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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
drug therapy (26):
- Polypharmacy
- Fluid Therapy
- Enema
- Self Medication
- Medication Errors
- Pleurodesis
- Drug Therapy, Combination
- Orthomolecular Therapy
- Hormone Replacement Therapy
- Chemoprevention
- Home Infusion Therapy
- Drug Dosage Calculations
- Drug Delivery Systems
- Drug Administration Schedule
- Thrombolytic Therapy
- Self Administration
- Premedication
- Antineoplastic Protocols
- Drug Therapy, Computer-Assisted
- Drug Administration Routes
- Chelation Therapy
- Photochemotherapy
- Electrochemotherapy
- Drug Prescriptions
- Sclerotherapy
- Chemotherapy, Adjuvant
Recent article
drug therapy
Abstract
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Abstract
Abstract
Abstract
We experienced a case of a peritoneal dialysis patient with chronic hepatitis C who was successfully treated with PEG-IFN monotherapy. A 50-year old man was undergoing peritoneal dialysis because of diabetic nephropathy. Considering that his HCV genotype was 2, we decided to treat him with PEG-IFN a...
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PMID: 21873827
PDF is available here.
PDF is available here.
Abstract
We reported that vitamin K₃ (menadione, 2-methyl-1,4-naphthoquinone) (compound 2) inhibits the activity of human mitochondrial DNA polymerase γ (pol γ). In this study, we investigated the inhibitory effects (IEs) of vitamin K3 and its derivatives, such as 1,4-naphthoquinone (compound 1) and 1,2-...
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PMID: 21837358
PDF is available here.
PDF is available here.
Journal of Infectious Diseases (204)10 2011
Abstract
We have previously developed a rat model of K. pneumoniae meningoencephalitis. Cortistatin (CST) is a recently discovered neuropeptide with endocrine activities in humans. In this study, we found that brain infection by K. pneumoniae increased endogenous prepro-CST messenger RNA expression, which oc...
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PMID: 21940421
PDF is available here.
PDF is available here.
Abstract
We analyzed the ability of each management strategy to control anemia and neutropenia and the percentage of subjects who achieved a successful treatment outcome according to the different management strategies.
During treatment, 43 subjects developed anemia (human erythropoietin, n =...
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PMID: 21876446
PDF is available here.
PDF is available here.
Abstract
We found that high-fat diet (HFD) feeding strikingly promoted daytime rather than nighttime caloric intake in mice, leading to feeding circadian arrhythmicity. Using scheduled feeding with a defined amount of daily HFD intake, we found that an increase in the ratio of daytime to nighttime feeding pr...
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PMID: 21828335
PDF is available here.
PDF is available here.
Abstract
Abstract
Transplantation (92)8 2011
Abstract
We examined 10 stable kidney transplant patients (mean estimated glomerular filtration rate 51±10 mL/min/1.73 m(2)) who received cinacalcet daily for persistent hyperparathyroidism. Urine specimens were collected at baseline and every 2 hr for a total study period of 6 hr after ingestion of 30 mg c...
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PMID: 21876476
PDF is available here.
PDF is available here.
Abstract
The omega-3 (n-3) fatty acids docosahexaenoic acid and eicosapentaenoic acid, along with γ-linolenic acid and antioxidants, may modulate systemic inflammatory response and improve oxygenation and outcomes in patients with acute lung injury.
To determine if dietary su...
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PMID: 21976613
PDF is available here.
PDF is available here.
Abstract
Attempts to determine the clinical significance of BRCA1/2 mutations in ovarian cancer have produced conflicting results.
To determine the relationships between BRCA1/2 deficiency (ie, mutation and promoter hypermethylation) and overall survival (OS), progression-free...
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PMID: 21990299
PDF is available here.
PDF is available here.
Abstract
We would like to report our experience of using rituximab in cyclophosphamide refractory, rapidly progressive interstitial lung disease (ILD) in a patient with limited scleroderma. A 40-year-old man presented with 10-week history of inflammatory polyarthritis, which responded to a short course of or...
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PMID: 21593063
PDF is available here.
PDF is available here.
Translational Research (158)4 2011
Abstract
We have verified its dendritic cell (DC) maturating ability from monocytes of cervical cancer stage IIIB (CaCx-IIIB) patients. First, we evaluated the status of monocytes from CaCx-IIIB and healthy women by conducting flow cytometric studies of various activation markers and a cytokine analysis by e...
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PMID: 21925117
PDF is available here.
PDF is available here.
Translational Research (158)4 2011
Abstract
We have verified its dendritic cell (DC) maturating ability from monocytes of cervical cancer stage IIIB (CaCx-IIIB) patients. First, we evaluated the status of monocytes from CaCx-IIIB and healthy women by conducting flow cytometric studies of various activation markers and a cytokine analysis by e...
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PMID: 21925117
PDF is available here.
PDF is available here.
Abstract
We present the results from those patients included in the EPIBAND study who did not initiate HCV treatment for different reasons.
A total of 195 patients were evaluated (average age 39 ± 6.6 years, 86.7% male and 96.9% Spanish nationality). The reasons why this population did not i...
