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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Central Nervous System Viral Diseases (5):
Recent article
Central Nervous System Viral Diseases
Canadian Journal of Neurological Sciences (37 Suppl 2) 2010
Abstract
The human microbiome is comprised of commensal and pathogenic microorganisms, which exert diverse effects in close proximity to the site of intection as well as in remote tissues through immune-mediated mechanisms. Multiple infectious agents have been implicated in the pathogenesis of multiple scler...
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PMID: 21246932
PDF is available here.
PDF is available here.
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Progress in Neurobiology (91)2 2010
Abstract
Neurologic disease is a major cause of disability in resource-poor countries and a substantial portion of this disease is due to infections of the CNS. A wide variety of emerging and re-emerging viruses contribute to this disease burden. New emerging infections are commonly due to RNA viruses that h...
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PMID: 20004230
PDF is available here.
PDF is available here.
Progress in Neurobiology (91)2 2010
Abstract
We further describe in this review the capacity of CHIKV to infect neurons and glial cells, delineate the fundamental innate (intrinsic) immune defence mechanisms to protect from infection and argue about the possible mechanisms involved in the encephalopathy.
(c) 2010 Elsevier Ltd. All rights reser...
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PMID: 20026374
PDF is available here.
PDF is available here.
Abstract
Abstract
Viral infections of the pediatric central nervous system (CNS) encompass a broad spectrum of both perinatally and postnatally acquired diseases with potentially devastating effects on the developing brain. In children, viral infections have been associated with chronic encephalopathy, encephalitis,...
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PMID: 20425240
PDF is available here.
PDF is available here.
Pediatric Emergency Care (26)2 2010
Abstract
To identify factors associated with cerebrospinal fluid (CSF) pleocytosis among infants aged 90 days or younger with enterovirus (EV) infections of the central nervous system (CNS).
This is a retrospective cohort study performed at an urban academic children's hospital. Patients aged 90 days or youn...
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PMID: 20093996
PDF is available here.
PDF is available here.
Abstract
Viral infections of CNS are difficult to diagnose, especially in an early phase. In diagnosis, beside the examination of the cerebrospinal fluid, many other diagnostic tools are used, such a serological tests (in cases with TBE suspicion), PCR (in cases with CMV, VZV, HSV, WNV, enteroviruses infecti...
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PMID: 20976946
PDF is available here.
PDF is available here.
New Microbiologica (32)4 2009
Abstract
We found: VZV in 13, HSV-1 in 12, EBV in 6, HHV-6 in 4, and HSV-2 in 4. Co-infections of EBV and HSV-2, HSV-1 and HSV-2, HSV-1 and VZV were also disclosed in four cases. In addition, two patients with Guillain-Barré syndrome had HCMV and one showed HHV6 positivity, two patients with myelitis / poly...
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PMID: 20128439
PDF is available here.
PDF is available here.
Epidemiologie, mikrobiologie, imunologie : casopis Spolecnosti pro epidemiologii a mikrobiologii Ceske lekarske spolecnosti J.E. Purkyne (58)3 2009
Abstract
We have implemented a commercially available PCR-based test for the detection of enteroviral infections. In 2008, we analyzed biological specimens from 125 patients with suspected enteroviral disease, most often involving the nervous system. The presence of enterovirus was detected in 39 patients. T...
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PMID: 19750824
PDF is available here.
PDF is available here.
Abstract
We used double-stranded RNA (dsRNA), a viral replication intermediate, to mimic the acute phase of viral infection. C57BL/6 mice were injected intraperitoneally with 12 mg/kg of synthetic dsRNA, i.e., polyinosinic-polycytidylic acid (PIC). The treatment induced severe sickness behavior in the animal...
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PMID: 19115408
PDF is available here.
PDF is available here.
Abstract
We begin to pursue investigation of the inflamed CNS in real time....
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PMID: 19521688
PDF is available here.
PDF is available here.
Abstract
We detected CHIKV in plasma samples of 8 (14%) of 58 children with suspected central nervous system infection in Bellary, India. CHIKV was also detected in the cerebrospinal fluid of 3 children....
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PMID: 19193287
PDF is available here.
