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Viremia (0):
Recent article
Viremia
Abstract
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Veterinary Microbiology (149)1-2 2011
Abstract
These results differ from what has been reported in in vitro studies, and indicate that different PBMC subpopulations may play different roles in EHV-1 viremia.
Copyright © 2010 Elsevier B.V. All rights reserved....
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PMID: 21093993
PDF is available here.
PDF is available here.
The Lancet (377)9773 2011
Abstract
The Lancet (377)9773 2011
Abstract
We undertook a phase-2 randomised placebo controlled trial in adults awaiting kidney or liver transplantation at the Royal Free Hospital, London, UK. Exclusion criteria were pregnancy, receipt of blood products (except albumin) in the previous 3 months, and simultaneous multiorgan transplantation. 7...
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PMID: 21481708
PDF is available here.
PDF is available here.
Abstract
A recombinant live attenuated tetravalent dengue vaccine (TDV) is safe and immunogenic in adults and children in dengue-naïve populations. Data are needed in dengue endemic populations. In a phase I, randomized, controlled, blind-observer study in the Philippines, groups of participants aged 2-5, 6-...
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PMID: 21477675
PDF is available here.
PDF is available here.
Abstract
We hypothesized that a weak T regulatory cell (Treg) response might contribute to the control of viral replication in HIV controllers, but might also contribute to generalized immune activation, contributing to CD4+ T cell loss. To address these hypotheses, we measured frequencies of activated (CD38...
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PMID: 21305005
PDF is available here.
PDF is available here.
Voprosy Virusologii (56)3 2011
Abstract
The paper gives data on retherapy with lamivudine in seven HBeAg-negative chronic hepatitis B patients previously unresponsive to interferon-alpha and peginterferon-alpha2b therapy (6 unresponsive patients and 1 with recurrence). Prior to lamivudine therapy, hepatic biopsy and HBV genotyping were car...
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PMID: 21786626
PDF is available here.
PDF is available here.
Intervirology (54)1 2011
Abstract
Human herpesvirus 7 (HHV-7) is spread worldwide and has been described as a potential pathogen in immunosuppressed patients. Different clinical manifestations have been described including fever and skin rash; HHV-7 may also be a possible cofactor for cytomegalovirus disease in transplant recipients...
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PMID: 20689313
PDF is available here.
PDF is available here.
New Microbiologica (33)4 2010
Abstract
HIV-1 infection causes a severe T-cell impairment with alteration of immune response. However, in children the natural decline of lymphocytes and CD4 cells in early life makes it more difficult to monitor immunocompetence and progression of HIV-infection. Aim of this study was to characterize the CD...
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PMID: 21213588
PDF is available here.
PDF is available here.
Abstract
Annals of Internal Medicine (153)4 2010
Abstract
Proportions of patients meeting quality indicators varied, ranging from 21.5% for vaccination to 79% for the HCV genotype testing indicator. Overall, 18.5% of patients (95% CI, 18% to 19%) received all recommended care. Older age and presence of comorbid conditions were associated with lower quality...
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PMID: 20713791
PDF is available here.
PDF is available here.
Virus Research (151)2 2010
Abstract
These results demonstrate that evolution of the envelope in SHIV-infected macaques may lead to the emergence of a viral variant with altered immunological characteristics.
Copyright 2010 Elsevier B.V. All rights reserved....
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PMID: 20417670
PDF is available here.
PDF is available here.
Abstract
Patients with LCV had a higher prevalence of moderate and high levels of HCV-RNA viremia (P = .038) than those with NAE. However, there was no significant difference in HCV genotype between LCV and NAE groups (P = .211). LIMITATIONS: Small number of cases is a limitation. CONCLUSION: Viral load seem...
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PMID: 20462666
PDF is available here.
PDF is available here.
Clinical Nephrology (74)2 2010
Abstract
Mean immune response in 61 samples was 368 +/- 179 ATP ng/ml. Immune response was lower during BK virus (BKV) or CMV viremia compared to no viremia (p = 0.009 and p = 0.017), and no viremia was seen if immune response was > 380. BK or JC viruria was not associated with low immune response. Immune re...
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PMID: 20630132
PDF is available here.
PDF is available here.
Journal of Virology (84)16 2010
Abstract
We describe a new adult wild-type mouse model of chikungunya virus arthritis, which recapitulates the self-limiting arthritis, tenosynovitis, and myositis seen in humans. Rheumatic disease was associated with a prolific infiltrate of monocytes, macrophages, and NK cells and the production of monocyt...
