Abstract
We describe two patients with cerebral manifestations of influenza A (H1N1)v. A 13-year-old boy developed severe cerebral oedema and increased intracranial pressure despite medical treatment and external drainage of cerebrospinal fluid. He was treated with bifrontal decompressive craniectomy with go...
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PMID: 21118668
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Abstract
An outbreak of acute encephalitis syndrome (AES) among children from Nagpur division, Maharashtra was investigated to confirm the aetiology and to describe clinico-epidemiological features.
AES cases among children<15 yr, from Nagpur division, hospitalized between June-September 2007, were investiga...
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PMID: 20966517
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Abstract
Acute encephalopathy is one of the most serious complications of pediatrics viral infections including influenza. It is characterized clinically by rapidly progressive brain damage following viral infection, and pathologically by brain edema in the absence of direct invasion of the virus and inflamm...
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PMID: 20845744
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Abstract
In Japan, about 20 million people were infected with pandemic (H1N1) 2009 virus between July 2009 and March 2010. About 60% of them were under 15 years, but only 38 pediatric deaths were reported. The reasons for hospitalization were respiratory and neurological complications. Children with pneumoni...
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PMID: 20845741
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Abstract
We demonstrated the importance of the complement system within the CNS in the development of behavioral seizures following Theiler's murine encephalomyelitis virus (TMEV) infection. C57BL/6 mice, deficient in complement component C3, developed significantly fewer behavioral seizures following TMEV i...
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PMID: 20427530
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Abstract
We have analyzed changes in the expression of mir-146a in primary human fetal microglial cells upon infection with HIV-1 and found increased expression of mir-146a. We further show that CCL8/MCP-2 is a target for mir-146a in HIV-1 infected microglia, as overexpression of mir-146a prevented HIV-induc...
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PMID: 20181935
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Abstract
We report on an adolescent female who failed to respond to induction immunochemotherapy and was salvaged by allogeneic hematopoietic stem cell transplantation from her human leukocyte antigen-identical, Epstein-Barr virus-seropositive brother leading to rapid clearance of Epstein-Barr virus from blo...
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PMID: 20508480
PDF is available here.
Phenix Lan Quan,
Thor A Wagner,
Thomas Briese,
Troy R Torgerson,
Mady Hornig,
Alla Tashmukhamedova,
Cadhla Firth,
Gustavo Palacios,
Ada Baisre-De-Leon,
Christopher D Paddock,
Stephen K Hutchison,
Michael Egholm,
Sherif R Zaki,
James E Goldman,
Hans D Ochs and
W Ian Lipkin
Abstract
We detected an astrovirus as the causative agent for encephalitis in a 15-year-old boy with agammaglobulinemia; several laboratories had failed to identify the agent. Our findings expand the spectrum of causative agents associated with encephalitis and highlight unbiased molecular technology as a va...
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PMID: 20507741
PDF is available here.
Abstract
We present a rare and interesting case of a cerebellopontine angle cyst containing ectopic choroid plexus tissue in a 26 year-old female. Surgical resection was performed, and histological examination confirmed the presence of choroid plexus in the cyst wall. This is the first reported case of ectop...
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PMID: 19806308
PDF is available here.
Abstract
We describe a rare case of Influenza B-associated encephalopathy with hemorrhagic lesions of the corpus callosum. A 12-year-old Caucasian girl presented a 24-h fever followed by partial seizure, secondarily generalized, and disturbance of consciousness. Magnetic resonance imaging on Day 2 of her ill...
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PMID: 20338734
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Abstract
We present a case of a young woman in puerperium period, who developed herpetic encephalitis. Despite proper treatment patient required long term hospitalization in ICU, where she was placed in pharmacological coma. Despite severe course of the disease no neurological sequelae were observed. The aim...
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PMID: 20568406
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Abstract
To understand the impact of surveillance system of viral encephalitis during 2005-2007 in Baoji city of Shaanxi province, to find epidemiological characteristic, control strategies and measurement to Japanese Encephalitis (JE).
