Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Hepatitis, Viral, Animal (2):
Recent article
Hepatitis, Viral, Animal
Abstract
Hepatoprotective effect of metabolism correctors has been studied on the model of experimental viral and toxic damage of the liver. Reamberin-based substrate compositions (cytoflavin and remaxol) exhibit antihypoxic effect, antioxidant activity, and cytoprotective action on the background of metabol...
|
PMID: 20919557
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Journal of Immunology (185)2 2010
Abstract
We previously reported that the adaptive immune response plays an important protective role in MHV-1-infected resistant B6 mice and that both CD4 and CD8 T cells play a significant role in the development of morbidity and lung pathology following intranasal MHV-1 infection of susceptible C3H/HeJ and...
|
PMID: 20554960
PDF is available here.
PDF is available here.
Poultry Science (89)6 2010
Abstract
The live attenuated vaccine against duck viral hepatitis currently available in Korea requires special freezers for storage and transportation with extra costs involved. The development of a lyophilization stabilizer for live attenuated duck viral hepatitis virus (DHV) vaccines, therefore, has been...
|
PMID: 20460663
PDF is available here.
PDF is available here.
Abstract
Two outbreaks of severe acute disease characterised by hepatitis and hydropericardium were observed in young goslings on large-scale farms in Hungary. Histological examination revealed multifocal necrotic areas and two types of intranuclear inclusion bodies adjacent to necrotic areas...
|
PMID: 20159738
PDF is available here.
PDF is available here.
Journal of General Virology (91)Pt 3 2010
Abstract
We compared evolutionary features in acute resolving and persistent GBV-B infection. We detected no evidence of evolution in four animals with clearance during weeks 9-12, whereas three animals with clearance during weeks 13-26 had several substitutions in their polyprotein sequence. A single tamari...
|
PMID: 19906942
PDF is available here.
PDF is available here.
Abstract
Previous study on TNFR1-mediated hepatocyte apoptosis has been implicated in the development of fulminant viral hepatitis. To interfere with the potentially effective target, plasmid named p-mTNFR1shRNA complimentary to the sequence responsible for mTNFR1 was also constructed and further confirmed b...
|
PMID: 20960284
PDF is available here.
PDF is available here.
Journal of Virology (84)4 2010
Abstract
We have investigated the role of the nucleocapsid protein in MHV-induced disease. The multifunctional nucleocapsid protein is complexed with the genomic RNA, interacts with the viral membrane protein during virion assembly, and plays an import role in enhancing the efficiency of transcription. A pai...
|
PMID: 20007284
PDF is available here.
PDF is available here.
Acta Microbiologica Sinica (49)12 2009
Abstract
The results of RT-PCR, indirect immunofluorescence assay and immunoelectron microscope showed that infectious virus was rescued. After inoculating into SPF chick embryos, the rescued virus was able to kill embryos with pathogenic changes. CONCLUSION: This is the first report on generation of infecti...
|
PMID: 20222452
PDF is available here.
PDF is available here.
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology (17)10 2009
Abstract
Abstract
The genome of DHV-N G consists of 7774 nucleotides excluding a poly (A) tail of 12 nucleotides. It contains a single large open reading frame encoding a polypeptide of 2251 amino acid residues. The length of 3' UTR of DHV-N G is 366 nucleotides, which is 52 nucleotides longer than that of DHV-1 C80...
|
PMID: 19623953
PDF is available here.
PDF is available here.
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology (17)3 2009
Abstract
To investigate role of CD4-CD8- T cells in murine hepatitis virus type 3 (MHV-3) induced chronic viral hepatitis in C3H/Hej mice and to identify their surface markers.
Thirty C3H/Hej mice received 10 Pfu MHV-3 intraperitoneally, the CD4-CD8- T cells were isolated using magnetic bead sorting on 0, 4,...
|
PMID: 19335979
PDF is available here.
PDF is available here.
Abstract
Hepatology (49)2 2009
Abstract
We present insight into the immunological mechanisms involved in FH caused by murine hepatitis virus strain 3 (MHV-3), indicating a critical role for CD4(+)CD25(+) regulatory T cells (Tregs) and production of the novel Treg effector molecule FGL2. Before infection with MHV-3, susceptible BALB/cJ mic...
|
PMID: 19085958
PDF is available here.
