Abstract
We describe and conduct a pilot test of a multiplex sequencing strategy suitable for achieving total reads of > 300 bases per extracted DNA molecule on the IGA. Results show that all proposed primers produce products of the expected size and that correct sequences can be obtained, with all propo...
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PMID: 21361774
PDF is available here.
Abstract
The epidemiology of trauma to genitourinary (GU) organs following Road Traffic Collisions (RTC) is not well-studied, especially in the Middle East.
The data of the RTC Injury Registry in Al-Ain City were collected prospectively from April 2006-October 2007.
Of the 1,008 patients in the registry, the...
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PMID: 21038124
PDF is available here.
Abstract
The role of the general internist in the care of breast cancer survivors is increasing as the number of women living with breast cancer continues to rise. Most breast cancers occurring in women older than 50 years are estrogen receptor- and/or progesterone receptor-positive, and adjuvant endocrine t...
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PMID: 20511486
PDF is available here.
Abstract
We analyzed Klf4 expression in different mouse tissues using northern blot analysis and immunohistochemistry. Focusing on the male and female reproductive tract, we showed for the first time that KLF4 is expressed in the epithelia of the murine uterus and the vagina. In the male reproductive tract,...
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PMID: 20051481
PDF is available here.
Abstract
Our findings indicate that the RXFP2 signaling pathway plays an important role in mediating androgen action to stimulate gubernaculum development during inguinoscrotal testis descent....
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PMID: 20154177
PDF is available here.
Abstract
The secreted SLIT glycoproteins and their Roundabout (ROBO) receptors were originally identified as important axon guidance molecules. They function as a repulsive cue with an evolutionarily conserved role in preventing axons from migrating to inappropriate locations during the assembly of the nervo...
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PMID: 20100881
PDF is available here.
Abstract
Visceral pain models are used to study afferent nerve traffic during noxious stimulation at the level of the visceral organ. This chapter provides details on several in vitro and in vivo models of organs in the gastrointestinal and genitourinary tract that use electrophysiological recordings of affe...
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PMID: 20336418
PDF is available here.
Abstract
Florentine wax sculptures of human anatomy in general and of the urogenital tract in particular constitute an iconographic specialty of the eighteenth century. In the Age of Enlightenment research and representation of the human organism also met with broad interest. To counteract the lack of preser...
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PMID: 20182694
PDF is available here.
Abstract
Injury to the urethra results in erectile dysfunction in 50 % of the injured patients it is often associated with urinary incontinence that has a strong effect on the patient's life quality. Isolated trauma to the urinary bladder has a good prognosis. The incidence of post-traumatic incontinence is...
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PMID: 20214856
PDF is available here.
Abstract
Selective estrogen receptor modulators (SERMs) have the ability to provide mixed functional estrogen receptor (ER) agonist or antagonist activity, depending on the target tissue. Tamoxifen, the first SERM available for clinical use, is regarded as a highly effective agent for the prevention and trea...
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PMID: 20107426
PDF is available here.
Abstract
There was a total of 61 injuries in 50 patients. Road traffic accidents was the commonest cause of GUI (58%) followed by straddle injuries (18%) and iatrogenic causes (12%) and miscellaneous (12%). The male- female ratio was 6:1. The urethral was also the most commonly injured organ (60.6%), followe...
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PMID: 20450029
PDF is available here.
Abstract
Normal morphogenesis of the kidney, ureteral bud differentiation, ureteropelvic junction formation, and bladder and trigone development are regulated by complex epithelial-mesenchymal signaling events. Failure of these signaling events to occur at specified times results in developmental anomalies....
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PMID: 19461520
PDF is available here.
Abstract
Median follow-up was 64 months. The 5-year bNED rates according to 66 Gy, 70 Gy and 74 Gy were 37%, 64% and 63% (ASTRO), and 54%, 74% and 69% (Phoenix), respectively. In multivariate analysis, age and T-stage were significant in predicting bNED. The 5-year bNED rates (ASTRO) according to 66 Gy, 70 G...
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PMID: 19714305
PDF is available here.
Abstract
Although cryptorchidism and hypospadias were not associated with in utero PBB exposure, this study suggests that other GU conditions may be associated with exposure to endocrine-disrupting chemicals during development....
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PMID: 19654930
PDF is available here.
Abstract
Investigations in microcirculation are an essential way to understand basic pathologic mechanisms and detect early signs of various diseases. Up until the last decade there was only limited amount of information available in the field of urological microcirculation. Due to advanced technologies, new...
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PMID: 19525178
PDF is available here.
Abstract
We will review these recent studies and examine the evidence for the effects of estrogen on the postmenopausal urogenital tract....
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PMID: 19259853
PDF is available here.
Abstract
Seminal bactericidal activity (SBA) that is referred to as a factor of natural resistance and that controls bacterial survival in the male urogenital tract is an integral index of the congenital adaptive mechanisms of mucosal defense. The paper shows changes in SBA and other indices of the functiona...
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PMID: 19388484
PDF is available here.