PDF is available here.
Abstract
Measles virus (MV) is one of the most transmissible microorganisms known, continuing to result in extensive morbidity and mortality worldwide. While rare, MV can infect the human central nervous system, triggering fatal CNS diseases weeks to years after exposure. The advent of crucial laboratory too...
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PMID: 19203102
PDF is available here.
PDF is available here.
Abstract
The ferret is a standard laboratory animal that can be accommodated in most animal facilities. While not susceptible to measles, ferrets are a natural host of canine distemper virus (CDV), the closely related carnivore morbillivirus. CDV infection in ferrets reproduces all clinical signs associated...
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PMID: 19203105
PDF is available here.
PDF is available here.
Abstract
Prenatal viral infection has been associated with neurodevelopmental disorders such as schizophrenia and autism. It has previously been demonstrated that viral infection causes deleterious effects on brain structure and function in mouse offspring following late first trimester (E9) and middle-late...
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PMID: 18693086
PDF is available here.
PDF is available here.
New Microbiologica (31)4 2008
Abstract
Cerebrospinal fluid specimens from 226 patients with suspected viral infections of the central nervous system (CNS) were tested by polymerase chain reaction (PCR) to identify the most frequent viruses involved in these infections. A positive PCR result was obtained in 18 patients (7 cases positive f...
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PMID: 19123298
PDF is available here.
PDF is available here.
Pediatrics (122)2 2008
Abstract
Enterovirus 71 central nervous system infection may affect long-term regulation of attention and emotion and cause hyperactivity-impulsivity in children....
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PMID: 18606624
PDF is available here.
PDF is available here.
Neurologic Clinics (26)3 2008
Abstract
Almost 65 million people worldwide have been infected with HIV since it was first identified in the early 1980s. Neurologic disorders associated with HIV type 1 affect between 40% and 70% of infected individuals. The most significant of these disorders include HIV-associated neurocognitive disorder,...
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PMID: 18657727
PDF is available here.
PDF is available here.
Neurologic Clinics (26)3 2008
Abstract
In the current era of escalating globalization with rapid transport, changing climate, and an ever growing human population with associated changes in lifestyle, poverty, and war, the emergence of new neurologic infections is accelerated. Understanding their origins using epidemiologic and molecular...
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PMID: 18657730
PDF is available here.
PDF is available here.
Neurologic Clinics (26)3 2008
Abstract
Neurologic Clinics (26)3 2008
Abstract
We review cells of the healthy nervous system, the types of viruses that infect them, the nervous system's specialized immune response to viral infections, and how this host-virus interaction influences the clinical examination findings. We discuss a diagnostic approach to viral infections of the ne...
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PMID: 18657718
PDF is available here.
PDF is available here.
Veterinary Record (163)2 2008
Abstract
Abstract
Abstract
The revised HSV-PCR and new HSV- and VZV-oligonucleotides were found to function well and be more sensitive, thereby increasing reliability of the method....
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PMID: 18295539
PDF is available here.
PDF is available here.
Abstract
Abstract
After Hurricane Katrina, the number of reported cases of West Nile neuroinvasive disease (WNND) sharply increased in the hurricane-affected regions of Louisiana and Mississippi. In 2006, a >2-fold increase in WNND incidence was observed in the hurricane-affected areas than in previous years.
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PMID: 18439367
PDF is available here.
PDF is available here.
Abstract
Influenza imposes a sizeable burden of CNS disease. Increased awareness and monitoring of CNS function is indicated, especially in infants and young children....
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PMID: 18486065
PDF is available here.
PDF is available here.
Virus Genes (36)2 2008
Abstract
These results and other studies suggest that control of virulence is polygenic, and that the SFV 5' UTR acts as a pathogenicity determinant in synergy with other determinants in the genome....
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PMID: 18264748
PDF is available here.
PDF is available here.
Abstract
Abstract
The aim of this study was to evaluate viral DNA load in paediatric patients with herpes simplex infections of the central nervous system. A real-time PCR assay for herpes simplex types 1 and 2 was developed for this 8-year retrospective study that included children with herpes simplex infection of t...
