Abstract
The cytokine patterns in maculopapular exanthema have a Th1 or Th0 pattern, according to whether the reaction is induced by a drug or a virus, respectively. Additionally, the involvement of CD4 T-lymphocytes with cytotoxic capabilities has been shown in the former. Different chemokines and their rec...
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PMID: 19398898
PDF is available here.
Abstract
We also place particular emphasis on aptamers evolved against cell membrane receptors and possibilities for translation to clinical applications....
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PMID: 21182455
PDF is available here.
Abstract
We tested if details of a routine vaccination programme delivered to conventional grow-out broilers were associated with the burden of Salmonella in the flock as it progressed through its production cycle. None of the flocks studied were vaccinated against Salmonella or received a competitive exclus...
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PMID: 20426884
PDF is available here.
Abstract
Interferon-inducible protein 10 (IP-10) is a chemokine playing an important role in the restriction of viral spread. A time- and dose-dependent increase in IP-10 is found upon activation of viral receptors expressed on mesothelial cells, which provides novel evidence for a link betwe...
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PMID: 21106778
PDF is available here.
Abstract
We probed the structure, function and energetics of EBO₁₆ and its mutant W8A, in the absence or presence of different lipid membranes, including isolated domain-resistant membranes (DRM), a good experimental model for lipid rafts. The depletion of cholesterol from living mammalian cells reduced...
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PMID: 21249196
PDF is available here.
Abstract
For a virus to establish persistence in the host, it has to exploit the host immune system such that the active T-cell responses against the virus are curbed. On the other hand, the goal of the immune system is to clear the virus, following which the immune responses need to be downregulated, by a p...
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PMID: 20941625
PDF is available here.
Abstract
Viral infection activates both the innate and adaptive immunity and is implicated as a trigger of autoimmune diseases including Hashimoto's thyroiditis. This review summarizes our knowledge respecting the role of viral infection in the cause of Hashimoto's thyroiditis....
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PMID: 20625285
PDF is available here.
Abstract
We highlight some of the major challenges we face in unraveling this complexity and summarize current efforts under way to improve the efficacy of viral vaccines....
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PMID: 21034678
PDF is available here.
Abstract
One of the key questions in the study of mammalian gene regulation is how epigenetic methylation patterns on histones and DNA are initiated and established. These stable, heritable, covalent modifications are largely associated with the repression or silencing of gene transcription, and when deregul...
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PMID: 20724161
PDF is available here.
Abstract
Facial nerve palsy has a broad differential diagnosis and possible psychological and anatomical consequences. A thorough investigation must be performed to determine the cause of the palsy and to direct treatment. If no cause can be found, therapy with prednisone with or without an antiviral medicat...
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PMID: 20930602
PDF is available here.
Abstract
Viruses are the most common causes of respiratory tract infections in children. The implementation of rapid virology assays can identify the most common pathogens involved. This study was undertaken on Iranian children less than 6 years old with respiratory infection.
A total of 202 specimens were t...
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PMID: 20879092
PDF is available here.
Abstract
We aimed to prospectively assess viral NI occurring during and shortly after hospitalization in children.
Prospective surveillance was performed during a 24-month period. Electronic standardized questionnaires were completed for each patient by physicians during hospital stay. On a ward-based rotati...
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PMID: 20879093
PDF is available here.
Abstract
Ménière's disease (MD), which by definition is idiopathic, has been ascribed to various causes, including inhalant and food allergies. Patients with MD report higher rates of allergy history and positive skin or in vitro tests compared with a control group of patients with other otologic diseases...
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PMID: 20713244
PDF is available here.
Abstract
We review the etiology, clinical features, pathology, epidemiology, and diagnosis of these DNA viruses....
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PMID: 20424393
PDF is available here.
Abstract
We examined stool specimens for viral pathogens from 50 children referred to hospital due to acute gastroenteritis (AGE) resulting from consuming drinking water contaminated with sewage in a Finnish community using PCR methods. Rotavirus was detected in 33 (66%), human calicivirus in 31 (62%), and b...
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PMID: 20092670
PDF is available here.
Abstract
The order Passeriformes comprises the largest number of families and species of birds of any avian order. Brazil is rich in passerine birds, which are a common victim of wildlife trafficking in Brazil. Annually, many birds die as a consequence of illegal trade. To investigate the occurrence of the p...
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PMID: 21046940
PDF is available here.
Antoni Sisó,
Manuel Ramos-Casals,
Albert Bové,
Pilar Brito-Zerón,
Natalia Soria,
Norma Nardi,
Adriana Testi,
Marta Perez-de-Lis,
Cándido Díaz-Lagares,
Alejandro Darnell,
Juan Sentís and
Antonio Coca
Abstract
We describe the natural history of lupus nephritis (LN) in a historical cohort of 190 white patients with the diagnosis of biopsy-proven LN followed in a single reference center.We evaluated 670 patients with systemic lupus erythematosus (SLE) consecutively followed in our department from 1970 until...
