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Drug Administration Schedule (2):
Recent article
Drug Administration Schedule
Orvosi Hetilap (152)40 2011
Abstract
Therapeutic methotrexate serum concentrations (30-100µmol/l) were achieved in 72.5% of the cases. Repeated treatments resulted similar serum levels. Hepatotoxicity and hypoproteinemia occurred in 17% and in 48.9% of the cases. There was significant correlation between serum 7-hydroxi-methotrexate a...
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PMID: 21945870
PDF is available here.
PDF is available here.
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Orvosi Hetilap (152)37 2011
Abstract
Nearly 90% of the diabetic patients are suffering of type 2 diabetes while approximately 60-65% of patients with type 2 diabetes are treated with oral antidiabetic drugs. In the last couple of years a new treatment option, namely incretin-based therapy, became available. The dipeptid...
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PMID: 21893477
PDF is available here.
PDF is available here.
Abstract
To study prospectively the impact of initiating insulin glargine in suboptimally controlled insulin-naïve patients with Type 2 diabetes on health-related quality of life in relation to glycaemic control.
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PMID: 21843305
PDF is available here.
PDF is available here.
Poultry Science (90)9 2011
Abstract
Central composite design (CCD; 5 levels and 4 factors), response surface methodology (RSM), and artificial neural network-genetic algorithm (ANN-GA) were used to evaluate the response of broiler chicks [ADG and feed conversion ratio (FCR)] to dietary standardized ileal digestible protein (dP), lysine...
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PMID: 21844277
PDF is available here.
PDF is available here.
l Orthodontie Française (82)3 2011
Abstract
Bisphosphonates have unique pharmacological characteristics unlike those of any other drug group. Millions of adults take oral bisphosphonates for long-term treatment of osteoporosis and osteopenia; some of these people will most likely also seek orthodontic treatment. Adverse dental effects from bis...
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PMID: 21914435
PDF is available here.
PDF is available here.
Abstract
Abstract
Patients with chronic disabling gout refractory to conventional urate-lowering therapy need timely treatment to control disease manifestations related to tissue urate crystal deposition. Pegloticase, monomethoxypoly(ethylene glycol)-conjugated mammalian recombinant uricase, was developed to fulfill t...
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PMID: 21846852
PDF is available here.
PDF is available here.
Abstract
A phase 2 trial was conducted to determine the toxicity and efficacy of combined weekly topotecan and biweekly bevacizumab in patients with primary or secondary platinum-resistant ovarian, peritoneal, or fallopian tube cancer (OC).
Patients were treated with bevacizum...
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PMID: 21815133
PDF is available here.
PDF is available here.
Abstract
The objective of this study was to investigate the effects of a preparation from herbal extracts (PHE) on libido and semen quality in breeding artificial insemination boars. Ten fertile boars were divided into control and experimental groups according to significant difference of libido. There were n...
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PMID: 21092065
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (52 Suppl 5) 2011
Abstract
Lennox-Gastaut syndrome (LGS) is an intractable childhood-onset epileptic encephalopathy. Seizure freedom is rare in LGS. One of the hallmarks of LGS is medical intractability, with generally poor response to antiepileptic drugs (AEDs). Nevertheless, several treatment options are available that can m...
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PMID: 21790561
PDF is available here.
PDF is available here.
Abstract
To investigate the use of statins and their effect on the risk for subsequent vascular events in young adults with ischemic stroke of undetermined etiology.
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PMID: 21810695
PDF is available here.
PDF is available here.
Abstract
Non-response, loss of response, or intolerance to anti-tumour necrosis factor alpha (anti-TNFα) therapy is well recognised in Crohn's disease (CD) patients. Data concerning outcomes following the use of a second anti-TNFα therapy, particularly in patients who do not respond to a fi...
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PMID: 21683302
PDF is available here.
PDF is available here.
Abstract
To assess the therapeutic effects and safety of different doses of immunoglobulin in the treatment of Kawasaki disease.
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PMID: 21849113
PDF is available here.
PDF is available here.
Abstract
To review outcomes of pregnancy termination between 14-32 weeks of gestation based on a 10-year-experience of misoprostol use at Maharaj Nakorn Chiang Mai Hospital.
A retrospective, descriptive study
Based on the authors' prospective database, all preg...
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PMID: 21863669
PDF is available here.
PDF is available here.
MMW Fortschritte der Medizin (153)29-31 2011
Abstract
MMW Fortschritte der Medizin (153)29-31 2011
Abstract
Abstract
We summarized available plasma pharmacokinetic data derived from neonates or children following intravenous administration of fosfomycin. Subsequently, we used this information for recalculation of different dosing strategies and simulated a variety of clinically applied dosing regimens. The percent...
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PMID: 21740073
PDF is available here.
PDF is available here.
Abstract
We define as "laboratory aspirin resistance") would be associated with greater risk for death, myocardial infarction (MI) or stroke among patients with coronary artery disease regularly using aspirin....
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PMID: 21742104
PDF is available here.
PDF is available here.