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PMID: 20519386
PDF is available here.
PDF is available here.
Abstract
HIV infection can persist in spite of efficacious antiretroviral therapies. Although incomplete inhibition of viral replication may contribute to this phenomenon, this is largely due to the early establishment of a stable reservoir of latently infected cells. Thus, life-long antiviral therapy may be...
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PMID: 20616270
PDF is available here.
PDF is available here.
Abstract
We tested infants in Ghana. A viremia rate of 8.6% over 2 years indicates that this infection is common in children in Africa....
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PMID: 20587191
PDF is available here.
PDF is available here.
Journal of Virology (84)13 2010
Abstract
We sequentially measured the TTV loads in the plasma of four TTV-positive leukemia patients who were strongly myelosuppressed and then transplanted with haploidentical hematopoietic stem cells. The findings provide clear quantitative evidence for an extremely important role of hematopoietic cells in...
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PMID: 20410268
PDF is available here.
PDF is available here.
Journal of General Virology (91)Pt 7 2010
Abstract
I FCoV, over different time periods and with or without detectable viraemia. The colon was identified as the major site of FCoV persistence and probable source for recurrent shedding, but the virus was shown also to persist in several other organs, mainly in tissue macrophages. These might represent...
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PMID: 20237226
PDF is available here.
PDF is available here.
Abstract
The cell-mediated immune (CMI) response of foals to virulent equine herpesvirus-1 (EHV-1) infection was evaluated by multi-parameter flow cytometry (FCM). Ten 7-8-month-old EHV-1 seronegative foals were infected intranasally with virulent EHV-1 and 10 foals served as uninfected controls. Blood sampl...
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PMID: 20116862
PDF is available here.
PDF is available here.
Abstract
We have developed RepliVAX WN, a single-cycle flavivirus with an expected safety profile superior to other types of live-attenuated viral vaccines. In this report we describe studies examining RepliVAX WN safety, potency, and efficacy in a non-human primate model of WNV infection. A single immunizat...
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PMID: 20519618
PDF is available here.
PDF is available here.
Abstract
We developed a simple assay system using pseudotype viruses expressing green fluorescent protein (GFP). We prepared gfp pseudotype viruses, named gfp(FeLV-A), gfp(FeLV-B) and gfp(FeLV-C) harboring envelopes of FeLV-A, B and C, respectively. The gfp pseudotype viruses completely interfered with the s...
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PMID: 20124765
PDF is available here.
PDF is available here.
Abstract
Abstract
BACKGROUND.: Polyomavirus-associated nephropathy (PVAN) is an important cause of kidney graft loss but there is no consensus on its management. This study aimed to systematically document all published treatments for PVAN to determine the most effective therapy. METHODS.: A computerized search in ME...
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PMID: 20090569
PDF is available here.
PDF is available here.
médecine/sciences (26)5 2010
Abstract
Vojnosanitetski pregled (67)5 2010
Abstract
Activation of CMV was detected in 10/49 (20.48%) of the patients. The median posttransplantation time for the first positive PCR result was 6 weeks for the stem cell transplant patients. Viremia became negative in all the cases after the antiviral therapy with ganciclovir. CONCLUSION: Our data show...
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PMID: 20499730
PDF is available here.
PDF is available here.
Abstract
We tested the spring recrudescence hypothesis in a controlled laboratory experiment using hatching-year gray catbirds (Dumatella carolinensis) captured in northern Ohio (July-August 2006). Catbirds (n = 60) were experimentally infected (September 2006) and later examined for the effects of immunosup...
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PMID: 20496593
PDF is available here.
PDF is available here.
Veterinary Microbiology (142)1-2 2010
Abstract
Our objective was to improve our knowledge of the diverse range of signs that different CSFV strains can cause by characterising the experimental infection of domestic pigs with both a recent strain of CSFV and a divergent strain. Conventional pigs were inoculated with a genotype 2.1 isolate, that c...
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PMID: 19875252
PDF is available here.
PDF is available here.
Abstract
We inoculated young chicks with NY strains of WN virus containing either glycosylated or non-glycosylated variants of the E protein. The glycosylated variants were more virulent and had higher viremic levels than the non-glycosylated variants. The glycosylation status of the variant did not affect v...
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PMID: 20348522
PDF is available here.
PDF is available here.
Abstract
We observed that molecular detection of the virus in stool specimens commonly precedes AdV viremia, suggesting that intestinal infections may represent a common source of virus dissemination. To address this notion, we have investigated 153 consecutive allogeneic transplantations in 138 pediatric pa...