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PMID: 20827107
PDF is available here.
Abstract
Untreated infection may cause stillbirth by several mechanisms, including direct fetal infection, placental damage, and severe maternal illness. Many bacteria, viruses, and protozoa have been associated with stillbirth. In developed countries, up to 24% of stillbirths have been attributed to infecti...
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PMID: 20661048
PDF is available here.
Abstract
We report that the transcription factor MafB thwarts auto-amplification by a metastable switch activity. MafB acted as a weak positive basal regulator of transcription at the IFNB1 promoter through activity at transcription factor AP-1-like sites. Interferon elicitors recruited the transcription fac...
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PMID: 20581830
PDF is available here.
Abstract
Although the involvement of common childhood infections in the aetiology of acute appendicitis has long been conjectured, supporting evidence is largely restricted to a disparate set of clinical case reports. A systematic population-based analysis of the implied comorbid associations is lacking in t...
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PMID: 20003616
PDF is available here.
Abstract
Mathematical modeling can be used for the development and implementation of infection control policy to combat outbreaks and epidemics of communicable viral diseases. Here an outline is provided of basic concepts and approaches used in mathematical modeling and parameterization of disease transmissi...
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PMID: 20218764
PDF is available here.
Abstract
We present a case of delayed facial paresis in a pediatric patient with a clinical course consistent with viral reactivation....
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PMID: 20737373
PDF is available here.
Abstract
We showed that 8.8% of patients with KD had documented respiratory viral infections. Patients with concomitant viral infections had a higher frequency of coronary artery dilatations and were significantly more often diagnosed with incomplete KD. The presence of a concomitant viral infection should n...
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PMID: 20354462
PDF is available here.
Abstract
Viral and microbial infections often elicit programmed cell death as part of the host defense system or as a component of the survival strategy of the pathogen. It is thus not surprising that pathogens have evolved an array of toxins and virulence factors to modulate host cell death...
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PMID: 20638641
PDF is available here.
Abstract
RNA-based viral immunity (RVI) operates in fungi, plants, and invertebrates to specifically destroy viral RNAs using the cellular RNA interference machinery. Discovery of diverse viral proteins as suppressors of RNA silencing provides strong validation for the effectiveness of RVI. H...
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PMID: 20638637
PDF is available here.
Abstract
The activation of inflammasomes containing NBD-LRR (NLRs) or non-NLRs is critical for effective host defense against microbial pathogens. Recent discoveries have uncovered a plethora of pathogenic strategies to inhibit inflammasome-mediated processing of IL-1beta and IL-18. We review...
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PMID: 20638636
PDF is available here.
Abstract
We focus on host factors that influence the outcome of viral infection, including genetic susceptibility, the age of the host when infected, the dose and route of infection, the induction of anti-inflammatory cells and proteins, as well as the presence of concurrent infections and past exposure to c...
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PMID: 20577268
PDF is available here.
Abstract
The 4th European Congress of Virology, hosted by the Italian Society for Virology, attracted approximately 1300 scientists from 46 countries worldwide. It also represented the first conference of the European Society for Virology, which was established in Campidoglio, Rome, Italy in 2009. The main g...
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PMID: 20624042
PDF is available here.
Abstract
The risk of transmission of human immunodeficiency virus (HIV), hepatitis B (HBV) and hepatitis C virus (HCV) during invasive procedures may not be negligible, although it has been poorly assessed. The risk of hepatitis B transmission during amniocentesis seems to be low, but it may be increased in...
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PMID: 20558971
PDF is available here.
Abstract
A proportion of HIV-positive adults lack evidence of immunity against common, vaccine-preventable viral infections. Efforts are needed to improve knowledge and records of vaccination history.
Copyright (c) 2010 The British Infection Society. Published by Elsevier Ltd. All rights reserved....
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PMID: 20403382
PDF is available here.
Abstract
Procalcitonin (PCT) is synthesized by a large number of tissues and organs in response to invasion by pathogenic bacteria, fungi, and some parasites. Current PCT assays are rapid, specific, and of sufficient sensitivity to detect increases in PCT serum levels within 4 to 6 h of initi...
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PMID: 20421436
PDF is available here.
Jean-Louis H Kerkhoffs,
Wim L J van Putten,
Viera M J Novotny,
Peter A W Te Boekhorst,
Martin R Schipperus,
Jaap Jan Zwaginga,
Lizzy C M van Pampus,
Georgine E de Greef,
Marleen Luten,
Peter C Huijgens,
Anneke Brand,
Dick J van Rhenen and
Dutch - Belgian HOVON cooperative group
Abstract
We conducted a multicentre, open-label, randomized, non-inferiority trial comparing the clinical effectiveness of buffy-coat derived leukoreduced platelet concentrates (PC) stored for up to 7 d in plasma with platelets stored in platelet additive solution III (PASIII) without and with treatment with...
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PMID: 20507310
PDF is available here.