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PMID: 21750854
PDF is available here.
PDF is available here.
Translational Research (158)4 2011
Abstract
I receptor (AT1R) blocker (ARB) on the progression of renal injury in rat anti-glomerular basement membrane glomerulonephritis (GN), with a particular focus on the participation of glomerular RAS activation in glomerular structural alterations, inflammation, and oxidative stress. Nephritic rats were...
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PMID: 21925120
PDF is available here.
PDF is available here.
New England Journal of Medicine (365)14 2011
Abstract
We wanted to evaluate the efficacy and safety of a new nonanthracycline regimen with trastuzumab.
We randomly assigned 3222 women with HER2-positive early-stage breast cancer to receive doxorubicin and cyclophosphamide followed by docetaxel every 3 weeks (AC-T), the same regimen plus...
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PMID: 21991949
PDF is available here.
PDF is available here.
New England Journal of Medicine (365)14 2011
Abstract
New England Journal of Medicine (365)14 2011
Abstract
New England Journal of Medicine (365)14 2011
Abstract
We enrolled neonates with HSV disease in two parallel, identical, double-blind, placebo-controlled studies. Neonates with central nervous system (CNS) involvement were enrolled in one study, and neonates with skin, eye, and mouth involvement only were enrolled in the other. After completing a regime...
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PMID: 21991950
PDF is available here.
PDF is available here.
New England Journal of Medicine (365)14 2011
Abstract
We concluded a randomized trial involving 1088 patients with multiple sclerosis, 18 to 55 years of age, with a score of 0 to 5.5 on the Expanded Disability Status Scale and at least one relapse in the previous year or at least two relapses in the previous 2 years. Patients were randomly assigned (in...
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PMID: 21991951
PDF is available here.
PDF is available here.
New England Journal of Medicine (365)14 2011
Abstract
New England Journal of Medicine (365)14 2011
Abstract
The Lancet (378)9798 2011
Abstract
Abstract
The Children's Asthma Care (CAC) measure set evaluates whether children admitted to hospitals with asthma receive relievers (CAC-1) and systemic corticosteroids (CAC-2) and whether they are discharged with a home management plan of care (CAC-3). It is the only Joint Commission core m...
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PMID: 21972307
PDF is available here.
PDF is available here.
Cytotherapy (13)9 2011
Abstract
We studied the combined effect of MSC and IBD drugs in in vitro functionality assays.
The effects of azathioprine, methotrexate, 6-mercaptopurine and anti-tumor necrosis factor (TNF)-α on MSC phenotype, survival, differentiation capacity and immunosuppressive capacity were studied....
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PMID: 21846292
PDF is available here.
PDF is available here.
Abstract
We also observed synergic co-inhibition of the cell cycle of SK-OV-3 in the S phase.
We conclude that CH12 antibody is a promising candidate for clinical therapy for ovarian cancer cells, which has lower sensitivity to cisplatin treatment; however, the underlying mechanism needs furt...
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PMID: 21809030
PDF is available here.
PDF is available here.
New England Journal of Medicine (365)13 2011
Abstract
We hypothesized that a genomewide association study would reveal novel pharmacogenetic determinants of the response to inhaled glucocorticoids.
We analyzed a small number of statistically powerful variants selected on the basis of a family-based screening algorithm from among 534,290...
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PMID: 21991891
PDF is available here.
PDF is available here.
New England Journal of Medicine (365)13 2011
Abstract
New England Journal of Medicine (365)13 2011
Abstract
We enrolled 3493 infants receiving antibiotics for suspected or proven serious infection and randomly assigned them to receive two infusions of either polyvalent IgG immune globulin (at a dose of 500 mg per kilogram of body weight) or matching placebo 48 hours apart. The primary outcome was death or...
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PMID: 21962214
PDF is available here.
PDF is available here.
New England Journal of Medicine (365)13 2011
Abstract
New England Journal of Medicine (365)13 2011
Abstract
New England Journal of Medicine (365)13 2011
Abstract
New England Journal of Medicine (365)13 2011
Abstract
New England Journal of Medicine (365)13 2011
Abstract
The Lancet (378)9797 2011
Abstract
New England Journal of Medicine (365)12 2011
Abstract
New England Journal of Medicine (365)12 2011
Abstract
New England Journal of Medicine (365)12 2011
Abstract
New England Journal of Medicine (365)12 2011
Abstract
A total of 432 patients underwent randomization to receive one of four doses of BIBF 1120 (50 mg once a day, 50 mg twice a day, 100 mg twice a day, or 150 mg twice a day) or placebo. In the group receiving 150 mg of BIBF 1120 twice a day, FVC declined by 0.06 liters per year, as compared with 0.19 l...
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PMID: 21992121
PDF is available here.
PDF is available here.