PDF is available here.
Journal of Immunology (182)2 2009
Abstract
I IFNs is one of the fundamental aspects of innate immune responses against viruses. Plasmacytoid dendritic cell-derived type I IFNs are of prime importance for the initial control of highly cytopathic viruses such as the mouse hepatitis virus (MHV). The aim of this study was to determine the major...
|
PMID: 19124753
PDF is available here.
PDF is available here.
Genes and Immunity (10)1 2009
Abstract
We cloned and characterized the woodchuck IL-8 cDNA and genomic DNA. Sequence analysis revealed that the organization of the wk-IL-8 gene is similar to that of the human IL-8 gene and consists of four exons and three introns. Woodchuck IL-8 protein exhibits the conserved ELRCXC motif of IL-8 and sho...
|
PMID: 18971938
PDF is available here.
PDF is available here.
Abstract
These results indicate that AC may promote recovery from viral hepatitis and inhibit HBV replication....
|
PMID: 19589248
PDF is available here.
PDF is available here.
Journal of Immunology (182)1 2009
Abstract
We crossed the TNF-alpha knockout mouse and HBsAg-Tg mouse to establish the HBsAg-Tg/TNF-alpha KO mouse, and examined the influence of TNF-alpha on liver injury. The severity of liver damage, as determined by serum alanine aminotransferase activity, was approximately 100 times greater in HBsAg-Tg/TN...
|
PMID: 19109170
PDF is available here.
PDF is available here.
Abstract
The role of the CXC chemokine ligand 9 (CXCL9) in host defense following infection with mouse hepatitis virus (MHV) was determined. Inoculation of the central nervous system (CNS) of CXCL9-/- mice with MHV resulted in accelerated and increased mortality compared to wild type mice supporting an impor...
|
PMID: 18973912
PDF is available here.
PDF is available here.
Abstract
We generated spreading-competent chimeric DHBVs with L proteins in which segments 22-90 (Du-He4) or its subsegments 22-37 and 37-90 (Du-He2, Du-He3) are derived from HHBV. Infectivity for duck hepatocytes of Du-He4 and Du-He3, though not Du-He2, was indeed clearly reduced compared to wild-type DHBV....
|
PMID: 19057662
PDF is available here.
PDF is available here.
Abstract
Our result implied that the VP1 probably was the major virulent determinant of DHV-1. In addition, 13 DHV-1 strains from different area were analyzed in phylogeny and they can be grouped into four distinct lineages. The new-identified JX strain was grouped into one lineage with A66 and C80 strains,...
|
PMID: 18486957
PDF is available here.
PDF is available here.
Journal of General Virology (89)Pt 12 2008
Abstract
We concentrated this antigen from the supernatants of persistently infected primary duck liver cell cultures by ammonium sulphate precipitation, adsorption chromatography over concanavalin A Sepharose, preparative isoelectric focusing and molecular sieve chromatography. The combined treatment of duc...
|
PMID: 19008388
PDF is available here.
PDF is available here.
Journal of Virology (82)24 2008
Abstract
We report an unexpected correlation between the expression of a functional X domain encoded by the hepatotropic mouse hepatitis virus strain A59 (MHV-A59), the high-level production of inflammatory cytokines, and the induction of acute viral hepatitis in mice. X-domain (also called macro domain) pro...
|
PMID: 18922871
PDF is available here.
PDF is available here.
Abstract
We have found that CD11c defines a distinct subset of NK cells (NK1.1(+)CD3(-)) in the murine liver whose function was currently unknown. In naïve animals, CD11c(+) liver NK cells displayed an activated phenotype and possessed enhanced effector functions when compared with CD11c(-) liver NK cells...
|
PMID: 18664530
PDF is available here.
PDF is available here.
Virus Research (137)1 2008
Abstract
I (DHV-I), originally taken from the field in southeast China was determined. It was 7691 nucleotides long and had 5'- and 3'-terminal non-coding regions of 626 and 315 nucleotides, respectively. The poly(A) tail contained at least 22 residues and the single open reading frame encoded a polypeptide...
|
PMID: 18585813
PDF is available here.
PDF is available here.