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PMID: 17976830
PDF is available here.
PDF is available here.
Journal of Neuroimmunology (194)1-2 2008
Abstract
We used IFN-gammaR1(-/-) mice to examine the target of IFN-gamma in CD8 T cell-mediated demyelination. In IFN-gammaR1(-/-)RAG1(-/-) recipients, demyelination is decreased, but not eliminated, while viral titers are significantly increased when compared to IFN-gammaR1(+/+)RAG1(-/-) recipients. IFN-ga...
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PMID: 18082272
PDF is available here.
PDF is available here.
Abstract
Infections caused by enteroviruses, rabies, adenoviruses, and Nipah and Hanta viruses are discussed. Several studies defined the pattern of MR imaging findings in these disease processes that reflect parenchymal infiltration with inflammatory cells, typically visualized as areas of low attenuation o...
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PMID: 18319156
PDF is available here.
PDF is available here.
Abstract
Many viral infections can involve the central nervous systems (CNS) of fetuses, neonates, infants, and children. The pathogenesis, patterns of CNS involvement, and species of viral infection may differ in the developing fetus, infant and neonate, and early childhood. Familiarity with the clinical co...
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PMID: 18319158
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Diagnosis of CNS viral infections is challenging; yet, significant progress in laboratory diagnosis of CNS infections has come through applications of serology and polymerase chain reaction (PCR) to CSF and tissues. Advances in molecular and laboratory techniques, together with neuroimaging, epidemi...
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PMID: 18319152
PDF is available here.
PDF is available here.
Abstract
Serious viral CNS infections during childhood appear to be associated with the later development of schizophrenia and nonaffective psychoses. The association with specific viruses suggests that the risk is related to infectious agents with a propensity to invade the brain parenchyma....
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PMID: 18056223
PDF is available here.
PDF is available here.
Abstract
We retrieved 89 articles reporting on severe CMV infection in 290 immunocompetent adults. Among these reports, the gastrointestinal tract (colitis) and the central nervous system (meningitis, encephalitis, transverse myelitis) were the most frequent sites of severe CMV infection. Manifestations from...
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PMID: 18371229
PDF is available here.
PDF is available here.
Abstract
Abstract
The CVB have long been recognized as significant pathogens of infants and children. Although the major route for transmission of the CVB is fecal-oral, vertical transmission from mother to infant is also possible. This review will focus on the more common or clinically relevant CVB-related syndromes...
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PMID: 18357772
PDF is available here.
PDF is available here.
Abstract
The most of registered in Poland cases of encephalitis and meningitis have viral aetiology. Confirmation of viral central nervous system (CNS) infection and diagnosis of pathogenic agent is critical for therapeutic treatment, especially if antiviral chemotherapy is available. The aim of this work wa...
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PMID: 19143179
PDF is available here.
PDF is available here.
Abstract
It is intriguing to note that RABV progression is interrupted neither by destruction of the infected neuron nor by the immune response. Thus, it is likely that RABV has developed a subversive strategy to avoid functional neuron impairment, which compromises the infectious cycle. Rabies virus neuroin...
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PMID: 18634503
PDF is available here.
PDF is available here.
Abstract
The neurological complications of AIDS (NeuroAIDS) include neurocognitive impairment and HIV-associated dementia (HAD; also known as AIDS dementia and HIV encephalopathy). HAD is the most significant and devastating central nervous system (CNS) complications associated with HIV infection. Despite re...
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PMID: 18288880
PDF is available here.
PDF is available here.
Abstract
We examined whether the induction of immunosuppressive neuropeptides, in particular CGRP, may contribute to the ability of RABV to evade immune responses. RABV infection of mice caused a strong induction of calcitonin gene-related peptide (CGRP) in neurons and fibres in the neocortex as well as in t...
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PMID: 18634468
PDF is available here.
PDF is available here.
Inflammatory responses in the nervous system of mice infected with a street isolate of rabies virus.
Abstract
We studied the neuropathology and CNS gene expression patterns in a murine model of rabies using a 'street' isolate RV61. This virus was derived from a human case of disease. In this model, infection of the CNS progresses rapidly following inoculation in the periphery, leading to extensive virus rep...
