Abstract
The purpose of this study was to present results on cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) of appendiceal adenocarcinoid (AAC) with peritoneal carcinomatosis (PC), to assess drug sensitivity of AAC, as compared with colorectal cancer (CRC),...
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PMID: 21859562
PDF is available here.
Abstract
To review the clinical features and management of circumscribed choroidal hemangioma.
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PMID: 21706839
PDF is available here.
Abstract
This experience demonstrates that long-term survival is anticipated in patients who undergo complete cytoreduction followed by HIPEC for PSD from OC. These findings not only highlight the potential utility of HIPEC in the treatment of OC but also underscore the importance of maximal cytoreduction fo...
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PMID: 21474115
PDF is available here.
Abstract
CD133(+) cells in glioblastoma (GBM) display cancer stem cell-like properties and have been considered as the culprit of tumor recurrence, justifying exploration of potential therapeutic modalities targeting CD133(+) cancer stem-like cells (CSCs). For photothermolysis studies, GBM-CD...
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PMID: 20620237
PDF is available here.
Abstract
Multimodality therapy in selected patients with peritoneal carcinomatosis is gaining acceptance. Treatment-directing decision support tools are needed to individualize care and select patients best suited for cytoreductive surgery +/- hyperthermic intraperitoneal chemotherapy (CRS +/...
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PMID: 21337884
PDF is available here.
Abstract
Controversy has surrounded the role of isolated limb perfusion (ILP) for unresectable extremity sarcomas. However, there remains a group of sarcoma patients for whom amputation is the only potential treatment. Because systemic therapies are limited, the authors evaluated ILP in an effort to provide a...
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PMID: 21246524
PDF is available here.
Abstract
We investigated whether 8-week-old male and female R6/1 transgenic HD mice display depressive-like endophenotypes associated with serotonergic impairments. We also studied the behavioral effects of acute treatment with sertraline. We found that only female HD mice exhibited a decreased preference fo...
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PMID: 21760962
PDF is available here.
Author(s) unavailable
Abstract
The study aimed to prove the prognostic meaning of micrometastases blood circulation during liver resections for cancer lesions. 33 patients took part in the study. Circulating micrometastases were detected in blood using immunocytological method with pancytoceratine antibodies KL-1 and CAN 5.2. The...
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PMID: 21716214
PDF is available here.
Author(s) unavailable
Abstract
Our optimal cryo-temporal regimens and intraoperative intrapelvic chemotherapy proved highly effective....
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PMID: 21809661
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Abstract
We sought to assess the long-term success rate of the HydroThermAblator system (HTA).
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PMID: 21144493
PDF is available here.
Abstract
We report a multifunctional, nanotechnology-driven, gold nano-popcorn-based surface-enhanced Raman scattering (SERS) assay for targeted sensing, nanotherapy treatment, and in situ monitoring of photothermal nanotherapy response during the therapy process. Our experimental data show that, in the pres...
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PMID: 21128627
PDF is available here.
Abstract
We highlight the biology of therapeutic fever-range hyperthermia, discuss how hyperthermia is administered and dosed, demonstrate how heat can be added to other treatment regimens, and summarize the data supporting the role of hyperthermia in the management of bladder cancer....
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PMID: 21141697
PDF is available here.
Abstract
To evaluate whether expression of L-type amino acid transporter 1 (LAT1) in pretreatment rectal cancer biopsies is predictive of tumour response to neoadjuvant hyperthermo-chemoradiotherapy (HCRT).
Forty-four patients with rectal adenocarcinoma who received neoadjuvant HCRT were investigated. LAT1 e...
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PMID: 21036745
PDF is available here.
Abstract
The 70 MHz AMC-4 system, with one ring of four waveguides, provides 2D power steering. The newly developed AMC-8 system enables 3D steering, using two rings of four 70 MHz waveguides. The current waveguide aperture size is 20.2 x 34.3 cm(2). Waveguides and water boluses cover a large area of the bod...
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PMID: 20679701
PDF is available here.
Abstract
We discuss the manner by which focused ultrasound exposures at low rates of energy deposition are being developed for a variety of clinically translatable applications for the treatment of cancer. Specific preclinical studies will be highlighted. Additional information will also be provided for opti...