Therapeutische Umschau (68)7 2011
Abstract
Tuberculosis is the second most common cause of death from an infectious disease after HIV/AIDS and the leading cause of death from an infectious disease in HIV-co-infected patients. Currently, drug susceptible TB is treated with a four drug regimen given over a period of two months followed by two d...
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PMID: 21728158
PDF is available here.
PDF is available here.
Abstract
Abstract
We report the successful use of a specific chromogenic antifactor IIa assay in a patient with heparin-induced thrombocytopenia who received anticoagulation therapy with bivalirudin during cardiopulmonary bypass for coronary artery bypass graft surgery....
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PMID: 21718867
PDF is available here.
PDF is available here.
Abstract
This multicenter, open-label, single-arm, Phase II study assessed the efficacy of a neoadjuvant chemotherapy with docetaxel (75 mg/m(2) q3w) followed by 5-fluorouracil 500 mg/m(2), epirubicin 100 mg/m(2) and cyclophosphamide 500 mg/m(2) q3w in patients with early-stage breast cancer.
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PMID: 21719750
PDF is available here.
PDF is available here.
Abstract
Taiwan has never implemented supervised intermittent chemotherapy for pulmonary tuberculosis, and its application and results are unknown. The purpose of this study was to evaluate the efficacy and feasibility of a 62-dose, four-drug, 6-month, twice-weekly regimen administered by directly observed th...
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PMID: 21742247
PDF is available here.
PDF is available here.
Abstract
No standard chemotherapy has been established yet for large-cell neuroendocrine carcinoma of the lung. Amrubicin is active for both small cell and non-small cell lung cancers, but its activity for large-cell neuroendocrine carcinoma is still unknown.
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PMID: 21636606
PDF is available here.
PDF is available here.
Abstract
Herpes zoster is the most common infection in patients treated with bortezomib-containing regimens for multiple myeloma. Some clinical trials have reported on the use of acyclovir prophylaxis to decrease the incidence of herpes zoster. However, the appropriate acyclovir dose and duration of prophylax...
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PMID: 21616919
PDF is available here.
PDF is available here.
Abstract
Treatment with budesonide/formoterol maintenance and reliever therapy led to a 21% reduction in time to first severe asthma exacerbation compared with CBST, although not statistically significant (hazard ratio 0.794, P = 0.189). A trend towards a reduction in the rate of severe exacerbations...
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PMID: 21679353
PDF is available here.
PDF is available here.
Abstract
Downstaging by neoadjuvant chemotherapy improves the survival of patients with muscle-invasive bladder cancer. In salvage setting, gemcitabine plus cisplatin has demonstrated an efficacy similar to that of methotrexate, vinblastine, doxorubicin and cisplatin with less toxicity. Therefore, the applica...
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PMID: 21665907
PDF is available here.
PDF is available here.
Abstract
MMW Fortschritte der Medizin (153)23 2011
Abstract
Abstract
Neoadjuvant chemoradiation followed by surgery is the standard of care for locally advanced rectal cancer. The aim of this study was to correlate tumor response to survival and to identify predictive factors for tumor response after chemoradiation.
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PMID: 21093174
PDF is available here.
PDF is available here.
Abstract
Twenty years ago, ribavirin was first used in the treatment for chronic hepatitis C. After few years, ribavirin, in combination with interferon-alpha, showed a dramatic synergistic efficacy against hepatitis C virus infection, leading to viral clearance in about 50% of patients. Recent discovery of p...
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PMID: 21093391
PDF is available here.
PDF is available here.
Abstract
A week on/week off capecitabine schedule with oxaliplatin/bevacizumab was evaluated in patients with metastatic colorectal cancer (mCRC).
Forty patients were required. The projected median progression-free survival (PFS) was 12 months (81% power, 1-sided level 0.1 log...
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PMID: 21859564
PDF is available here.
PDF is available here.
Abstract
Late prosthetic valve endocarditis is usually caused by streptococci, staphylococci, gram-negative bacilli and candida. The authors report the first case of prosthetic valve endocarditis caused by Gemella sanguinis. The patient's risk factors for the development of Gemella endocardit...
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PMID: 21613938
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Abstract
: Daily chest radiation schedules can be cumbersome for some patients and could also delay the administration of higher, systemic doses of chemotherapy.
: Thirty-six patients with advanced non-small cell lung cancer (stages IIIB and IV) were treated using a once weekl...
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PMID: 21613934
PDF is available here.
PDF is available here.
Rinsho Ketsueki (52)6 2011
Abstract
The safety, tolerability, pharmacokinetics and efficacy of nelarabine were evaluated in adult and pediatric patients with relapsed or refractory T-ALL/T-LBL. Adult patients received nelarabine i.v. over 2 hours on days 1, 3 and 5 in every 21 days, and pediatric patients received this regimen over 1 h...
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PMID: 21737993
PDF is available here.
PDF is available here.
Abstract
Clarithromycin resistance has decreased the eradication rates of Helicobacter pylori.
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PMID: 21766091
PDF is available here.
PDF is available here.
Abstract
Reversal of overanticoagulation to minimize the bleeding risk is important in elderly inpatients receiving vitamin K antagonist therapy. However, no study has specifically focused on this population. The objective of this study is to evaluate whether guidelines based on American College of Chest Phys...