Abstract
In the metanephric kidney (metanephros), the renal tubule was selectively positive for HNF-1beta. HNF-1beta expression was detected in mesonephric (wolffian) duct derivatives, including the efferent duct or epididymis, in fetuses at the 12th, 21st and 22nd gestational weeks, but not detected in the...
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PMID: 19320191
PDF is available here.
Abstract
The purpose of this study was to assess the current role of robot-assisted urological surgery in the female pelvis. The recently published English literature was reviewed to evaluate this role, with special emphasis on reconstructive procedures. These included colposuspension for genuine female stre...
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PMID: 19526187
PDF is available here.
Abstract
We studied the ontogeny and regulation of AMH in the tammar wallaby testis and related it to the expression of the androgen receptor in Sertoli cells. Testicular AMH expression was high between days 10-30 post partum, then fell to basal levels by day 60 and remained low until day 90, the oldest age...
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PMID: 20051675
PDF is available here.
Abstract
Sixty-eight patients (63%) had blunt, 25 (24%) had penetrating, and 12 (11%) had iatrogenic trauma, and 3 patients (3%) had spontaneous organ injury. When we considered the affected organ, renal trauma was determined in 34 patients (32%), ureteral trauma in 11 (10%), bladder injuries in 18 (17%), ur...
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PMID: 19130341
PDF is available here.
Abstract
We investigated potential factors altering contractions of the male reproductive tracts in vitro. Tracts from 0-day (newly emerged) males displayed relatively little motility in vitro; however, those from 5-day (intermediate stage of sexual maturity) and 8-day (fully mature) males pulsed vigorously....
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PMID: 18824120
PDF is available here.
Abstract
We conclude that the timing of 5alpha-reductase expression in the testes of the grey short-tailed possum resembles that of rodents and the brushtail possum rather than that of the tammar wallaby and that dihydrotestosterone is probably the intracellular androgen responsible for virilisation of the u...
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PMID: 19486601
PDF is available here.
Abstract
Endocrinology of the oestrous cycle, pregnancy and early lactation was investigated in captive Western Australian greater bilbies (Macrotis lagotis). Initially, six females were monitored for changes in urogenital cytology, plasma progestogen, pericloacal and pouch morphology in the absence of a mal...
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PMID: 19210918
PDF is available here.
Abstract
This article is the second in a three-part series discussing the effects of long periods of bedrest on the body. It explores what happens to the gastrointestinal, endocrine and renal systems when a person is confined to bed. The effects on the reproductive and nervous systems are also covered. Part...
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PMID: 19579399
PDF is available here.
Abstract
The peptide hormone relaxin (RLX) has been shown to exert a variety of functions in both reproductive and non-reproductive tissues. The molecular mechanism of RLX on its target cells appears to involve multiple intracellular signalling systems, including the nitric oxide (NO) pathway. NO is an ubiqu...
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PMID: 19075752
PDF is available here.
Abstract
These results demonstrated that tumorigenic features of androgen-insensitive AR-positive prostate cancer cells could be significantly influenced by rUGM. Therefore, this in vivo recombination model with rUGM may be useful in developing new treatment strategies....
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PMID: 19018772
PDF is available here.
Abstract
The review provides a description of a physical examination protocol to rule out significant neurologic disease as a cause for a woman's sexual complaints, or to confirm a neurologic cause for the sexual dysfunction, particularly in women with known neurologic disease.
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PMID: 19006496
PDF is available here.
Abstract
We discuss the divergent roles of these cells in immune defense against STIs as well as in maternal tolerance to the fetus....
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PMID: 19079212
PDF is available here.
Abstract
We report the generation of a Hoxa11eGFP targeted knock-in allele in mice in which eGFP replaces the first coding exon of Hoxa11 as an in-frame fusion. This allele closely recapitulates the reported mRNA expression patterns for Hoxa11. Hoxa11eGFP can be visualized in the tail, neural tube, limbs, ki...
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PMID: 18942146
PDF is available here.
Abstract
BALB/c mice were infected with Schistosoma japonicum cercariae (40+/-2 per mouse) through abdominal skin. Mice were sacrificed after 35 days to acquire the adult worms which were then fixed, stained, clarified, dehydrated and mounted. The specimens were observed under the confocal laser scanning mic...
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PMID: 19157309
PDF is available here.
Abstract
The ability to control hospital-acquired infections is highly dependent upon control of cross-contamination from health-care workers to patients, and from one anatomical area of the patient to another anatomical area. Hand hygiene has been demonstrated to be an essential prerequisite in preventing c...
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PMID: 18931275
PDF is available here.
Abstract
We have used yeast two-hybrid analysis to identify Nkx3.1 interacting proteins, and have isolated Fem1b, a mammalian homolog of the C. elegans sex-determining gene Fem-1. In mice, the Fem1b and Nkx3.1 genes encode proteins that interact in glutathione-S-transferase (GST) pull-down and co-immunopreci...
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PMID: 18816836
PDF is available here.
Abstract
Based on these anatomical data during surgical repair of a urogenital sinus we would advocate minimal mobilization of the lateral faces of the vagina, avoiding dissection of the proximal urethra above the pubic bone and electing a vaginal flap in severe cases....
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PMID: 18708223
PDF is available here.
