (19)3 2010
Abstract
A vast range of dressings can be used on pressure ulcers, but despite this and the high expense often involved, there is no gold standard for the local treatment of these wounds. This literature review therefore set out to examine the evidence.
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PMID: 20559190
PDF is available here.
PDF is available here.
Abstract
English articles on abatacept, golimumab, and tocilizumab in rheumatoid arthritis published between 2002 and 2009 were reviewed systematically. All randomized clinical trials, open-label extensions, meta-analyses, and reviews were examined. There were thirteen articles on abatacept, four on golimuma...
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PMID: 20195397
PDF is available here.
PDF is available here.
Abstract
Abstract
The introduction of biologic therapy for the treatment of IBD has substantially changed its management. The safety concerns associated with biologic therapies include the increased risk of infection, autoimmunity, development of lymphoma and demyelinating disease, and the risk of worsening heart fai...
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PMID: 20134491
PDF is available here.
PDF is available here.
Abstract
The past decade has been marked by the introduction and expanding use of biologic therapies for the induction and maintenance of response in patients with IBD. Although widely heralded for their efficacy, these agents have also stirred controversy over the potential economic impact that they will ha...
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PMID: 20134492
PDF is available here.
PDF is available here.
Abstract
The treatment of patients with IBD has evolved towards biologic therapy, which seeks to target specific immune and biochemical abnormalities at the molecular and cellular level. Multiple genes have been associated with susceptibility to IBD, and many of these can be linked to alterations in immune p...
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PMID: 20134493
PDF is available here.
PDF is available here.
Abstract
We performed a literature research for papers published in MEDLINE database until January 2009. We selected the most significant data presented as abstract or poster during the relevant international meetings for breast cancer (ASCO, ESMO and San Antonio Breast Cancer Symposium). Moreover, we system...
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PMID: 20088791
PDF is available here.
PDF is available here.
Indian Journal of Cancer (47)3 2010
Abstract
Despite significant improvements in the treatment and outcomes of patients with squamous cell carcinoma of the head and neck (SCCHN) that have resulted from technological advances in radiation delivery and the use of cytotoxic chemotherapy, there is still a pressing need for novel therapies. In the...
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PMID: 20587899
PDF is available here.
PDF is available here.
Abstract
Biological drugs are used in the treatment of active inflammatory athritides refractory to conventional treatment. Data from the Finnish registry of biological treatment (ROB-FIN) indicates that the effectiveness of the biologicals in clinical practice corresponds to or even excels that of randomize...
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PMID: 20617752
PDF is available here.
PDF is available here.
Abstract
A 27-year-old male with a 2 year history of ankylosing spondylitis (AS) was investigated for intermittent episodes of diarrhea and found to have granulomatous ileitis. Differential diagnosis, discussions regarding similarities in immune alterations in both AS and Crohn's disease and therapeutic optio...
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PMID: 21528764
PDF is available here.
PDF is available here.
Abstract
The ability to externally regulate the expression or function of a gene product has proven to be a powerful tool in the study of proteins and disease in vitro, and more recently in transgenic animal models. The transfer of these technologies to regulate a therapeutic, adoptively transferred gene pro...
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PMID: 20064281
PDF is available here.
PDF is available here.
Abstract
The introduction of biologic agents and particularly of anti-tumor necrosis factor antibodies dramatically changed the therapeutic algorithm in patients with inflammatory bowel diseases. Although the efficacy of these agents has been demonstrated clearly, optimal treatment strategies are debated. Re...
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PMID: 19903427
PDF is available here.
PDF is available here.
Abstract
We summarise the available data, mainly derived from retrospective and case-control studies, about IBD management in pregnancy, focusing mostly on the safety of drugs during gestation and peripartum....
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PMID: 19832551
PDF is available here.
PDF is available here.
Cutis; cutaneous medicine for the practitioner (84)4 Suppl 2009
Abstract
Psoriasis is a chronic inflammatory, immune-mediated, genetic disease predominantly affecting the skin and associated with significant patient morbidity. Conventional topical and systemic treatment options are numerous and generally effective, with varying degrees of success and rapidity of action....
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PMID: 19916298
PDF is available here.
PDF is available here.
Abstract
Psoriasis or psoriasiform skin lesions, as an adverse effect of treatment with antitumor necrosis factor antibody therapy, have been described relatively recently. Patients with these lesions have no personal or family history of psoriasis. In a small number of cases, an association with Chlamydia h...
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PMID: 19826641
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
The present study shows that there were clinically significant differences in weight gain effects between efalizumab and anti-TNF-alpha agents in psoriatic patients. The changes in body weight gain increase did not reach statistical significance, although there is a trend towards this, and this may...
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PMID: 19635043
PDF is available here.
PDF is available here.
Abstract
Since the discovery and synthesis of a novel DNA mimic, peptide nucleic acid (PNA) in 1991, PNAs have attracted tremendous interest and have shown great promise as potential antisense drugs. They have been used extensively as tools for specific modulation of gene expression by targeting translation...