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PMID: 20147979
PDF is available here.
PDF is available here.
Abstract
Since 1998, the Aquitaine-Limousin branch of the French Blood Institute has set up a parvovirus B19 (PV B19) systematic screening on each unit of plasma to be treated by solvent-detergent procedure for virus inactivation. Parvovirus B19 nucleic acid systematic testing in plasma pools became mandator...
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PMID: 20674438
PDF is available here.
PDF is available here.
Journal of Virology (84)8 2010
Abstract
We therefore constructed a recombinant RSV expressing murine interleukin 18 (RSV/IL-18), a cytokine capable of inducing strong antiviral immune responses. In vitro RSV/IL-18 replicated at wild-type levels and produced soluble IL-18. In naïve BALB/c mice, RSV/IL-18 infection significantly increased...
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PMID: 20130064
PDF is available here.
PDF is available here.
Abstract
Intensification of antiretroviral therapy with a potent HIV-1 integrase inhibitor did not decrease persistent viremia in subjects receiving suppressive regimens, indicating that rapidly cycling cells infected with HIV-1 were not present. Eradication of HIV-1 from infected persons will require new th...
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PMID: 20156060
PDF is available here.
PDF is available here.
Abstract
We examined viral loads in simian immunodeficiency virus (SIV)-infected major histocompatibility complex (MHC)-homozygous and MHC-heterozygous Mauritian cynomolgus macaques. Chronic viremia in MHC-homozygous macaques was 80 times that in MHC-heterozygous macaques. Virus from MHC-homozygous macaques...
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PMID: 20375000
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Liver International (30)3 2010
Abstract
(i) HBsAg levels correlated with HDV viraemia in chronic HDV. (ii) Biochemical parameters did not accurately indicate the stage and grade of liver disease in chronic HDV and thus liver biopsy seems to remain the major tool for the evaluation of delta hepatitis patients....
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PMID: 19840253
PDF is available here.
PDF is available here.
Medicina Intensiva (34)2 2010
Abstract
The pandemic strain of H1N1 supposes a challenge to the health care system in general and for Intensive Care Units (ICU) in particular. Therefore, it will undoubtedly have repercussions on the organ and tissue donation process. In a possible scenario of bed shortage in the ICU and difficulties in ma...
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PMID: 19963302
PDF is available here.
PDF is available here.
Transfusion (50)2 2010
Abstract
This study is the first to systematically quantify the risks of transfusion-transmitted infections across sub-Saharan Africa. Although the results are limited by the quality and quantity of available data, these may be the most reliable estimates at this time....
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PMID: 19843290
PDF is available here.
PDF is available here.
Selection and counterselection of the rtI233V adefovir resistance mutation during antiviral therapy.
Abstract
We reported on three patients with chronic hepatitis B virus (HBV) infection for whom adefovir (ADF) therapy virologically failed, most likely due to a preexisting rtI233V HBV polymerase mutation. Here, we describe two further patients with chronic HBV infection who were found to develop the rtI233V...
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PMID: 20007398
PDF is available here.
PDF is available here.
Journal of Virology (84)4 2010
Abstract
We demonstrated that type I interferon (IFN-alpha/beta) or a combination of IFN-alpha/beta and type II IFN (IFN-gamma) delivered by a replication-defective human adenovirus 5 (Ad5) vector protected swine when challenged 1 day later with foot-and-mouth disease virus (FMDV). To gain a more comprehensi...
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PMID: 19955313
PDF is available here.
PDF is available here.
Transplantation (89)1 2010
Abstract
We demonstrated a peripheral blood DC (PBDC) deficiency in patients with biopsy-proven BKVN, raising the possibility that reduction in DC predisposed to BK reactivation.
In this study, we refined our previous analysis by comparing random posttransplant PBDC levels between an expanded...
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PMID: 20061927
PDF is available here.
PDF is available here.
Abstract
A new vaccination strategy for dengue virus (DENV) was evaluated in rhesus macaques by priming with tetravalent purified inactivated virus (TPIV) or tetravalent plasmid DNA vaccines expressing the structural prME gene region (TDNA) then boosting 2 months later with a tetravalent live...
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PMID: 19913867
PDF is available here.
PDF is available here.
Abstract
CMV-IgM and IgG antibodies assessment was not a potential discriminative test to identify congenitally infected newborns. In addition, low birth weight and small head circumference at birth failed to predict congenital CMV infection. CMV-DNA detection in umbilical cord blood at the time of delivery...