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PMID: 20919832
PDF is available here.
Abstract
Measuring tissue temperature distribution during electromagnetically induced hyperthermia (HT) is challenging. High resistance thermistors with nonmetallic leads have been used successfully in commercial HT systems for about three decades. The single 1 mm thick temperature sensing element is mechanic...
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PMID: 20964179
PDF is available here.
Abstract
This new hybrid method for MR thermometry in moving organs combines the strengths of both multi-baseline subtraction and referenceless thermometry and overcomes their fundamental weaknesses....
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PMID: 20964221
PDF is available here.
Abstract
Temperature-based optimization proves to be superior to SAR-based optimization both under variation of perfusion level as well as under the application of intratissue variation. The spread in achieved temperatures is comparable. These results are valid under the assumption of constant perfusion at h...
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PMID: 20964171
PDF is available here.
Abstract
We created pleural metastatic animal model in 24 immune deficiency mice (male nu/nu mice) to evaluate inhibitory effect of systemic EMW hyperthermia for disseminated tumor growth. Out of 24 mice, 8 received mild and 8 received moderate hyperthermia, and remaining 8 were the no treatment control. Who...
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PMID: 20664962
PDF is available here.
Abstract
We measured the association between clinical examination findings at hospital arrival, 24, and 72 h after cardiac arrest in a modern intensive care unit setting.
Between 1/1/2005 and 3/31/2009, hospital charts were reviewed in 272 subjects for neurologic examination findings (Glasgow Coma Score--mot...
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PMID: 20732605
PDF is available here.
Abstract
Combining hyperthermia and viral treatment produced a synergistic effect on cell kill. Viral growth increased greater than 6-fold in the presence of hyperthermia (P < .05). Hyperthermia alone showed minimal cytotoxic activity against Hs 700T cells, while NV1066 infection resulted in approximately 50...
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PMID: 20633729
PDF is available here.
Abstract
The targeted cell line Panc-1 had a viability of 46% +/- 12%, whereas the Cama-1 cell had a viability of 92% +/- 2% after RF field exposure (P < .008). Transmission electron microscopy showed gold nanoparticle uptake in Panc-1 cells but negligible uptake by Cama-1 cells. Nontargeted cells do not int...
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PMID: 20541785
PDF is available here.
Abstract
The bleeding stoppage and the wound sanitation constitute an important problem of modern surgery. There is information presented concerning the apparatuses elaboration for the bleeding stoppage, processing of the soft living tissues wounds, including the infected, during surgical operations conducti...
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PMID: 20825094
PDF is available here.
Abstract
While local hyperthermia application the intratumoral blood flow is enhancing, leading to oxygenation and vascular permeability for antitumoral medicines. The work objective was to investigate the dependence of the development kinetics in carcinoma Gereni (CG) from combined action of doxorubicin (DR...
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PMID: 20825095
PDF is available here.
Abstract
A controlled internal electric field perpendicular to the skin-fat interface is selective in heating up fat and, consequently, has the ability to induce lethal thermal damage to subcutaneous adipose tissues while sparing overlying and underlying tissues. In vitro adipocyte cells are heat sensitive t...
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PMID: 20583242
PDF is available here.
Abstract
We hypothesized that these T(c) responses are mediated by a change in the temperature setpoint. T(c) (+/- 0.1 degrees C; radiotelemetry) of male C57BL/6J mice was monitored while they were housed in a temperature gradient with ambient temperature (T(a)) range of 20-39 degrees C to monitor behavioral...
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PMID: 20427722
PDF is available here.
Abstract
The purpose of this study is to test the hypothesis that gold nanoparticle (AuNP, nanogold)-enhanced radiation therapy (nanogold radiation therapy, NRT) is efficacious when treating the radiation resistant and highly aggressive mouse head and neck squamous cell carcinoma model, SCCVII, and to identi...
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PMID: 20463371
PDF is available here.