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PMID: 19534584
PDF is available here.
PDF is available here.
Abstract
Current treatments for autoimmune disease are hampered by the non-specificity of immunomodulatory interventions, having to accept broad suppression of immunoresponsiveness with potentially serious side effects, such as infection or malignancy. The development of antigen-specific approaches, downregu...
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PMID: 19522557
PDF is available here.
PDF is available here.
Abstract
The colorectal cancer treatment has significantly changed in last few years. Use of new drugs such as oxaliplatin, irinotecan, or capecitabine improved long term survival of patient with this disease. Research of biologic and genetic behavior of CRC has brought new ways in therapy called "biologic t...
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PMID: 19642320
PDF is available here.
PDF is available here.
Irish medical journal (102)6 2009
Abstract
Abstract
Since the current standards for drug approval were established nearly half a century ago, no drug has been approved for the treatment of systemic lupus erythematosus (SLE). Despite this sobering history, interest in drug development for SLE has heightened in the past few years. This enthusiasm has b...
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PMID: 19491915
PDF is available here.
PDF is available here.
Journal of wound care (18)6 2009
Abstract
No adverse events were attributed to the study product. No significant difference (p>0.05) was determined between the test and control groups for frequency of adverse events, rate of healing, or frequency of healing. CONCLUSION: This study found no safety concerns with the bacteriophage treatment. E...
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PMID: 19661847
PDF is available here.
PDF is available here.
Efficacy of bacteriophage treatment in murine burn wound infection induced by klebsiella pneumoniae.
Abstract
In the present study, the therapeutic potential of purified and well-characterized bacteriophages was evaluated in thermally injured mice infected with Klebsiella pneumoniae B5055. The efficacy of five Klebsiella phages (Kpn5, Kpn12, Kpn13, Kpn17, and Kpn22) was evaluated on the basis of survival ra...
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PMID: 19597322
PDF is available here.
PDF is available here.
Actas Dermo-Sifiliográficas (100)4 2009
Abstract
The treatment of psoriasis has been revolutionized by the introduction of biologic agents; these agents achieve skin clearance and long-term improvement without the risk of toxicity that has limited use of the classic systemic treatments. The role of systemic treatment in the management of psoriasis...
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PMID: 19463230
PDF is available here.
PDF is available here.
Abstract
Treatment of epithelial ovarian cancer generally involves surgical staging followed by chemotherapy with a combination of a platinum and a taxane-containing agent. However, a majority of patients recur and ultimately succumb to their cancer. Novel therapies that target specific pathw...
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PMID: 19381822
PDF is available here.
PDF is available here.
Abstract
Cell Cycle (8)6 2009
Abstract
We report here a new targeting strategy for primary bone tumor and lung metastasis with a modified auxotrophic strain of Salmonella typhimurium. We have previously developed the genetically-modified strain of S. typhimurium, selected for tumor targeting and therapy in vivo. Normal tissue is cleared...
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PMID: 19221501
PDF is available here.
PDF is available here.
Cell Cycle (8)6 2009
Abstract
Investigacion clinica (50)1 2009
Abstract
The incidence of immune diseases has had a steady significant increase in the industrialized countries since the end of the last century. Epidemiological data suggest that prevention of exposure to helminths may be one of the factors promoting the rise in these diseases. Animal models of immune dise...
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PMID: 19418721
PDF is available here.
PDF is available here.
Anticancer Research (29)3 2009
Abstract
Abstract
Ulcerative colitis (UC), Crohn's disease (CD) and indeterminate colitis are defined as inflammatory bowel diseases (IBD). Those diseases involve disorders of numerous immunological mechanisms associated with cellular and humoral immune response. In CD cellular response is considered to be of crucial...
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PMID: 19341184
PDF is available here.
PDF is available here.
Abstract
I programmed cell death) as compared to the highly cellular centre of the tumor, and this may contribute to their resistance to conventional pro-apoptotic chemotherapy and radiotherapy. Resistance to apoptosis results from changes at the genomic, transcriptional and post-transcriptional level of pro...
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PMID: 19368079
PDF is available here.
PDF is available here.
Abstract
Nearly all chemotherapy and biotherapy drugs used in cancer treatment today can cause hypersensitivity reactions. Certain groups of drugs frequently associated with these reactions include the asparaginases, taxanes, platinum compounds, epipodophyllotoxins, and the monoclonal antibodies. Recognizing...
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PMID: 19444023
PDF is available here.
PDF is available here.
Abstract
We combine experimental and modelling approaches to make a detailed examination of such kinetics for the important food-borne pathogen Campylobacter jejuni and a suitable virulent phage in an in vitro system. Phage-insensitive populations of C. jejuni arise readily, and as far as we are aware this i...
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PMID: 19119417
PDF is available here.
PDF is available here.