New England Journal of Medicine (365)12 2011
Abstract
HIV Medicine (12) 2011
Abstract
Brain research (1411) 2011
Abstract
We show MMP-9 overexpression conferred a poor prognosis in 163 GBM patients. Furthermore, MMP-9 specific miRNA expression profile (14 positively and 31 negatively correlated miRNAs with MMP-9) was established via miRNA microarrays in 60 GBM samples. Among them, two miRNAs: miR-885-5p and miR-491-5p,...
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PMID: 21831363
PDF is available here.
PDF is available here.
Biomacromolecules (12)9 2011
Abstract
We investigated the properties of micellar siRNA delivery vehicles prepared with poly(ethylene glycol)-block-poly(l-lysine) (PEG-b-PLL) comprising lysine amines modified to contain amidine and thiol functionality. Lysine modification was achieved using 2-iminothiolane (2-IT) [yielding PEG-b-PLL(N2IM...
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PMID: 21863796
PDF is available here.
PDF is available here.
Cancer Biology & Therapy (12)6 2011
Abstract
We therefore developed a strategy to combine K vitamins with sorafenib to treat HCC, and found that this combination enhanced sorafenib-induced HCC cell growth inhibition. To explore the mechanisms involved, we examined the role of Raf kinase, since both vitamins K and sorafenib were reported to inh...
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PMID: 21734462
PDF is available here.
PDF is available here.
New England Journal of Medicine (365)11 2011
Abstract
We designed a noninferiority trial (noninferiority margin, -10.5%) to compare rates of sustained virologic response among patients receiving two treatment durations.
We enrolled patients with chronic infection with HCV genotype 1 who had not previously received treatment. All patient...
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PMID: 21916639
PDF is available here.
PDF is available here.
New England Journal of Medicine (365)11 2011
Abstract
Journal of Clinical Oncology (29)26 2011
Abstract
Abstract
This paper in the series from the World Congress of Gastroenterology addresses the safety and immunogenicity of biological therapy. The safety profile in randomized controlled studies of all biological agents in Crohn's disease (CD) and ulcerative colitis has been generally favorable...
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PMID: 21844919
PDF is available here.
PDF is available here.
Abstract
This paper in the series from the World Congress of Gastroenterology addresses the safety and immunogenicity of biological therapy. The safety profile in randomized controlled studies of all biological agents in Crohn's disease (CD) and ulcerative colitis has been generally favorable...
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PMID: 21844919
PDF is available here.
PDF is available here.
Abstract
Polyethylenimine-cyclodextrin-tegafur (PEI-CyD-tegafur) conjugate was synthesized as a novel multifunctional prodrug of tegafur for co-delivery of chemotherapeutic agent tegafur and enhanced green fluorescent protein (EGFP) reporter plasmid DNA. Conjugation of tegafur to PEI-CyD via...
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PMID: 21887847
PDF is available here.
PDF is available here.
Abstract
B-cell-directed therapy-the use of agents that eliminate B cells or block cytokines important for B-cell function-is emerging as a promising approach to the treatment of rheumatic disease. Target diseases, including systemic lupus erythematosus (SLE), display diverse patterns of auto...
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PMID: 21808289
PDF is available here.
PDF is available here.
Abstract
Experimental evidences have shown that tumor necrosis factor (TNF)-α may play a role in the pathogenesis of nonsegmental vitiligo, and successful cases of vitiligo treated with TNF-α inhibitors have been recently reported.
Two cases of refractory generalized vitilig...
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PMID: 21388239
PDF is available here.
PDF is available here.
Autoimmunity Reviews (10)11 2011
Abstract
We designed a phase II single-arm two-stage study (EUDRACT n. 2008-000086-38) to evaluate the efficacy of a lower dosage of rituximab, 250mg/m(2) given twice, for refractory mixed cryoglobulinemia. We present here the preliminary results in the first 27 patients enrolled. The overall response rate i...
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PMID: 21570494
PDF is available here.
PDF is available here.
Autoimmunity Reviews (10)11 2011
Abstract
We will use the term "refractory" LN, for those cases with none or partial response to first-line therapies. In this sense, numerous epidemiological factors, including racial, socioeconomic, histological and serological parameters, may influence treatment response and, therefore, may have an impact...
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PMID: 21565286
PDF is available here.
PDF is available here.
Abstract
Cancer-associated thrombosis and enduring inflammation are strongly associated with cancer progression and metastasis. Heparin is the mostly clinically used anticoagulant/antithrombotic drug, and has recently been shown to exhibit antimetastatic and anti-inflammatory activities that...
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PMID: 21676168
PDF is available here.
PDF is available here.
Abstract
Hypertension is found in more than 50% of pediatric patients with CKD. However, its prevalence varies according to the cause of CKD. It is relatively infrequent in children with structural disorders. Acquired renal disorders are associated with an increased prevalence of hypertension...
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PMID: 21896377
PDF is available here.
PDF is available here.
Autoimmunity Reviews (10)11 2011
Abstract
We have experience exciting developments regarding the approval of new treatment options but few patients are reaching sustained remission and refractory patients continue to be a problem. Thus, it is critical to understand how clinicians can decrease the risk of refractoriness by close monitoring d...
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PMID: 21570496
PDF is available here.
PDF is available here.