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PMID: 20130378
PDF is available here.
PDF is available here.
PLoS Pathogens (6)1 2010
Abstract
We studied viral dynamics during antiretroviral treatment of simian immunodeficiency virus (SIV) infected rhesus macaques following CD8+ T-cell depletion to test the importance of adaptive cytotoxic effects in clearance of cells productively infected with SIV. As previously described, plasma viral l...
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PMID: 20126442
PDF is available here.
PDF is available here.
Abstract
Hepatitis C virus (HCV) infection is a global medical problem. The role of Nitric oxide (NO) in chronic viral hepatitis is still unknown. It may play a prominent role as an antiviral agent that reduces its replication or as a mediator that causes accumulation of oxidative DNA damage and oncogenesis....
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PMID: 20653427
PDF is available here.
PDF is available here.
Abstract
Because varicella zoster virus (VZV) is an exclusively human pathogen, the development of an animal model is necessary to study pathogenesis, latency, and reactivation. The pathological, virological, and immunological features of simian varicella virus (SVV) infection in nonhuman primates are simila...
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PMID: 20186611
PDF is available here.
PDF is available here.
BMC Infectious Diseases (10)1 2010
Abstract
HBV core and polymerase-specific T-cell responses were detected and a low-dose viremia was observed in children after successful immunoprophylaxis treatment. Although the presence of viremia was not related to HBV-specific T-cell responses, CTLs might play a role in the control of HBV infection in c...
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PMID: 20423521
PDF is available here.
PDF is available here.
Abstract
Variants of wild-type dengue serotype 2 (DEN-2) virus containing nucleotide substitutions at positions 14, 15, or 57 in the 5' NCR were constructed by PCR-mediated site-directed mutagenesis. All three viruses containing a single point substitution demonstrated attenuation phenotype as evidenced by d...
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PMID: 20339476
PDF is available here.
PDF is available here.
Antiviral Therapy (15)1 2010
Abstract
During the first year after RTx, the incidence of intragraft CMV infection was relatively low with comparable rates in patients managed by pre-emptive valganciclovir therapy and valacyclovir prophylaxis....
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PMID: 20167988
PDF is available here.
PDF is available here.
Abstract
We speculate that during co-infection by multiple strains, a preferential extraintestinal dissemination of some variants may occur, possibly because of differential viral characteristics....
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PMID: 19644393
PDF is available here.
PDF is available here.
Journal of Virology (84)1 2010
Abstract
We provide an analysis of HCV pathogenesis during the course of infection in tupaias over a 3-year period. The animals were inoculated with hepatitis C patient serum HCR6 or viral particles reconstituted from full-length cDNA. In either case, inoculation caused mild hepatitis and intermittent viremi...
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PMID: 19846521
PDF is available here.
PDF is available here.
New England Journal of Medicine (361)25 2009
Abstract
New England Journal of Medicine (361)25 2009
Abstract
Abstract
We used SIV(agmVer90) to infect vervet AGM and pigtailed macaques (PTM). This infection results in robust viral replication in both vervet AGM and pigtailed macaques (PTM) but only induces AIDS in the latter species. We delayed the development of adaptive immune responses through combined administra...
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PMID: 20011508
PDF is available here.
PDF is available here.
Abstract
We vaccinated healthy macaques via the palatine/lingual tonsils with aldrithiol 2 (AT-2) inactivated Simian immunodeficiency virus (SIV)mac239, combined with CpG-C immunostimulatory oligonucleotide (CpG-C ISS-ODN, C274) as the adjuvant.
Macaques received 5 doses of C274 or control OD...
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PMID: 19779309
PDF is available here.
PDF is available here.
Abstract
Anti-HCV S/CO ratio was found to be highly accurate at predicting HCV viremia. The anti-HCV S/CO ratio can be used to determine whether a quantitative or qualitative HCV RNA test should be used to confirm HCV viremia in patients with a positive anti-HCV by the following criteria: if the anti-HCV S/C...
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PMID: 19949727
PDF is available here.
PDF is available here.
Abstract
Journal of Neurovirology (15)5-6 2009
Abstract
We hypothesized that natalizumab may also lead to reactivation of BK, a related human polyomavirus capable of causing morbidity in immunosuppressed groups. Patients with relapsing remitting multiple sclerosis treated with natalizumab were prospectively monitored for reactivation of BK virus in blood...
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PMID: 19670070
PDF is available here.
PDF is available here.