Establishing the monitoring system of viral encephalitis, special monito...
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PMID: 20575272
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Abstract
We examined 14 patients with encephalitis (8 JE, 1 dengue, 5 nonspecific encephalitis) and 10 healthy controls. CSF cytokines (IL-1beta, IL-6, IL-10, IL-12p70, TNF-alpha, IL-8) and chemokines (IP-10, MCP-1, MIG, IL-8 and RANTES) were estimated using Cytometric Bead Array, compared with controls and...
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PMID: 20153811
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Abstract
Rabies is a serious zoonotic disease. Recovery has been well documented in only six human patients worldwide. Five of those patients had received rabies vaccinations before illness; one had not received rabies vaccination but survived infection after prolonged intensive care. In most of these surviv...
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PMID: 20186117
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Abstract
We report a case of encephalitis diagnosed as the H1N1 virus infection. We describe a 17-year-old patient who had a seizure attack, diagnosed with a H1N1 virus infection via real time reverse-transcriptase polymerase chain reaction (RT-PCR). The H1N1 virus infection can be causative of the encephali...
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PMID: 20191027
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Abstract
We therefore sought to determine whether microRNA targets could be engineered into VSV to ameliorate its neuropathogenicity. Using a panel of recombinant VSVs incorporating microRNA target sequences corresponding to neuron-specific or control microRNAs (in forward and reverse orientations), we teste...
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PMID: 19906911
PDF is available here.
Abstract
We have previously shown that susceptibility to HSE was host-strain dependent, as severe, lethal HSE developed after injection of human Herpes simplex type 1 virus (HSV-1) into the whiskers area of DA rats, whereas PVG rats remained completely asymptomatic. In the present study we investigated the e...
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PMID: 20806060
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Abstract
149 children were enrolled in the study. 129 had a lumbar puncture and CSF examination; 66 had a normal CSF white cell count. A clinical or laboratory-based diagnosis was possible for 140 children, but a definite pathogen was identifiable for only 55 (37%). The diagnoses included bacterial meningiti...
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PMID: 20522297
PDF is available here.
M Ogata,
T Satou,
R Kawano,
S Takakura,
K Goto,
J Ikewaki,
K Kohno,
T Ikebe,
T Ando,
Y Miyazaki,
E Ohtsuka,
Y Saburi,
T Saikawa and
J Kadota
Abstract
We next analyzed plasma concentrations of IL-6, IL-10 and tumor necrosis factor-alpha among patients who displayed high-level plasma HHV-6 DNA and found elevated IL-6 concentrations preceding HHV-6 infection in patients who developed CNS dysfunction. (Mean+/-s.d.: 865.7+/-1036.3 pg/ml in patients wi...
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PMID: 19465942
PDF is available here.
Abstract
We report acute encephalopathy associated with influenza A infection in 3 adults. We detected high cerebrospinal fluid (CSF) and plasma concentrations of CXCL8/IL-8 and CCL2/MCP-1 (CSF/plasma ratios > or =3), and interleukin-6, CXCL10/IP-10, but no evidence of viral neuroinvasion. Patients recovered...
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PMID: 20031062
PDF is available here.
Abstract
Nipah virus (NiV) is a highly pathogenic paramyxovirus that was first isolated in 1999 during an outbreak in Malaysia. In contrast to other paramyxoviruses NiV infects many mammalian species. Because of its zoonotic potential, the high pathogenicity and the lack of therapeutic treatment, NiV was cla...
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PMID: 19967130
PDF is available here.
Abstract
Vegetative nerve functional disturbance is the main clinical feature of brainstem encephalitis caused by EV71 infection in children. An early identification and treatment of pulmonary edema or hemorrhage is of great importance....
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PMID: 20113599
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Abstract
The appropriate management of acute viral encephalitis is a challenge. Clinical picture includes general symptoms and a wide range of neurological signs. Etiological diagnosis cannot be performed only by clinical means and depends on neuroimaging studies and cerebrospinal fluid molecular analyses. I...
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PMID: 20464335
PDF is available here.