C Pomel,
G Ferron,
G Lorimier,
A Rey,
C Lhomme,
J M Classe,
J M Bereder,
F Quenet,
P Meeus,
F Marchal,
P Morice and
D Elias
Abstract
The grade 3 morbidity rate was 29% (95 CI: 14-45%). Nine patients experienced a total of 13 exploratory laparotomies for intra-abdominal bleeding after HIPEC. Two-year disease free and overall survival were 27% and 67% respectively. As a result of this high level of morbidity the trial was closed. C...
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PMID: 20466507
PDF is available here.
Abstract
FBP was significantly lower in patients with SSc (p < 0.05) compared to controls. Heating of the LDF probe at 36 degrees C induced a significant increase of FBP in all subjects (p < 0.001), but the slope of variation was significantly lower in patients with SSc compared to controls (p < 0.05). Patie...
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PMID: 20436070
PDF is available here.
Abstract
Few problems were observed. The general satisfaction was good, 76% was very or fairly satisfied. More than 80% reported reduced bleeding, but only 7% became amenorrheic. CONCLUSION: Thermablate is suitable in treatment of menorrhagia and can be done in paracervical block to outpatients. It is a simp...
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PMID: 20470654
PDF is available here.
Abstract
We have designed and built a site-specific phased-array applicator. Earlier, we demonstrated its features in parameter studies, validated those by phantom measurements and clinically introduced the system. In this paper we will critically review our first clinical experiences and demonstrate the piv...
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PMID: 20371911
PDF is available here.
Abstract
We investigate the influence of therapeutic hypothermia on hemodynamic parameters in resuscitated patients and on contractility in failing human myocardium. We analyzed hemodynamic data from 200 cardiac arrest survivors during the hypothermia period. The initial LVEF was 32.6 +/- 1.2% indicating a s...
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PMID: 20130890
PDF is available here.
Abstract
For late-stage cancer, whole-body hyperthermia (WBH) is highly regarded by physicians as a promising alternative to conventional therapies. Although WBH is still under scrutiny due to potential toxicity, its benefits are incomparable, as diversified devices and very promising treatment protocols in...
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PMID: 20420562
PDF is available here.
Abstract
We therefore explored the role of CaV1.3 L-type Ca2+ channels in depression- and anxiety-like behaviours using CaV1.3-deficient mice (CaV1.3-/-). We showed that CaV1.3-/- mice displayed less immobility in the forced swim test as well as in the tail suspension test, indicating an antidepressant-like...
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PMID: 19664321
PDF is available here.
Abstract
Our simulations to the acoustic field induced by a self-focused concave spherical transducer (0.5MHz, 9cm aperture width, 8.0cm focal length) show that the distribution of temperature can keep the same "cigar shape" in the focal region during ultrasound insonation. Based on the characteristic of the...
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PMID: 20156630
PDF is available here.
Abstract
We determined whether p53 and bcl-2 are involved in the hypothermia-induced neuroprotection.
Male Sprague-Dawley rats were divided into four groups: normothermic (37-38 degrees C) ischemia, hypothermic (31-32 degrees C) ischemia, hyperthermic (41-42 degrees C) ischemia and sham-operated group. Globa...
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PMID: 20483005
PDF is available here.
Abstract
The standard treatment for advanced ovarian cancer consist in complete surgical debulking and intravenous platin and taxane based chemotherapy. Despite research efforts, a lot of patients still die from peritoneal carcinomatosis. The aim of our work was to present the state of art about intraperiton...
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PMID: 20116179
PDF is available here.
Abstract
I (randomised controlled trials [RCTs]) or level II (epidemiological cohort studies), in accordance with recommendations of the Centre for Evidence-Based Medicine, University of Oxford, UK. Evidence-based treatment of cancer follows recommendations of international expert panels and includes indicat...
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PMID: 20592376
PDF is available here.
Abstract
A fast beam-forming method for hyperthermia treatment of deep-seated tumors is described and verified. The approach is based on the time-reversal characteristics of Maxwell equations. The basic principle of the method is coupling of the electromagnetic modeling of the system with the actual applicat...
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PMID: 20348605
PDF is available here.
Abstract
We did an observational study of the risk factors and clinicopathological factors of 20 patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal mesothelioma at the St George Hospital, Sydney. Survival analysis was performed using the Kaplan-Meier method...
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PMID: 20420251
PDF is available here.