Journal of Virology (82)20 2008
Abstract
I interferon (IFN) response in several cell types in vitro despite the fact that the type I IFN response is important in protecting the mouse from infection in vivo. When infected with MHV, mice deficient in IFN-associated receptor expression (IFNAR(-/-)) became moribund by 48 h postinfection. MHV a...
|
PMID: 18667505
PDF is available here.
PDF is available here.
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology (16)9 2008
Abstract
Our results suggest that liver NK cells may play a pivotal role in the pathogenesis of fulminant viral hepatitis....
|
PMID: 18822205
PDF is available here.
PDF is available here.
Journal of General Virology (89)Pt 9 2008
Abstract
The establishment of clonal infection of hepatitis C virus (HCV) in a small-animal model is important for the analysis of HCV virology. A previous study developed models of molecularly cloned genotype 1a and 2a HCV infection using human hepatocyte-transplanted chimeric mice. This study developed a n...
|
PMID: 18753219
PDF is available here.
PDF is available here.
Virus Genes (37)1 2008
Abstract
We propose that the three genetic groups should be termed DHV types A, B, and C. All DHV-1 strains grouped in genotype A, whereas the new serotype strains isolated in Taiwan and the new serotype strains isolated in South Korea clustered into genotypes B and C, respectively, suggesting a potential ge...
|
PMID: 18437547
PDF is available here.
PDF is available here.
Antiviral Research (79)2 2008
Abstract
We examined the effect of the polyphenolic extract from Geranium carolinianum L. (PPGC) on HBV replication both in vitro and in vivo. In the human HBV-transfected liver cell line HepG(2) 2.2.15, PPGC effectively suppressed the secretion of the HBV antigens in a dose-dependent manner with IC(50) valu...
|
PMID: 18423640
PDF is available here.
PDF is available here.
Abstract
Postmortal examinations revealed a severe multifocal to coalescing necotizing hepatitis with numerous intranuclear basophilic inclusion bodies. Transmission electron microscopy of the liver resulted in the finding of adenovirus like particles arranged in paracrystalline arrays within the nuclei of h...
|
PMID: 18773508
PDF is available here.
PDF is available here.
Nature Medicine (14)7 2008
Abstract
We have analyzed the role of platelet-derived vasoactive serotonin during virus-induced CD8(+) T cell-dependent immunopathological hepatitis in mice infected with the noncytopathic lymphocytic choriomeningitis virus. After virus infection, platelets were recruited to the liver, and their activation...
|
PMID: 18516052
PDF is available here.
PDF is available here.
Virus Research (135)1 2008
Abstract
We attempted to define the quasispecies variation of GBV-B 17 days post-infection, by PCR amplification of GBV-B RNA extracted from serum and liver. Cloning followed by sequencing revealed a small number of changes in the three regions studied, namely the 5' untranslated region, E2 and NS3. Moreover...
|
PMID: 18455258
PDF is available here.
PDF is available here.
Journal of Ethnopharmacology (118)1 2008
Abstract
The traditional Chinese medicine Oenanthe javanica (OJ) has been used for many years, mainly for the treatment of inflammatory conditions including hepatitis. In this study, human hepatoma Hep G2.2.15 cells culture system and duck hepatitis B virus (DHBV) infection model were used as in vivo and in...
|
PMID: 18495393
PDF is available here.
PDF is available here.
Abstract
The prevalence of woodchuck hepatitis virus (WHV) in wild populations of woodchucks is understudied and therefore unclear. Although infection is common in the southeastern region of Pennsylvania and surrounding states, it is virtually absent in New York and New England. Sera were collected from wild...
|
PMID: 18634221
PDF is available here.
PDF is available here.
Abstract
These results indicate that viral permissivity of KC and LSEC is involved in the decrease of IL-10 and PGE2, while KC may play an additional role in the apoptosis of NK and NK T cells during acute viral hepatitis....
|
PMID: 18336588
PDF is available here.
PDF is available here.
Journal of General Virology (89)Pt 5 2008
Abstract
These results also highlight the importance of antiviral drug potency and an effective DNA immunization protocol for the design of therapeutic vaccines against chronic hepatitis B....
|
PMID: 18420797
PDF is available here.
PDF is available here.
Abstract
Short-term antiviral therapy with the nucleoside analogue entecavir (ETV), given at an early stage of duck hepatitis B virus (DHBV) infection, restricts virus spread and leads to clearance of DHBV-infected hepatocytes in approximately 50% of ETV-treated ducks, whereas widespread and persistent DHBV...
|
PMID: 18206204
PDF is available here.