Abstract
We reasoned that ART carriage could be facilitated within blood-borne macrophages traveling across the blood-brain barrier. To test this idea, an HIV-1 encephalitis (HIVE) rodent model was used where HIV-1-infected human monocyte-derived macrophages were stereotactically injected into the subcortex...
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PMID: 19535632
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Abstract
Physical examination of the rabbit revealed bilateral conjunctivitis, hypersalivation, and severe signs of CNS dysfunction such as incoordination, intermittent myoclonic seizures, and opisthotonus. Results of hematologic and serum biochemical analyses revealed only lymphopenia, a relative monocytosi...
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PMID: 19566457
PDF is available here.
Abstract
Between 1993 and 1999, encephalitis caused by morbillivirus was diagnosed by immunohistochemistry and histology in six lynx (Lynx canadensis) and one bobcat (Lynx rufus) in the eastern Canadian provinces of New Brunswick and Nova Scotia. Five of the six cases in lynx occurred within an 11-mo period...
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PMID: 19617471
PDF is available here.
Abstract
Human herpesvirus 6 (HHV-6) isolates are classified into two variants, HHV-6A and HHV-6B, based on distinct genetic, antigenic and biological characteristics. HHV-6 has been associated with encephalitis in children recently. This study aimed to establish a real time PCR assay for simultaneous detect...
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PMID: 19951517
PDF is available here.
Abstract
I review the recent advances from the two research programs on influenza and other encephalopathy in Japan supported by MEXT and MHLW....
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PMID: 19927990
PDF is available here.
Abstract
Human rabies encephalitis by a vampire bat bite in an urban area of Colombia A case of rabies encephalitis is presented in a teenaged male, which developed four months after a bat bite in the urban area of Floridablanca, Santander Province, Colombia. The complex clinical manifestations prevented the...
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PMID: 20128344
PDF is available here.
Abstract
Dengue infection has been implicated as a cause of neurologic manifestations since the beginning of the 20th century. An enhanced surveillance system for encephalitis and aseptic meningitis developed by the Puerto Rico Department of Health in collaboration with the Dengue Branch, Centers for Disease...
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PMID: 19530552
PDF is available here.
Abstract
Twelve, (4.7%), cases were diagnosed as meningitis. Risk factors significantly associated with meningitis were: age < 12 months, lethargy, irritability, vomiting, nuchal rigidity, bulging fontanel, headache, drowsiness, toxicity, coma, complex seizure, and prior antibiotic use, (p < 0.05). All child...
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PMID: 19438132
PDF is available here.
Abstract
We herein report an investigation of nitric oxide (NO) levels, a candidate molecule for neuronal toxicity and dysfunction, in the brain of rabbits during experimental neurological infection by bovine herpesvirus 5 (BoHV-5). Spectrophotometry for NO products (NO(2) and NO(3)) revealed that NO levels...
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PMID: 19115129
PDF is available here.
Abstract
We describe the clinical, EEG, and MRI features of children with reduced diffusion in the unilateral hemispheres. Seven patients with reduced diffusion in the subcortical white matter of the unilateral hemisphere alone were identified. Their median age was 32 months. Human herpesvirus 6 infection wa...
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PMID: 18573669
PDF is available here.
Abstract
Our analysis indicates that the clinical course, laboratory data, and brain imaging findings of influenza-associated encephalopathy exhibits patterns that vary with age....
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PMID: 19291091
PDF is available here.
Gajanan N Sapkal,
Vijay P Bondre,
Pradip V Fulmali,
Pooja Patil,
V Gopalkrishna,
Vipul Dadhania,
Vijay M Ayachit,
Daya Gangale,
K P Kushwaha,
A K Rathi,
Shobha D Chitambar,
Akhilesh Chandra Mishra and
Milind M Gore
Abstract
An outbreak of viral encephalitis occurred in northern India in 2006. Attempts to identify an etiologic agent in cerebrospinal fluid by using reverse transcription-PCR showed positivity to enterovirus (EV) in 66 (21.6%) of 306 patients. Sequencing and phylogenetic analyses of PCR products from 59 (8...