Abstract
We suggest that familiarity with the manifestations of inflammatory pseudotumor can help avoid unnecessary radical surgery before histopathologic proof of malignancy is obtained....
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PMID: 18806173
PDF is available here.
Abstract
We previously described the characterization of an isoform-specific monoclonal antibody against AKR1C3 that does not cross-react with related, >86% sequence identity, human AKR1C1, AKR1C2, or AKR1C4, human aldehyde reductase AKR1A1, or rat 3alpha-hydroxysteroid dehydrogenase (AKR1C9). In this study,...
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PMID: 18574251
PDF is available here.
Abstract
Grade 1 and 2 persistent GU toxicities developed in 36 (21%) and 3 (2%) patients, respectively. The use of long-course ADT (>or=24 months) and acute GU toxicity were associated with the occurrence of persistent toxicity by multivariate analysis (p = 0.016 and p = 0.048, respectively), but short-cour...
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PMID: 18456419
PDF is available here.
Abstract
We present our experience of laparoscopic management of two cases of retrovesical hydatid cyst treated by laparoscopic aspiration, instillation, and suction and two cases of renal hydatid cyst treated by partial nephrectomy and cystopericystectomy with preservation of renal parenchyma....
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PMID: 18620503
PDF is available here.
Abstract
We conducted a matched case-control study to investigate social factors associated with gonorrhoea acquisition among genitourinary (GU) medicine clinic attendees, designed to inform appropriate prevention strategies. Detailed social and behavioural data were elicited using a self-completed questionn...
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PMID: 18663042
PDF is available here.
Abstract
While most genitourinary (GU) medicine clinics achieve a high uptake for testing HIV in new patients, they may still miss testing those at highest risk. Point-of-care testing (POCT) and salivary samples are acceptable and feasible but have not yet been shown to increase uptake among high-risk patien...
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PMID: 18663043
PDF is available here.
Abstract
We compared the lower urogenital tract (LUT) anatomy and function in LOXL1-KO mice with and without POP. LUT anatomy was assessed in LOXL1-KO mice over 28 wk. Pelvic visceral anatomy in LOXL1-KO was evaluated with a 7-Tesla magnetic resonance imaging (MRI) scanner. LUT function was assessed using co...
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PMID: 18495804
PDF is available here.
Abstract
We examined gene expression profiles of whole female flies at four time points following copulation. We found that, soon after copulation ends, a large number of small-magnitude transcriptional changes occurred in the mated female. At later time points, larger magnitude changes were seen, although t...
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PMID: 18562649
PDF is available here.
Fiana Levitin,
Mordechai Weiss,
Yoonsoo Hahn,
Omer Stern,
Roger L Papke,
Robert Matusik,
Srinivas R Nandana,
Ravit Ziv,
Edward Pichinuk,
Sharbel Salame,
Tapan Bera,
James Vincent,
Byungkook Lee,
Ira Pastan and
Daniel H Wreschner
Abstract
We report here syntenic loci in humans and mice incorporating gene clusters coding for secreted proteins each comprising 10 cysteine residues. These conform to three-fingered protein/Ly-6/urokinase-type plasminogen activator receptor (uPAR) domains that shape three-fingered proteins (TFPs). The foun...
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PMID: 18387948
PDF is available here.
Abstract
To compare the toxicity and biochemical outcomes of intensity-modulated radiation therapy (IMRT) and (125)I transperineal permanent prostate seed implant ((125)I) for patients with low-risk prostate cancer.
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PMID: 18207665
PDF is available here.
Abstract
Thirty-seven patients (8%) experienced acute Grade 2 gastrointestinal (GI) toxicity. There was no acute Grade 3 or 4 GI toxicity. One hundred and five patients (22%) experienced acute Grade 2 genitourinary (GU) toxicity and three patients (0.6%) had Grade 3 GU toxicity. There was no acute Grade 4 GU...
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PMID: 18164858
PDF is available here.
Abstract
A dose-response function for acute GI toxicity was elicited. The acute GI Grade 2 or greater toxicity was lower in the definitive RT group than in the postoperative RT group (25% vs. 41%, p <0.05). Acute GU Grade 2 or greater toxicity was comparable between the two groups. No grade 3 or greater comp...
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PMID: 18164841
PDF is available here.
Abstract
The bacterial diversity of the openings of the urogenital and anal tracts of the adult female tammar wallaby, Macropus eugenii, was determined in order to ascertain whether the physical proximity of the openings of these tracts within the cloaca affected the two populations of bacteria. Terminal res...
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PMID: 18451062
PDF is available here.
Abstract
We analyzed a dataset including 1009 primiparous women with singleton pregnancies and vaginal deliveries, and we examined risk factors for third- and fourth-degree perineal lacerations and periurethral, vaginal, and labial lacerations using logistic regression analysis. Large fetal size (> or = 3500...
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PMID: 18509884
PDF is available here.
Abstract
The field of regenerative medicine continues to make substantial advancements in therapeutic strategies addressing urologic diseases. Tissue engineering borrows principles from the fields of cell biology, materials science, transplantation and engineering in an effort to repair or replace damaged ti...
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PMID: 18427290
PDF is available here.