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PMID: 21605730
PDF is available here.
PDF is available here.
New England Journal of Medicine (364)21 2011
Abstract
New England Journal of Medicine (364)21 2011
Abstract
New England Journal of Medicine (364)21 2011
Abstract
New England Journal of Medicine (364)21 2011
Abstract
Abstract
Cardiac surgery improves life expectancy and quality of life for the constantly ageing population in developed countries. Mediated by their lipid-dependent and lipid-independent mechanisms, statins are sought to provide benefit with regard to better outcomes after cardiac surgery. Current guidelines...
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PMID: 21620371
PDF is available here.
PDF is available here.
Presse Medicale (40)11 2011
Abstract
Abstract
Nonmetabolic effects of intensive insulin therapy in critically ill patients have been reported, but the underlying mechanisms are unclear. This study was designed to test the hypothesis that intensive insulin treatment would attenuate burn-induced acute lung injury by protecting the...
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PMID: 21436719
PDF is available here.
PDF is available here.
Abstract
In short-term trials, aspirin is associated with gastrointestinal bleeding. However, the effect of dose and duration of aspirin use on risk remains unclear.
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PMID: 21531232
PDF is available here.
PDF is available here.
Abstract
Statins decrease postoperative atrial fibrillation (AF) if given before cardiac surgery. However, whether early administration of statins after surgery decreases the risk of postoperative AF is unknown. The association of early reinstitution of postoperative statin therapy within 48 hours to the occu...
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PMID: 21545983
PDF is available here.
PDF is available here.
Orvosi Hetilap (152)21 2011
Abstract
Venous thromboembolism occurs approximately in 1 of 1000 pregnancies. It is one of the leading causes of maternal mortality. Physiologic changes associated with pregnancy and delivery favor for developing venous thromboembolism, and there are individual risk factors, too, contributing to its manifest...
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PMID: 21546339
PDF is available here.
PDF is available here.
Abstract
Our results show that although the incidence of back pain was high in both randomized groups, women randomized to zoledronic acid experienced, on average, 18 fewer days of back pain compared with placebo over the course of the trial (p = .0092). The back pain among women randomized to zoledronic...
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PMID: 21542001
PDF is available here.
PDF is available here.
Abstract
The aim of this retrospective study was to evaluate the efficacy and safety of weekly high-dose 5-fluorouracil (5-FU)/folinic acid (FA) as 24-h infusion (AIO regimen) plus irinotecan in patients with histologically proven metastatic gastroesophageal adenocarcinoma (UICC stage IV).
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PMID: 21525806
PDF is available here.
PDF is available here.
Abstract
A slow up-titration of clozapine is recommended in order to reach the optimal dosage of clozapine and diminish the risk of dose-dependent side-effects. Particularly, in case of partial response or non-response, the use of therapeutic drug monitoring of clozapine is recommended. Plasma levels abov...
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PMID: 21534935
PDF is available here.
PDF is available here.
Abstract
AP was not superior to placebo in reducing the number of weekly heartburn events over 4 weeks in the primary analysis of the entire study population. Exploratory subgroup analyses suggest that response to PPI treatment before the study was associated with a response to AP treatment.Am J Gastroenterol...
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PMID: 21519360
PDF is available here.
PDF is available here.
Abstract
The purpose of this study was to compare 2 weekly docetaxel-based regimens as first-line treatments for advanced gastric cancer and to investigate the expression of secreted protein acidic and rich in cysteine (SPARC) and its abilities to predict treatment-related clinical outcomes.
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PMID: 21523716
PDF is available here.
PDF is available here.
Abstract
Belotecan (CKD602; Camtobell, Chong Keun Dang Corp., Seoul, Korea) is a recently developed camptothecin derivative with antitumor properties. This phase II study was designed to evaluate the toxicity and efficacy of belotecan combined with carboplatin in patients with recurrent epithelial ovarian can...
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PMID: 21523722
PDF is available here.
PDF is available here.
Abstract
Abstract
The year 5 cumulative measures of the incidence of new and advanced adenomas were significantly lower in the celecoxib group than in the placebo group, but the year 5 interval rates of these measures were significantly lower in the placebo group than the celecoxib group, perhaps suggesting a release...
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PMID: 21503000
PDF is available here.
PDF is available here.
Orvosi Hetilap (152)18 2011
Abstract
Acromegaly is a rare disease with typical clinical manifestations. Untreated acromegaly carries a 2-4-fold increase in mortality in long-term outcome. The goal of treatment is double, including biochemical control of the disease (normalization of serum IGF1 levels compared to age and gender matched c...
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PMID: 21498160
PDF is available here.
PDF is available here.
Orvosi Hetilap (152)19 2011
Abstract
Physiological changes in lipoprotein levels occur in normal pregnancy. Women with hyperlipoproteinemia are advised to discontinue statins, fibrates already when they consider pregnancy up to and including breast-feeding the newborn, because of the fear for teratogenic effects. Hypertriglyceridemia in...
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PMID: 21498165
PDF is available here.
PDF is available here.