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PMID: 19193277
PDF is available here.
Abstract
We selected the mouse encephalitis model. Mice were immunized with a single dose of infective dengue 2 virus and different markers of both branches of the induced adaptive immunity were measured. Animals elicited a broad antibody response against the four dengue virus serotypes, but neutralizing act...
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PMID: 19210225
PDF is available here.
Abstract
Continued Nipah encephalitis outbreaks in Bangladesh highlight the need for preventative and control measures to reduce transmission from bats to humans and human-to-human spread. Qualitative research was conducted at the end of an encephalitis outbreak in Faridpur, Bangladesh in May 2004 and contin...
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PMID: 19141846
PDF is available here.
Abstract
We conducted a retrospective register-based study on the Swedish National Inpatient Register, which covers all Swedish hospitals. In 1987-1998, a total number of 14,250 hospitalized individuals had an influenza diagnosis (population incidence: 137 per million person-years). In-hospital mortality was...
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PMID: 19295216
PDF is available here.
Abstract
We present a 3.5-year-old patient with diagnosed encephalitis, probably viral etiology. In comparison with the prevalence of systemic viral infections, viral central nervous system disease in uncommon. We describe a course of diseases--diagnosis and treatment. In the central nervous system were obse...
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PMID: 19899599
PDF is available here.
Acosta Belsy,
Valdés Odalys,
Piñón Alexander,
Savón Clara,
Goyenechea Angel,
Gonzalez Grehete,
Gonzalez Guelsys,
Sarmiento Luis,
Más Pedro,
Guzmán MarÃa Guadalupe,
Llop Alina,
Perez Breña Ma Pilar and
Casas Inmaculada
Abstract
Our data demonstrate a surprising result about the identification of an unusual association of viruses of the species Human adenovirus D with different clinical syndromes. This observation could be evaluated as a possible indicator of the emergence of a novel strain but further studies are required....
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PMID: 19280320
PDF is available here.
Abstract
30 encephalitis patients including 16 JE, 2 HSE and 12 nonspecific whose median age was 24 (13-53) years were prospectively evaluated. P3 was studied after a median duration of 3 months. MMSE was abnormal in 19 patients. CzP3 was abnormal in 6; 5 of whom had abnormal MMSE. MRI was abnormal in 18 sho...
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PMID: 19280797
PDF is available here.
Abstract
We report on an 8-year-old boy with acute tetraventricular hydrocephalus caused by mumps meningoencephalitis and treated by external ventricular drainage and following ventriculoperitoneal shunt.
Copyright 2009 S. Karger AG, Basel....
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PMID: 20051701
PDF is available here.
Abstract
On July 22, 2008, a previously healthy 8 years old boy from Jujuy, Argentina, died of encephalitis later confirmed as rabies. Diagnosis was made on the basis rabies-specific antibodies presence in a serum sample and it was confirmed by detection of the viral antigens in brain necropsy using the immu...
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PMID: 20053605
PDF is available here.
Abstract
Increasing evidence supports early brain infection by human immunodeficiency virus (HIV). Definitive temporal studies determining when and within which brain cells viral DNA is present are lacking. This study utilized simian immunodeficiency virus (SIV)-infected macaques sacrificed at days 10, 21, 5...
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PMID: 19593698
PDF is available here.
Abstract
The purpose of the investigation was to study whether latent virus infection may activate in the murine brain using a model of hemorrhagic stroke. Acute intracerebral hemorrhagic stroke was induced in the internal capsule in accordance with the original technology. For experimental reproduction of v...
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PMID: 19708551
PDF is available here.
Abstract
The role of the CXC chemokine ligand 9 (CXCL9) in host defense following infection with mouse hepatitis virus (MHV) was determined. Inoculation of the central nervous system (CNS) of CXCL9-/- mice with MHV resulted in accelerated and increased mortality compared to wild type mice supporting an impor...
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PMID: 18973912
PDF is available here.