Abstract
HIPEC with/without debulking is an efficient method for controlling, managing or preventing the development of malignant ascites, it extends the mean survival time of the patients (especially when bulking is feasible) with low morbidity and lethality rates of the procedure....
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PMID: 20586160
PDF is available here.
Abstract
In choroidal melanomas the chance of local tumour control and preservation of the globe decreases with increase of the tumour prominence. In small choroidal melanomas with posterior location local tumour control was achieved significantly faster after TTT than after RB.
Copyright Georg Thieme Verlag...
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PMID: 20408070
PDF is available here.
Abstract
The passive Hygrovent Gold provided adequate heat and moisture in normothermia, but the active Hygrovent Gold provided the highest humidity, in both normothermia and hypothermia....
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PMID: 20406514
PDF is available here.
Abstract
Wide-field adaptive phased-array FMT can be safely administered in a preoperative setting, and data from randomized studies suggest both a reduction in positive tumor margins as a heat-alone treatment for early-stage breast cancer and a reduction in tumor volume when used in combination with anthrac...
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PMID: 20033319
PDF is available here.
Abstract
To investigate the possible mechanism of local hyperthermia in the treatment of warts through detecting the differences in CD1a/CD83 of Langerhans cells (LCs) in émigrés from HPV-infected skin, as compared to normal skin.
Confocal microscopy were performed on Condyloma Accuminatum (CA)and normal s...
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PMID: 21110432
PDF is available here.
Konstantinos Lasithiotakis,
George Economou,
Helen Gogas,
Christos Ioannou,
Konstantinos Perisynakis,
Dimitrios Filis,
Ourania Kastana,
Dimitrios Bafaloukos,
Marios Decatris,
Nikolaos Catodritis,
Konstantina Frangia,
George Papadakis,
Michael Magarakis,
Dimosthenis Tsoutsos,
Emmanuel Chrysos,
George Chalkiadakis and
Odysseas Zoras
Abstract
We present the experience of the Hellenic collaborating centers with TM-HILP for inoperable in-transit melanoma and soft tissue sarcoma (STS) of the extremities to examine safety and feasibility of collaborating as a multi-institutional group for future research studies. From 2001 to 2009, twenty pa...
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PMID: 20204294
PDF is available here.
Abstract
Twenty-two patients (12 interval debulking procedures and 10 recurrence procedures) were enrolled between September 2003 and September 2007. HIPEC was not performed in four patients because of operative findings. No patient received adjuvant chemotherapy after HIPEC. Patients were followed up routin...
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PMID: 20202920
PDF is available here.
Abstract
We examined the effect of leg hyperthermia on oxidative stress in bedridden subjects with type 2 diabetes mellitus using 15-min sessions of far infrared rays over a two-week period. Four subjects (male 1, female 3) incapacitated by a stroke were recruited for this study. All patients were admitted t...
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PMID: 20424670
PDF is available here.
Abstract
Waon therapy is a form of thermal treatment in a dry sauna maintained at a temperature of 60 degrees C, which differs from the traditional sauna. Waon therapy reportedly improves the hemodynamics, cardiac function, ventricular arrhythmias, vascular endothelial function, neurohormonal factors, sympat...
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PMID: 20154403
PDF is available here.
Abstract
Peritoneal carcinomatosis is one of the most common routes of dissemination of colorectal cancer (CRC). It is encountered in 7% of patients at primary surgery, while it develops in about 4% to 19% of patients after curative surgery and in up to 44% of patients with recurrent CRC. Peritoneal involvem...
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PMID: 20238394
PDF is available here.
Abstract
IMPORTANCE OF THE FIELD: Cutaneous leishmaniasis (CL) is a major tropical skin disease. Its incidence continues to increase, and disease control and management are challenging. Available therapies remain inadequate and are associated with low efficacy, toxicity, difficulties with administration, or...
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PMID: 20163267
PDF is available here.
Abstract
A nonlinear system reconstruction can theoretically provide timely system reconstruction when designing a real-time image-guided adaptive control for multisource heating for hyperthermia. This clinical need motivates an analysis of the essential mathematical characteristics and constraints of such an...
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PMID: 20384234
PDF is available here.