PDF is available here.
Abstract
Fowl adenoviruses (FAdV) are generally considered ubiquitous, but certain serotypes and strains are known to be associated with primary diseases, such as inclusion body hepatitis (IBH). Fifty-two FAdV isolates were collected from the provinces of Ontario and Quebec over a 4-year period. These 2 prov...
|
PMID: 18505186
PDF is available here.
PDF is available here.
AADE editors' journal (15)4 2008
Abstract
The Tibetan herb Potentilla anserina L. has been widely used in China for many thousands of years to treat hepatitis-B. Bioassay-guided fractionation of the ethanol extract of the rhizomes led to the isolation of a triterpenoid saponin (TS) that was determined to be 2alpha,3beta,19alpha-trihydroxyur...
|
PMID: 18337074
PDF is available here.
PDF is available here.
Avian Pathology (37)2 2008
Abstract
Duck hepatitis can be caused by four types of viruses: duck hepatitis virus (DHV) type 1 (DHV-1), DHV-1a (a variant strain of DHV-1), DHV-2 and DHV-3. In Korea, duck hepatitis has been associated with two types of DHV-1, original DHV-1 type-specific strain (DHV-1s) and the recently reported DHV-1 va...
|
PMID: 18393095
PDF is available here.
PDF is available here.
Journal of Virology (82)6 2008
Abstract
Inoculation with the neurotropic JHM strain of mouse hepatitis virus (JHMV) into the central nervous system (CNS) of mice results in an acute encephalitis associated with an immune-mediated demyelinating disease. During acute disease, infiltrating CD8(+) T cells secrete gamma interferon (IFN-gamma)...
|
PMID: 18160433
PDF is available here.
PDF is available here.
Journal of Virology (82)6 2008
Abstract
We investigated virus-specific T-cell responses in marmosets infected with GBV-B. Gamma interferon (IFN-gamma) enzyme-linked immunospot (ELISPOT) assay responses in the peripheral blood of two marmosets were assessed throughout the course of GBV-B infection. These T-cell responses were directed agai...
|
PMID: 18094181
PDF is available here.
PDF is available here.
Journal of Virology (82)5 2008
Abstract
Replication of the neurotropic mouse hepatitis virus strain JHM (JHMV) is controlled primarily by CD8(+) T-cell effectors utilizing gamma interferon (IFN-gamma) and perforin-mediated cytotoxicity. CD4(+) T cells provide an auxiliary function(s) for CD8(+) T-cell survival; however, their direct contr...
|
PMID: 18094171
PDF is available here.
PDF is available here.
Avian Pathology (37)1 2008
Abstract
Five hundred and seventy-three clinical submissions with fowl adenovirus (FAdV) involvement were examined to investigate the association of different types of FAdV with clinical problems related to FAdV infection. Samples were received from 2000 to 2006 and originated from seven Canadian provinces....
|
PMID: 18202956
PDF is available here.
PDF is available here.
Journal of General Virology (89)Pt 2 2008
Abstract
Avian hepatitis E virus (avian HEV) is genetically and antigenically related to human HEV, the causative agent of hepatitis E. To identify the neutralizing epitopes on the capsid (ORF2) protein of avian HEV, four mAbs (7B2, 1E11, 10A2 and 5G10) against recombinant avian HEV ORF2 protein were generat...
|
PMID: 18198381
PDF is available here.
PDF is available here.
BMC Genomics (9)1 2008
Abstract
In this study we used coronaviruses as a model to show that vRNA indeed interferes with microarray analysis, decreasing both sensitivity and accuracy. We also demonstrate that the removal of vRNA from total RNA samples, by means of virus-specific oligonucleotide capturing, significantly reduced the...
|
PMID: 18479515
PDF is available here.
PDF is available here.
Abstract
Viral infection of the central nervous system (CNS) results in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences. One of the principal factors that directs the outcome of infection is the localized innate immune response, which is proceeded by the adapt...
|
PMID: 18508518
PDF is available here.
PDF is available here.
Abstract
We have used GBV-B infection of tamarins, which develop acute hepatitis following experimental infection, as a surrogate model to study protective immunity. As challenge virus, we first produced a GBV-B pool from an infected tamarin, which was not infected with the related GBV-A viruses. Its infecti...
|
PMID: 18041000
PDF is available here.