Abstract
We highlight the metabolic aspects of viral infection found in these studies, and focus on the opportunities these requirements present for metabolic engineers. In particular, the objectives and approaches that metabolic engineers use are readily comparable to the behaviors exhibited by viruses duri...
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PMID: 20665642
PDF is available here.
Abstract
Respiratory viruses can be found in patients with serious acute respiratory illness by use of PCR assays more frequently than previously appreciated. IP-10 may be a useful biomarker for respiratory viral infection....
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PMID: 20627924
PDF is available here.
Abstract
We performed this randomized controlled trial. The results showed that application of the rIFNalpha-2b nasal spray had the benefits in prevention of infections caused by influenza A virus, influenza B virus parainfluenza viruses 1-3 and adenovirus species B. However, no benefit was seen in preventin...
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PMID: 20394720
PDF is available here.
Abstract
Respiratory tract viral infections are responsible for an incredible amount of morbidity and mortality throughout the world. Older diagnostic methods, such as tissue culture and serology, have been replaced with more advanced molecular techniques, such as PCR and reverse-transcriptase PCR, nucleic a...
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PMID: 20521935
PDF is available here.
Abstract
The conjugation between nanotubes, coated with different doses of polyethylene imine (PEI) and hepatitis A virus (HAV) was investigated by scanning electron microscopy, Z-potential, thermogravimetric and differential thermal analysis, transmission electron microscopy, energy dispersive x-ray diffrac...
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PMID: 20404402
PDF is available here.
Abstract
I have hypothesized that mammalian offspring sex ratios (proportions male at birth) are partially controlled by the hormone levels of both parents around the time of conception. Recently data have been published (privately) which impugn suggestions of mine (based on that hypothesis) relating to the...
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PMID: 20608473
PDF is available here.
Abstract
Guillain-Barré syndrome, a randomly acquired inflammatory condition that can lead to progressive muscle weakness and paralysis, is a rare presentation in emergency departments, and differentiating its early stages from common viral illnesses can be difficult. Emergency practitioners should be aware...
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PMID: 20608399
PDF is available here.
Abstract
We have only recently gained insight into the underlying cellular and molecular mechanisms, and we are just beginning to understand its physiological importance in health and disease. Here we summarize current concepts on the cross-talk between the immune cells involved in CTL cross-priming and on i...
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PMID: 20498667
PDF is available here.
Abstract
We will consider severe acute infectious gastroenteritis as follows: watery diarrhea accompanied by, or at high risk for, moderate to severe dehydration due to abrupt onset of vomiting that reduces oral intake, and/or frequent emission of liquid stools, or moderate to severe dysenteric/bloody diarrh...
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PMID: 20521895
PDF is available here.
Abstract
We review many of the current infection control challenges facing outpatient dialysis centers and discuss recommended infection control policies and practices aimed at combating these challenges....
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PMID: 20521893
PDF is available here.
Abstract
It is shown here that although the high number of FcgammaRI on neutrophils is a sensitive marker of bacterial infection, it is highly expressed also in DNA virus infections. As a consequence, neutrophil FcgammaRI cannot be used in distinguishing between bacterial and viral infections. It is also cle...
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PMID: 20407370
PDF is available here.
Abstract
Temperature had a key role in increasing significantly the virucidal activity of VANTOCIL TG, reducing virus concentration by 4-log(10) within 10 minutes at 40 degrees C. The high temperature was linked to a reduction of viral aggregates despite the exposure to the biguanide. In addition, the viral...
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PMID: 20006410
PDF is available here.
Abstract
Nosocomial infections are one of the major causes of morbidity and mortality in the newborn intensive care unit (NICU). They result in prolonged hospital stays and increased hospital costs. Neonates are susceptible hosts because of prematurity of organ systems, immaturity of immune system, low birth...
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PMID: 21090073
PDF is available here.
J Granerod,
R Cunningham,
M Zuckerman,
K Mutton,
N W S Davies,
A L Walsh,
K N Ward,
D A Hilton,
H E Ambrose,
J P Clewley,
D Morgan,
M P Lunn,
T Solomon,
D W G Brown and
N S Crowcroft
Abstract
We present the UK perspective on aetiological case definitions for acute encephalitis and extend them to include immune-mediated causes. Expert opinion was primarily used and was supplemented by literature-based methods. Wide usage of these definitions will facilitate comparison between studies and...
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PMID: 20388231
PDF is available here.
Abstract
We have developed a complementary approach in which viral and synthetic components are combined to form hybrid nanoparticulate vectors. In particular, we complexed non-infectious retrovirus-like particles lacking a viral envelope protein, from Moloney murine leukemia virus (M-VLP) or human immunodef...
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PMID: 20117154
PDF is available here.
Abstract
We have shown that high-dose intravenous immune globulin (IVIG; 2 g/kg x2 doses)+rituximab (1 g x2 doses) was effective in lowering anti-human leukocyte antigen (HLA) antibodies and improving rates of transplantation. The aim of this report was to evaluate the efficacy of IVIG+rituximab on reduction...
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PMID: 20110854
PDF is available here.