Abstract
Physiological roles of endocannabinoids, a group of endogenously produced cannabinoid-like lipid molecules that activate G protein-coupled cannabinoid receptors, are being increasingly appreciated in female reproduction. Adverse effects of cannabinoids on female fertility have been suspected for dec...
|
PMID: 18294762
PDF is available here.
Andrew P McMahon,
Bruce J Aronow,
Duncan R Davidson,
Jamie A Davies,
Kevin W Gaido,
Sean Grimmond,
James L Lessard,
Melissa H Little,
S Steven Potter,
Elizabeth L Wilder,
Pumin Zhang and
GUDMAP project
Abstract
In late 2004, an International Consortium of research groups were charged with the task of producing a high-quality molecular anatomy of the developing mammalian urogenital tract (UGT). Given the importance of these organ systems for human health and reproduction, the need for a systematic molecular...
|
PMID: 18287559
PDF is available here.
Abstract
Female pelvic anatomy encompasses the reproductive, urologic, and gastrointestinal systems. Knowledge of the inherent relations between these organ systems, as well as the ability to develop pelvic spaces, will enable the surgeon to approach pelvic pathology confidently. This article highlights basi...
|
PMID: 18381111
PDF is available here.
Abstract
UC781 was well tolerated in this initial dose ranging safety study when used once daily for 6 days in sexually abstinent women. Five safety/pharmacokinetic studies of UC781 are currently underway in women and men, all utilizing UC781 concentrations less than 1%, with twice-daily dosing in some studi...
|
PMID: 18362865
PDF is available here.
Abstract
The data presented here show that late GI morbidity after prostate RT is low and subsides with time....
|
PMID: 18060703
PDF is available here.
Abstract
We 1) focus on external rather than internal genitalia, 2) measure both male and female structures, and 3) examine a strepsirrhine rather than an anthropoid primate. The subjects for morphological study were 21 reproductively intact, adult ring-tailed lemurs (Lemur catta), including 10 females and 1...
|
PMID: 17972270
PDF is available here.
Abstract
Serious late toxicity was unusual despite the delivery of high radiation dose levels in these patients. Higher doses were associated with increased GI and GU Grade 2 toxicities, but the risk of proctitis was significantly reduced with IMRT. Acute symptoms were a precursor of late toxicities in these...
|
PMID: 18313526
PDF is available here.
Abstract
We have investigated collagen turnover in urogenital tissue in urologically healthy women with (UP patients) and without UP or any history of UP (controls). Markers of collagen turnover, carboxy-terminal propeptide of type I procollagen (PICP), amino-terminal propeptide of procollagen III (PIIINP) a...
|
PMID: 18230625
PDF is available here.
Abstract
The aim of this study was to investigate the incidence of reinfection with sexually transmitted infection (STI) and its possible predicting factors among patients reattending a department of genitourinary (GU) medicine. The method included a retrospective study on consecutive patients re-screened fo...
|
PMID: 18397556
PDF is available here.
Abstract
We discuss the estrogenic and anti-estrogenic effects of early SERMs, such as clomiphene citrate, used for treatment of ovulation induction, and the triphenylethylene, tamoxifen, which has ER antagonist activity in the breast, and is used for prevention and treatment of ER-positive breast cancer. Si...
|
PMID: 18279543
PDF is available here.
Abstract
The sexual differentiation of the brain and behavior occurs as the result of prenatal hormonal influences. Knowledge of this area is helpful for the construction of an appropriately modern psychoanalytically informed developmental paradigm of psychosexuality.
|
PMID: 18430706
PDF is available here.
Abstract
We report the detailed expression of the murine gene (Nat2) and encoded protein in mouse embryos, using a transgenic mouse model bearing a lacZ transgene inserted into the coding region of mouse Nat2. In mouse embryos, the transgene was expressed in sensory epithelia, epithelial placodes giving rise...
|
PMID: 17896208
PDF is available here.
Abstract
We serendipitously discovered an essential contribution of GATA-2 to urogenital development when the hematopoietic deficiency of Gata2 null mutant animals was complemented by a Gata2 yeast artificial chromosome (YAC) transgene; these mice died from a perinatal lethal urogenital abnormality. Here, we...
|
PMID: 18233958
PDF is available here.
Abstract
The successful placements and acceptability suggest that further product development is warranted and could target over-the-counter use. During increased duration of use or more frequent dosing, cervicovaginal monitoring is advised based on the extent of peeling and external colposcopic findings in...
|
PMID: 18226678
PDF is available here.
Abstract
The toxicity and early biochemical response rates were consistent with expectations from conventional fractionation. Additional follow-up is required to better document the biochemical control, but these results suggest that hypofractionation is a well-tolerated approach for salvage radiotherapy....
|
PMID: 17869014
PDF is available here.
Abstract
These data show that external beam radiation therapy remains a safe option for locally advanced/high-risk prostate cancer, and the use of hormonal manipulation does appear to be protective for GU and GI toxicity depending upon length of treatment....
|
PMID: 17881145
PDF is available here.
Abstract
We evaluated the acute and late toxicity after high-dose intensity-modulated radiotherapy (IMRT) with fiducial marker-based position verification for prostate cancer. Between 2001 and 2004, 331 patients with prostate cancer received 76 Gy in 35 fractions using IMRT combined with fiducial marker-base...
|
PMID: 18495016
PDF is available here.
Abstract
When antibodies from women urogenitally infected with C. trachomatis were reacted with the plasmid proteins, all 8 pORFs were positively recognized by one or more human antibody samples with the recognition of pORF5 protein (known as pgp3) by most antibodies and with the highest titers. The antibody...
|
PMID: 18541036
PDF is available here.
Abstract
Qualitative and quantitative composition of microbiocenosis of urogenital tract (UGT) of mice has been studied. When investigating UGT of mice in norm (n = 8), microorganisms of several genera with following occurrence frequency were detected: Lactobacillus (100%), Streptococcus (100%), Staphylococc...
|
PMID: 19351049
PDF is available here.
Abstract
Four polyvinyl chloride (PVC) matrix membrane electrodes responsive to 2 drugs affecting the urogenital system--oxybutynin hydrochloride (OX) and flavoxate hydrochloride (FX)--were developed, described, and characterized. A precipitation-based technique with tungstophosphate (TP) and ammonium reinec...
|
PMID: 19202792
PDF is available here.
Abstract
Patients with focal single-organ vasculitis affecting abdominal and genitourinary organs, breast and aorta have been reported as individual cases and small series. Single-organ vasculitis differs from systemic forms of vasculitis in disease expression and prognosis. Occasionally, what appears to be...
|
PMID: 18281856
PDF is available here.