PDF is available here.
Journal of Viral Hepatitis (14 Suppl 1)s1 2007
Abstract
Journal of Medical Virology (79)11 2007
Abstract
Members of the family Hepadnaviridae are divided into two genera, Orthohepadnavirus (from mammalian) and Avihepadnavirus (from avian). Recombination had been found to occur among human hepatitis B virus (HBV) strains of different genotypes, or between hepadnavirus strains from human and nonhuman pri...
|
PMID: 17854046
PDF is available here.
PDF is available here.
Hepatology (46)5 2007
Abstract
These results indicate that the regulated expression of SPI-6 in hepatocytes during viral infection or following noninfectious causes of liver injury protects hepatocytes against excessively vigorous granzyme B-dependent killing but may also delay immune clearance of virally infected hepatocytes....
|
PMID: 17685438
PDF is available here.
PDF is available here.
Abstract
Differential gene expression profiles in Balb/cJ mouse model of acute hepatic failure infected with MHV-3 virus intervened by anti-hepatic failure compound (AHFC) and the changes of cytokines regulated by genes were investigated. The Balb/cj mice were divided into AHFC-intervened gro...
|
PMID: 18060630
PDF is available here.
PDF is available here.
Abstract
Four outbreaks of infectious canine hepatitis (ICH) occurring in Italy between 2001 and 2006 are reported. Three outbreaks were observed in animal shelters of southern Italy, whereas a fourth outbreak involved two purebred pups imported from Hungary few days before the onset of clinical symptoms. In...
|
PMID: 17197003
PDF is available here.
PDF is available here.
Abstract
We performed genome-wide microarray analyses of the expression patterns of mouse hepatitis coronavirus (MHV)-infected cells. At the time of MHV-induced host translational shutoff, downregulation of numerous mRNAs, many of which encode protein translation-related factors, was observed. This downregul...
|
PMID: 17490409
PDF is available here.
PDF is available here.
Abstract
These results indicate that farm pigs in Mongolia are frequently infected with presumably indigenous HEV strains of genotype 3 and could be a source of HEV infections in humans in Mongolia....
|
PMID: 17597486
PDF is available here.
PDF is available here.
Journal of Immunology (179)2 2007
Abstract
We demonstrate a potent antiviral role for CXCL10 in host defense. Instillation of MHV-CXCL10 into the CNS of CXCL10-deficient (CXCL10(-/-)) mice resulted in viral infection and replication in both brain and liver. Expression of virally encoded CXCL10 within the brain protected mice from death and c...
|
PMID: 17617609
PDF is available here.
PDF is available here.
Veterinary Pathology (44)4 2007
Abstract
A 10-year-old female Eurasian river otter (Lutra lutra) died after prolonged anorexia and weight loss in the Seoul Grand Park Zoo, Seoul, Republic of Korea. On necropsy, the liver was found to be swollen and friable with 1 lobe enlarged and necrotic. The other organs showed no significant alteration...
|
PMID: 17606519
PDF is available here.
PDF is available here.
Journal of Virology (81)13 2007
Abstract
These results indicate that MHV infection causes an inhibition of IFN-beta production at a posttranscriptional level, without altering RNA or protein stability. In contrast, MHV induced IFN-beta mRNA and protein production in the brains of infected animals, suggesting that the inhibitory mechanisms...
|
PMID: 17459917
PDF is available here.
PDF is available here.
Abstract
We found recently that 4-1BB costimulation increased the expression of IL-13 from CD4(+) T cells, as well as CD8(+) T cells. The enhanced IL-13 expression by agonistic anti-4-1BB treatment was mediated via MAPK1/2, PI-3K, JNK, mammalian target of rapamycin, NF-AT, and NF-kappaB signaling pathways. T...
|
PMID: 17389581
PDF is available here.
PDF is available here.
Avian Diseases (51)2 2007
Abstract
The present study describes a subclinical necrotizing granulomatous hepatitis in normal broilers routinely slaughtered in a medium-sized (72,000 birds per day) abattoir in the Netherlands. An exploratory investigation was scheduled on line during 20-min periods for 82 flocks (3000 birds examined per...
|
PMID: 17626499
PDF is available here.
PDF is available here.