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PMID: 18634467
PDF is available here.
PDF is available here.
Mayo Clinic Proceedings (82)12 2007
Abstract
Abstract
An outbreak of neurologic EV71 disease occurred in Denver, Colorado, during 2003 and 2005. Likely, EV71 disease remains unrecognized in other parts of the United States, because EV-PCR of cerebrospinal fluid frequently yields negative results. EV-PCR of specimens from the respiratory and gastrointes...
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PMID: 17879907
PDF is available here.
PDF is available here.
Pediatric Neurology (37)3 2007
Abstract
We studied 21 children with suspected HHV-6 infection, drawn from a prospective, large-scale study of neurologic infections in Finland. Human herpesvirus-6 polymerase chain reaction was performed on cerebrospinal fluid samples, and antibody tests were performed on serum and cerebrospinal fluid. We i...
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PMID: 17765806
PDF is available here.
PDF is available here.
Abstract
Journal of Neurosurgery (107)1 2007
Abstract
Compared with rodent models that are limited by very small brains, the dog is an excellent preclinical model in which to assess the distribution and safety of emerging gene transfer technologies. In this study, short-term gene transfer was evaluated as a prelude to long-term expression and safety st...
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PMID: 17639883
PDF is available here.
PDF is available here.
Movement Disorders (22)8 2007
Abstract
Abstract
Invasion of human immunodeficiency virus (HIV) into the central and peripheral nervous system produces a wide range of neurological symptoms, which continue to persist even with adequate therapeutic suppression of the systemic viremia. The development of therapies designed to prevent the neurologica...
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PMID: 18040840
PDF is available here.
PDF is available here.
Abstract
1) PCR proved to be a suitable method for diagnosing VZV-mediated nervous system infections. 2) VZV DNA can be present in CSF of patients with a wide range of neurological symptoms, even with no history of either herpes zoster or varicella. 3) VZV DNA detection in CSF needs to be interpreted with ca...
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PMID: 17703403
PDF is available here.
PDF is available here.
Abstract
Over the last decade, many cases of multiphasic ADEM have been reported. The occurrence of relapses potentially poses a diagnostic dilemma for the treating physician, as it may be difficult to distinguish multiphasic ADEM from multiple sclerosis (MS). Many retrospective patient studies have thus foc...
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PMID: 17495616
PDF is available here.
PDF is available here.
Epidemiology and Infection (135)4 2007
Abstract
The United States national mortality statistics and HIV/AIDS surveillance data were analysed to determine trends in encephalitis-associated deaths and to assess the impact of HIV infection on those deaths during 1979-1998, a period when ICD-9 codes were used for coding deaths in the United States. A...
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PMID: 16938142
PDF is available here.
PDF is available here.
Abstract
Abstract
Progesterone has neuroprotective effects including augmentation of myelination in the central and peripheral nervous system. This study was designed to determine if demyelinating lesions in the cerebellum resulting from canine distemper virus (CDV) infection are associated with progesterone levels....
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PMID: 16919304
PDF is available here.
PDF is available here.
Abstract
The prevalence of HIV-associated brain disorders is reportedly increasing due, in part, to the prolonged life span of individuals who are surviving well on highly active antiretroviral treatments (HAART). While clinicians report CNS-related deficits that are more subtle in presentation than the fran...
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PMID: 18040818
PDF is available here.
PDF is available here.
Abstract
On May 15 and 16, 2006, the National Institute of Mental Health sponsored a workshop designed to facilitate discussion and collaboration between basic and clinical investigators in neuroAIDS. Day 2 of the meeting featured a series of talks by clinical investigators. Three of these (those by J. McArt...
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PMID: 18040822
PDF is available here.
PDF is available here.
Validation of laboratory screening criteria for herpes simplex virus testing of cerebrospinal fluid.
Abstract
We implemented screening criteria based on CSF values and host immune status to guide testing. All CSF samples submitted for HSV PCR analysis from January 1999 through December 2004 were included in the study. Specimens from patients with human immunodeficiency virus, a history of transplants, an ag...
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PMID: 17202281
PDF is available here.
PDF is available here.